Details for: NLK

Gene ID: 51701

Symbol: NLK

Ensembl ID: ENSG00000087095

Description: nemo like kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 322.0928
    Cell Significance Index: -50.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 196.4175
    Cell Significance Index: -49.8200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 97.8198
    Cell Significance Index: -39.7400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 75.5713
    Cell Significance Index: -50.7100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 41.6971
    Cell Significance Index: -39.8100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 41.1207
    Cell Significance Index: -50.7000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.8061
    Cell Significance Index: -47.7000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.3706
    Cell Significance Index: -47.2100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.9588
    Cell Significance Index: -30.5500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.9269
    Cell Significance Index: -51.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 5.4370
    Cell Significance Index: 145.6900
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 3.7070
    Cell Significance Index: 52.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.7816
    Cell Significance Index: 557.9900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.7714
    Cell Significance Index: 39.8600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 2.2384
    Cell Significance Index: 29.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.1046
    Cell Significance Index: 118.1000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.8510
    Cell Significance Index: 116.6600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.7919
    Cell Significance Index: 120.4900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.6796
    Cell Significance Index: 1161.6700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6670
    Cell Significance Index: 330.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.6572
    Cell Significance Index: 41.4300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.6367
    Cell Significance Index: 20.3000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.6234
    Cell Significance Index: 124.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.5905
    Cell Significance Index: 70.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4660
    Cell Significance Index: 525.8200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.3743
    Cell Significance Index: 52.0400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.3397
    Cell Significance Index: 38.2300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9837
    Cell Significance Index: 888.1700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.9639
    Cell Significance Index: 7.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5218
    Cell Significance Index: 84.8700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5029
    Cell Significance Index: 54.7000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.4898
    Cell Significance Index: 10.4700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4740
    Cell Significance Index: 29.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4736
    Cell Significance Index: 891.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4222
    Cell Significance Index: 5.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.3528
    Cell Significance Index: 160.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2901
    Cell Significance Index: 446.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2737
    Cell Significance Index: 173.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2642
    Cell Significance Index: 359.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2205
    Cell Significance Index: 406.5800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2101
    Cell Significance Index: 4.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1963
    Cell Significance Index: 5.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1901
    Cell Significance Index: 18.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1633
    Cell Significance Index: 29.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1620
    Cell Significance Index: 19.9300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1620
    Cell Significance Index: 18.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1396
    Cell Significance Index: 3.9000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1258
    Cell Significance Index: 0.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0928
    Cell Significance Index: 17.6700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0353
    Cell Significance Index: 1.2400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0337
    Cell Significance Index: 18.4100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0013
    Cell Significance Index: -0.0300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0076
    Cell Significance Index: -0.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0126
    Cell Significance Index: -1.8300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0217
    Cell Significance Index: -0.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0298
    Cell Significance Index: -5.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0371
    Cell Significance Index: -4.3800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0420
    Cell Significance Index: -18.5700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0426
    Cell Significance Index: -31.2000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0455
    Cell Significance Index: -1.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0485
    Cell Significance Index: -35.9100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0585
    Cell Significance Index: -2.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0686
    Cell Significance Index: -51.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0830
    Cell Significance Index: -46.8000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0897
    Cell Significance Index: -56.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1470
    Cell Significance Index: -42.3100
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.1616
    Cell Significance Index: -1.6300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2106
    Cell Significance Index: -14.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2246
    Cell Significance Index: -30.8400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2484
    Cell Significance Index: -52.3100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2622
    Cell Significance Index: -4.3200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.2879
    Cell Significance Index: -3.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2909
    Cell Significance Index: -30.2900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2936
    Cell Significance Index: -5.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3062
    Cell Significance Index: -31.2800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3205
    Cell Significance Index: -3.8200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3211
    Cell Significance Index: -41.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3377
    Cell Significance Index: -17.5500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3384
    Cell Significance Index: -43.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3699
    Cell Significance Index: -42.3800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3750
    Cell Significance Index: -24.1900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5333
    Cell Significance Index: -42.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5352
    Cell Significance Index: -39.8900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5459
    Cell Significance Index: -8.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5565
    Cell Significance Index: -14.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5587
    Cell Significance Index: -26.2600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5676
    Cell Significance Index: -29.5700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5851
    Cell Significance Index: -12.4600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5999
    Cell Significance Index: -42.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6048
    Cell Significance Index: -28.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6480
    Cell Significance Index: -39.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6860
    Cell Significance Index: -21.9700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.6940
    Cell Significance Index: -11.6900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7173
    Cell Significance Index: -37.6600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.7193
    Cell Significance Index: -10.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7495
    Cell Significance Index: -24.5400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8111
    Cell Significance Index: -17.2200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.8220
    Cell Significance Index: -7.5700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8537
    Cell Significance Index: -27.1900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.8595
    Cell Significance Index: -17.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural Homology**: NLK shares structural homology with the Drosophila Nemo protein, which is involved in the Wnt signaling pathway. 2. **Serine/Threonine Phosphorylation**: NLK is a serine/threonine kinase that phosphorylates specific substrates, influencing various cellular processes. 3. **Regulation of Signaling Pathways**: NLK modulates multiple signaling pathways, including the Wnt, MAPK, and TGF-β pathways. 4. **Cellular Localization**: NLK is found in both the cytoplasm and nucleus, suggesting its involvement in both intracellular and nuclear signaling. **Pathways and Functions:** 1. **Wnt Signaling**: NLK negatively regulates Wnt signaling, which is crucial for cell proliferation, differentiation, and survival. 2. **MAPK Cascade**: NLK is involved in the MAPK cascade, which regulates cell growth, differentiation, and apoptosis. 3. **TGF-β Signaling**: NLK negatively regulates TGF-β signaling, which is essential for cell growth, differentiation, and immune responses. 4. **DNA-templated Transcription**: NLK regulates DNA-templated transcription, influencing gene expression and cellular differentiation. 5. **Cellular Response to Osmotic Stress**: NLK is involved in the cellular response to osmotic stress, ensuring cell survival and adaptation to changing environmental conditions. **Clinical Significance:** 1. **Hematological Disorders**: NLK has been implicated in various hematological disorders, including leukemia, lymphoma, and anemia. 2. **Immune System Dysregulation**: NLK is involved in immune system dysregulation, including autoimmune diseases and cancer. 3. **Cancer**: NLK has been found to be overexpressed in various types of cancer, including breast, lung, and colon cancer. 4. **Neurological Disorders**: NLK has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. In conclusion, NLK is a multifunctional kinase that plays a critical role in various cellular signaling pathways. Its dysregulation has been implicated in numerous diseases, highlighting the need for further research into the molecular mechanisms underlying NLK's functions and its clinical significance.

