Details for: UBE2D4

Gene ID: 51619

Symbol: UBE2D4

Ensembl ID: ENSG00000078967

Description: ubiquitin conjugating enzyme E2 D4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 106.2713
    Cell Significance Index: -16.5300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 61.4248
    Cell Significance Index: -15.5800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 34.4932
    Cell Significance Index: -16.2900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 30.3663
    Cell Significance Index: -15.6200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.6785
    Cell Significance Index: -16.8700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.3194
    Cell Significance Index: -14.2500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.3309
    Cell Significance Index: -17.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.5469
    Cell Significance Index: 32.9500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1444
    Cell Significance Index: 186.1300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9984
    Cell Significance Index: 59.9400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9636
    Cell Significance Index: 870.0300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8417
    Cell Significance Index: 91.5500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8287
    Cell Significance Index: 22.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.8111
    Cell Significance Index: 233.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5966
    Cell Significance Index: 119.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5846
    Cell Significance Index: 30.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4157
    Cell Significance Index: 19.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3936
    Cell Significance Index: 5.3700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3377
    Cell Significance Index: 39.3500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2891
    Cell Significance Index: 20.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2831
    Cell Significance Index: 51.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2730
    Cell Significance Index: 97.9100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2694
    Cell Significance Index: 51.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2418
    Cell Significance Index: 15.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2192
    Cell Significance Index: 26.9500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2177
    Cell Significance Index: 2.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1894
    Cell Significance Index: 8.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1779
    Cell Significance Index: 97.1400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1521
    Cell Significance Index: 3.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1470
    Cell Significance Index: 29.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1457
    Cell Significance Index: 20.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1375
    Cell Significance Index: 7.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1204
    Cell Significance Index: 15.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1108
    Cell Significance Index: 2.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1033
    Cell Significance Index: 7.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1007
    Cell Significance Index: 6.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0836
    Cell Significance Index: 6.4200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0754
    Cell Significance Index: 7.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0655
    Cell Significance Index: 28.9700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0578
    Cell Significance Index: 0.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0430
    Cell Significance Index: 7.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0366
    Cell Significance Index: 4.7000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0344
    Cell Significance Index: 0.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0108
    Cell Significance Index: 0.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0050
    Cell Significance Index: 7.6500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0034
    Cell Significance Index: 6.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0033
    Cell Significance Index: 2.5200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0031
    Cell Significance Index: 5.9000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0034
    Cell Significance Index: -2.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0037
    Cell Significance Index: -2.6800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0093
    Cell Significance Index: -12.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0122
    Cell Significance Index: -9.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0171
    Cell Significance Index: -7.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0173
    Cell Significance Index: -1.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0222
    Cell Significance Index: -12.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0226
    Cell Significance Index: -3.2800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0280
    Cell Significance Index: -17.4900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0348
    Cell Significance Index: -1.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0354
    Cell Significance Index: -4.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0533
    Cell Significance Index: -3.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0618
    Cell Significance Index: -1.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0687
    Cell Significance Index: -1.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0722
    Cell Significance Index: -8.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0739
    Cell Significance Index: -3.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0760
    Cell Significance Index: -2.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0794
    Cell Significance Index: -16.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0851
    Cell Significance Index: -5.2300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0856
    Cell Significance Index: -2.2500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1076
