Details for: SPOUT1

Gene ID: 51490

Symbol: SPOUT1

Ensembl ID: ENSG00000198917

Description: SPOUT domain containing methyltransferase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 36.1332
    Cell Significance Index: -14.8900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 30.6948
    Cell Significance Index: -12.4700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.2077
    Cell Significance Index: -12.6100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 5.4837
    Cell Significance Index: 1043.5900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.7553
    Cell Significance Index: -10.0600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 3.3282
    Cell Significance Index: 69.0400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.0214
    Cell Significance Index: -9.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 2.9520
    Cell Significance Index: 62.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5074
    Cell Significance Index: 149.1200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.3753
    Cell Significance Index: 22.0700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1424
    Cell Significance Index: 1031.5300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.0998
    Cell Significance Index: 16.4800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9140
    Cell Significance Index: 99.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9121
    Cell Significance Index: 54.7600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8038
    Cell Significance Index: 130.7300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.4902
    Cell Significance Index: 141.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4738
    Cell Significance Index: 16.6500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4510
    Cell Significance Index: 31.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3936
    Cell Significance Index: 45.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3542
    Cell Significance Index: 70.2900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3434
    Cell Significance Index: 237.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3093
    Cell Significance Index: 55.7500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3038
    Cell Significance Index: 9.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2651
    Cell Significance Index: 7.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2581
    Cell Significance Index: 51.7700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.2476
    Cell Significance Index: 3.7600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2022
    Cell Significance Index: 14.3000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1881
    Cell Significance Index: 83.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1772
    Cell Significance Index: 11.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1771
    Cell Significance Index: 21.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1754
    Cell Significance Index: 95.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1711
    Cell Significance Index: 61.3800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1376
    Cell Significance Index: 17.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1330
    Cell Significance Index: 18.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1145
    Cell Significance Index: 8.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1042
    Cell Significance Index: 3.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1019
    Cell Significance Index: 12.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0840
    Cell Significance Index: 2.1000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0741
    Cell Significance Index: 3.8600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0651
    Cell Significance Index: 3.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0470
    Cell Significance Index: 2.2100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0444
    Cell Significance Index: 5.7400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0385
    Cell Significance Index: 0.9900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.0032
    Cell Significance Index: 0.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0024
    Cell Significance Index: -1.8400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0061
    Cell Significance Index: -0.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0068
    Cell Significance Index: -12.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0071
    Cell Significance Index: -0.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0077
    Cell Significance Index: -0.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0094
    Cell Significance Index: -17.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0114
    Cell Significance Index: -17.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0126
    Cell Significance Index: -9.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0130
    Cell Significance Index: -17.6200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0160
    Cell Significance Index: -11.8300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0179
    Cell Significance Index: -0.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0218
    Cell Significance Index: -13.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0220
    Cell Significance Index: -12.4200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0225
    Cell Significance Index: -1.7300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0251
    Cell Significance Index: -15.6700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0270
    Cell Significance Index: -2.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0292
    Cell Significance Index: -3.3400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0300
    Cell Significance Index: -0.6500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0310
    Cell Significance Index: -0.9100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0330
    Cell Significance Index: -14.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0411
    Cell Significance Index: -7.0100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0438
    Cell Significance Index: -1.1200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0458
    Cell Significance Index: -0.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0695
    Cell Significance Index: -3.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0745
    Cell Significance Index: -15.6900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0781
    Cell Significance Index: -4.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0891
    Cell Significance Index: -4.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0913
    Cell Significance Index: -2.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0949
    Cell Significance Index: -13.7900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1170
    Cell Significance Index: -2.4500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1298
    Cell Significance Index: -3.7200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1309
    Cell Significance Index: -2.1900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1393
    Cell Significance Index: -8.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1467
    Cell Significance Index: -6.4900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1474
    Cell Significance Index: -6.0400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1537
    Cell Significance Index: -12.1700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1628
    Cell Significance Index: -1.7700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1684
    Cell Significance Index: -4.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1777
    Cell Significance Index: -6.7300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2202
    Cell Significance Index: -13.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2260
    Cell Significance Index: -11.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2469
    Cell Significance Index: -6.7200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.2608
    Cell Significance Index: -3.5200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2711
    Cell Significance Index: -6.6200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2870
    Cell Significance Index: -4.7300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2923
    Cell Significance Index: -5.0100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2963
    Cell Significance Index: -10.3800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.3018
    Cell Significance Index: -2.4100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.3047
    Cell Significance Index: -3.8500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3052
    Cell Significance Index: -6.3700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3084
    Cell Significance Index: -11.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3099
    Cell Significance Index: -14.4500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.3102
    Cell Significance Index: -4.6400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3155
    Cell Significance Index: -2.6500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3246
    Cell Significance Index: -7.5000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3282
    Cell Significance Index: -7.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **SPOUT domain:** The SPOUT domain is a characteristic feature of the SPOUT1 protein, which is responsible for its methyltransferase activity. This domain is conserved across different species, suggesting its importance in maintaining cellular homeostasis. 2. **Methyltransferase activity:** SPOUT1's primary function is to methylate specific RNA sequences, thereby modulating mRNA stability and translation. This activity is essential for regulating gene expression in response to various cellular cues. 3. **Cell-type specificity:** SPOUT1 is significantly expressed in various cell types, including immune cells, stem cells, and epithelial cells. This cell-type specificity underscores the importance of SPOUT1 in maintaining cellular homeostasis and immune function. 4. **Kinetochore and centrosome regulation:** SPOUT1 is also involved in regulating kinetochore and centrosome function, highlighting its role in maintaining proper chromosome segregation during cell division. **Pathways and Functions:** 1. **Post-transcriptional regulation of gene expression:** SPOUT1's methyltransferase activity plays a crucial role in regulating gene expression by modulating mRNA stability and translation. 2. **Cell division:** SPOUT1 is involved in regulating kinetochore and centrosome function, ensuring proper chromosome segregation during cell division. 3. **Immune regulation:** SPOUT1 is significantly expressed in immune cells and plays a role in regulating T-cell development and function. 4. **Methylation:** SPOUT1's methyltransferase activity is essential for methylation of specific RNA sequences, which in turn regulates gene expression. **Clinical Significance:** 1. **Immune-related disorders:** Dysregulation of SPOUT1 has been implicated in various immune-related disorders, including autoimmune diseases and cancer. 2. **Cancer:** SPOUT1's role in regulating gene expression and cell division makes it a potential target for cancer therapy. 3. **Neurological disorders:** SPOUT1's involvement in regulating gene expression and methylation patterns may also contribute to the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Stem cell regulation:** SPOUT1's role in regulating stem cell function and differentiation makes it a potential target for regenerative medicine applications. In conclusion, SPOUT1 is a gene with far-reaching implications in immune regulation and cellular homeostasis. Its involvement in regulating gene expression, cell division, and methylation patterns makes it a crucial component of various cellular processes. Further research is necessary to fully elucidate the role of SPOUT1 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 1006502517

