Details for: AZIN1

Gene ID: 51582

Symbol: AZIN1

Ensembl ID: ENSG00000155096

Description: antizyme inhibitor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 321.3856
    Cell Significance Index: -49.9900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 219.7179
    Cell Significance Index: -55.7300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 140.1392
    Cell Significance Index: -57.7300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 123.3154
    Cell Significance Index: -58.2200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 120.1948
    Cell Significance Index: -48.8300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 110.2384
    Cell Significance Index: -56.7100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 86.8675
    Cell Significance Index: -58.2900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 51.8778
    Cell Significance Index: -49.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 46.3926
    Cell Significance Index: -57.2000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.8032
    Cell Significance Index: -53.0500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.8858
    Cell Significance Index: -58.7400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.3976
    Cell Significance Index: -41.1500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.2206
    Cell Significance Index: -20.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 6.1266
    Cell Significance Index: 163.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.1556
    Cell Significance Index: 484.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.9146
    Cell Significance Index: 208.2500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5494
    Cell Significance Index: 251.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3953
    Cell Significance Index: 276.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3773
    Cell Significance Index: 276.2800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1808
    Cell Significance Index: 32.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.1261
    Cell Significance Index: 32.2800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0006
    Cell Significance Index: 69.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8815
    Cell Significance Index: 103.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8352
    Cell Significance Index: 24.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7494
    Cell Significance Index: 33.9700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7044
    Cell Significance Index: 384.6700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6952
    Cell Significance Index: 85.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6541
    Cell Significance Index: 117.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6504
    Cell Significance Index: 14.0900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6265
    Cell Significance Index: 48.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6085
    Cell Significance Index: 45.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5903
    Cell Significance Index: 112.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5565
    Cell Significance Index: 34.2100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.5327
    Cell Significance Index: 5.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5290
    Cell Significance Index: 189.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4473
    Cell Significance Index: 25.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4209
    Cell Significance Index: 57.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3802
    Cell Significance Index: 17.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3475
    Cell Significance Index: 16.2000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2989
    Cell Significance Index: 132.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2889
    Cell Significance Index: 10.0400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2845
    Cell Significance Index: 196.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2833
    Cell Significance Index: 36.3200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2759
    Cell Significance Index: 249.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2531
    Cell Significance Index: 13.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2125
    Cell Significance Index: 36.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1663
    Cell Significance Index: 306.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1537
    Cell Significance Index: 5.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1278
    Cell Significance Index: 196.7900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1059
    Cell Significance Index: 199.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0834
    Cell Significance Index: 113.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0823
    Cell Significance Index: 10.6400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0316
    Cell Significance Index: 3.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0080
    Cell Significance Index: 5.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0064
    Cell Significance Index: -0.4100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0163
    Cell Significance Index: -0.8500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0268
    Cell Significance Index: -0.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0318
    Cell Significance Index: -14.4300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0427
    Cell Significance Index: -32.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0485
    Cell Significance Index: -35.9200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0496
    Cell Significance Index: -36.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0628
    Cell Significance Index: -9.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0694
    Cell Significance Index: -7.0900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0713
    Cell Significance Index: -4.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0944
    Cell Significance Index: -53.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0986
    Cell Significance Index: -61.6000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1156
    Cell Significance Index: -6.0700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1227
    Cell Significance Index: -3.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1341
    Cell Significance Index: -3.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1533
    Cell Significance Index: -10.3100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1585
    Cell Significance Index: -11.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1659
    Cell Significance Index: -47.7400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1876
    Cell Significance Index: -3.1400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2985
    Cell Significance Index: -62.8800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3305
    Cell Significance Index: -6.4500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3728
    Cell Significance Index: -6.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3747
    Cell Significance Index: -42.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4142
    Cell Significance Index: -18.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4264
    Cell Significance Index: -44.4000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4552
    Cell Significance Index: -14.5800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.4558
    Cell Significance Index: -2.8100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4829
    Cell Significance Index: -12.0700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5129
    Cell Significance Index: -11.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5173
    Cell Significance Index: -19.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.5180
    Cell Significance Index: -31.1000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5209
    Cell Significance Index: -13.3900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5409
    Cell Significance Index: -9.2700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5479
    Cell Significance Index: -13.1400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5541
    Cell Significance Index: -7.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6093
    Cell Significance Index: -48.2600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6679
    Cell Significance Index: -13.9800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7044
    Cell Significance Index: -10.4000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7110
    Cell Significance Index: -20.2900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7136
    Cell Significance Index: -13.1900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.7646
    Cell Significance Index: -7.9200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.8203
    Cell Significance Index: -24.0900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8245
    Cell Significance Index: -50.5500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8976
    Cell Significance Index: -24.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9481
    Cell Significance Index: -25.4100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.9840
    Cell Significance Index: -11.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** AZIN1 is a protein-coding gene located on chromosome 4q11.23 in humans. It encodes a protein that inhibits antizymes, which are small proteins that regulate the activity of ODC. AZIN1 is highly expressed in cells involved in immune function, such as hematopoietic cells, stem cells, and immune cells. It is also expressed in non-immune cells, including embryonic stem cells, smooth muscle fibers, and goblet cells. **Pathways and Functions:** AZIN1 is involved in several key pathways, including: 1. **Polyamine biosynthesis:** AZIN1 inhibits antizymes, which in turn regulates the activity of ODC. ODC is a key enzyme involved in the biosynthesis of polyamines, such as putrescine and spermidine. 2. **Immune regulation:** AZIN1 is highly expressed in immune cells, such as hematopoietic cells, stem cells, and immune cells. It is involved in the regulation of immune responses, including the activation and proliferation of immune cells. 3. **Cellular proliferation:** AZIN1 is also involved in the regulation of cellular proliferation, particularly in stem cells and embryonic cells. 4. **Negative regulation of protein catabolic process:** AZIN1 has been shown to inhibit the activity of protein-catabolic enzymes, which suggests its role in maintaining protein homeostasis. **Clinical Significance:** AZIN1 has been implicated in various diseases, including: 1. **Immune disorders:** AZIN1 has been shown to play a role in the regulation of immune responses, and its dysregulation has been implicated in autoimmune disorders, such as rheumatoid arthritis. 2. **Cancer:** AZIN1 has been shown to be overexpressed in certain types of cancer, including leukemia and lymphoma. 3. **Neurological disorders:** AZIN1 has been implicated in the regulation of neuronal function and has been shown to be involved in the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease. In conclusion, AZIN1 is a key player in polyamine metabolism and immune regulation. Its dysregulation has been implicated in various diseases, including immune disorders, cancer, and neurological disorders. Further research is needed to fully understand the function and significance of AZIN1 in human health and disease. **References:** * [Insert references to relevant studies on AZIN1] **Author's Note:** As an expert immunologist, I would like to emphasize the importance of further research on AZIN1 to fully understand its function and significance in human health and disease. The clinical significance of AZIN1 highlights the need for further investigation into its role in various diseases, including immune disorders, cancer, and neurological disorders.

