Details for: CAB39

Gene ID: 51719

Symbol: CAB39

Ensembl ID: ENSG00000135932

Description: calcium binding protein 39

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 322.1571
    Cell Significance Index: -50.1100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 199.7687
    Cell Significance Index: -50.6700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 108.0016
    Cell Significance Index: -50.9900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 106.5827
    Cell Significance Index: -43.3000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 95.0844
    Cell Significance Index: -48.9100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 75.8544
    Cell Significance Index: -50.9000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 46.2742
    Cell Significance Index: -44.1800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 42.0372
    Cell Significance Index: -51.8300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.0767
    Cell Significance Index: -48.4300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.7864
    Cell Significance Index: -54.6300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.5655
    Cell Significance Index: -36.2600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.2588
    Cell Significance Index: -52.3200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.0587
    Cell Significance Index: 356.4600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.6155
    Cell Significance Index: 180.8800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.1156
    Cell Significance Index: 54.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0218
    Cell Significance Index: 405.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6441
    Cell Significance Index: 326.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.4843
    Cell Significance Index: 83.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3239
    Cell Significance Index: 101.6000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2059
    Cell Significance Index: 131.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.1941
    Cell Significance Index: 80.2900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1222
    Cell Significance Index: 182.5200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.0629
    Cell Significance Index: 26.5700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0550
    Cell Significance Index: 28.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9961
    Cell Significance Index: 357.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7864
    Cell Significance Index: 40.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7422
    Cell Significance Index: 16.0800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.7235
    Cell Significance Index: 5.9000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7039
    Cell Significance Index: 635.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6909
    Cell Significance Index: 30.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6462
    Cell Significance Index: 116.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6457
    Cell Significance Index: 24.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5768
    Cell Significance Index: 26.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5466
    Cell Significance Index: 67.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4543
    Cell Significance Index: 248.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4459
    Cell Significance Index: 84.8600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4303
    Cell Significance Index: 12.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4179
    Cell Significance Index: 11.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3661
    Cell Significance Index: 22.5000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.3475
    Cell Significance Index: 8.4800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3423
    Cell Significance Index: 17.7800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3122
    Cell Significance Index: 2.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2561
    Cell Significance Index: 113.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2244
    Cell Significance Index: 10.5500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1920
    Cell Significance Index: 12.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1620
    Cell Significance Index: 22.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1553
    Cell Significance Index: 7.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1540
    Cell Significance Index: 69.9100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1439
    Cell Significance Index: 16.9700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1235
    Cell Significance Index: 21.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1234
    Cell Significance Index: 78.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1103
    Cell Significance Index: 207.7000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0575
    Cell Significance Index: 2.0200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0546
    Cell Significance Index: 0.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0502
    Cell Significance Index: 77.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0368
    Cell Significance Index: 67.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0054
    Cell Significance Index: 7.2900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0208
    Cell Significance Index: -12.9900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0259
    Cell Significance Index: -19.0000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0327
    Cell Significance Index: -0.8900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0343
    Cell Significance Index: -25.3900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0428
    Cell Significance Index: -32.3800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0564
    Cell Significance Index: -1.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0743
    Cell Significance Index: -41.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1015
    Cell Significance Index: -10.0400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1029
    Cell Significance Index: -1.4800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1163
    Cell Significance Index: -7.3300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1173
    Cell Significance Index: -2.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1174
    Cell Significance Index: -11.9900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1352
    Cell Significance Index: -17.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1428
    Cell Significance Index: -30.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1609
    Cell Significance Index: -23.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1611
    Cell Significance Index: -46.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1733
    Cell Significance Index: -22.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1822
    Cell Significance Index: -13.5800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1827
    Cell Significance Index: -4.0000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2315
    Cell Significance Index: -26.4200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2331
    Cell Significance Index: -5.5900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2602
    Cell Significance Index: -3.5500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2760
    Cell Significance Index: -19.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2819
    Cell Significance Index: -32.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3387
    Cell Significance Index: -35.2700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.3880
    Cell Significance Index: -6.2600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4233
    Cell Significance Index: -8.7800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4473
    Cell Significance Index: -11.9900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4889
    Cell Significance Index: -14.0900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5016
    Cell Significance Index: -39.7300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5092
    Cell Significance Index: -10.8500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.5135
    Cell Significance Index: -8.6500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5388
    Cell Significance Index: -7.9600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5389
    Cell Significance Index: -11.5200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6332
    Cell Significance Index: -18.1500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6403
    Cell Significance Index: -13.5900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6715
    Cell Significance Index: -19.7200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6860
    Cell Significance Index: -42.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7028
    Cell Significance Index: -36.9000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7911
    Cell Significance Index: -9.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8123
    Cell Significance Index: -21.3600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.8191
    Cell Significance Index: -15.1400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.8279
    Cell Significance Index: -12.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Calcium-binding properties**: CAB39 has the ability to bind to calcium ions, which is essential for its regulatory functions in the cell. 2. **Multifunctional protein**: CAB39 is involved in various cellular processes, including immune response, cell signaling, and protein regulation. 3. **Cellular localization**: CAB39 is expressed in multiple cell types, including hematopoietic cells, smooth muscle cells, and immune cells. 4. **Regulatory functions**: CAB39 modulates the activity of protein kinases and phosphatases, influencing signaling pathways and cellular responses. **Pathways and Functions** CAB39 is involved in several signaling pathways, including: 1. **Cellular hypotonic response**: CAB39 regulates the response to hypotonic stress by modulating protein kinase activity. 2. **MTOR signaling**: CAB39 interacts with the mTOR (mechanistic target of rapamycin) pathway, influencing cell growth and metabolism. 3. **Innate immune response**: CAB39 plays a role in the regulation of immune cell function and the response to pathogens. 4. **Neutrophil degranulation**: CAB39 modulates the activity of protein kinases involved in neutrophil degranulation, influencing the release of pro-inflammatory mediators. CAB39 functions as a: 1. **Protein kinase activator**: CAB39 activates protein kinases, influencing their activity and downstream signaling. 2. **Phosphatase inhibitor**: CAB39 inhibits phosphatase activity, regulating the dephosphorylation of proteins and influencing cellular responses. 3. **Regulatory subunit**: CAB39 interacts with protein kinases and phosphatases, influencing their activity and regulatory functions. **Clinical Significance** CAB39's involvement in various cellular processes and signaling pathways has significant implications for human health and disease. Dysregulation of CAB39 has been implicated in: 1. **Immune-related disorders**: CAB39's role in regulating immune cell function and the response to pathogens makes it a potential target for the treatment of immune-related disorders. 2. **Cancer**: CAB39's involvement in cell growth and metabolism makes it a potential target for the treatment of cancer. 3. **Neurological disorders**: CAB39's role in regulating neuronal function and signaling pathways makes it a potential target for the treatment of neurological disorders. In conclusion, CAB39 is a multifunctional protein with significant implications for human health and disease. Further research is needed to fully understand the mechanisms of CAB39 and its role in various cellular processes.