Genular Protein ID: 3421560667

Symbol: NLK_HUMAN

Name: Serine/threonine-protein kinase NLK

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10863097

Title: Characterization of the Fugu rubripes NLK and FN5 genes flanking the NF1 (Neurofibromatosis type 1) gene in the 5' direction and mapping of the human counterparts.

PubMed ID: 10863097

DOI: 10.1016/s0378-1119(00)00188-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12482967

Title: The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling.

PubMed ID: 12482967

DOI: 10.1128/mcb.23.1.131-139.2003

PubMed ID: 15004007

Title: Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction.

PubMed ID: 15004007

DOI: 10.1101/gad.1166904

PubMed ID: 15082531

Title: Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK.

PubMed ID: 15082531

DOI: 10.1101/gad.1170604

PubMed ID: 14960582

Title: Wnt activates the Tak1/Nemo-like kinase pathway.

PubMed ID: 14960582

DOI: 10.1074/jbc.m307801200

PubMed ID: 15764709

Title: STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation.

PubMed ID: 15764709

DOI: 10.1073/pnas.0500679102

PubMed ID: 16714285

Title: NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF).

PubMed ID: 16714285

DOI: 10.1074/jbc.m602089200

PubMed ID: 17952062

Title: A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation.

PubMed ID: 17952062

DOI: 10.1038/ncb1647

PubMed ID: 25358353

Title:

PubMed ID: 25358353

DOI: 10.1038/ncb3069

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20061393

Title: Regulation of FOXO1 by TAK1-Nemo-like kinase pathway.

PubMed ID: 20061393

DOI: 10.1074/jbc.m110.101824

PubMed ID: 20118921

Title: Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex.

PubMed ID: 20118921

DOI: 10.1038/ncb2028

PubMed ID: 20874444

Title: Oxidative stress-dependent regulation of Forkhead box O4 activity by nemo-like kinase.

PubMed ID: 20874444

DOI: 10.1089/ars.2010.3243

PubMed ID: 21454679

Title: Zipper-interacting protein kinase (ZIPK) modulates canonical Wnt/beta-catenin signaling through interaction with Nemo-like kinase and T-cell factor 4 (NLK/TCF4).

PubMed ID: 21454679

DOI: 10.1074/jbc.m110.189829

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26588989

Title: NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition.

PubMed ID: 26588989

DOI: 10.1101/gad.265116.115

PubMed ID: 25512613

Title: Stabilization of ATF5 by TAK1-Nemo-like kinase critically regulates the interleukin-1beta-stimulated C/EBP signaling pathway.

PubMed ID: 25512613

DOI: 10.1128/mcb.01228-14

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 527
  • Mass: 58283
  • Checksum: CE6AEBA7D8133989
  • Sequence:
  • MSLCGARANA KMMAAYNGGT SAAAAGHHHH HHHHLPHLPP PHLHHHHHPQ HHLHPGSAAA 
    VHPVQQHTSS AAAAAAAAAA AAAMLNPGQQ QPYFPSPAPG QAPGPAAAAP AQVQAAAAAT 
    VKAHHHQHSH HPQQQLDIEP DRPIGYGAFG VVWSVTDPRD GKRVALKKMP NVFQNLVSCK 
    RVFRELKMLC FFKHDNVLSA LDILQPPHID YFEEIYVVTE LMQSDLHKII VSPQPLSSDH 
    VKVFLYQILR GLKYLHSAGI LHRDIKPGNL LVNSNCVLKI CDFGLARVEE LDESRHMTQE 
    VVTQYYRAPE ILMGSRHYSN AIDIWSVGCI FAELLGRRIL FQAQSPIQQL DLITDLLGTP 
    SLEAMRTACE GAKAHILRGP HKQPSLPVLY TLSSQATHEA VHLLCRMLVF DPSKRISAKD 
    ALAHPYLDEG RLRYHTCMCK CCFSTSTGRV YTSDFEPVTN PKFDDTFEKN LSSVRQVKEI 
    IHQFILEQQK GNRVPLCINP QSAAFKSFIS STVAQPSEMP PSPLVWE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.