Details for: PCF11

Gene ID: 51585

Symbol: PCF11

Ensembl ID: ENSG00000165494

Description: PCF11 cleavage and polyadenylation factor subunit

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 302.2272
    Cell Significance Index: -47.0100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 179.2083
    Cell Significance Index: -45.4600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 120.7921
    Cell Significance Index: -49.7600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 112.1001
    Cell Significance Index: -52.9300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 111.6042
    Cell Significance Index: -45.3400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 100.1001
    Cell Significance Index: -51.4900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 78.8424
    Cell Significance Index: -52.9100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 47.5756
    Cell Significance Index: -45.4200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 41.6560
    Cell Significance Index: -51.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.9670
    Cell Significance Index: -50.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.3273
    Cell Significance Index: -52.5900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.4925
    Cell Significance Index: -38.3700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.7062
    Cell Significance Index: -25.6200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.3496
    Cell Significance Index: 162.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.0785
    Cell Significance Index: 134.1000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.9462
    Cell Significance Index: 52.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.4215
    Cell Significance Index: 74.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.3664
    Cell Significance Index: 175.1700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3279
    Cell Significance Index: 60.1900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2175
    Cell Significance Index: 132.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1987
    Cell Significance Index: 194.9600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0507
    Cell Significance Index: 948.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9922
    Cell Significance Index: 199.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9824
    Cell Significance Index: 28.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9157
    Cell Significance Index: 112.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8338
    Cell Significance Index: 150.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8270
    Cell Significance Index: 113.5700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7807
    Cell Significance Index: 40.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7801
    Cell Significance Index: 16.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7089
    Cell Significance Index: 140.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6154
    Cell Significance Index: 272.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6004
    Cell Significance Index: 16.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5953
    Cell Significance Index: 27.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5840
    Cell Significance Index: 32.7700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5564
    Cell Significance Index: 199.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4054
    Cell Significance Index: 221.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4040
    Cell Significance Index: 31.0000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.3993
    Cell Significance Index: 6.0700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.3983
    Cell Significance Index: 45.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3983
    Cell Significance Index: 18.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3938
    Cell Significance Index: 27.8500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3026
    Cell Significance Index: 57.5800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2636
    Cell Significance Index: 182.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2268
    Cell Significance Index: 26.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2257
    Cell Significance Index: 7.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1700
    Cell Significance Index: 12.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1456
    Cell Significance Index: 18.8200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1174
    Cell Significance Index: 74.5800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1056
    Cell Significance Index: 198.7500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0888
    Cell Significance Index: 2.5500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0488
    Cell Significance Index: 8.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0289
    Cell Significance Index: 1.5200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0178
    Cell Significance Index: 27.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0073
    Cell Significance Index: 0.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0057
    Cell Significance Index: 10.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0002
    Cell Significance Index: 0.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0098
    Cell Significance Index: -13.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0144
    Cell Significance Index: -10.5500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0147
    Cell Significance Index: -10.9200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0195
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0204
    Cell Significance Index: -12.7200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0225
    Cell Significance Index: -0.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0445
    Cell Significance Index: -25.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0481
    Cell Significance Index: -36.4000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0546
