Details for: PDK2

Gene ID: 5164

Symbol: PDK2

Ensembl ID: ENSG00000005882

Description: pyruvate dehydrogenase kinase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 129.4800
    Cell Significance Index: -20.1400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 73.5284
    Cell Significance Index: -18.6500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 45.6449
    Cell Significance Index: -21.5500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 43.5685
    Cell Significance Index: -17.7000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 32.1152
    Cell Significance Index: -21.5500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.1052
    Cell Significance Index: -21.0900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.0515
    Cell Significance Index: -18.8900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.4789
    Cell Significance Index: -21.6200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.5776
    Cell Significance Index: -14.0600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.0977
    Cell Significance Index: 17.6200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.0039
    Cell Significance Index: 16.0000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.5634
    Cell Significance Index: 1411.6600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3164
    Cell Significance Index: 17.9600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0530
    Cell Significance Index: 72.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9595
    Cell Significance Index: 43.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8964
    Cell Significance Index: 19.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8148
    Cell Significance Index: 42.7800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6789
    Cell Significance Index: 14.2100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6654
    Cell Significance Index: 9.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6266
    Cell Significance Index: 18.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6026
    Cell Significance Index: 120.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5591
    Cell Significance Index: 65.1600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.4736
    Cell Significance Index: 6.0700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4642
    Cell Significance Index: 16.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4097
    Cell Significance Index: 19.1000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3322
    Cell Significance Index: 20.9400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3180
    Cell Significance Index: 8.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2958
    Cell Significance Index: 40.6200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2950
    Cell Significance Index: 37.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2360
    Cell Significance Index: 84.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2136
    Cell Significance Index: 16.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2113
    Cell Significance Index: 20.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1897
    Cell Significance Index: 83.8900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1694
    Cell Significance Index: 8.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1585
    Cell Significance Index: 31.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1508
    Cell Significance Index: 27.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1463
    Cell Significance Index: 24.9800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1414
    Cell Significance Index: 97.8000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1407
    Cell Significance Index: 26.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1167
    Cell Significance Index: 8.2600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1141
    Cell Significance Index: 3.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1093
    Cell Significance Index: 13.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1044
    Cell Significance Index: 57.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0918
    Cell Significance Index: 6.1700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0874
    Cell Significance Index: 1.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0811
    Cell Significance Index: 1.3900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0677
    Cell Significance Index: 4.3700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0555
    Cell Significance Index: 1.9500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0343
    Cell Significance Index: 4.0500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0315
    Cell Significance Index: 3.4300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0287
    Cell Significance Index: 0.9200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0128
    Cell Significance Index: 9.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0071
    Cell Significance Index: 13.2900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0029
    Cell Significance Index: 0.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0042
    Cell Significance Index: -0.0900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0045
    Cell Significance Index: -0.0800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0051
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0077
    Cell Significance Index: -4.8200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0085
    Cell Significance Index: -15.5900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0090
    Cell Significance Index: -6.6600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0098
    Cell Significance Index: -13.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0105
    Cell Significance Index: -6.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0107
    Cell Significance Index: -16.5300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0140
    Cell Significance Index: -0.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0141
    Cell Significance Index: -10.7100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0244
    Cell Significance Index: -13.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0253
    Cell Significance Index: -11.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0282
    Cell Significance Index: -2.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0397
    Cell Significance Index: -2.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0472
    Cell Significance Index: -6.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0556
    Cell Significance Index: -11.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0596
    Cell Significance Index: -17.1500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0608
    Cell Significance Index: -2.6900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0614
    Cell Significance Index: -2.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0832
    Cell Significance Index: -9.5300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0890
    Cell Significance Index: -10.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0952
    Cell Significance Index: -13.8400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0978
    Cell Significance Index: -7.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1445
    Cell Significance Index: -6.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1534
    Cell Significance Index: -12.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1730
    Cell Significance Index: -18.0100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1791
    Cell Significance Index: -5.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1882
    Cell Significance Index: -5.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1899
    Cell Significance Index: -5.0800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2039
    Cell Significance Index: -5.2100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2117
    Cell Significance Index: -6.0400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2635
    Cell Significance Index: -13.7300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2706
    Cell Significance Index: -7.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3015
    Cell Significance Index: -16.9200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3156
    Cell Significance Index: -7.7000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3401
    Cell Significance Index: -20.8500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3588
    Cell Significance Index: -8.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3604
    Cell Significance Index: -9.0100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3937
    Cell Significance Index: -10.1200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4185
    Cell Significance Index: -13.3300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4350
    Cell Significance Index: -15.2400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4372
    Cell Significance Index: -9.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4407
    Cell Significance Index: -14.4300
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.4437
    Cell Significance Index: -2.7500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4518
    Cell Significance Index: -10.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PDK2 is a mitochondrial enzyme that belongs to the protein kinase family. It is specifically localized to the mitochondrial matrix and is part of the PDC, a multi-enzyme complex that catalyzes the conversion of pyruvate into acetyl-CoA. PDK2's primary function is to phosphorylate and inhibit PDH, thereby regulating the activity of the PDC and the subsequent production of acetyl-CoA. This regulation is essential for maintaining energy balance and glucose homeostasis in various tissues, including the brain, heart, and liver. **Pathways and Functions** PDK2's activity is regulated by multiple signaling pathways, including: 1. **Insulin Receptor Signaling Pathway**: PDK2 is inhibited by insulin, which promotes glucose uptake and storage in tissues. 2. **Calcium-Mediated Signaling Pathway**: PDK2 is activated by calcium ions, which triggers the dephosphorylation and activation of PDH. 3. **Nuclear Receptor Signaling Pathway**: PDK2 is regulated by nuclear receptors, such as PPARγ, which influence glucose metabolism and energy balance. 4. **Cytosolic Signaling Pathway**: PDK2 is also regulated by cytosolic signaling molecules, such as cAMP and cGMP, which modulate PDH activity. PDK2's functions include: 1. **Regulation of Acetyl-CoA Biosynthesis**: PDK2 modulates the activity of PDH, which is essential for the production of acetyl-CoA, a critical energy source for the citric acid cycle and fatty acid synthesis. 2. **Regulation of Gluconeogenesis**: PDK2 inhibits gluconeogenesis, a metabolic pathway that generates glucose from non-carbohydrate sources, thereby maintaining glucose homeostasis. 3. **Regulation of Cellular Ketone Metabolism**: PDK2 modulates the activity of PDH, which is essential for the production of ketone bodies, an alternative energy source for the brain and other tissues. **Clinical Significance** Dysregulation of PDK2 activity has been implicated in various diseases, including: 1. **Type 2 Diabetes**: PDK2's activity is reduced in type 2 diabetes, leading to impaired glucose metabolism and insulin resistance. 2. **Metabolic Syndrome**: PDK2's dysregulation contributes to the development of metabolic syndrome, a cluster of conditions that increase the risk of developing type 2 diabetes and cardiovascular disease. 3. **Neurodegenerative Diseases**: PDK2's activity is altered in neurodegenerative diseases, such as Alzheimer's and Parkinson's, which may contribute to the development of these diseases. 4. **Cancer**: PDK2's dysregulation has been implicated in cancer development and progression, particularly in tumors that rely on glucose metabolism for energy production. In conclusion, PDK2 is a critical enzyme that regulates glucose metabolism, energy production, and cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding PDK2's functions and regulation in maintaining human health.

