Details for: C9orf78

Gene ID: 51759

Symbol: C9orf78

Ensembl ID: ENSG00000136819

Description: chromosome 9 open reading frame 78

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 189.0768
    Cell Significance Index: -29.4100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 137.9299
    Cell Significance Index: -34.9900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 98.4066
    Cell Significance Index: -46.4600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 94.8705
    Cell Significance Index: -48.8000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 69.4016
    Cell Significance Index: -46.5700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.5176
    Cell Significance Index: -32.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.1045
    Cell Significance Index: -47.7700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.2004
    Cell Significance Index: -31.3300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.2679
    Cell Significance Index: -18.1000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.8547
    Cell Significance Index: -13.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3712
    Cell Significance Index: 88.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3077
    Cell Significance Index: 235.7300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.2501
    Cell Significance Index: 359.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1842
    Cell Significance Index: 145.6100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.1804
    Cell Significance Index: 10.8700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.1553
    Cell Significance Index: 33.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1038
    Cell Significance Index: 151.5800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0181
    Cell Significance Index: 919.2800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9324
    Cell Significance Index: 25.3800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.9106
    Cell Significance Index: 9.6800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9052
    Cell Significance Index: 400.1900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8374
    Cell Significance Index: 57.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7910
    Cell Significance Index: 37.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7364
    Cell Significance Index: 52.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6913
    Cell Significance Index: 36.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6606
    Cell Significance Index: 77.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6471
    Cell Significance Index: 82.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6338
    Cell Significance Index: 47.2400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6036
    Cell Significance Index: 329.6500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5848
    Cell Significance Index: 12.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5769
    Cell Significance Index: 26.9000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4967
    Cell Significance Index: 17.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4557
    Cell Significance Index: 91.4200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4201
    Cell Significance Index: 7.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4190
    Cell Significance Index: 18.9900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3556
    Cell Significance Index: 4.0400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2994
    Cell Significance Index: 38.6800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2852
    Cell Significance Index: 6.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2719
    Cell Significance Index: 14.1300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.2712
    Cell Significance Index: 2.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2363
    Cell Significance Index: 5.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2344
    Cell Significance Index: 40.0300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2117
    Cell Significance Index: 40.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1729
    Cell Significance Index: 62.0300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1658
    Cell Significance Index: 4.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1527
    Cell Significance Index: 4.4000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0933
    Cell Significance Index: 9.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0826
    Cell Significance Index: 16.4000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0556
    Cell Significance Index: 1.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0142
    Cell Significance Index: 0.3800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0107
    Cell Significance Index: 7.8100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0055
    Cell Significance Index: -4.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0080
    Cell Significance Index: -6.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0122
    Cell Significance Index: -23.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0134
    Cell Significance Index: -0.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0221
    Cell Significance Index: -2.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0233
    Cell Significance Index: -14.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0240
    Cell Significance Index: -44.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0256
    Cell Significance Index: -14.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0288
    Cell Significance Index: -44.2900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0344
    Cell Significance Index: -46.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0428
    Cell Significance Index: -1.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0541
    Cell Significance Index: -3.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0559
    Cell Significance Index: -35.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0835
    Cell Significance Index: -37.8800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0859
    Cell Significance Index: -18.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1419
    Cell Significance Index: -16.5400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1560
    Cell Significance Index: -17.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1947
    Cell Significance Index: -22.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2195
    Cell Significance Index: -31.9000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2391
    Cell Significance Index: -8.4000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2537
    Cell Significance Index: -6.4800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2953
    Cell Significance Index: -32.1200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3140
    Cell Significance Index: -19.3000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3768
    Cell Significance Index: -10.5300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3827
    Cell Significance Index: -4.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4066
    Cell Significance Index: -8.6600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4138
    Cell Significance Index: -11.0700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4186
    Cell Significance Index: -33.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4246
    Cell Significance Index: -28.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4516
    Cell Significance Index: -47.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4890
    Cell Significance Index: -37.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5120
    Cell Significance Index: -28.7300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5871
    Cell Significance Index: -8.0100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.5942
    Cell Significance Index: -3.2400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6032
    Cell Significance Index: -36.9800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.6131
    Cell Significance Index: -5.1500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.6193
    Cell Significance Index: -5.0500
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.6331
    Cell Significance Index: -4.7800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6349
    Cell Significance Index: -11.2200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6605
    Cell Significance Index: -16.5100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.6625
    Cell Significance Index: -11.4200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7368
    Cell Significance Index: -14.3800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7978
    Cell Significance Index: -9.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8335
    Cell Significance Index: -22.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8453
    Cell Significance Index: -37.3900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.8549
    Cell Significance Index: -12.8100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.8630
    Cell Significance Index: -14.7900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9673
    Cell Significance Index: -28.4900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9830
    Cell Significance Index: -34.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** C9orf78 is a non-coding gene, with no known protein-coding sequence. Its expression is widespread across various cell types, including hematopoietic cells, smooth muscle cells, and immune cells such as T cells and dendritic cells. The gene is predominantly expressed in cells that undergo rapid proliferation, such as erythroblasts and hematopoietic progenitor cells. Notably, C9orf78 is also expressed in tissues with high levels of immune cells, suggesting its potential role in modulating immune responses. **Pathways and Functions** C9orf78 is involved in several cellular pathways, including: 1. **RNA metabolism**: C9orf78 is a critical component of the spliceosome, a complex responsible for splicing pre-mRNA transcripts. The gene's expression is tightly regulated, and its dysregulation has been implicated in various diseases, including cancer and autoimmune disorders. 2. **Protein binding**: C9orf78 interacts with various proteins, including TLS1, a hepatocellular carcinoma-associated antigen. This interaction suggests that the gene may play a role in regulating protein-protein interactions, which are essential for cellular signaling and function. 3. **Chromosome segregation**: C9orf78 is involved in the regulation of homologous chromosome segregation, a process critical for maintaining genome stability. **Clinical Significance** The clinical significance of C9orf78 is an area of active research. Studies have implicated the gene in various diseases, including: 1. **Autoimmune disorders**: C9orf78 has been shown to be overexpressed in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. The gene's dysregulation may contribute to the development of autoimmune responses. 2. **Cancer**: C9orf78 is overexpressed in various types of cancer, including hepatocellular carcinoma and colorectal cancer. The gene's interaction with TLS1 may contribute to cancer progression and metastasis. 3. **Immune-mediated diseases**: C9orf78 has been implicated in immune-mediated diseases, such as graft-versus-host disease and multiple sclerosis. The gene's dysregulation may contribute to immune dysfunction and disease progression. In conclusion, C9orf78 is a gene of emerging immunological significance, with implications in RNA metabolism, protein binding, and chromosome segregation. Further research is needed to fully understand the gene's functions and its role in various diseases.

