Details for: VTA1

Gene ID: 51534

Symbol: VTA1

Ensembl ID: ENSG00000009844

Description: vesicle trafficking 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 203.9921
    Cell Significance Index: -31.7300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 123.9141
    Cell Significance Index: -31.4300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 86.4188
    Cell Significance Index: -35.6000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 75.3194
    Cell Significance Index: -35.5600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 74.5095
    Cell Significance Index: -30.2700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 53.1428
    Cell Significance Index: -35.6600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 31.8620
    Cell Significance Index: -30.4200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.4868
    Cell Significance Index: -33.8900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.6990
    Cell Significance Index: -31.3400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.7860
    Cell Significance Index: -34.6700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.7450
    Cell Significance Index: -26.8600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.7846
    Cell Significance Index: -12.6600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3586
    Cell Significance Index: 81.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2855
    Cell Significance Index: 257.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1943
    Cell Significance Index: 237.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0029
    Cell Significance Index: 26.7800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8590
    Cell Significance Index: 11.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7871
    Cell Significance Index: 141.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7536
    Cell Significance Index: 42.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6043
    Cell Significance Index: 74.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5524
    Cell Significance Index: 89.8400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5447
    Cell Significance Index: 297.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4789
    Cell Significance Index: 171.7900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4287
    Cell Significance Index: 26.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4223
    Cell Significance Index: 9.1500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4121
    Cell Significance Index: 48.6000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4012
    Cell Significance Index: 277.4900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3374
    Cell Significance Index: 9.4300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3313
    Cell Significance Index: 146.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2995
    Cell Significance Index: 8.6300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2794
    Cell Significance Index: 53.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2560
    Cell Significance Index: 35.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2539
    Cell Significance Index: 17.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2297
    Cell Significance Index: 11.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1779
    Cell Significance Index: 11.2100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1727
    Cell Significance Index: 1.5900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1723
    Cell Significance Index: 7.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1641
    Cell Significance Index: 12.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1355
    Cell Significance Index: 5.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1353
    Cell Significance Index: 13.3800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1051
    Cell Significance Index: 2.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0997
    Cell Significance Index: 4.6500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0969
    Cell Significance Index: 6.8500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0955
    Cell Significance Index: 16.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0760
    Cell Significance Index: 3.5700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0743
    Cell Significance Index: 67.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0694
    Cell Significance Index: 4.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0322
    Cell Significance Index: 1.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0321
    Cell Significance Index: 1.6700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0130
    Cell Significance Index: 1.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0010
    Cell Significance Index: -1.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0049
    Cell Significance Index: -3.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0101
    Cell Significance Index: -7.4500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0101
    Cell Significance Index: -6.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0140
    Cell Significance Index: -25.8700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0169
    Cell Significance Index: -26.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0193
    Cell Significance Index: -26.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0222
    Cell Significance Index: -10.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0254
    Cell Significance Index: -18.5900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0305
    Cell Significance Index: -0.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0309
    Cell Significance Index: -23.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0319
    Cell Significance Index: -18.0000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0328
    Cell Significance Index: -0.6400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0598
    Cell Significance Index: -8.6900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0722
    Cell Significance Index: -2.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0771
    Cell Significance Index: -7.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0829
    Cell Significance Index: -6.1800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0902
    Cell Significance Index: -2.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0940
    Cell Significance Index: -19.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0998
    Cell Significance Index: -12.8900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1067
    Cell Significance Index: -30.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1174
    Cell Significance Index: -13.4500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1220
    Cell Significance Index: -2.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1296
    Cell Significance Index: -4.5600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1582
    Cell Significance Index: -4.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1708
    Cell Significance Index: -19.9000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1740
    Cell Significance Index: -3.8100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1945
    Cell Significance Index: -3.2600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2146
    Cell Significance Index: -4.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2206
    Cell Significance Index: -5.8000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2943
    Cell Significance Index: -33.5900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3095
    Cell Significance Index: -10.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3233
    Cell Significance Index: -8.3100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3241
    Cell Significance Index: -33.7500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3397
    Cell Significance Index: -7.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3535
    Cell Significance Index: -18.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3684
    Cell Significance Index: -29.1800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3703
    Cell Significance Index: -22.7000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3748
    Cell Significance Index: -9.5800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3783
    Cell Significance Index: -11.1100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4152
    Cell Significance Index: -8.8800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4444
    Cell Significance Index: -2.6900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4700
    Cell Significance Index: -4.8700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4862
    Cell Significance Index: -13.0100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5312
    Cell Significance Index: -12.2700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.5735
    Cell Significance Index: -9.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5945
    Cell Significance Index: -18.9400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5993
    Cell Significance Index: -19.6200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6374
    Cell Significance Index: -11.7800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6865
    Cell Significance Index: -14.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** VTA1 is a gene that has been significantly expressed in a range of cell types, including hematopoietic oligopotent progenitor cells, embryonic stem cells, and smooth muscle fibers of the ileum. The protein encoded by VTA1, VTA1_HUMAN, is a homolog of the Vacuolar Protein Sorting-Associated Protein (VPS) family, which plays a crucial role in the sorting and transport of proteins within the endosomal system. This gene has been identified as a key player in the budding and maturation of HIV virions, highlighting its importance in the viral life cycle. **Pathways and Functions:** VTA1 is involved in several key pathways, including the budding and maturation of HIV virions, the endosomal sorting complex required for transport (ESCRT) pathway, and the multivesicular body (MVB) sorting pathway. These pathways are critical for the proper sorting and transport of proteins within the endosomal system, and VTA1 is essential for the efficient budding and maturation of HIV virions. Additionally, VTA1 has been implicated in macroautophagy, a process by which cells recycle damaged or dysfunctional organelles and proteins. **Clinical Significance:** The clinical significance of VTA1 is multifaceted. As a gene involved in the budding and maturation of HIV virions, VTA1 plays a critical role in the viral life cycle and the development of HIV-associated diseases. Mutations in VTA1 have been associated with HIV-1 replication and the progression of HIV-associated diseases. Furthermore, VTA1 has been implicated in the development of other diseases, including cancer and autoimmune disorders, highlighting the importance of this gene in the regulation of cellular trafficking and immune response. In conclusion, VTA1 is a gene that plays a critical role in the regulation of cellular trafficking and immune response. Its involvement in the budding and maturation of HIV virions highlights its importance in the viral life cycle, and its implications in the development of other diseases underscore its significance in the broader context of immunology and disease. As research into VTA1 continues to uncover its complexities, it is essential to consider the potential therapeutic applications of this gene in the treatment of infectious diseases and other conditions associated with impaired cellular trafficking and immune response.

