Details for: GDE1

Gene ID: 51573

Symbol: GDE1

Ensembl ID: ENSG00000006007

Description: glycerophosphodiester phosphodiesterase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 167.0897
    Cell Significance Index: -25.9900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 94.6605
    Cell Significance Index: -24.0100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 68.5415
    Cell Significance Index: -32.3600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 66.3619
    Cell Significance Index: -26.9600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 59.0802
    Cell Significance Index: -30.3900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 48.2398
    Cell Significance Index: -32.3700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.5103
    Cell Significance Index: -27.2200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.0470
    Cell Significance Index: -25.9500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.1689
    Cell Significance Index: -29.9200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.7673
    Cell Significance Index: -30.6500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.3812
    Cell Significance Index: -7.4000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.8620
    Cell Significance Index: 1681.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3787
    Cell Significance Index: 71.6200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0860
    Cell Significance Index: 593.0900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.9844
    Cell Significance Index: 9.0700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.9163
    Cell Significance Index: 31.8400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9114
    Cell Significance Index: 164.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.8493
    Cell Significance Index: 63.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8341
    Cell Significance Index: 102.5700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7666
    Cell Significance Index: 20.4700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7603
    Cell Significance Index: 75.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7581
    Cell Significance Index: 34.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7301
    Cell Significance Index: 21.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6432
    Cell Significance Index: 29.9900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6370
    Cell Significance Index: 13.8000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5495
    Cell Significance Index: 38.0000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5281
    Cell Significance Index: 37.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5276
    Cell Significance Index: 14.3600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5232
    Cell Significance Index: 15.3700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4936
    Cell Significance Index: 13.2300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4865
    Cell Significance Index: 7.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4521
    Cell Significance Index: 62.0900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.4348
    Cell Significance Index: 4.5000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4241
    Cell Significance Index: 187.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4083
    Cell Significance Index: 81.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3397
    Cell Significance Index: 58.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2117
    Cell Significance Index: 13.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2032
    Cell Significance Index: 40.3300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.1914
    Cell Significance Index: 4.8900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1849
    Cell Significance Index: 9.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1737
    Cell Significance Index: 62.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1616
    Cell Significance Index: 7.6000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1574
    Cell Significance Index: 20.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1507
    Cell Significance Index: 3.2100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1398
    Cell Significance Index: 18.0600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1369
    Cell Significance Index: 26.0600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1364
    Cell Significance Index: 8.6000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0501
    Cell Significance Index: 37.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0497
    Cell Significance Index: 2.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0391
    Cell Significance Index: 1.2500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0343
    Cell Significance Index: 23.6900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0053
    Cell Significance Index: 0.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0011
    Cell Significance Index: 0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0029
    Cell Significance Index: -2.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0062
    Cell Significance Index: -0.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0066
    Cell Significance Index: -4.8400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0071
    Cell Significance Index: -4.4400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0102
    Cell Significance Index: -19.2600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0155
    Cell Significance Index: -0.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0190
    Cell Significance Index: -35.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0229
    Cell Significance Index: -35.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0239
    Cell Significance Index: -2.4400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0258
    Cell Significance Index: -35.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0265
    Cell Significance Index: -16.8000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0276
    Cell Significance Index: -0.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0319
    Cell Significance Index: -14.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0372
    Cell Significance Index: -20.9700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0635
    Cell Significance Index: -7.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0681
    Cell Significance Index: -19.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0724
    Cell Significance Index: -15.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0831
    Cell Significance Index: -9.6800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0960
    Cell Significance Index: -1.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1070
    Cell Significance Index: -12.2600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1447
    Cell Significance Index: -3.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1578
    Cell Significance Index: -4.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1584
    Cell Significance Index: -23.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1655
    Cell Significance Index: -9.2900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1792
    Cell Significance Index: -12.0500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1831
    Cell Significance Index: -29.7800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2524
    Cell Significance Index: -6.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2588
    Cell Significance Index: -19.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2910
    Cell Significance Index: -30.3000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3086
    Cell Significance Index: -24.4400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3365
    Cell Significance Index: -6.2200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3709
    Cell Significance Index: -8.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3729
    Cell Significance Index: -22.9200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3850
    Cell Significance Index: -4.5900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3956
    Cell Significance Index: -4.1000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.4054
    Cell Significance Index: -2.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4555
    Cell Significance Index: -20.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4618
    Cell Significance Index: -28.3100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5125
    Cell Significance Index: -13.7100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5556
    Cell Significance Index: -21.0400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5575
    Cell Significance Index: -15.9100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5626
    Cell Significance Index: -16.5700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5800
    Cell Significance Index: -16.6300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5951
    Cell Significance Index: -30.0800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.6083
    Cell Significance Index: -5.1100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6120
    Cell Significance Index: -13.4000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6396
    Cell Significance Index: -23.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GDE1 belongs to the family of phosphodiesterases, enzymes that catalyze the hydrolysis of phosphodiester bonds. Unlike other phosphodiesterases, GDE1 is specifically involved in the breakdown of glycerophospholipids, which are crucial for maintaining cellular membrane structure and function. The enzyme's substrate specificity and tissue distribution suggest that GDE1 plays a unique role in regulating lipid metabolism and immune responses. **Pathways and Functions:** GDE1 is involved in several key pathways, including: 1. **Glycerophospholipid catabolism:** GDE1 hydrolyzes glycerophospholipids, releasing phosphocholine and diacylglycerol. This process is essential for maintaining cellular membrane homeostasis and regulating lipid metabolism. 2. **Ethanolamine metabolic process:** GDE1 is also involved in the breakdown of ethanolamine, a key component of glycerophospholipids. This process is essential for maintaining cellular membrane structure and function. 3. **Lipid metabolic process:** GDE1's activity in glycerophospholipid catabolism and ethanolamine metabolic process suggests its role in regulating lipid metabolism and maintaining cellular homeostasis. 4. **Immune regulation:** GDE1's expression in immune cells, such as hematopoietic cells and mast cells, indicates its involvement in immune responses. The enzyme's activity may regulate the breakdown of glycerophospholipids, which are essential components of immune cell membranes. **Clinical Significance:** GDE1's involvement in lipid metabolism and immune regulation suggests its potential role in various diseases, including: 1. **Metabolic disorders:** Dysregulation of GDE1 activity may contribute to metabolic disorders, such as lipid metabolism disorders and diabetes. 2. **Autoimmune diseases:** GDE1's expression in immune cells and its involvement in immune regulation suggest its potential role in autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer:** GDE1's expression in hematopoietic cells and its involvement in immune regulation suggest its potential role in cancer development and progression. In conclusion, GDE1 is a membrane-bound enzyme that plays a crucial role in regulating lipid metabolism and immune responses. Further research is necessary to fully understand the mechanisms underlying GDE1's function and its potential role in various diseases.