    Cell Significance Index: -4.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1184
    Cell Significance Index: -7.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1230
    Cell Significance Index: -6.9000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1416
    Cell Significance Index: -2.3700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1417
    Cell Significance Index: -2.9400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1428
    Cell Significance Index: -11.3100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1436
    Cell Significance Index: -4.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1587
    Cell Significance Index: -16.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1802
    Cell Significance Index: -11.0500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2013
    Cell Significance Index: -3.7200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2127
    Cell Significance Index: -5.6900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2187
    Cell Significance Index: -6.2400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2234
    Cell Significance Index: -5.4500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2256
    Cell Significance Index: -5.8000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2352
    Cell Significance Index: -2.4400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2533
    Cell Significance Index: -2.1300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2615
    Cell Significance Index: -3.9400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2772
    Cell Significance Index: -6.4100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2864
    Cell Significance Index: -8.4100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2914
    Cell Significance Index: -5.1500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2921
    Cell Significance Index: -5.7000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2944
    Cell Significance Index: -9.4300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3011
    Cell Significance Index: -6.3900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3046
    Cell Significance Index: -9.7000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3113
    Cell Significance Index: -8.9300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3121
    Cell Significance Index: -3.4000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3174
    Cell Significance Index: -11.1200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3224
    Cell Significance Index: -9.0100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3271
    Cell Significance Index: -10.7100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3603
    Cell Significance Index: -8.6400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3617
    Cell Significance Index: -5.1800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3644
    Cell Significance Index: -9.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** UBE2D4 is a member of the ubiquitin-conjugating enzyme family, characterized by its ability to catalyze the transfer of ubiquitin molecules to lysine residues on target proteins. This process, known as ubiquitination, is a post-translational modification that regulates protein activity, localization, and stability. UBE2D4 is specifically involved in the transfer of ubiquitin to lysine residues 48 (K48), 63 (K63), and other ubiquitination sites, which are critical for protein degradation, protein-protein interactions, and signal transduction. **Pathways and Functions:** UBE2D4 is involved in several key pathways, including: 1. **Antigen processing and presentation:** UBE2D4 plays a crucial role in the processing and presentation of antigens to the immune system. By ubiquitinating proteins involved in antigen processing, UBE2D4 regulates the activity of antigen-presenting cells (APCs) and the subsequent activation of T cells. 2. **Adaptive immune system:** UBE2D4 is essential for the development and function of immune cells, including T cells, B cells, and dendritic cells. Its ubiquitinating activity regulates the activity of key immune molecules, such as cytokines and chemokines. 3. **Protein degradation:** UBE2D4 is involved in the ubiquitin-proteasome system, which is responsible for the degradation of proteins marked for destruction. This process is critical for maintaining protein homeostasis and regulating cellular signaling pathways. 4. **Cellular homeostasis:** UBE2D4 regulates various cellular processes, including cell cycle progression, apoptosis, and DNA repair. Its ubiquitinating activity is essential for maintaining the balance of protein homeostasis and preventing protein misfolding and aggregation. **Clinical Significance:** Dysregulation of UBE2D4 has been implicated in various diseases, including: 1. **Autoimmune disorders:** UBE2D4 has been shown to play a role in the development of autoimmune disorders, such as rheumatoid arthritis and lupus. 2. **Cancer:** Aberrant ubiquitination by UBE2D4 has been linked to the development and progression of various cancers, including breast cancer and lung cancer. 3. **Neurodegenerative diseases:** UBE2D4 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 4. **Infectious diseases:** UBE2D4 has been shown to play a role in the regulation of immune responses to infectious diseases, including HIV and tuberculosis. In conclusion, UBE2D4 is a critical component of the ubiquitin-proteasome system, playing a pivotal role in immune regulation, cellular homeostasis, and disease pathogenesis. Further research is necessary to fully understand the mechanisms by which UBE2D4 regulates cellular processes and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 3870277694

Symbol: UB2D4_HUMAN

Name: Ubiquitin-conjugating enzyme E2 D4

UniProtKB Accession Codes:

Q9Y2X8 A4D1V0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20061386

Title: The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.

PubMed ID: 20061386

DOI: 10.1074/jbc.m109.089003

Sequence Information:

  • Length: 147
  • Mass: 16649
  • Checksum: 5F91A2C6BC667254
  • Sequence:
    • MALKRIQKEL TDLQRDPPAQ CSAGPVGDDL FHWQATIMGP NDSPYQGGVF FLTIHFPTDY 
PFKPPKVAFT TKIYHPNINS NGSICLDILR SQWSPALTVS KVLLSICSLL CDPNPDDPLV 
PEIAHTYKAD REKYNRLARE WTQKYAM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.