Details for: LARS1

Gene ID: 51520

Symbol: LARS1

Ensembl ID: ENSG00000133706

Description: leucyl-tRNA synthetase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 319.8748
    Cell Significance Index: -49.7600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 177.5919
    Cell Significance Index: -45.0500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 149.1634
    Cell Significance Index: -61.4500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 130.7976
    Cell Significance Index: -61.7500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 124.3547
    Cell Significance Index: -50.5200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 112.0172
    Cell Significance Index: -57.6200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 92.3815
    Cell Significance Index: -61.9900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 53.2971
    Cell Significance Index: -50.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 45.6221
    Cell Significance Index: -56.2500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.6438
    Cell Significance Index: -57.7900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.3976
    Cell Significance Index: -41.1500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.2545
    Cell Significance Index: -26.8200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.1849
    Cell Significance Index: 237.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6313
    Cell Significance Index: 327.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5381
    Cell Significance Index: 41.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.3766
    Cell Significance Index: 64.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3581
    Cell Significance Index: 244.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3153
    Cell Significance Index: 161.7300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2818
    Cell Significance Index: 254.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.2711
    Cell Significance Index: 34.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1741
    Cell Significance Index: 53.2200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.1159
    Cell Significance Index: 25.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0981
    Cell Significance Index: 150.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0760
    Cell Significance Index: 385.9400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0557
    Cell Significance Index: 73.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9840
    Cell Significance Index: 55.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9688
    Cell Significance Index: 45.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8019
    Cell Significance Index: 61.5400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7356
    Cell Significance Index: 401.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7205
    Cell Significance Index: 20.1400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7126
    Cell Significance Index: 45.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6938
    Cell Significance Index: 19.9900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6153
    Cell Significance Index: 43.5200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5053
    Cell Significance Index: 223.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4078
    Cell Significance Index: 52.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3968
    Cell Significance Index: 25.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3817
    Cell Significance Index: 8.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3715
    Cell Significance Index: 43.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3582
    Cell Significance Index: 18.6100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3541
    Cell Significance Index: 244.9100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2883
    Cell Significance Index: 7.5800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2595
    Cell Significance Index: 2.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2477
    Cell Significance Index: 24.5000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2444
    Cell Significance Index: 12.3500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2301
    Cell Significance Index: 1.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2298
    Cell Significance Index: 15.4500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2162
    Cell Significance Index: 195.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1781
    Cell Significance Index: 7.8800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1665
    Cell Significance Index: 8.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1622
    Cell Significance Index: 20.7900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1202
    Cell Significance Index: 4.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0961
    Cell Significance Index: 7.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0948
    Cell Significance Index: 3.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0844
    Cell Significance Index: 155.5900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0788
    Cell Significance Index: 148.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0784
    Cell Significance Index: 13.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0713
    Cell Significance Index: 109.7700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0529
    Cell Significance Index: 8.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0299
    Cell Significance Index: 18.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0197
    Cell Significance Index: 26.8500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0136
    Cell Significance Index: 9.9400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0086
    Cell Significance Index: 0.2300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0063
    Cell Significance Index: -4.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0074
    Cell Significance Index: -3.3400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0572
    Cell Significance Index: -1.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0584