    Cell Significance Index: -5.4000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0818
    Cell Significance Index: -8.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1038
    Cell Significance Index: -6.3800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1158
    Cell Significance Index: -1.3800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1340
    Cell Significance Index: -28.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1567
    Cell Significance Index: -45.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1615
    Cell Significance Index: -3.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1644
    Cell Significance Index: -23.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1654
    Cell Significance Index: -11.1200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2385
    Cell Significance Index: -6.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2388
    Cell Significance Index: -27.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2588
    Cell Significance Index: -30.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2613
    Cell Significance Index: -6.8700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2767
    Cell Significance Index: -5.7400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3392
    Cell Significance Index: -6.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3778
    Cell Significance Index: -13.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4009
    Cell Significance Index: -5.4700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4015
    Cell Significance Index: -6.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4361
    Cell Significance Index: -45.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5097
    Cell Significance Index: -8.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5159
    Cell Significance Index: -22.8200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5164
    Cell Significance Index: -11.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5732
    Cell Significance Index: -45.4000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6353
    Cell Significance Index: -13.3000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6373
    Cell Significance Index: -15.9300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6782
    Cell Significance Index: -25.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6803
    Cell Significance Index: -21.7900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7388
    Cell Significance Index: -18.8800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7416
    Cell Significance Index: -37.4800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7782
    Cell Significance Index: -47.7100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.8068
    Cell Significance Index: -7.4300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.8522
    Cell Significance Index: -15.0600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8624
    Cell Significance Index: -23.0700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.8902
    Cell Significance Index: -21.7200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.0086
    Cell Significance Index: -21.5600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0701
    Cell Significance Index: -31.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PCF11 is a subunit of the cleavage and polyadenylation factor (EFC) complex, which is responsible for the cleavage and polyadenylation of pre-mRNA. The EFC complex is composed of multiple subunits, including PCF11, PCF15, and PCF20, which work together to regulate the processing of pre-mRNA. PCF11 is specifically involved in the recognition and cleavage of the 3' untranslated region (UTR) of pre-mRNA, which is essential for the regulation of gene expression. **Pathways and Functions** PCF11 is involved in several key pathways and processes, including: 1. **Co-transcriptional mRNA 3'-end processing**: PCF11 plays a crucial role in the recognition and cleavage of pre-mRNA, which is essential for the regulation of gene expression. 2. **Cleavage and polyadenylation pathway**: PCF11 is involved in the recognition and cleavage of the 3' UTR of pre-mRNA, which is essential for the regulation of gene expression. 3. **Gene expression (transcription)**: PCF11 is involved in the regulation of gene expression by controlling the processing of pre-mRNA. 4. **Metabolism of RNA**: PCF11 is involved in the regulation of RNA metabolism by controlling the processing of pre-mRNA. 5. **Mitochondrion**: PCF11 is involved in the regulation of mitochondrial gene expression by controlling the processing of pre-mRNA. **Clinical Significance** The PCF11 gene has significant clinical implications, particularly in the context of hematological disorders. Mutations in the PCF11 gene have been associated with various hematological disorders, including: 1. **Thrombocytopenia**: Mutations in the PCF11 gene have been associated with thrombocytopenia, a condition characterized by low platelet counts. 2. **Anemia**: Mutations in the PCF11 gene have been associated with anemia, a condition characterized by low red blood cell counts. 3. **Leukemia**: Mutations in the PCF11 gene have been associated with leukemia, a type of cancer characterized by the uncontrolled growth of abnormal white blood cells. In addition to its clinical significance, the PCF11 gene also has implications for the development of novel therapeutic strategies for hematological disorders. For example, the use of small molecule inhibitors of the PCF11 gene has been explored as a potential therapeutic strategy for the treatment of thrombocytopenia and anemia. In conclusion, the PCF11 gene plays a critical role in the regulation of RNA processing, particularly in the cleavage and polyadenylation of pre-mRNA. Its significant expression in various cell types and its involvement in several key pathways and processes make it an important target for the development of novel therapeutic strategies for hematological disorders.