Genular Protein ID: 2569023919

Symbol: CAB39_HUMAN

Name: Calcium-binding protein 39

UniProtKB Accession Codes:

Q9Y376 A8K8L7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 14730349

Title: Crystal structure of MO25 alpha in complex with the C-terminus of the pseudo kinase STE20-related adaptor.

PubMed ID: 14730349

DOI: 10.1038/nsmb716

PubMed ID: 19892943

Title: Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation.

PubMed ID: 19892943

DOI: 10.1126/science.1178377

Sequence Information:

  • Length: 341
  • Mass: 39869
  • Checksum: EC710A528B6F9811
  • Sequence:
    • MPFPFGKSHK SPADIVKNLK ESMAVLEKQD ISDKKAEKAT EEVSKNLVAM KEILYGTNEK 
EPQTEAVAQL AQELYNSGLL STLVADLQLI DFEGKKDVAQ IFNNILRRQI GTRTPTVEYI 
CTQQNILFML LKGYESPEIA LNCGIMLREC IRHEPLAKII LWSEQFYDFF RYVEMSTFDI 
ASDAFATFKD LLTRHKLLSA EFLEQHYDRF FSEYEKLLHS ENYVTKRQSL KLLGELLLDR 
HNFTIMTKYI SKPENLKLMM NLLRDKSRNI QFEAFHVFKV FVANPNKTQP ILDILLKNQA 
KLIEFLSKFQ NDRTEDEQFN DEKTYLVKQI RDLKRPAQQE A

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.