    Cell Significance Index: -11.1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0740
    Cell Significance Index: -2.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0789
    Cell Significance Index: -58.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0839
    Cell Significance Index: -8.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0864
    Cell Significance Index: -4.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1013
    Cell Significance Index: -57.1500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1075
    Cell Significance Index: -67.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1637
    Cell Significance Index: -23.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1733
    Cell Significance Index: -49.8600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1845
    Cell Significance Index: -3.9300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1875
    Cell Significance Index: -2.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1883
    Cell Significance Index: -21.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3176
    Cell Significance Index: -66.9100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3476
    Cell Significance Index: -12.0800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3624
    Cell Significance Index: -3.9400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3674
    Cell Significance Index: -8.0500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3730
    Cell Significance Index: -7.2800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3808
    Cell Significance Index: -7.9700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4078
    Cell Significance Index: -6.8300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4589
    Cell Significance Index: -47.7800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5001
    Cell Significance Index: -12.5000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5343
    Cell Significance Index: -42.3200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5746
    Cell Significance Index: -18.4100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5809
    Cell Significance Index: -14.8400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6023
    Cell Significance Index: -7.1800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6186
    Cell Significance Index: -8.4400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6384
    Cell Significance Index: -9.4300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6465
    Cell Significance Index: -18.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7346
    Cell Significance Index: -45.0400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.7353
    Cell Significance Index: -21.6000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.7889
    Cell Significance Index: -24.9500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.0705
    Cell Significance Index: -22.7200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0829
    Cell Significance Index: -34.4900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.1060
    Cell Significance Index: -36.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LARS1 is a member of the aminoacyl-tRNA synthetase family, which is responsible for the accurate attachment of amino acids to their corresponding tRNA molecules. The LARS1 enzyme specifically catalyzes the aminoacylation of leucine, a branched-chain amino acid. This enzyme is highly specific, with a high degree of accuracy in attaching leucine to its corresponding tRNA molecule. LARS1 is also involved in the regulation of cell size, protein binding, and the response to amino acid starvation and stimulation. **Pathways and Functions:** LARS1 is involved in several key pathways, including: 1. **Aminoacyl-trna editing activity:** LARS1 plays a crucial role in the accurate editing of tRNA molecules, ensuring that the correct amino acid is attached to the corresponding tRNA molecule during protein synthesis. 2. **Aminoacyl-trna metabolism involved in translational fidelity:** LARS1 is involved in the regulation of protein synthesis, ensuring that the correct amino acid is incorporated into the growing protein chain. 3. **Aminoacyl-trna synthetase multienzyme complex:** LARS1 is part of a larger complex that includes multiple aminoacyl-tRNA synthetases, which work together to ensure the accurate attachment of amino acids to tRNA molecules. 4. **ATP binding:** LARS1 has been shown to bind ATP, which is necessary for the catalytic activity of the enzyme. 5. **Cellular response to amino acid starvation:** LARS1 plays a crucial role in the regulation of protein synthesis in response to amino acid starvation, ensuring that cells can adapt to changes in their environment. 6. **Cellular response to amino acid stimulus:** LARS1 is also involved in the regulation of protein synthesis in response to amino acid stimulation, ensuring that cells can respond to changes in their environment. **Clinical Significance:** LARS1 has been implicated in several diseases, including: 1. **Amino acid deficiencies:** LARS1 plays a crucial role in the regulation of protein synthesis in response to amino acid deficiencies, making it a potential target for the treatment of amino acid deficiencies. 2. **Protein synthesis disorders:** LARS1 has been implicated in protein synthesis disorders, such as myotonic dystrophy, which is characterized by muscle weakness and wasting. 3. **Cancer:** LARS1 has been shown to be overexpressed in certain types of cancer, including leukemia and lymphoma, making it a potential target for cancer therapy. 4. **Neurological disorders:** LARS1 has been implicated in several neurological disorders, including Alzheimer's disease and Parkinson's disease, which are characterized by protein misfolding and aggregation. In conclusion, LARS1 is a multifaceted enzyme involved in the regulation of protein synthesis and cellular metabolism. Its dysregulation has been implicated in several diseases, making it a potential target for the treatment of these conditions. Further research is needed to fully understand the role of LARS1 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 879320348