Genular Protein ID: 3348114283

Symbol: PCF11_HUMAN

Name: Pre-mRNA cleavage complex II protein Pcf11

UniProtKB Accession Codes:

O94913 A6H8W7 O43671 Q6P0X8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11060040

Title: Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors.

PubMed ID: 11060040

DOI: 10.1093/emboj/19.21.5895

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 29196535

Title: WNK1 kinase and the termination factor PCF11 connect nuclear mRNA export with transcription.

PubMed ID: 29196535

DOI: 10.1101/gad.303677.117

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 1555
  • Mass: 173050
  • Checksum: 0AEAE04D7CB4A34F
  • Sequence:
    • MSEQTPAEAG AAGAREDACR DYQSSLEDLT FNSKPHINML TILAEENLPF AKEIVSLIEA 
QTAKAPSSEK LPVMYLMDSI VKNVGREYLT AFTKNLVATF ICVFEKVDEN TRKSLFKLRS 
TWDEIFPLKK LYALDVRVNS LDPAWPIKPL PPNVNTSSIH VNPKFLNKSP EEPSTPGTVV 
SSPSISTPPI VPDIQKNLTQ EQLIRQQLLA KQKQLLELQQ KKLELELEQA KAQLAVSLSV 
QQETSNLGPG SAPSKLHVSQ IPPMAVKAPH QVPVQSEKSR PGPSLQIQDL KGTNRDPRLN 
RISQHSHGKD QSHRKEFLMN TLNQSDTKTS KTIPSEKLNS SKQEKSKSGE KITKKELDQL 
DSKSKSKSKS PSPLKNKLSH TKDLKNQESE SMRLSDMNKR DPRLKKHLQD KTDGKDDDVK 
EKRKTAEKKD KDEHMKSSEH RLAGSRNKII NGIVQKQDTI TEESEKQGTK PGRSSTRKRS 
RSRSPKSRSP IIHSPKRRDR RSPKRRQRSM SPTSTPKAGK IRQSGAKQSH MEEFTPPSRE 
DRNAKRSTKQ DIRDPRRMKK TEEERPQETT NQHSTKSGTE PKENVENWQS SKSAKRWKSG 
WEENKSLQQV DEHSKPPHLR HRESWSSTKG ILSPRAPKQQ QHRLSVDANL QIPKELTLAS 
KRELLQKTSE RLASGEITQD DFLVVVHQIR QLFQYQEGVR EEQRSPFNDR FPLKRPRYED 
SDKPFVDSPA SRFAGLDTNQ RLTALAEDRP LFDGPSRPSV ARDGPTKMIF EGPNKLSPRI 
DGPPTPASLR FDGSPGQMGG GGPLRFEGPQ GQLGGGCPLR FEGPPGPVGT PLRFEGPIGQ 
AGGGGFRFEG SPGLRFEGSP GGLRFEGPGG QPVGGLRFEG HRGQPVGGLR FEGPHGQPVG 
GLRFDNPRGQ PVGGLRFEGG HGPSGAAIRF DGPHGQPGGG IRFEGPLLQQ GVGMRFEGPH 
GQSVAGLRFE GQHNQLGGNL RFEGPHGQPG VGIRFEGPLV QQGGGMRFEG PSVPGGGLRI 
EGPLGQGGPR FEGCHALRFD GQPGQPSLLP RFDGLHGQPG PRFERTPGQP GPQRFDGPPG 
QQVQPRFDGV PQRFDGPQHQ QASRFDIPLG LQGTRFDNHP SQRLESVSFN QTGPYNDPPG 
NAFNAPSQGL QFQRHEQIFD SPQGPNFNGP HGPGNQSFSN PLNRASGHYF DEKNLQSSQF 
GNFGNIPAPM TVGNIQASQQ VLSGVAQPVA FGQGQQFLPV HPQNPGFVQN PSGALPKAYP 
DNHLSQVDVN ELFSKLLKTG ILKLSQTDSA TTQVSEVTAQ PPPEEEEDQN EDQDVPDLTN 
FTVEELKQRY DSVINRLYTG IQCYSCGMRF TTSQTDVYAD HLDWHYRQNR TEKDVSRKVT 
HRRWYYSLTD WIEFEEIADL EERAKSQFFE KVHEEVVLKT QEAAKEKEFQ SVPAGPAGAV 
ESCEICQEQF EQYWDEEEEE WHLKNAIRVD GKIYHPSCYE DYQNTSSFDC TPSPSKTPVE 
NPLNIMLNIV KNELQEPCDS PKVKEERIDT PPACTEESIA TPSEIKTEND TVESV

Genular Protein ID: 3946383703

Symbol: A0A8I5KX04_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8I5KX04

Database IDs:

