Details for: NLK
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 322.0928
Cell Significance Index: -50.1000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 196.4175
Cell Significance Index: -49.8200 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 97.8198
Cell Significance Index: -39.7400 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 75.5713
Cell Significance Index: -50.7100 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 41.6971
Cell Significance Index: -39.8100 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 41.1207
Cell Significance Index: -50.7000 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 17.8061
Cell Significance Index: -47.7000 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 15.3706
Cell Significance Index: -47.2100 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 13.9588
Cell Significance Index: -30.5500 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 12.9269
Cell Significance Index: -51.0100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 5.4370
Cell Significance Index: 145.6900 - Cell Name: photoreceptor cell (CL0000210)
Fold Change: 3.7070
Cell Significance Index: 52.0700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.7816
Cell Significance Index: 557.9900 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 2.7714
Cell Significance Index: 39.8600 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 2.2384
Cell Significance Index: 29.8600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 2.1046
Cell Significance Index: 118.1000 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.8510
Cell Significance Index: 116.6600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 1.7919
Cell Significance Index: 120.4900 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.6796
Cell Significance Index: 1161.6700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.6670
Cell Significance Index: 330.8200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 1.6572
Cell Significance Index: 41.4300 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.6367
Cell Significance Index: 20.3000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.6234
Cell Significance Index: 124.5800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.5905
Cell Significance Index: 70.3500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.4660
Cell Significance Index: 525.8200 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.3743
Cell Significance Index: 52.0400 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 1.3397
Cell Significance Index: 38.2300 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.9837
Cell Significance Index: 888.1700 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.9639
Cell Significance Index: 7.4300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5218
Cell Significance Index: 84.8700 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.5029
Cell Significance Index: 54.7000 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.4898
Cell Significance Index: 10.4700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.4740
Cell Significance Index: 29.1400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.4736
Cell Significance Index: 891.7900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.4222
Cell Significance Index: 5.7600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.3528
Cell Significance Index: 160.1100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.2901
Cell Significance Index: 446.5600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.2737
Cell Significance Index: 173.8300 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.2642
Cell Significance Index: 359.2400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.2205
Cell Significance Index: 406.5800 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.2101
Cell Significance Index: 4.6000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1963
Cell Significance Index: 5.6600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1901
Cell Significance Index: 18.8100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1633
Cell Significance Index: 29.4300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1620
Cell Significance Index: 19.9300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.1620
Cell Significance Index: 18.8800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1396
Cell Significance Index: 3.9000 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.1258
Cell Significance Index: 0.7600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0928
Cell Significance Index: 17.6700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0353
Cell Significance Index: 1.2400 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0337
Cell Significance Index: 18.4100 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0013
Cell Significance Index: -0.0300 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0076
Cell Significance Index: -0.1300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0126
Cell Significance Index: -1.8300 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0217
Cell Significance Index: -0.4700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0298
Cell Significance Index: -5.0900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0371
Cell Significance Index: -4.3800 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0420
Cell Significance Index: -18.5700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0426
Cell Significance Index: -31.2000 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0455
Cell Significance Index: -1.1700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0485
Cell Significance Index: -35.9100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0585
Cell Significance Index: -2.6500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0686
Cell Significance Index: -51.9200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0830
Cell Significance Index: -46.8000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0897
Cell Significance Index: -56.0300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1470
Cell Significance Index: -42.3100 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: -0.1616
Cell Significance Index: -1.6300 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.2106
Cell Significance Index: -14.5700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.2246
Cell Significance Index: -30.8400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2484
Cell Significance Index: -52.3100 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.2622
Cell Significance Index: -4.3200 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: -0.2879
Cell Significance Index: -3.4900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2909
Cell Significance Index: -30.2900 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.2936
Cell Significance Index: -5.7300 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.3062
Cell Significance Index: -31.2800 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.3205
Cell Significance Index: -3.8200 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.3211
Cell Significance Index: -41.4900 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.3377
Cell Significance Index: -17.5500 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.3384
Cell Significance Index: -43.3800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3699
Cell Significance Index: -42.3800 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.3750
Cell Significance Index: -24.1900 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5333
Cell Significance Index: -42.2400 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.5352
Cell Significance Index: -39.8900 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.5459
Cell Significance Index: -8.0600 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.5565
Cell Significance Index: -14.8600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.5587
Cell Significance Index: -26.2600 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.5676
Cell Significance Index: -29.5700 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.5851
Cell Significance Index: -12.4600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.5999
Cell Significance Index: -42.4300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.6048
Cell Significance Index: -28.2000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.6480
Cell Significance Index: -39.7300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.6860
Cell Significance Index: -21.9700 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.6940
Cell Significance Index: -11.6900 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.7173
Cell Significance Index: -37.6600 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.7193
Cell Significance Index: -10.2400 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.7495
Cell Significance Index: -24.5400 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.8111
Cell Significance Index: -17.2200 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.8220
Cell Significance Index: -7.5700 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.8537
Cell Significance Index: -27.1900 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.8595
Cell Significance Index: -17.0000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3421560667
Symbol: NLK_HUMAN
Name: Serine/threonine-protein kinase NLK
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10863097
Title: Characterization of the Fugu rubripes NLK and FN5 genes flanking the NF1 (Neurofibromatosis type 1) gene in the 5' direction and mapping of the human counterparts.
