Details for: PCYOX1

Gene ID: 51449

Symbol: PCYOX1

Ensembl ID: ENSG00000116005

Description: prenylcysteine oxidase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 226.1722
    Cell Significance Index: -35.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 135.8403
    Cell Significance Index: -34.4600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 88.9433
    Cell Significance Index: -36.6400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 73.0319
    Cell Significance Index: -34.4800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 70.9157
    Cell Significance Index: -28.8100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 51.6973
    Cell Significance Index: -34.6900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 30.1757
    Cell Significance Index: -28.8100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 28.6547
    Cell Significance Index: -35.3300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.0238
    Cell Significance Index: -32.2100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.9583
    Cell Significance Index: -35.3500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.2143
    Cell Significance Index: -25.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.0189
    Cell Significance Index: 94.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6123
    Cell Significance Index: 262.2200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4816
    Cell Significance Index: 88.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2605
    Cell Significance Index: 173.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0139
    Cell Significance Index: 201.2100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.9981
    Cell Significance Index: 19.4800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8626
    Cell Significance Index: 155.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8617
    Cell Significance Index: 172.8500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8047
    Cell Significance Index: 98.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7999
    Cell Significance Index: 436.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7634
    Cell Significance Index: 20.4600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6426
    Cell Significance Index: 230.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6274
    Cell Significance Index: 32.5900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6026
    Cell Significance Index: 41.6800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5842
    Cell Significance Index: 5.3800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5473
    Cell Significance Index: 70.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5379
    Cell Significance Index: 485.7200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4478
    Cell Significance Index: 197.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3895
    Cell Significance Index: 20.4500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3637
    Cell Significance Index: 25.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2572
    Cell Significance Index: 14.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2132
    Cell Significance Index: 4.6200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1752
    Cell Significance Index: 4.7700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1577
    Cell Significance Index: 15.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1520
    Cell Significance Index: 28.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1482
    Cell Significance Index: 25.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1117
    Cell Significance Index: 1.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1027
    Cell Significance Index: 2.9600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0989
    Cell Significance Index: 0.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0673
    Cell Significance Index: 49.3700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0354
    Cell Significance Index: 24.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0123
    Cell Significance Index: 23.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0075
    Cell Significance Index: 0.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0037
    Cell Significance Index: 0.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0054
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0060
    Cell Significance Index: -4.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0061
    Cell Significance Index: -4.5900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0085
    Cell Significance Index: -5.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0141
    Cell Significance Index: -0.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0155
    Cell Significance Index: -23.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0160
    Cell Significance Index: -29.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0239
    Cell Significance Index: -15.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0245
    Cell Significance Index: -33.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0392
    Cell Significance Index: -22.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0413
    Cell Significance Index: -18.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0421
    Cell Significance Index: -1.9100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0594
    Cell Significance Index: -6.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0685
    Cell Significance Index: -3.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0705
    Cell Significance Index: -14.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0774
    Cell Significance Index: -5.7700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0804
    Cell Significance Index: -9.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0811
    Cell Significance Index: -9.2900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0814
    Cell Significance Index: -2.8300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0870
    Cell Significance Index: -1.3800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0948
    Cell Significance Index: -2.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1013
    Cell Significance Index: -11.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1020
    Cell Significance Index: -29.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1140
    Cell Significance Index: -14.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1229
    Cell Significance Index: -9.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1261
    Cell Significance Index: -2.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1569
    Cell Significance Index: -22.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1700
    Cell Significance Index: -2.3200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2035
    Cell Significance Index: -4.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2206
    Cell Significance Index: -14.8400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2214
    Cell Significance Index: -5.6900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2352
    Cell Significance Index: -27.7400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2430
    Cell Significance Index: -5.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2740
    Cell Significance Index: -17.6800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3105
    Cell Significance Index: -24.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3106
    Cell Significance Index: -8.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3228
    Cell Significance Index: -33.6100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3317
    Cell Significance Index: -17.2800
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.3861
    Cell Significance Index: -2.9200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4332
    Cell Significance Index: -10.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4394
    Cell Significance Index: -26.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4540
    Cell Significance Index: -14.5400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4619
    Cell Significance Index: -3.8800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4625
    Cell Significance Index: -11.5600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4682
    Cell Significance Index: -9.8000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4721
    Cell Significance Index: -20.8800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4815
    Cell Significance Index: -12.6600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4827
    Cell Significance Index: -13.7800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.5373
    Cell Significance Index: -4.2900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5591
    Cell Significance Index: -21.1700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.5769
    Cell Significance Index: -5.9700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6028
    Cell Significance Index: -17.2800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6386
    Cell Significance Index: -12.8200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6820
    Cell Significance Index: -22.3300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6842
    Cell Significance Index: -21.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PCYOX1 is characterized by its involvement in the following key pathways and functions: 1. **Prenylcysteine catabolic process**: PCYOX1 is responsible for the degradation of prenylated proteins, which are essential for various cellular functions, including cell signaling and protein-protein interactions. 2. **Lipid metabolism**: The gene is involved in the regulation of lipid metabolism, particularly in the catabolism of prenylated lipids, which are essential for cellular membrane structure and function. 3. **Immune regulation**: PCYOX1 is highly expressed in immune cells, such as T cells and mast cells, suggesting its role in regulating immune responses and inflammation. 4. **Cellular differentiation**: The gene is involved in the differentiation of various cell types, including hematopoietic cells, smooth muscle fibers, and epithelial cells. **Pathways and Functions:** PCYOX1 is involved in the following pathways and functions: 1. **Extracellular exosome**: PCYOX1 is involved in the formation and regulation of extracellular exosomes, which are small vesicles that play a crucial role in intercellular communication. 2. **Fad binding**: The gene is involved in the regulation of fatty acid binding proteins, which are essential for lipid metabolism and cellular energy production. 3. **Farnesylcysteine lyase activity**: PCYOX1 is involved in the degradation of prenylated proteins, which are essential for various cellular functions, including cell signaling and protein-protein interactions. 4. **Lysosome**: The gene is involved in the regulation of lysosomal function, which is essential for cellular digestion and recycling of cellular components. **Clinical Significance:** PCYOX1 has significant clinical implications in the following areas: 1. **Immune disorders**: Dysregulation of PCYOX1 has been implicated in various immune disorders, including rheumatoid arthritis, multiple sclerosis, and asthma. 2. **Cancer**: The gene is involved in the regulation of cancer cell growth and differentiation, making it a potential target for cancer therapy. 3. **Neurological disorders**: PCYOX1 has been implicated in the regulation of neuroinflammation and neuronal function, making it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Metabolic disorders**: The gene is involved in the regulation of lipid metabolism, making it a potential target for the treatment of metabolic disorders, such as hyperlipidemia and obesity. In conclusion, PCYOX1 is a multifaceted gene that plays a crucial role in lipid metabolism, immune regulation, and cellular differentiation. Its dysregulation has significant clinical implications in various diseases, making it a potential target for therapeutic intervention.

