Details for: NBAS

Gene ID: 51594

Symbol: NBAS

Ensembl ID: ENSG00000151779

Description: NBAS subunit of NRZ tethering complex

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 378.4751
    Cell Significance Index: -58.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 237.8931
    Cell Significance Index: -60.3400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 146.8633
    Cell Significance Index: -60.5000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 132.5715
    Cell Significance Index: -62.5900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 120.9825
    Cell Significance Index: -49.1500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 51.6055
    Cell Significance Index: -49.2700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 50.2451
    Cell Significance Index: -61.9500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 21.9067
    Cell Significance Index: -58.6900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 18.8412
    Cell Significance Index: -57.8700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.3621
    Cell Significance Index: -35.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.8665
    Cell Significance Index: -62.6100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.9535
    Cell Significance Index: 130.6400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.8455
    Cell Significance Index: 107.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.7560
    Cell Significance Index: 552.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.6888
    Cell Significance Index: 964.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.5950
    Cell Significance Index: 145.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.5128
    Cell Significance Index: 168.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.4809
    Cell Significance Index: 190.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.3750
    Cell Significance Index: 471.3200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 2.2562
    Cell Significance Index: 34.0000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.1036
    Cell Significance Index: 50.4500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.9712
    Cell Significance Index: 50.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.8770
    Cell Significance Index: 115.3700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.2958
    Cell Significance Index: 25.2900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2466
    Cell Significance Index: 1125.6000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.2275
    Cell Significance Index: 35.0300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.2037
    Cell Significance Index: 832.5200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9399
    Cell Significance Index: 109.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8544
    Cell Significance Index: 138.9600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8451
    Cell Significance Index: 91.9300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.6514
    Cell Significance Index: 8.0800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.6306
    Cell Significance Index: 13.4800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6181
    Cell Significance Index: 37.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5031
    Cell Significance Index: 14.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4633
    Cell Significance Index: 872.4000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3782
    Cell Significance Index: 37.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.3483
    Cell Significance Index: 158.0800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3168
    Cell Significance Index: 21.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3155
    Cell Significance Index: 56.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3092
    Cell Significance Index: 196.3600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2953
    Cell Significance Index: 6.4700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2597
    Cell Significance Index: 4.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2549
    Cell Significance Index: 470.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2443
    Cell Significance Index: 376.0500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2294
    Cell Significance Index: 4.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2273
    Cell Significance Index: 27.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2231
    Cell Significance Index: 121.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1451
    Cell Significance Index: 197.3500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.1349
    Cell Significance Index: 1.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1062
    Cell Significance Index: 4.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0972
    Cell Significance Index: 3.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0691
    Cell Significance Index: 30.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0462
    Cell Significance Index: 6.3500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0116
    Cell Significance Index: -0.3100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0167
    Cell Significance Index: -0.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0214
    Cell Significance Index: -0.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0259
    Cell Significance Index: -3.7600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0338
    Cell Significance Index: -25.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0338
    Cell Significance Index: -21.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0477
    Cell Significance Index: -34.9700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0508
    Cell Significance Index: -8.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0628
    Cell Significance Index: -11.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0716