PubMed ID: 10863097
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12482967
Title: The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling.
PubMed ID: 12482967
PubMed ID: 15004007
Title: Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction.
PubMed ID: 15004007
DOI: 10.1101/gad.1166904
PubMed ID: 15082531
Title: Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK.
PubMed ID: 15082531
DOI: 10.1101/gad.1170604
PubMed ID: 14960582
Title: Wnt activates the Tak1/Nemo-like kinase pathway.
PubMed ID: 14960582
PubMed ID: 15764709
Title: STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation.
PubMed ID: 15764709
PubMed ID: 16714285
Title: NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF).
PubMed ID: 16714285
PubMed ID: 17952062
Title: A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation.
PubMed ID: 17952062
DOI: 10.1038/ncb1647
PubMed ID: 25358353
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20061393
Title: Regulation of FOXO1 by TAK1-Nemo-like kinase pathway.
PubMed ID: 20061393
PubMed ID: 20118921
Title: Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex.
PubMed ID: 20118921
DOI: 10.1038/ncb2028
PubMed ID: 20874444
Title: Oxidative stress-dependent regulation of Forkhead box O4 activity by nemo-like kinase.
PubMed ID: 20874444
PubMed ID: 21454679
Title: Zipper-interacting protein kinase (ZIPK) modulates canonical Wnt/beta-catenin signaling through interaction with Nemo-like kinase and T-cell factor 4 (NLK/TCF4).
PubMed ID: 21454679
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 26588989
Title: NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition.
PubMed ID: 26588989
PubMed ID: 25512613
Title: Stabilization of ATF5 by TAK1-Nemo-like kinase critically regulates the interleukin-1beta-stimulated C/EBP signaling pathway.
PubMed ID: 25512613
DOI: 10.1128/mcb.01228-14
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 527
- Mass: 58283
- Checksum: CE6AEBA7D8133989
- Sequence:
MSLCGARANA KMMAAYNGGT SAAAAGHHHH HHHHLPHLPP PHLHHHHHPQ HHLHPGSAAA VHPVQQHTSS AAAAAAAAAA AAAMLNPGQQ QPYFPSPAPG QAPGPAAAAP AQVQAAAAAT VKAHHHQHSH HPQQQLDIEP DRPIGYGAFG VVWSVTDPRD GKRVALKKMP NVFQNLVSCK RVFRELKMLC FFKHDNVLSA LDILQPPHID YFEEIYVVTE LMQSDLHKII VSPQPLSSDH VKVFLYQILR GLKYLHSAGI LHRDIKPGNL LVNSNCVLKI CDFGLARVEE LDESRHMTQE VVTQYYRAPE ILMGSRHYSN AIDIWSVGCI FAELLGRRIL FQAQSPIQQL DLITDLLGTP SLEAMRTACE GAKAHILRGP HKQPSLPVLY TLSSQATHEA VHLLCRMLVF DPSKRISAKD ALAHPYLDEG RLRYHTCMCK CCFSTSTGRV YTSDFEPVTN PKFDDTFEKN LSSVRQVKEI IHQFILEQQK GNRVPLCINP QSAAFKSFIS STVAQPSEMP PSPLVWE
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.