Symbol: CI114_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5T280 Q0D2P6 Q6P469 Q6PGP9 Q6PIJ1 Q6PJV9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20813266

Title: The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics.

PubMed ID: 20813266

DOI: 10.1016/j.cell.2010.07.047

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25657325

Title: CENP-32 is required to maintain centrosomal dominance in bipolar spindle assembly.

PubMed ID: 25657325

DOI: 10.1091/mbc.e14-09-1366

PubMed ID: 28431233

Title: A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis.

PubMed ID: 28431233

DOI: 10.1016/j.molcel.2017.03.014

PubMed ID: 21750715

Title: The inhibitor of growth protein 5 (ING5) depends on INCA1 as a co-factor for its antiproliferative effects.

PubMed ID: 21750715

DOI: 10.1371/journal.pone.0021505

Sequence Information:

  • Length: 376
  • Mass: 42009
  • Checksum: 30A5AA406834DC27
  • Sequence:
    • MAERGRKRPC GPGEHGQRIE WRKWKQQKKE EKKKWKDLKL MKKLERQRAQ EEQAKRLEEE 
EAAAEKEDRG RPYTLSVALP GSILDNAQSP ELRTYLAGQI ARACAIFCVD EIVVFDEEGQ 
DAKTVEGEFT GVGKKGQACV QLARILQYLE CPQYLRKAFF PKHQDLQFAG LLNPLDSPHH 
MRQDEESEFR EGIVVDRPTR PGHGSFVNCG MKKEVKIDKN LEPGLRVTVR LNQQQHPDCK 
TYHGKVVSSQ DPRTKAGLYW GYTVRLASCL SAVFAEAPFQ DGYDLTIGTS ERGSDVASAQ 
LPNFRHALVV FGGLQGLEAG ADADPNLEVA EPSVLFDLYV NTCPGQGSRT IRTEEAILIS 
LAALQPGLIQ AGARHT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.