    Cell Significance Index: -40.4000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0819
    Cell Significance Index: -62.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1628
    Cell Significance Index: -4.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1749
    Cell Significance Index: -18.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1859
    Cell Significance Index: -53.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1946
    Cell Significance Index: -40.9800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2301
    Cell Significance Index: -27.1300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2364
    Cell Significance Index: -3.4900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2518
    Cell Significance Index: -3.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2905
    Cell Significance Index: -29.6700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3237
    Cell Significance Index: -41.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3595
    Cell Significance Index: -46.4500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3607
    Cell Significance Index: -18.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3717
    Cell Significance Index: -19.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3719
    Cell Significance Index: -17.4800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3861
    Cell Significance Index: -5.5500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4032
    Cell Significance Index: -14.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4073
    Cell Significance Index: -25.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4331
    Cell Significance Index: -49.6200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4693
    Cell Significance Index: -9.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4734
    Cell Significance Index: -12.6900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4869
    Cell Significance Index: -31.4200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5401
    Cell Significance Index: -13.5000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5763
    Cell Significance Index: -65.7800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5974
    Cell Significance Index: -7.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6128
    Cell Significance Index: -13.0500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6408
    Cell Significance Index: -45.3200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6465
    Cell Significance Index: -15.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6528
    Cell Significance Index: -48.6600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6819
    Cell Significance Index: -54.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6863
    Cell Significance Index: -21.9800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6976
    Cell Significance Index: -9.9900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.7161
    Cell Significance Index: -14.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7291
    Cell Significance Index: -44.7000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7730
    Cell Significance Index: -24.6200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7999
    Cell Significance Index: -26.1900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.8244
    Cell Significance Index: -16.5500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8307
    Cell Significance Index: -17.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit of the NRZ tethering complex**: NBAS is a component of the NRZ complex, which is responsible for regulating retrograde trafficking pathways. 2. **Regulation of retrograde trafficking**: NBAS participates in the control of protein and lipid transport between the Golgi apparatus and the ER. 3. **Involvement in nuclear mRNA catabolism**: NBAS is also implicated in the regulation of nuclear-transcribed mRNA catabolic processes, including nonsense-mediated decay and negative regulation of nuclear-transcribed mRNA catabolic process. 4. **Significant expression in various cell types**: NBAS is expressed in hematopoietic cells, stem cells, immune cells, and epithelial cells, indicating its widespread importance in cellular homeostasis. **Pathways and Functions:** NBAS is involved in several cellular pathways, including: 1. **Copi-dependent Golgi-to-ER retrograde traffic**: NBAS regulates the transport of proteins and lipids between the Golgi apparatus and the ER. 2. **Intra-golgi and retrograde Golgi-to-ER traffic**: NBAS participates in the regulation of protein and lipid transport within the Golgi apparatus and between the Golgi and ER. 3. **Retrograde vesicle-mediated transport**: NBAS is involved in the regulation of vesicle-mediated transport between the Golgi apparatus and the ER. 4. **Negative regulation of nuclear-transcribed mRNA catabolic process**: NBAS regulates the degradation of nuclear-transcribed mRNA, preventing excessive mRNA degradation. 5. **Nonsense-mediated decay**: NBAS is involved in the regulation of nonsense-mediated decay, a process that degrades aberrant mRNAs. **Clinical Significance:** Dysregulation of NBAS has been implicated in various diseases, including: 1. **Neurological disorders**: Mutations in NBAS have been associated with neurological disorders, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). 2. **Immune-related disorders**: NBAS dysfunction has been linked to immune-related disorders, including autoimmune diseases and immunodeficiency syndromes. 3. **Cancer**: NBAS expression is often downregulated in cancer cells, suggesting a potential role in cancer progression and metastasis. In conclusion, NBAS is a crucial component of the NRZ tethering complex, regulating retrograde trafficking pathways and nuclear mRNA catabolism. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its function and regulation in maintaining cellular homeostasis and immune function.

