Details for: STK26

Gene ID: 51765

Symbol: STK26

Ensembl ID: ENSG00000134602

Description: serine/threonine kinase 26

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 28.5533
    Cell Significance Index: -11.6000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 27.0031
    Cell Significance Index: -13.8900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.7495
    Cell Significance Index: -12.1700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.5635
    Cell Significance Index: -12.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.5005
    Cell Significance Index: 475.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.1496
    Cell Significance Index: 212.6400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.1373
    Cell Significance Index: 57.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.0294
    Cell Significance Index: 236.5000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.5941
    Cell Significance Index: 17.3300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.3662
    Cell Significance Index: -2.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3130
    Cell Significance Index: 35.7400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.0868
    Cell Significance Index: 29.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0845
    Cell Significance Index: 69.9700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9187
    Cell Significance Index: 55.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8436
    Cell Significance Index: 761.7500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8082
    Cell Significance Index: 87.9100
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.6705
    Cell Significance Index: 4.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6626
    Cell Significance Index: 107.7600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4794
    Cell Significance Index: 95.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4253
    Cell Significance Index: 54.5200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4054
    Cell Significance Index: 28.0400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3577
    Cell Significance Index: 7.7500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.3435
    Cell Significance Index: 4.8900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2247
    Cell Significance Index: 6.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1886
    Cell Significance Index: 8.5500
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.1786
    Cell Significance Index: 1.9000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1708
    Cell Significance Index: 20.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1577
    Cell Significance Index: 86.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1529
    Cell Significance Index: 18.8000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1322
    Cell Significance Index: 3.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1203
    Cell Significance Index: 21.6900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1116
    Cell Significance Index: 3.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0655
    Cell Significance Index: 3.4000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0634
    Cell Significance Index: 28.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0148
    Cell Significance Index: 0.3700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0008
    Cell Significance Index: -0.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0012
    Cell Significance Index: -0.7600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0055
    Cell Significance Index: -10.3700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0080
    Cell Significance Index: -0.2800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0089
    Cell Significance Index: -6.1900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0102
    Cell Significance Index: -0.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0119
    Cell Significance Index: -21.9200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0121
    Cell Significance Index: -8.9000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0151
    Cell Significance Index: -23.2100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0154
    Cell Significance Index: -1.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0175
    Cell Significance Index: -23.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0188
    Cell Significance Index: -13.9100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0221
    Cell Significance Index: -12.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0230
    Cell Significance Index: -4.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0251
    Cell Significance Index: -1.1700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0260
    Cell Significance Index: -16.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0277
    Cell Significance Index: -9.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0293
    Cell Significance Index: -13.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0310
    Cell Significance Index: -1.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0369
    Cell Significance Index: -10.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0376
    Cell Significance Index: -5.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0460
    Cell Significance Index: -2.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0461
    Cell Significance Index: -7.8700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0482
    Cell Significance Index: -1.0000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0513
    Cell Significance Index: -0.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0520
    Cell Significance Index: -2.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0553
    Cell Significance Index: -7.1500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0624
    Cell Significance Index: -1.3300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0660
    Cell Significance Index: -0.4100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0667
    Cell Significance Index: -0.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0687
    Cell Significance Index: -7.8800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0742
    Cell Significance Index: -3.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0825
    Cell Significance Index: -11.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0831
    Cell Significance Index: -17.5100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0898
    Cell Significance Index: -6.7000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0963
    Cell Significance Index: -1.7800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0998
    Cell Significance Index: -3.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1010
    Cell Significance Index: -10.3200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1140
    Cell Significance Index: -1.6200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1231
    Cell Significance Index: -5.0500
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1281
    Cell Significance Index: -0.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1301
    Cell Significance Index: -13.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1535
    Cell Significance Index: -10.3200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1584
    Cell Significance Index: -12.5500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1632
    Cell Significance Index: -2.4600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1821
    Cell Significance Index: -13.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1844
    Cell Significance Index: -3.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1905
    Cell Significance Index: -11.6800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1964
    Cell Significance Index: -8.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2063
    Cell Significance Index: -10.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2131
    Cell Significance Index: -13.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2287
    Cell Significance Index: -14.0600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2487
    Cell Significance Index: -2.2900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2590
    Cell Significance Index: -6.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2813
    Cell Significance Index: -14.7700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2846
    Cell Significance Index: -9.8900
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.3014
    Cell Significance Index: -2.8900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.3040
    Cell Significance Index: -5.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3069
    Cell Significance Index: -9.8300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3334
    Cell Significance Index: -5.5800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.3361
    Cell Significance Index: -3.3700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3372
    Cell Significance Index: -12.3800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3443
    Cell Significance Index: -12.0600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3570
    Cell Significance Index: -5.3500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3605
    Cell Significance Index: -10.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serine/Threonine Kinase Activity**: STK26 possesses intrinsic serine/threonine kinase activity, enabling it to phosphorylate and regulate downstream targets. 2. **Apoptosis Regulation**: STK26 plays a crucial role in regulating apoptosis, a process of programmed cell death, by modulating the activity of pro-apoptotic proteins. 3. **Cellular Migration**: STK26 negatively regulates cell migration, suggesting its involvement in maintaining tissue architecture and cell-cell interactions. 4. **Oxidative Stress Response**: STK26 is involved in cellular response to oxidative stress, highlighting its role in protecting cells from damage caused by reactive oxygen species. **Pathways and Functions:** 1. **Apoptotic Execution Phase**: STK26 interacts with pro-apoptotic proteins, modulating their activity and influencing the apoptotic process. 2. **Intracellular Signal Transduction**: STK26 phosphorylates and regulates various intracellular signaling molecules, influencing cellular responses to stimuli. 3. **Histone H2AS1 Kinase Activity**: STK26 exhibits histone H2AS1 kinase activity, suggesting its role in chromatin remodeling and gene expression regulation. 4. **Protein Phosphorylation**: STK26 phosphorylates and regulates various proteins, including those involved in cell migration, apoptosis, and oxidative stress response. **Clinical Significance:** 1. **Immunological Disorders**: Dysregulation of STK26 has been implicated in various immunological disorders, including autoimmune diseases and cancer. 2. **Cancer Therapy**: Targeting STK26 may provide a novel therapeutic strategy for cancer treatment, particularly in cases where apoptosis is disrupted. 3. **Inflammatory Diseases**: STK26's role in regulating cell migration and oxidative stress response may contribute to the development of inflammatory diseases, such as atherosclerosis and arthritis. 4. **Neurological Disorders**: Further investigation into STK26's functions in the nervous system may shed light on the underlying mechanisms of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the STK26 gene represents a fascinating example of a serine/threonine kinase with far-reaching implications for our understanding of cellular regulation, apoptosis, and immune system function. Further research into the functions and clinical significance of STK26 is essential for unraveling its potential therapeutic applications and improving human health.

