Details for: CTDSPL2

Gene ID: 51496

Symbol: CTDSPL2

Ensembl ID: ENSG00000137770

Description: CTD small phosphatase like 2

Associated with

  • Negative regulation of bmp signaling pathway
    (GO:0030514)
  • Nucleoplasm
    (GO:0005654)
  • Phosphoprotein phosphatase activity
    (GO:0004721)
  • Positive regulation of protein export from nucleus
    (GO:0046827)
  • Protein binding
    (GO:0005515)
  • Protein export from nucleus
    (GO:0006611)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii ctd heptapeptide repeat phosphatase activity
    (GO:0008420)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 301.4236
    Cell Significance Index: -46.8900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 180.2334
    Cell Significance Index: -45.7200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 104.8245
    Cell Significance Index: -49.4900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 98.0291
    Cell Significance Index: -39.8300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 73.8128
    Cell Significance Index: -49.5300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 41.8647
    Cell Significance Index: -39.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 39.0971
    Cell Significance Index: -48.2100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.3171
    Cell Significance Index: -46.3900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.5306
    Cell Significance Index: -44.6300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.6017
    Cell Significance Index: -27.5800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.3161
    Cell Significance Index: -48.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.0145
    Cell Significance Index: 113.0500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.9151
    Cell Significance Index: 311.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8290
    Cell Significance Index: 362.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7189
    Cell Significance Index: 344.8100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.4418
    Cell Significance Index: 28.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0277
    Cell Significance Index: 368.6000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9535
    Cell Significance Index: 103.7200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8846
    Cell Significance Index: 611.8400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8825
    Cell Significance Index: 54.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8452
    Cell Significance Index: 64.8600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8452
    Cell Significance Index: 23.6200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.7839
    Cell Significance Index: 16.7600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7672
    Cell Significance Index: 46.0600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.7396
    Cell Significance Index: 19.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5748
    Cell Significance Index: 519.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5656
    Cell Significance Index: 16.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5630
    Cell Significance Index: 25.5200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.4199
    Cell Significance Index: 10.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4045
    Cell Significance Index: 27.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4039
    Cell Significance Index: 55.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3813
    Cell Significance Index: 68.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3665
    Cell Significance Index: 45.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3321
    Cell Significance Index: 146.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3292
    Cell Significance Index: 14.5600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2866
    Cell Significance Index: 14.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2507
    Cell Significance Index: 15.8000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2374
    Cell Significance Index: 129.6300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2290
    Cell Significance Index: 8.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1999
    Cell Significance Index: 376.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1824
    Cell Significance Index: 34.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1729
    Cell Significance Index: 266.2500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1560
    Cell Significance Index: 15.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1556
    Cell Significance Index: 286.8900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1348
    Cell Significance Index: 15.9000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1242
    Cell Significance Index: 1.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1084
    Cell Significance Index: 68.8500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1031
    Cell Significance Index: 140.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0995
    Cell Significance Index: 45.1600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0864
    Cell Significance Index: 1.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0794
    Cell Significance Index: 5.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0405
    Cell Significance Index: 1.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0390
    Cell Significance Index: 1.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0213
    Cell Significance Index: 2.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0049
    Cell Significance Index: 0.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0040
    Cell Significance Index: 0.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0199
    Cell Significance Index: -0.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0310
    Cell Significance Index: -4.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0356
    Cell Significance Index: -26.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0448
    Cell Significance Index: -33.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0561
    Cell Significance Index: -42.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0629
    Cell Significance Index: -10.7400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0846
    Cell Significance Index: -47.7200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0858
    Cell Significance Index: -53.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1463
    Cell Significance Index: -42.0900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1664
    Cell Significance Index: -4.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1731
    Cell Significance Index: -8.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1742
    Cell Significance Index: -17.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2016
    Cell Significance Index: -14.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2023
    Cell Significance Index: -9.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2378
    Cell Significance Index: -30.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2428
    Cell Significance Index: -51.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2527
    Cell Significance Index: -29.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2747
    Cell Significance Index: -5.8500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2824
    Cell Significance Index: -4.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3163
    Cell Significance Index: -16.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3302
    Cell Significance Index: -34.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3337
    Cell Significance Index: -38.2300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3579
    Cell Significance Index: -5.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3764
    Cell Significance Index: -28.0500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3877
    Cell Significance Index: -8.4000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4019
    Cell Significance Index: -5.7800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4625
    Cell Significance Index: -6.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4665
    Cell Significance Index: -14.9400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4783
    Cell Significance Index: -2.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4993
    Cell Significance Index: -17.3500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5050
    Cell Significance Index: -7.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5167
    Cell Significance Index: -40.9200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6043
    Cell Significance Index: -17.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6372
    Cell Significance Index: -16.7600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6380
    Cell Significance Index: -18.2900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.6473
    Cell Significance Index: -17.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6648
    Cell Significance Index: -40.7600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6755
    Cell Significance Index: -14.7900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7026
    Cell Significance Index: -20.0500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8200
    Cell Significance Index: -21.9400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8556
    Cell Significance Index: -27.2500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8815
    Cell Significance Index: -28.8600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.9134
    Cell Significance Index: -7.0400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.9614
    Cell Significance Index: -11.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CTDSPL2 is a gene that belongs to the CTD (C-terminal domain) family of phosphatases, which are involved in the regulation of transcription and chromatin remodeling. The encoded protein, CTSL2_HUMAN, is a small phosphatase-like protein that exhibits phosphatase activity. This activity is crucial for the negative regulation of the BMP (Bone Morphogenetic Protein) signaling pathway, which is involved in various cellular processes, including cell differentiation and proliferation. **Pathways and Functions:** CTDSPL2 is involved in several key pathways, including: 1. **Negative regulation of BMP signaling pathway**: CTDSPL2 acts as a phosphatase that dephosphorylates and inactivates BMP proteins, thereby regulating their activity and preventing excessive signaling. 2. **Regulation of transcription by RNA polymerase II**: CTDSPL2 interacts with RNA polymerase II, a key enzyme involved in transcription, and regulates its activity by dephosphorylating and activating it. 3. **Positive regulation of protein export from nucleus**: CTDSPL2 also regulates the export of proteins from the nucleus by interacting with exportin-1 and other export receptors. 4. **Phosphoprotein phosphatase activity**: CTDSPL2 exhibits phosphatase activity, which is essential for the dephosphorylation of phosphoproteins and the regulation of various cellular processes. **Clinical Significance:** The clinical significance of CTDSPL2 is multifaceted and far-reaching. Dysregulation of CTDSPL2 has been implicated in various diseases, including: 1. **Immunological disorders**: CTDSPL2 is expressed in hematopoietic cells, including T cells and B cells, and its dysregulation has been linked to immunological disorders, such as autoimmune diseases and cancer. 2. **Cancer**: CTDSPL2 is overexpressed in several types of cancer, including breast cancer and lung cancer, and its dysregulation has been linked to tumorigenesis and cancer progression. 3. **Neurological disorders**: CTDSPL2 is also expressed in the brain and has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, CTDSPL2 is a gene with far-reaching implications in immune regulation and beyond. Its dysregulation has been implicated in various diseases, and further research is needed to fully understand its role in human health and disease.