Genular Protein ID: 396687914

Symbol: GDE1_HUMAN

Name: RGS16-interacting membrane protein

UniProtKB Accession Codes:

Q9NZC3 O43334 Q6PKF7 Q7KYR4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 49 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 18 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10760272

Title: MIR16, a putative membrane glycerophosphodiester phosphodiesterase, interacts with RGS16.

PubMed ID: 10760272

DOI: 10.1073/pnas.97.8.3999

PubMed ID: 10493829

Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.

PubMed ID: 10493829

DOI: 10.1006/geno.1999.5927

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16472945

Title: Genomic organization, characterization, and molecular 3D model of GDE1, a novel mammalian glycerophosphoinositol phosphodiesterase.

PubMed ID: 16472945

DOI: 10.1016/j.gene.2005.11.023

Sequence Information:

  • Length: 331
  • Mass: 37718
  • Checksum: EFE567E71DBD4AC5
  • Sequence:
    • MWLWEDQGGL LGPFSFLLLV LLLVTRSPVN ACLLTGSLFV LLRVFSFEPV PSCRALQVLK 
PRDRISAIAH RGGSHDAPEN TLAAIRQAAK NGATGVELDI EFTSDGIPVL MHDNTVDRTT 
DGTGRLCDLT FEQIRKLNPA ANHRLRNDFP DEKIPTLREA VAECLNHNLT IFFDVKGHAH 
KATEALKKMY MEFPQLYNNS VVCSFLPEVI YKMRQTDRDV ITALTHRPWS LSHTGDGKPR 
YDTFWKHFIF VMMDILLDWS MHNILWYLCG ISAFLMQKDF VSPAYLKKWS AKGIQVVGWT 
VNTFDEKSYY ESHLGSSYIT DSMVEDCEPH F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.