Genular Protein ID: 2794865805

Symbol: STK26_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11641781

Title: MST4, a new Ste20-related kinase that mediates cell growth and transformation via modulating ERK pathway.

PubMed ID: 11641781

DOI: 10.1038/sj.onc.1204818

PubMed ID: 11306563

Title: Cloning and characterization of MST4, a novel Ste20-like kinase.

PubMed ID: 11306563

DOI: 10.1074/jbc.m009323200

PubMed ID: 11741893

Title: Cloning of MASK, a novel member of the mammalian germinal center kinase III subfamily, with apoptosis-inducing properties.

PubMed ID: 11741893

DOI: 10.1074/jbc.m110882200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15037601

Title: YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta.

PubMed ID: 15037601

DOI: 10.1083/jcb.200310061

PubMed ID: 17360971

Title: PDCD10 interacts with Ste20-related kinase MST4 to promote cell growth and transformation via modulation of the ERK pathway.

PubMed ID: 17360971

DOI: 10.1091/mbc.e06-07-0608

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19370760

Title: Functional analyses of human and zebrafish 18-amino acid in-frame deletion pave the way for domain mapping of the cerebral cavernous malformation 3 protein.

PubMed ID: 19370760

DOI: 10.1002/humu.20996

PubMed ID: 18782753

Title: A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein.

PubMed ID: 18782753

DOI: 10.1074/mcp.m800266-mcp200

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20332113

Title: CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation.

PubMed ID: 20332113

DOI: 10.1242/jcs.061341

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27807006

Title: RHO binding to FAM65A regulates Golgi reorientation during cell migration.

PubMed ID: 27807006

DOI: 10.1242/jcs.198614

PubMed ID: 29232556

Title: MST4 phosphorylation of ATG4B regulates autophagic activity, tumorigenicity, and radioresistance in glioblastoma.

PubMed ID: 29232556

DOI: 10.1016/j.ccell.2017.11.005

PubMed ID: 20730082

Title: Structural comparison of human mammalian ste20-like kinases.

PubMed ID: 20730082

DOI: 10.1371/journal.pone.0011905

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 416
  • Mass: 46529
  • Checksum: 3E31B7E3CBDA5768
  • Sequence:
  • MAHSPVAVQV PGMQNNIADP EELFTKLERI GKGSFGEVFK GIDNRTQQVV AIKIIDLEEA 
    EDEIEDIQQE ITVLSQCDSS YVTKYYGSYL KGSKLWIIME YLGGGSALDL LRAGPFDEFQ 
    IATMLKEILK GLDYLHSEKK IHRDIKAANV LLSEQGDVKL ADFGVAGQLT DTQIKRNTFV 
    GTPFWMAPEV IQQSAYDSKA DIWSLGITAI ELAKGEPPNS DMHPMRVLFL IPKNNPPTLV 
    GDFTKSFKEF IDACLNKDPS FRPTAKELLK HKFIVKNSKK TSYLTELIDR FKRWKAEGHS 
    DDESDSEGSD SESTSRENNT HPEWSFTTVR KKPDPKKVQN GAEQDLVQTL SCLSMIITPA 
    FAELKQQDEN NASRNQAIEE LEKSIAVAEA ACPGITDKMV KKLIEKFQKC SADESP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.