Genular Protein ID: 1120815065

Symbol: PCYOX_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UHG3 B2RB14 B7Z9P8 O94982 Q8N4N5 Q96QM8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 19 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 11 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 Rhea 8 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10585463

Title: Cloning, expression, and cellular localization of a human prenylcysteine lyase.

PubMed ID: 10585463

DOI: 10.1074/jbc.274.50.35802

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11078725

Title: Lysosomal prenylcysteine lyase is a FAD-dependent thioether oxidase.

PubMed ID: 11078725

DOI: 10.1074/jbc.c000616200

PubMed ID: 12186880

Title: Stereospecificity and kinetic mechanism of human prenylcysteine lyase, an unusual thioether oxidase.

PubMed ID: 12186880

DOI: 10.1074/jbc.m208069200

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 505
  • Mass: 56640
  • Checksum: FB388AF70AF229F5
  • Sequence:
    • MGRVVAELVS SLLGLWLLLC SCGCPEGAEL RAPPDKIAII GAGIGGTSAA YYLRQKFGKD 
VKIDLFEREE VGGRLATMMV QGQEYEAGGS VIHPLNLHMK RFVKDLGLSA VQASGGLLGI 
YNGETLVFEE SNWFIINVIK LVWRYGFQSL RMHMWVEDVL DKFMRIYRYQ SHDYAFSSVE 
KLLHALGGDD FLGMLNRTLL ETLQKAGFSE KFLNEMIAPV MRVNYGQSTD INAFVGAVSL 
SCSDSGLWAV EGGNKLVCSG LLQASKSNLI SGSVMYIEEK TKTKYTGNPT KMYEVVYQIG 
TETRSDFYDI VLVATPLNRK MSNITFLNFD PPIEEFHQYY QHIVTTLVKG ELNTSIFSSR 
PIDKFGLNTV LTTDNSDLFI NSIGIVPSVR EKEDPEPSTD GTYVWKIFSQ ETLTKAQILK 
LFLSYDYAVK KPWLAYPHYK PPEKCPSIIL HDRLYYLNGI ECAASAMEMS AIAAHNAALL 
AYHRWNGHTD MIDQDGLYEK LKTEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.