Genular Protein ID: 3256161127

Symbol: AZIN1_HUMAN

Name: Antizyme inhibitor 1

UniProtKB Accession Codes:

O14977 A6NCD5 Q6IBQ7 Q96D20

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 8 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 4 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9349715

Title: Cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme inhibitor.

PubMed ID: 9349715

DOI: 10.1016/s0167-4781(97)00106-1

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17900240

Title: Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase.

PubMed ID: 17900240

DOI: 10.1042/bj20071004

PubMed ID: 26305948

Title: Structural basis of antizyme-mediated regulation of polyamine homeostasis.

PubMed ID: 26305948

DOI: 10.1073/pnas.1508187112

Sequence Information:

  • Length: 448
  • Mass: 49535
  • Checksum: DD26B22A993318E4
  • Sequence:
    • MKGFIDDANY SVGLLDEGTN LGNVIDNYVY EHTLTGKNAF FVGDLGKIVK KHSQWQNVVA 
QIKPFYTVKC NSAPAVLEIL AALGTGFACS SKNEMALVQE LGVPPENIIY ISPCKQVSQI 
KYAAKVGVNI LTCDNEIELK KIARNHPNAK VLLHIATEDN IGGEEGNMKF GTTLKNCRHL 
LECAKELDVQ IIGVKFHVSS ACKESQVYVH ALSDARCVFD MAGEIGFTMN MLDIGGGFTG 
TEFQLEEVNH VISPLLDIYF PEGSGVKIIS EPGSYYVSSA FTLAVNIIAK KVVENDKFPS 
GVEKTGSDEP AFMYYMNDGV YGSFASKLSE DLNTIPEVHK KYKEDEPLFT SSLWGPSCDE 
LDQIVESCLL PELNVGDWLI FDNMGADSFH EPSAFNDFQR PAIYYMMSFS DWYEMQDAGI 
TSDSMMKNFF FVPSCIQLSQ EDSFSAEA

Genular Protein ID: 438855571

Symbol: B3KTF6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KTF6

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 2 PROSITE 1 PeptideAtlas 1 Pfam 4 RefSeq 1 RuleBase 1 SUPFAM 2

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 363
  • Mass: 39855
  • Checksum: A3B30182D4824BF3
  • Sequence:
    • MKGFIDDANY SVGLLDEGTN LGNVIDNYVY EHTLTGKNAF FVGDLGKIVK KHSQWQNVVA 
QIKPFYTVKC NSAPAVLEIL AALGTGFACS SKNEMALVQE LGVPPENIIY ISPCKQVSQI 
KYAAKVGVNI LTCDNEIELK KIARNHPNAK VLLHIATEDN IGGEEGNMKF GTTLKNCRHL 
LECAKELDVQ IIGVKFHVSS ACKESQVYVH ALSDARCVFD MAGEIGFTMN MLDIGGGFTG 
TEFQLEEVNH VISPLLDIYF PEGSGVKIIS EPGSYYVSSA FTLAVNIIAK KVVENDKFPS 
GVEKTGSDEP AFMYYMNDGV YGSFASKLSE DLNTIPEVHK KYKEDEPLFT SSLWGPSCDE 
LFR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.