Genular Protein ID: 4253354016

Symbol: VTA1_HUMAN

Name: Vacuolar protein sorting-associated protein VTA1 homolog

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15644320

Title: The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells.

PubMed ID: 15644320

DOI: 10.1074/jbc.m413734200

PubMed ID: 17261583

Title: Targeting of AMSH to endosomes is required for epidermal growth factor receptor degradation.

PubMed ID: 17261583

DOI: 10.1074/jbc.m611635200

PubMed ID: 18385515

Title: Novel interactions of ESCRT-III with LIP5 and VPS4 and their implications for ESCRT-III disassembly.

PubMed ID: 18385515

DOI: 10.1091/mbc.e07-12-1263

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19129480

Title: Essential role of hIST1 in cytokinesis.

PubMed ID: 19129480

DOI: 10.1091/mbc.e08-05-0474

PubMed ID: 19129479

Title: Biochemical analyses of human IST1 and its function in cytokinesis.

PubMed ID: 19129479

DOI: 10.1091/mbc.e08-05-0475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21543490

Title: Mechanism of inhibition of retrovirus release from cells by interferon-induced gene ISG15.

PubMed ID: 21543490

DOI: 10.1128/jvi.02610-10

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

Sequence Information:

  • Length: 307
  • Mass: 33879
  • Checksum: C7DE611E50B58BF9
  • Sequence:
  • MAALAPLPPL PAQFKSIQHH LRTAQEHDKR DPVVAYYCRL YAMQTGMKID SKTPECRKFL 
    SKLMDQLEAL KKQLGDNEAI TQEIVGCAHL ENYALKMFLY ADNEDRAGRF HKNMIKSFYT 
    ASLLIDVITV FGELTDENVK HRKYARWKAT YIHNCLKNGE TPQAGPVGIE EDNDIEENED 
    AGAASLPTQP TQPSSSSTYD PSNMPSGNYT GIQIPPGAHA PANTPAEVPH STGVASNTIQ 
    PTPQTIPAID PALFNTISQG DVRLTPEDFA RAQKYCKYAG SALQYEDVST AVQNLQKALK 
    LLTTGRE

Genular Protein ID: 516139316

Symbol: A0A087WY55_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.M111.015131

Sequence Information:

  • Length: 280
  • Mass: 31102
  • Checksum: 96347EB4529D94A4
  • Sequence:
  • MAALAPLPPL PAQFKSIQHH LRTAQEHDKR DPVVAYYCRL YAMQTGMKID SKTPECRKFL 
    SKLMDQLEAL KKQLGDNEAI TQEIVGCAHL ENYALKMFLY ADNEDRAGRF HKNMIKSFYT 
    ASLLIDVITV FGELTDENVK HRKYARWKAT YIHNCLKNGE TPQAGPVGIE EDNDIEENED 
    AGAASLPTQP TQPSSSSTYD PSNMPSGNYT GIQIPPGAHA PANTPAEVPH STGDVRLTPE 
    DFARAQKYCK YAGSALQYED VSTAVQNLQK ALKLLTTGRE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.