Genular Protein ID: 3348407823

Symbol: NBAS_HUMAN

Name: N/A

UniProtKB Accession Codes:

A2RRP1 O95790 Q2VPJ7 Q53TK6 Q86V39 Q8NFY8 Q9Y3W5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12706883

Title: The neuroblastoma amplified gene, NAG: genomic structure and characterisation of the 7.3 kb transcript predominantly expressed in neuroblastoma.

PubMed ID: 12706883

DOI: 10.1016/s0378-1119(03)00459-1

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9926938

Title: Co-amplification of a novel gene, NAG, with the N-myc gene in neuroblastoma.

PubMed ID: 9926938

DOI: 10.1038/sj.onc.1202287

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 10882752

Title: Gene amplification in PNETs/medulloblastomas: mapping of a novel amplified gene within the MYCN amplicon.

PubMed ID: 10882752

DOI: 10.1136/jmg.37.7.501

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369418

Title: Identification of the neuroblastoma-amplified gene product as a component of the syntaxin 18 complex implicated in Golgi-to-endoplasmic reticulum retrograde transport.

PubMed ID: 19369418

DOI: 10.1091/mbc.e08-11-1104

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20577004

Title: Neuroblastoma amplified sequence gene is associated with a novel short stature syndrome characterised by optic nerve atrophy and Pelger-Huet anomaly.

PubMed ID: 20577004

DOI: 10.1136/jmg.2009.074815

PubMed ID: 20462495

Title: Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery.

PubMed ID: 20462495

DOI: 10.1016/j.str.2010.02.014

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26073778

Title: Biallelic mutations in NBAS cause recurrent acute liver failure with onset in infancy.

PubMed ID: 26073778

DOI: 10.1016/j.ajhg.2015.05.009

PubMed ID: 26286438

Title: NBAS mutations cause a multisystem disorder involving bone, connective tissue, liver, immune system, and retina.

PubMed ID: 26286438

DOI: 10.1002/ajmg.a.37338

PubMed ID: 28629372

Title: Novel NBAS mutations and fever-related recurrent acute liver failure in Chinese children: a retrospective study.

PubMed ID: 28629372

DOI: 10.1186/s12876-017-0636-3

PubMed ID: 27789416

Title: Compound heterozygous variants in NBAS as a cause of atypical osteogenesis imperfecta.

PubMed ID: 27789416

DOI: 10.1016/j.bone.2016.10.023

PubMed ID: 28576691

Title: Recurrent elevated liver transaminases and acute liver failure in two siblings with novel bi-allelic mutations of NBAS.

PubMed ID: 28576691

DOI: 10.1016/j.ejmg.2017.05.005

PubMed ID: 30825388

Title: NBAS pathogenic variants: Defining the associated clinical and facial phenotype and genotype-phenotype correlations.

PubMed ID: 30825388

DOI: 10.1002/humu.23734

PubMed ID: 32146038

Title: Mutations in NBAS and SCYL1, genetic causes of recurrent liver failure in children: Three case reports and a literature review.

PubMed ID: 32146038

DOI: 10.1016/j.arcped.2020.01.003

Sequence Information:

  • Length: 2371
  • Mass: 268571
  • Checksum: 54500EFAA487FB94
  • Sequence:
    • MAAPESGPAL SPGTAEGEEE TILYDLLVNT EWPPETEVQP RGNQKHGASF IITKAIRDRL 
LFLRQYIWYS PAPFLLPDGL VRLVNKQINW HLVLASNGKL LAAVQDQCVE IRSAKDDFTS 
IIGKCQVPKD PKPQWRRVAW SYDCTLLAYA ESTGTVRVFD LMGSELFVIS PASSFIGDLS 
YAIAGLIFLE YKASAQWSAE LLVINYRGEL RSYLVSVGTN QSYQESHCFS FSSHYPHGIN 
TAIYHPGHRL LLVGGCETAE VGMSKASSCG LSAWRVLSGS PYYKQVTNGG DGVTAVPKTL 
GLLRMLSVKF YSRQGQEQDG IFKMSLSPDG MLLAAIHFSG KLSIWAIPSL KQQGEWGQNE 
QPGYDDLNPD WRLSTEKRKK IKDKESFYPL IDVNWWADSA VTLARCSGAL TVSSVKTLKN 
LLGKSCEWFE PSPQVTATHD GGFLSLECEI KLAPKRSRLE TRAGEEDEGE EDSDSDYEIS 
AKARYFGYIK QGLYLVTEME RFAPPRKRPR TITKNYRLVS LRSTTPEELY QRKIESEEYE 
EALSLAHTYG LDTDLVYQRQ WRKSAVNVAS IQNYLSKIKK RSWVLHECLE RVPENVDAAK 
ELLQYGLKGT DLEALLAIGK GADDGRFTLP GEIDIDSISY EELSPPDEEP AKNKKEKELK 
KRQELLKLVN FSKLTLEQKE LCRCRRKLLT YLDRLATYEE ILGVPHASEQ RYDAEFFKKF 
RNQNIVLSAR TYAQESNVQA LEILFTYHGS DLLPHRLAIL SNFPETTSPH EYSVLLPEAC 
FNGDSLMIIP WHEHKHRAKD WCEELACRMV VEPNLQDESE FLYAAQPELL RFRMTQLTVE 
KVMDWYQTRA EEIEHYARQV DCALSLIRLG MERNIPGLLV LCDNLVTLET LVYEARCDVT 
LTLKELQQMK DIEKLRLLMN SCSEDKYVTS AYQWMVPFLH RCEKQSPGVA NELLKEYLVT 
LAKGDLKFPL KIFQHSKPDL QQKIIPDQDQ LMAIALECIY TCERNDQLCL CYDLLECLPE 
RGYGDKTEAT TKLHDMVDQL EQILSVSELL EKHGLEKPIS FVKNTQSSSE EARKLMVRLT 
RHTGRKQPPV SESHWRTLLQ DMLTMQQNVY TCLDSDACYE IFTESLLCSS RLENIHLAGQ 
MMHCSACSEN PPAGIAHKGK PHYRVSYEKS IDLVLAASRE YFNSSTNLTD SCMDLARCCL 
QLITDRPPAI QEELDLIQAV GCLEEFGVKI LPLQVRLCPD RISLIKECIS QSPTCYKQST 
KLLGLAELLR VAGENPEERR GQVLILLVEQ ALRFHDYKAA SMHCQELMAT GYPKSWDVCS 
QLGQSEGYQD LATRQELMAF ALTHCPPSSI ELLLAASSSL QTEILYQRVN FQIHHEGGEN 
ISASPLTSKA VQEDEVGVPG SNSADLLRWT TATTMKVLSN TTTTTKAVLQ AVSDGQWWKK 
SLTYLRPLQG QKCGGAYQIG TTANEDLEKQ GCHPFYESVI SNPFVAESEG TYDTYQHVPV 
ESFAEVLLRT GKLAEAKNKG EVFPTTEVLL QLASEALPND MTLALAYLLA LPQVLDANRC 
FEKQSPSALS LQLAAYYYSL QIYARLAPCF RDKCHPLYRA DPKELIKMVT RHVTRHEHEA 
WPEDLISLTK QLHCYNERLL DFTQAQILQG LRKGVDVQRF TADDQYKRET ILGLAETLEE 
SVYSIAISLA QRYSVSRWEV FMTHLEFLFT DSGLSTLEIE NRAQDLHLFE TLKTDPEAFH 
QHMVKYIYPT IGGFDHERLQ YYFTLLENCG CADLGNCAIK PETHIRLLKK FKVVASGLNY 
KKLTDENMSP LEALEPVLSS QNILSISKLV PKIPEKDGQM LSPSSLYTIW LQKLFWTGDP 
HLIKQVPGSS PEWLHAYDVC MKYFDRLHPG DLITVVDAVT FSPKAVTKLS VEARKEMTRK 
AIKTVKHFIE KPRKRNSEDE AQEAKDSKVT YADTLNHLEK SLAHLETLSH SFILSLKNSE 
QETLQKYSHL YDLSRSEKEK LHDEAVAICL DGQPLAMIQQ LLEVAVGPLD ISPKDIVQSA 
IMKIISALSG GSADLGGPRD PLKVLEGVVA AVHASVDKGE ELVSPEDLLE WLRPFCADDA 
WPVRPRIHVL QILGQSFHLT EEDSKLLVFF RTEAILKASW PQRQVDIADI ENEENRYCLF 
MELLESSHHE AEFQHLVLLL QAWPPMKSEY VITNNPWVRL ATVMLTRCTM ENKEGLGNEV 
LKMCRSLYNT KQMLPAEGVK ELCLLLLNQS LLLPSLKLLL ESRDEHLHEM ALEQITAVTT 
VNDSNCDQEL LSLLLDAKLL VKCVSTPFYP RIVDHLLASL QQGRWDAEEL GRHLREAGHE 
AEAGSLLLAV RGTHQAFRTF STALRAAQHW V

Genular Protein ID: 1244999665

Symbol: G1UI26_HUMAN

Name: N/A

UniProtKB Accession Codes:

G1UI26

Database IDs:

ARBA 3 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 4 RefSeq 1 SUPFAM 1

Citations:

PubMed ID: 21697133

Title: Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.