Symbol: SYLC_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9P2J5 A2RRR4 A7E266 B4DJ10 Q2TU79 Q9NSE1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEBI 16 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 12 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 MoonProt 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 5 Rhea 8 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10718198

Title: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10718198

DOI: 10.1093/dnares/7.1.65

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25051973

Title: A bridge between the aminoacylation and editing domains of leucyl-tRNA synthetase is crucial for its synthetic activity.

PubMed ID: 25051973

DOI: 10.1261/rna.044404.114

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 19426743

Title: Crystal structures of the human and fungal cytosolic Leucyl-tRNA synthetase editing domains: A structural basis for the rational design of antifungal benzoxaboroles.

PubMed ID: 19426743

DOI: 10.1016/j.jmb.2009.04.073

PubMed ID: 32232361

Title: Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond.

PubMed ID: 32232361

DOI: 10.1093/nar/gkaa189

PubMed ID: 22607940

Title: Identification of a mutation in LARS as a novel cause of infantile hepatopathy.

PubMed ID: 22607940

DOI: 10.1016/j.ymgme.2012.04.017

Sequence Information:

  • Length: 1176
  • Mass: 134466
  • Checksum: 44A4D1A1EF31634A
  • Sequence:
    • MAERKGTAKV DFLKKIEKEI QQKWDTERVF EVNASNLEKQ TSKGKYFVTF PYPYMNGRLH 
LGHTFSLSKC EFAVGYQRLK GKCCLFPFGL HCTGMPIKAC ADKLKREIEL YGCPPDFPDE 
EEEEEETSVK TEDIIIKDKA KGKKSKAAAK AGSSKYQWGI MKSLGLSDEE IVKFSEAEHW 
LDYFPPLAIQ DLKRMGLKVD WRRSFITTDV NPYYDSFVRW QFLTLRERNK IKFGKRYTIY 
SPKDGQPCMD HDRQTGEGVG PQEYTLLKLK VLEPYPSKLS GLKGKNIFLV AATLRPETMF 
GQTNCWVRPD MKYIGFETVN GDIFICTQKA ARNMSYQGFT KDNGVVPVVK ELMGEEILGA 
SLSAPLTSYK VIYVLPMLTI KEDKGTGVVT SVPSDSPDDI AALRDLKKKQ ALRAKYGIRD 
DMVLPFEPVP VIEIPGFGNL SAVTICDELK IQSQNDREKL AEAKEKIYLK GFYEGIMLVD 
GFKGQKVQDV KKTIQKKMID AGDALIYMEP EKQVMSRSSD ECVVALCDQW YLDYGEENWK 
KQTSQCLKNL ETFCEETRRN FEATLGWLQE HACSRTYGLG THLPWDEQWL IESLSDSTIY 
MAFYTVAHLL QGGNLHGQAE SPLGIRPQQM TKEVWDYVFF KEAPFPKTQI AKEKLDQLKQ 
EFEFWYPVDL RVSGKDLVPN HLSYYLYNHV AMWPEQSDKW PTAVRANGHL LLNSEKMSKS 
TGNFLTLTQA IDKFSADGMR LALADAGDTV EDANFVEAMA DAGILRLYTW VEWVKEMVAN 
WDSLRSGPAS TFNDRVFASE LNAGIIKTDQ NYEKMMFKEA LKTGFFEFQA AKDKYRELAV 
EGMHRELVFR FIEVQTLLLA PFCPHLCEHI WTLLGKPDSI MNASWPVAGP VNEVLIHSSQ 
YLMEVTHDLR LRLKNYMMPA KGKKTDKQPL QKPSHCTIYV AKNYPPWQHT TLSVLRKHFE 
ANNGKLPDNK VIASELGSMP ELKKYMKKVM PFVAMIKENL EKMGPRILDL QLEFDEKAVL 
MENIVYLTNS LELEHIEVKF ASEAEDKIRE DCCPGKPLNV FRIEPGVSVS LVNPQPSNGH 
FSTKIEIRQG DNCDSIIRRL MKMNRGIKDL SKVKLMRFDD PLLGPRRVPV LGKEYTEKTP 
ISEHAVFNVD LMSKKIHLTE NGIRVDIGDT IIYLVH

Genular Protein ID: 1833866938

Symbol: B4E266_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E266

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 IntAct 1 InterPro 7 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 5 RefSeq 1 RuleBase 1 SUPFAM 3

Sequence Information:

  • Length: 1130
  • Mass: 129188
  • Checksum: 51E2A40F82229059
  • Sequence:
    • MAERKGTAKV DFLKKIEKEI QQKWDTERVF EVNASNLEKQ TSKGKYFVTF PYPYMNGRLH 
LGHTFSLSKC EFAVGYQRLK GKCCLFPFGL HCTGMPIKSK AAAKAGSSKY QWGIMKSLGL 
SDEEIVKFSE AEHWLDYFPP LAIQDLKRMG LKVDWRRSFI TTDVNPYYDS FVRWQFLTLR 
ERNKIKFGKR YTIYSPKDGQ PCMDHDRQTG EGVGPQEYTL LKLKVLEPYP SKLSGLKGKN 
IFLVAATLRP ETMFGQTNCW VRPDMKYIGF ETVNGDIFIC TQKAARNMSY QGFTKDNGVV 
PVVKELMGEE ILGASLSAPL TSYKVIYVLP MLTIKEDKGT GVVTSVPSDS PDDIAALRDL 
KKKQALRAKY GIRDDMVLPF EPVPVIEIPG FGNLSAVTIC DELKIQSQND REKLAEAKEK 
IYLKGFYEGI MLVDGFKGQK VQDVKKTIQK KMIDAGDALI YMEPEKQVMS RSSDECVVAL 
CDQWYLDYGE ENWKKQTSQC LKNLETFCEE TRRNFEATLG WLQEHACSRT YGLGTHLPWD 
EQWLIESLSD STIYMAFYTV AHLLQGGNLH GQAESPLGIR PQQMTKEVWD YVFFKEAPFP 
KTQIAKEKLD QLKQEFEFWY PVDLRVSGKD LVPNHLSYYL YNHVAMWPEQ SDKWPTAVRA 
NGHLLLNSEK MSKSTGNFLT LTQAIDKFSA DGMRLALADA GDTVEDANFV EAMADAGILR 
LYTWVEWVKE MVANWDSLRS GPASTFNDRV FASELNAGII KTDQNYEKMM FKEALKTGFF 
EFQAAKDKYR ELAVEGMHRE LVFRFIEVQT LLLAPFCPHL CEHIWTLLGK PDSIMNASWP 
VAGPVDEVLI HSSQYLMEVT HDLRLRLKNY MMPAKGKKTD KQPLQKPSHC TIYVAKNYPP 
WQHTTLSVLR KHFEANNGKL PDNKVIASEL GSMPELKKYM KKVMPFVAMI KENLEKMGPR 
ILDLQLEFDE KAVLMENIVY LTNSLELEHI EVKFASEAED KIREDCCPGK PLNVFRIEPG 
VSVSLVNPQP SNGHFSTKIE IKQGDNCDSI IRRLMKMNRG IKDLSKVKLM RFDDPLLGPR 
RVPVLGKEYT EKTPISEHAV FNVDLMSKKI HLTENGIRVD IGDTIIYLVH

Genular Protein ID: 3256737136

Symbol: A0A6I8PL42_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A6I8PL42

Database IDs:

ARBA 8 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 2 GeneTree 1 HGNC 1 InterPro 7 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 2 Pfam 5 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SMR 1 SUPFAM 3

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 1130
  • Mass: 129215
  • Checksum: 4F4DFEFC09B211DB
  • Sequence:
    • MAERKGTAKV DFLKKIEKEI QQKWDTERVF EVNASNLEKQ TSKGKYFVTF PYPYMNGRLH 
LGHTFSLSKC EFAVGYQRLK GKCCLFPFGL HCTGMPIKSK AAAKAGSSKY QWGIMKSLGL 
SDEEIVKFSE AEHWLDYFPP LAIQDLKRMG LKVDWRRSFI TTDVNPYYDS FVRWQFLTLR 
ERNKIKFGKR YTIYSPKDGQ PCMDHDRQTG EGVGPQEYTL LKLKVLEPYP SKLSGLKGKN 
IFLVAATLRP ETMFGQTNCW VRPDMKYIGF ETVNGDIFIC TQKAARNMSY QGFTKDNGVV 
PVVKELMGEE ILGASLSAPL TSYKVIYVLP MLTIKEDKGT GVVTSVPSDS PDDIAALRDL 
KKKQALRAKY GIRDDMVLPF EPVPVIEIPG FGNLSAVTIC DELKIQSQND REKLAEAKEK 
IYLKGFYEGI MLVDGFKGQK VQDVKKTIQK KMIDAGDALI YMEPEKQVMS RSSDECVVAL 
CDQWYLDYGE ENWKKQTSQC LKNLETFCEE TRRNFEATLG WLQEHACSRT YGLGTHLPWD 
EQWLIESLSD STIYMAFYTV AHLLQGGNLH GQAESPLGIR PQQMTKEVWD YVFFKEAPFP 
KTQIAKEKLD QLKQEFEFWY PVDLRVSGKD LVPNHLSYYL YNHVAMWPEQ SDKWPTAVRA 
NGHLLLNSEK MSKSTGNFLT LTQAIDKFSA DGMRLALADA GDTVEDANFV EAMADAGILR 
LYTWVEWVKE MVANWDSLRS GPASTFNDRV FASELNAGII KTDQNYEKMM FKEALKTGFF 
EFQAAKDKYR ELAVEGMHRE LVFRFIEVQT LLLAPFCPHL CEHIWTLLGK PDSIMNASWP 
VAGPVNEVLI HSSQYLMEVT HDLRLRLKNY MMPAKGKKTD KQPLQKPSHC TIYVAKNYPP 
WQHTTLSVLR KHFEANNGKL PDNKVIASEL GSMPELKKYM KKVMPFVAMI KENLEKMGPR 
ILDLQLEFDE KAVLMENIVY LTNSLELEHI EVKFASEAED KIREDCCPGK PLNVFRIEPG 
VSVSLVNPQP SNGHFSTKIE IRQGDNCDSI IRRLMKMNRG IKDLSKVKLM RFDDPLLGPR 
RVPVLGKEYT EKTPISEHAV FNVDLMSKKI HLTENGIRVD IGDTIIYLVH

