Details for: CCZ1

Gene ID: 51622

Symbol: CCZ1

Ensembl ID: ENSG00000122674

Description: CCZ1 homolog, vacuolar protein trafficking and biogenesis associated

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 155.7746
    Cell Significance Index: -24.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 96.0009
    Cell Significance Index: -24.3500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 67.7756
    Cell Significance Index: -27.9200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 56.6696
    Cell Significance Index: -26.7600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 48.0185
    Cell Significance Index: -24.7000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.4096
    Cell Significance Index: -27.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.3483
    Cell Significance Index: -19.6900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.1464
    Cell Significance Index: -28.2000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.7898
    Cell Significance Index: -14.8600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 5.0824
    Cell Significance Index: 81.5400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.7749
    Cell Significance Index: 191.9000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.2437
    Cell Significance Index: 9.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1720
    Cell Significance Index: 15.9900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8654
    Cell Significance Index: 55.8300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8529
    Cell Significance Index: 23.2200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7542
    Cell Significance Index: 680.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7427
    Cell Significance Index: 52.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7266
    Cell Significance Index: 321.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7121
    Cell Significance Index: 44.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6932
    Cell Significance Index: 36.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6797
    Cell Significance Index: 136.3500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.6755
    Cell Significance Index: 18.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6628
    Cell Significance Index: 119.4800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6452
    Cell Significance Index: 22.4200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6098
    Cell Significance Index: 45.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5522
    Cell Significance Index: 75.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.5179
    Cell Significance Index: 149.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4885
    Cell Significance Index: 60.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4688
    Cell Significance Index: 256.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3378
    Cell Significance Index: 121.1500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3145
    Cell Significance Index: 59.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3133
    Cell Significance Index: 14.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3120
    Cell Significance Index: 40.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2889
    Cell Significance Index: 57.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2823
    Cell Significance Index: 14.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2639
    Cell Significance Index: 33.8300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2564
    Cell Significance Index: 6.4100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2337
    Cell Significance Index: 6.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2138
    Cell Significance Index: 9.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2068
    Cell Significance Index: 4.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1848
    Cell Significance Index: 5.3300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1558
    Cell Significance Index: 1.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1414
    Cell Significance Index: 24.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1368
    Cell Significance Index: 6.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1328
    Cell Significance Index: 7.4500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1282
    Cell Significance Index: 12.6900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0635
    Cell Significance Index: 1.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0401
    Cell Significance Index: 75.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0230
    Cell Significance Index: 0.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0078
    Cell Significance Index: 14.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0050
    Cell Significance Index: 7.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0046
    Cell Significance Index: 0.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0045
    Cell Significance Index: 2.8500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0042
    Cell Significance Index: 0.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0012
    Cell Significance Index: 0.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0007
    Cell Significance Index: 0.0500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0042
    Cell Significance Index: -0.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0064
    Cell Significance Index: -4.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0067
    Cell Significance Index: -3.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0071
    Cell Significance Index: -4.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0082
    Cell Significance Index: -11.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0108
    Cell Significance Index: -8.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0138
    Cell Significance Index: -10.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0172
    Cell Significance Index: -0.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0183
    Cell Significance Index: -10.3000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0252
    Cell Significance Index: -1.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0318
    Cell Significance Index: -2.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0382
    Cell Significance Index: -4.5000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0394
    Cell Significance Index: -0.9100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0584
    Cell Significance Index: -5.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0609
    Cell Significance Index: -12.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0675
    Cell Significance Index: -7.7300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0712
    Cell Significance Index: -2.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0789
    Cell Significance Index: -9.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0896
    Cell Significance Index: -13.0200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1393
    Cell Significance Index: -15.9000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1844
    Cell Significance Index: -3.8300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2176
    Cell Significance Index: -6.2100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2200
    Cell Significance Index: -5.6200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2331
    Cell Significance Index: -4.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2458
    Cell Significance Index: -25.5900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2479
    Cell Significance Index: -5.2800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2620
    Cell Significance Index: -4.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2790
    Cell Significance Index: -22.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3050
    Cell Significance Index: -13.4900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3157
    Cell Significance Index: -9.3000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3174
    Cell Significance Index: -6.9500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3534
    Cell Significance Index: -7.5600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3618
    Cell Significance Index: -13.7000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3639
    Cell Significance Index: -9.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4244
    Cell Significance Index: -26.0200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4667
    Cell Significance Index: -3.9200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4848
    Cell Significance Index: -8.9600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.4962
    Cell Significance Index: -6.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5155
    Cell Significance Index: -13.2500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5244
    Cell Significance Index: -12.5800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.5492
    Cell Significance Index: -5.9700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5582
    Cell Significance Index: -20.4900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5836
    Cell Significance Index: -11.3900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6121
    Cell Significance Index: -20.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CCZ1 is a gene that belongs to the CCZ1 homolog family, which is involved in the biogenesis and trafficking of vacuoles. The gene's expression is widespread across different cell types, including hematopoietic cells, stem cells, and immune cells. Its association with guanyl-nucleotide exchange factor activity, intracellular membrane-bounded organelle, and lysosomal membrane pathways underscores its role in regulating cellular trafficking and biogenesis processes. **Pathways and Functions:** CCZ1 is involved in various cellular pathways, including: 1. **Cytosol**: CCZ1 regulates the cytosolic trafficking of proteins and organelles, which is essential for maintaining cellular homeostasis. 2. **Guanyl-nucleotide exchange factor activity**: CCZ1 facilitates the exchange of GDP for GTP on Rabs, which regulates the activation and inactivation of Rabs, a family of small GTPases involved in membrane trafficking. 3. **Intracellular membrane-bounded organelle**: CCZ1 regulates the biogenesis and trafficking of intracellular membrane-bounded organelles, such as lysosomes and vacuoles. 4. **Lysosomal membrane**: CCZ1 is involved in the regulation of lysosomal membrane dynamics, which is essential for maintaining lysosomal function and cellular homeostasis. 5. **Membrane trafficking**: CCZ1 regulates the trafficking of proteins and organelles between different compartments, including the cytosol, endoplasmic reticulum, and lysosomes. 6. **Mon1-ccz1 complex**: CCZ1 forms a complex with Mon1, a guanine-nucleotide exchange factor, which regulates the activation and inactivation of Rabs. 7. **Protein binding**: CCZ1 interacts with various proteins, including Rab GTPases, to regulate their activity and localization. **Clinical Significance:** The clinical significance of CCZ1 is still emerging, but its dysregulation may contribute to various diseases, including: 1. **Hematological disorders**: CCZ1 dysregulation may contribute to hematological disorders, such as anemia and leukemia, due to its role in regulating cellular trafficking and biogenesis processes. 2. **Immunological disorders**: CCZ1 dysregulation may contribute to immunological disorders, such as autoimmune diseases and immunodeficiency disorders, due to its role in regulating immune cell trafficking and function. 3. **Neurological disorders**: CCZ1 dysregulation may contribute to neurological disorders, such as neurodegenerative diseases and developmental disorders, due to its role in regulating cellular trafficking and biogenesis processes. In conclusion, CCZ1 is a gene that plays a critical role in regulating cellular trafficking and biogenesis processes. Its dysregulation may contribute to various diseases, including hematological disorders, immunological disorders, and neurological disorders. Further research is needed to fully understand the clinical significance of CCZ1 and its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.