Genular Protein ID: 1337960267

Symbol: CTSL2_HUMAN

Name: CTD small phosphatase-like protein 2

UniProtKB Accession Codes:

Q05D32 Q3ZTU1 Q6AI06 Q8IYI9 Q9NVT2 Q9NZX8 Q9P030

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 10 Ensembl 3 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16533400

Title: NovelFam3000 -- uncharacterized human protein domains conserved across model organisms.

PubMed ID: 16533400

DOI: 10.1186/1471-2164-7-48

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 466
  • Mass: 52999
  • Checksum: E8BA6911EBD4B332
  • Sequence:
    • MRLRTRKASQ QSNQIQTQRT ARAKRKYSEV DDSLPSGGEK PSKNETGLLS SIKKFIKGST 
PKEERENPSK RSRIERDIDN NLITSTPRAG EKPNKQISRV RRKSQVNGEA GSYEMTNQHV 
KQNGKLEDNP SSGSPPRTTL LGTIFSPVFN FFSPANKNGT SGSDSPGQAV EAEEIVKQLD 
MEQVDEITTS TTTSTNGAAY SNQAVQVRPS LNNGLEEAEE TVNRDIPPLT APVTPDSGYS 
SAHAEATYEE DWEVFDPYYF IKHVPPLTEE QLNRKPALPL KTRSTPEFSL VLDLDETLVH 
CSLNELEDAA LTFPVLFQDV IYQVYVRLRP FFREFLERMS QMYEIILFTA SKKVYADKLL 
NILDPKKQLV RHRLFREHCV CVQGNYIKDL NILGRDLSKT IIIDNSPQAF AYQLSNGIPI 
ESWFMDKNDN ELLKLIPFLE KLVELNEDVR PHIRDRFRLH DLLPPD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.