Genular Protein ID: 3669501077

Symbol: B4DER1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DER1

Database IDs:

ARBA 8 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 6 Gene3D 2 GeneTree 1 HGNC 1 InterPro 7 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 5 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SUPFAM 3 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 1149
  • Mass: 131468
  • Checksum: 56C1AB96647E4D85
  • Sequence:
    • MAERKGTAKV DFLKKIEKEI QQKWDTERVF EVNASNLEKQ TSKGKYFVTF PYPYMNGRLH 
LGHTFSLSKC EACADKLKRE IELYGCPPDF PDEEEEEEET SVKTEDIIIK DKAKGKKSKA 
AAKAGSSKYQ WGIMKSLGLS DEEIVKFSEA EHWLDYFPPL AIQDLKRMGL KVDWRRSFIT 
TDVNPYYDSF VRWQFLTLRE RNKIKFGKRY TIYSPKDGQP CMDHDRQTGE GVGPQEYTLL 
KLKVLEPYPS KLSGLKGKNI FLVAATLRPE TMFGQTNCWV RPDMKYIGFE TVNGDIFICT 
QKAARNMSYQ GFTKDNGVVP VVKELMGEEI LGASLSAPLT SYKVIYVLPM LTIKEDKGTG 
VVTSVPSDSP DDIAALRDLK KKQALRAKYG IRDDMVLPFE PVPVIEIPGF GNLSAVTICD 
ELKIQSQNDR EKLAEAKEKI YLKGFYEGIM LVDGFKGQKV QDVKKTIQKK MIDAGDALIY 
MEPEKQVMSR SSDECVVALC DQWYLDYGEE NWKKQTSQCL KNLETFCEET RRNFEATLGW 
LQEHACSRTY GLGTHLPWDE QWLIESLSDS TIYMAFYTVA HLLQGGNLHG QAESPLGIRP 
QQMTKEVWDY VFFKEAPFPK TQIAKEKLDQ LKQEFEFWYP VDLRVSGKDL VPNHLSYYLY 
NHVAMWPEQS DKWPTAVRAN GHLLLNSEKM SKSTGNFLTL TQAIDKFSAD GMRLALADAG 
DTVEDANFVE AMADAGILRL YTWVEWVKEM VANWDSLRSG PASTFNDRVF ASELNAGIIK 
TDQNYEKMMF KEALKTGFFE FQAAKDKYRE LAVEGMHREL VFRFIEVQTL LLAPFCPHLC 
EHIWTLLGKP DSIMNASWPV AGPVNEVLIH SSQYLMEVTH DLRLRLKNYM MPAKGKKTDK 
QPLQKPSHCT IYVAKNYPPW QHTTLSVLRK HFEANNGKLP DNKVIASELG SMPELKKYMK 
KVMPFVAMIK ENLEKMGPRI LDLQLEFDEK AVLMENIVYL TNSLELEHIE VKFASEAEDK 
IREDCCPGKP LNVFRIEPGV SVSLVNPQPS NGHFSTKIEI RQGDNCDSII RRLMKMNRGI 
KDLSKVKLMR FDDPLLGPRR VPVLGKEYTE KTPISEHAVF NVDLMSKKIH LTENGIRVDI 
GDTIIYLVH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.