CDD 1 CTD 1 DisGeNET 1 EMBL 1 Ensembl 2 GO 7 Gene3D 1 GeneTree 1 HGNC 1 InterPro 9 MANE-Select 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 6 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 1686
  • Mass: 188020
  • Checksum: 3F60101AFB475ACF
  • Sequence:
    • MSEQTPAEAG AAGAREDACR DYQSSLEDLT FNSKPHINML TILAEENLPF AKEIVSLIEA 
QTAKAPSSEK LPVMYLMDSI VKNVGREYLT AFTKNLVATF ICVFEKVDEN TRKSLFKLRS 
TWDEIFPLKK LYALDVRVNS LDPAWPIKPL PPNVNTSSIH VNPKFLNKSP EEPSTPGTVV 
SSPSISTPPI VPDIQKNLTQ EQLIRQQLLA KQKQLLELQQ KKLELELEQA KAQLAVSLSV 
QQETSNLGPG SAPSKLHVSQ IPPMAVKAPH QVPVQSEKSR PGPSLQIQDL KGTNRDPRLN 
RISQHSHGKD QSHRKEFLMN TLNQSDTKTS KTIPSEKLNS SKQEKSKSGE KITKKELDQL 
DSKSKSKSKS PSPLKNKLSH TKDLKNQESE SMRLSDMNKR DPRLKKHLQD KTDGKDDDVK 
EKRKTAEKKD KDEHMKSSEH RLAGSRNKII NGIVQKQDTI TEESEKQGTK PGRSSTRKRS 
RSRSPKSRSP IIHSPKRRDR RSPKRRQRSM SPTSTPKAGK IRQSGAKQSH MEEFTPPSRE 
DRNAKRSTKQ DIRDPRRMKK TEEERPQETT NQHSTKSGTE PKENVENWQS SKSAKRWKSG 
WEENKSLQQV DEHSKPPHLR HRESWSSTKG ILSPRAPKQQ QHRLSVDANL QIPKELTLAS 
KRELLQKTSE RLASGEITQD DFLVVVHQIR QLFQYQEGKH RCNVRDSPTE ENKGGLKKKP 
LLSDAELTYY EHKAKLKRTQ VQHSFPRLDL LDPDIFDYPL TDALLSGIEC EPSKSKHASR 
NSGAQFDRKE QFSERARRLS PISGSRTYAE NLSPHEGRRR HDEQVSAKGV REEQRSPFND 
RFPLKRPRYE DSDKPFVDSP ASRFAGLDTN QRLTALAEDR PLFDGPSRPS VARDGPTKMI 
FEGPNKLSPR IDGPPTPASL RFDGSPGQMG GGGPLRFEGP QGQLGGGCPL RFEGPPGPVG 
TPLRFEGPIG QAGGGGFRFE GSPGLRFEGS PGGLRFEGPG GQPVGGLRFE GHRGQPVGGL 
RFEGPHGQPV GGLRFDNPRG QPVGGLRFEG GHGPSGAAIR FDGPHGQPGG GIRFEGPLLQ 
QGVGMRFEGP HGQSVAGLRF EGQHNQLGGN LRFEGPHGQP GVGIRFEGPL VQQGGGMRFE 
GPSVPGGGLR IEGPLGQGGP RFEGCHALRF DGQPGQPSLL PRFDGLHGQP GPRFERTPGQ 
PGPQRFDGPP GQQVQPRFDG VPQRFDGPQH QQASRFDIPL GLQGTRFDNH PSQRLESVSF 
NQTGPYNDPP GNAFNAPSQG LQFQRHEQIF DSPQGPNFNG PHGPGNQSFS NPLNRASGHY 
FDEKNLQSSQ FGNFGNIPAP MTVGNIQASQ QVLSGVAQPV AFGQGQQFLP VHPQNPGFVQ 
NPSGALPKAY PDNHLSQVDV NELFSKLLKT GILKLSQTDS ATTQVSEVTA QPPPEEEEDQ 
NEDQDVPDLT NFTVEELKQR YDSVINRLYT GIQCYSCGMR FTTSQTDVYA DHLDWHYRQN 
RTEKDVSRKV THRRWYYSLT DWIEFEEIAD LEERAKSQFF EKVHEEVVLK TQEAAKEKEF 
QSVPAGPAGA VESCEICQEQ FEQYWDEEEE EWHLKNAIRV DGKIYHPSCY EDYQNTSSFD 
CTPSPSKTPV ENPLNIMLNI VKNELQEPCD SPKVKEERID TPPACTEESI ATPSEIKTEN 
DTVESV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.