PubMed ID: 21697133

DOI: 10.1167/iovs.11-7479

Sequence Information:

  • Length: 1561
  • Mass: 176337
  • Checksum: 6B2395D89A9CBD02
  • Sequence:
    • MAAPESGPAL SPGTAEGEEE TILYDLLVNT EWPPETEVQP RGNQKHGASF IITKAIRDRL 
LFLRQYIWYS PAPFLLPDGL VRLVNKQINW HLVLASNGKL LAAVQDQCVE IRSAKDDFTS 
IIGKCQVPKD PKPQWRRVAW SYDCTLLAYA ESTGTVRVFD LMGSELFVIS PASSFIGDLS 
YAIAGLIFLE YKASAQWSAE LLVINYRGEL RSYLVSVGTN QSYQESHCFS FSSHYPHGIN 
TAVYHPGHRL LLVGGCETAE VGMSKASSCG LSAWRVLSGS PYYKQVTNGG DGVTAVPKTL 
GLLRMLSVKF YSRQGQEQDG IFKMSLSPDG MLLAAIHFSG KLSIWAIPSL KQQGEWGQNE 
QPGYDDLNPD WRLSTEKRKK IKDKESFYPL IDVNWWADSA VTLARCSGAL TVSSVKTLKN 
LLGKSCEWFE PSPQVTATHD GGFLSLECEI KLAPKRSRLE TRAGEEDEGE EDSDSDYEIS 
AKARYFGYIK QGLYLVTEME RFAPPRKRPR TITKNYRLVS LRSTTPEELY QRKIESEEYE 
EALSLAHTYG LDTDLVYQRQ WRKSAVNVAS IQNYLSKIKK RSWVLHECLE RVPENVDAAK 
ELLQYGLKGT DLEALLAIGK GADDGRFTLP GEIDIDSISY EELSPPDEEP AKNKREKELK 
KRQELLKLVN FSKLTLEQKE LCRCRRKLLT YLDRLATYEE ILGVPHASEQ RYDAEFFKKF 
RNQNIVLSAR TYAQESNVQA LEILFTYHGS DLLPHRLAIL SNFPETTSPH EYSVLLPEAC 
FNGDSLMIIP WHEHKHRAKD WCEELACRMV VEPNLQDESE FLYAAQPELL RFRMTQLTVE 
KVMDWYQTRA EEIEHYARQV DCALSLIRLG MERNIPGLLV LCDNLVTLET LVYEARCDVT 
LTLKELQQMK DIEKLRLLMN SCSEDKYVTS AYQWMVPFLH RCEKQSPGVA NELLKEYLVT 
LAKGDLKFPL KIFQHSKPDL QQKIIPDQDQ LMAIALECIY TCERNDQLCL CYDLLECLPE 
RGYGDKTEAT TKLHDMVDQL EQILSVSELL EKHGLEKPIS FVKNTQSSSE EARKLMVRLT 
RHTGRKQPPV SESHWRTLLQ DMLTMQQNVY TCLDSDACYE IFTESLLCSS RLENIHLAGQ 
MMHCSACSEN PPAGIAHKGK PHYRVSYEKS IDLVLAASRE YFNSSTNLTD SCMDLARCCL 
QLITDRPPAI QEELDLIQAV GCLEEFGVKI LPLQVRLCPD RISLIKECIS QSPTCYKQST 
KLLGLAELLR VAGENPEERR GQVLILLVEQ ALRFHDYKAA SMHCQELMAT GYPKSWDVCS 
QLGQSEGYQD LATRQELMAF ALTHCPPSSI ELLLAASSSL QTEILYQRVN FQIHHEGGEN 
ISASPLTSKA VQEDEVGVPG SNSADLLRWT TATTMKVLSN TTTTTKAVLQ AVSDGQWWKK 
SLTYLRPLQG QKCGGAYQIG TTANEDLEKQ GCHPFYESVI SNPFVAESEG TYDTYQHVPV 
ESFAEVLLRT GKLAEAKNKG EVFPTTEVLL QLASEALPND MTLALAYLLA LPQVLDANRC 
F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.