Genular Protein ID: 2497501005

Symbol: PDK2_HUMAN

Name: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial

UniProtKB Accession Codes:

Q15119 A8K3A7 B3KNW0 Q6P515 Q9BS05

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EC 2 EMBL 9 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 35 PDBsum 35 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 Rhea 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7499431

Title: Diversity of the pyruvate dehydrogenase kinase gene family in humans.

PubMed ID: 7499431

DOI: 10.1074/jbc.270.48.28989

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9787110

Title: Insulin downregulates pyruvate dehydrogenase kinase (PDK) mRNA: potential mechanism contributing to increased lipid oxidation in insulin-resistant subjects.

PubMed ID: 9787110

DOI: 10.1006/mgme.1998.2748

PubMed ID: 12816949

Title: Facilitated interaction between the pyruvate dehydrogenase kinase isoform 2 and the dihydrolipoyl acetyltransferase.

PubMed ID: 12816949

DOI: 10.1074/jbc.m212733200

PubMed ID: 15491150

Title: Pyruvate dehydrogenase kinase isoform 2 activity limited and further inhibited by slowing down the rate of dissociation of ADP.

PubMed ID: 15491150

DOI: 10.1021/bi049488x

PubMed ID: 16517984

Title: Ligand-induced effects on pyruvate dehydrogenase kinase isoform 2.

PubMed ID: 16517984

DOI: 10.1074/jbc.m513514200

PubMed ID: 17222789

Title: A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth.

PubMed ID: 17222789

DOI: 10.1016/j.ccr.2006.10.020

PubMed ID: 17669420

Title: Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta.

PubMed ID: 17669420

DOI: 10.1016/j.jmb.2007.06.091

PubMed ID: 19833728

Title: Pivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetate.

PubMed ID: 19833728

DOI: 10.1074/jbc.m109.065557

PubMed ID: 21283817

Title: Chronic CSE treatment induces the growth of normal oral keratinocytes via PDK2 upregulation, increased glycolysis and HIF1alpha stabilization.

PubMed ID: 21283817

DOI: 10.1371/journal.pone.0016207

PubMed ID: 22123926

Title: p53 negatively regulates transcription of the pyruvate dehydrogenase kinase Pdk2.

PubMed ID: 22123926

DOI: 10.1158/0008-5472.can-11-1215

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16401071

Title: Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands.

PubMed ID: 16401071

DOI: 10.1021/bi051402s

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 407
  • Mass: 46154
  • Checksum: 77DBA03EF922EF03
  • Sequence:
    • MRWVWALLKN ASLAGAPKYI EHFSKFSPSP LSMKQFLDFG SSNACEKTSF TFLRQELPVR 
LANIMKEINL LPDRVLSTPS VQLVQSWYVQ SLLDIMEFLD KDPEDHRTLS QFTDALVTIR 
NRHNDVVPTM AQGVLEYKDT YGDDPVSNQN IQYFLDRFYL SRISIRMLIN QHTLIFDGST 
NPAHPKHIGS IDPNCNVSEV VKDAYDMAKL LCDKYYMASP DLEIQEINAA NSKQPIHMVY 
VPSHLYHMLF ELFKNAMRAT VESHESSLIL PPIKVMVALG EEDLSIKMSD RGGGVPLRKI 
ERLFSYMYST APTPQPGTGG TPLAGFGYGL PISRLYAKYF QGDLQLFSME GFGTDAVIYL 
KALSTDSVER LPVYNKSAWR HYQTIQEAGD WCVPSTEPKN TSTYRVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.