Genular Protein ID: 3276219603

Symbol: TLS1_HUMAN

Name: Hepatocellular carcinoma-associated antigen 59

UniProtKB Accession Codes:

Q9NZ63 B3KPX8 Q8WVU6 Q9NT39

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 EMBL 7 EMDB 1 Ensembl 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12097419

Title: Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies.

PubMed ID: 12097419

DOI: 10.4049/jimmunol.169.2.1102

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 35167828

Title: C9ORF78 partially localizes to centromeres and plays a role in chromosome segregation.

PubMed ID: 35167828

DOI: 10.1016/j.yexcr.2022.113063

PubMed ID: 35241646

Title: A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.

PubMed ID: 35241646

DOI: 10.1038/s41467-022-28754-2

Sequence Information:

  • Length: 289
  • Mass: 33688
  • Checksum: 3F691E6D17D1360E
  • Sequence:
    • MPVVRKIFRR RRGDSESEED EQDSEEVRLK LEETREVQNL RKRPNGVSAV ALLVGEKVQE 
ETTLVDDPFQ MKTGGMVDMK KLKERGKDKI SEEEDLHLGT SFSAETNRRD EDADMMKYIE 
TELKKRKGIV EHEEQKVKPK NAEDCLYELP ENIRVSSAKK TEEMLSNQML SGIPEVDLGI 
DAKIKNIIST EDAKARLLAE QQNKKKDSET SFVPTNMAVN YVQHNRFYHE ELNAPIRRNK 
EEPKARPLRV GDTEKPEPER SPPNRKRPAN EKATDDYHYE KFKKMNRRY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.