Details for: METTL13

Gene ID: 51603

Symbol: METTL13

Ensembl ID: ENSG00000010165

Description: methyltransferase 13, eEF1A N-terminus and K55

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 54.9358
    Cell Significance Index: -8.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 37.7301
    Cell Significance Index: -9.5700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 27.9872
    Cell Significance Index: -11.3700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 19.8354
    Cell Significance Index: -13.3100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.9299
    Cell Significance Index: -11.3900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.6840
    Cell Significance Index: -11.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.9364
    Cell Significance Index: -10.5500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.1753
    Cell Significance Index: -12.5300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.3116
    Cell Significance Index: -7.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8528
    Cell Significance Index: 51.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3855
    Cell Significance Index: 5.2600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3717
    Cell Significance Index: 40.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3611
    Cell Significance Index: 18.7600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3473
    Cell Significance Index: 68.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3391
    Cell Significance Index: 9.7700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2544
    Cell Significance Index: 6.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2227
    Cell Significance Index: 121.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2195
    Cell Significance Index: 4.7600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2193
    Cell Significance Index: 9.9400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1885
    Cell Significance Index: 13.0400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1688
    Cell Significance Index: 10.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1650
    Cell Significance Index: 29.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1625
    Cell Significance Index: 32.6000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1613
    Cell Significance Index: 111.5400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1591
    Cell Significance Index: 1.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1456
    Cell Significance Index: 19.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1433
    Cell Significance Index: 6.6800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1300
    Cell Significance Index: 3.2500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1261
    Cell Significance Index: 2.6400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1222
    Cell Significance Index: 54.0100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1154
    Cell Significance Index: 21.9700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1130
    Cell Significance Index: 7.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1073
    Cell Significance Index: 13.1900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1062
    Cell Significance Index: 1.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1036
    Cell Significance Index: 12.2200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0918
    Cell Significance Index: 9.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0846
    Cell Significance Index: 10.8400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0832
    Cell Significance Index: 75.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0781
    Cell Significance Index: 12.7100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0781
    Cell Significance Index: 1.6200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0721
    Cell Significance Index: 5.1000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0621
    Cell Significance Index: 1.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0573
    Cell Significance Index: 1.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0555
    Cell Significance Index: 19.8900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0362
    Cell Significance Index: 0.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0288
    Cell Significance Index: 3.7200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0245
    Cell Significance Index: 0.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0213
    Cell Significance Index: 0.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0156
    Cell Significance Index: 0.8200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0024
    Cell Significance Index: 0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0018
    Cell Significance Index: -3.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0029
    Cell Significance Index: -0.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0039
    Cell Significance Index: -0.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0045
    Cell Significance Index: -8.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0049
    Cell Significance Index: -7.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0060
    Cell Significance Index: -0.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0062
    Cell Significance Index: -4.7000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0076
    Cell Significance Index: -10.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0079
    Cell Significance Index: -5.8200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0093
    Cell Significance Index: -5.9200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0167
    Cell Significance Index: -12.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0192
    Cell Significance Index: -1.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0197
    Cell Significance Index: -3.3700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0207
    Cell Significance Index: -0.5300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0217
    Cell Significance Index: -9.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0226
    Cell Significance Index: -12.7400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0228
    Cell Significance Index: -14.2100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0232
    Cell Significance Index: -0.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0269
    Cell Significance Index: -7.7500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0382
    Cell Significance Index: -0.6400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0396
    Cell Significance Index: -4.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0437
    Cell Significance Index: -0.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0455
    Cell Significance Index: -6.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0620
    Cell Significance Index: -3.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0632
    Cell Significance Index: -7.3700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0651
    Cell Significance Index: -0.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0677
    Cell Significance Index: -14.2500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0731
    Cell Significance Index: -1.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0740
    Cell Significance Index: -4.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0787
    Cell Significance Index: -6.0400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1195
    Cell Significance Index: -12.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1330
    Cell Significance Index: -6.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1332
    Cell Significance Index: -10.5500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1470
    Cell Significance Index: -4.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1616
    Cell Significance Index: -7.1500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1643
    Cell Significance Index: -1.3400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1751
    Cell Significance Index: -8.8500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1903
    Cell Significance Index: -2.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1987
    Cell Significance Index: -13.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2052
    Cell Significance Index: -7.7700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2118
    Cell Significance Index: -5.4500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2223
    Cell Significance Index: -3.8100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2292
    Cell Significance Index: -6.1300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2306
    Cell Significance Index: -3.2400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2451
    Cell Significance Index: -7.2200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2668
    Cell Significance Index: -3.1800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2844
    Cell Significance Index: -5.5500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2879
    Cell Significance Index: -10.5700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2966
    Cell Significance Index: -10.3900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3027
    Cell Significance Index: -9.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** METTL13 is a cytoplasmic enzyme that exhibits specificity for N-terminal lysine residues on eukaryotic translation initiation factor 1 alpha (eEF1A). Its unique substrate specificity, along with its ability to methylate K55, positions METTL13 as a key regulator of protein function and cellular behavior. The enzyme's expression in various cell types, including hematopoietic and epithelial cells, suggests a broad functional scope. Notably, METTL13's involvement in the methylation of eEF1A has been implicated in the regulation of protein synthesis and cellular proliferation. **Pathways and Functions:** METTL13's involvement in cellular processes is thought to be mediated through its ability to modify eEF1A. The eEF1A N-terminus plays a critical role in protein synthesis initiation, and its methylation by METTL13 may influence the efficiency and accuracy of translation. Furthermore, METTL13's expression in immune cells, such as alpha-beta intraepithelial T cells and regulatory T cells, suggests a potential role in immune regulation and tolerance. The enzyme's involvement in the methylation of other substrates, including proteins involved in cell cycle regulation and apoptosis, may also contribute to its functional significance. **Clinical Significance:** The identification of METTL13 as a key regulator of cellular processes has significant implications for our understanding of human disease. Its involvement in hematopoiesis, epithelial development, and immune regulation positions METTL13 as a potential therapeutic target for various diseases, including cancer, autoimmune disorders, and inflammatory conditions. Furthermore, the enzyme's expression in certain cell types, such as goblet cells and ciliated cells, suggests a potential role in gastrointestinal and respiratory diseases. Further research into METTL13's mechanisms and functional significance is therefore warranted, with a focus on elucidating its role in human disease and developing targeted therapeutic strategies. In conclusion, METTL13 is a unique and enigmatic enzyme that plays a critical role in regulating cellular processes. Its involvement in protein synthesis, immune regulation, and cellular proliferation positions METTL13 as a key player in various cellular and disease contexts. Further research into METTL13's mechanisms and functional significance is necessary to fully appreciate its significance and potential as a therapeutic target.

Genular Protein ID: 4279124267

Symbol: EFNMT_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8N6R0 A6NFK0 A8K6S5 O94940 Q53EZ6 Q5TGP9 Q5TGQ0 Q8N2P8 Q96J11 Q96SQ0 Q9Y2Z1 Q9Y3M6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 15 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 3 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 RefSeq 3 Rhea 12 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27659353

Title: Immunogenic FEAT protein circulates in the bloodstream of cancer patients.

PubMed ID: 27659353

DOI: 10.1186/s12967-016-1034-2

PubMed ID: 26763933

Title: METTL13 is downregulated in bladder carcinoma and suppresses cell proliferation, migration and invasion.

PubMed ID: 26763933

DOI: 10.1038/srep19261

PubMed ID: 29408807

Title: Modifier variant of METTL13 suppresses human GAB1-associated profound deafness.

PubMed ID: 29408807

DOI: 10.1172/jci97350

PubMed ID: 30612740

Title: METTL13 methylation of eEF1A increases translational output to promote tumorigenesis.

PubMed ID: 30612740

DOI: 10.1016/j.cell.2018.11.038

PubMed ID: 30143613

Title: The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates.

PubMed ID: 30143613

DOI: 10.1038/s41467-018-05646-y

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

Sequence Information:

  • Length: 699
  • Mass: 78768
  • Checksum: 14F80A4570047DBB
  • Sequence:
    • MNLLPKSSRE FGSVDYWEKF FQQRGKKAFE WYGTYLELCG VLHKYIKPRE KVLVIGCGNS 
ELSEQLYDVG YRDIVNIDIS EVVIKQMKEC NATRRPQMSF LKMDMTQMEF PDASFQVVLD 
KGTLDAVLTD EEEKTLQQVD RMLAEVGRVL QVGGRYLCIS LAQAHILKKA VGHFSREGWM 
VRVHQVANSQ DQVLEAEPQF SLPVFAFIMT KFRPVPGSAL QIFELCAQEQ RKPVRLESAE 
RLAEAVQERQ QYAWLCSQLR RKARLGSVSL DLCDGDTGEP RYTLHVVDSP TVKPSRDNHF 
AIFIIPQGRE TEWLFGMDEG RKQLAASAGF RRLITVALHR GQQYESMDHI QAELSARVME 
LAPAGMPTQQ QVPFLSVGGD IGVRTVQHQD CSPLSGDYVI EDVQGDDKRY FRRLIFLSNR 
NVVQSEARLL KDVSHKAQKK RKKDRKKQRP ADAEDLPAAP GQSIDKSYLC CEHHKAMIAG 
LALLRNPELL LEIPLALLVV GLGGGSLPLF VHDHFPKSCI DAVEIDPSML EVATQWFGFS 
QSDRMKVHIA DGLDYIASLA GGGEARPCYD VIMFDVDSKD PTLGMSCPPP AFVEQSFLQK 
VKSILTPEGV FILNLVCRDL GLKDSVLAGL KAVFPLLYVR RIEGEVNEIL FCQLHPEQKL 
ATPELLETAQ ALERTLRKPG RGWDDTYVLS DMLKTVKIV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.