Details for: SIX4

Gene ID: 51804

Symbol: SIX4

Ensembl ID: ENSG00000100625

Description: SIX homeobox 4

Associated with

  • Anatomical structure morphogenesis
    (GO:0009653)
  • Chromatin
    (GO:0000785)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Embryonic cranial skeleton morphogenesis
    (GO:0048701)
  • Fungiform papilla morphogenesis
    (GO:0061197)
  • Generation of neurons
    (GO:0048699)
  • Inner ear morphogenesis
    (GO:0042472)
  • Male gonad development
    (GO:0008584)
  • Male sex determination
    (GO:0030238)
  • Male sex differentiation
    (GO:0046661)
  • Metanephric mesenchyme development
    (GO:0072075)
  • Myoblast migration
    (GO:0051451)
  • Myotome development
    (GO:0061055)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Negative regulation of satellite cell differentiation
    (GO:1902725)
  • Nucleus
    (GO:0005634)
  • Olfactory placode formation
    (GO:0030910)
  • Pharyngeal system development
    (GO:0060037)
  • Positive regulation of branching involved in ureteric bud morphogenesis
    (GO:0090190)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of ureteric bud formation
    (GO:0072107)
  • Protein localization to nucleus
    (GO:0034504)
  • Regulation of branch elongation involved in ureteric bud branching
    (GO:0072095)
  • Regulation of epithelial cell proliferation
    (GO:0050678)
  • Regulation of protein localization
    (GO:0032880)
  • Regulation of synaptic assembly at neuromuscular junction
    (GO:0008582)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sarcomere organization
    (GO:0045214)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Skeletal muscle fiber differentiation
    (GO:0098528)
  • Skeletal muscle tissue development
    (GO:0007519)
  • Thymus development
    (GO:0048538)
  • Tongue development
    (GO:0043586)
  • Transcription regulator complex
    (GO:0005667)
  • Trigeminal ganglion development
    (GO:0061551)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 15.5320
    Cell Significance Index: -6.3100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 6.6405
    Cell Significance Index: -6.3400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.8108
    Cell Significance Index: 29.8400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.8172
    Cell Significance Index: 26.1800
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.7049
    Cell Significance Index: 5.8300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5999
    Cell Significance Index: 16.3300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.5795
    Cell Significance Index: 14.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5398
    Cell Significance Index: 28.0400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.4847
    Cell Significance Index: 5.1500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2616
    Cell Significance Index: 4.1500
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.2278
    Cell Significance Index: 2.3500
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.2244
    Cell Significance Index: 3.6200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2234
    Cell Significance Index: 122.0300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2221
    Cell Significance Index: 5.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1980
    Cell Significance Index: 32.2000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1845
    Cell Significance Index: 6.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1772
    Cell Significance Index: 35.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1663
    Cell Significance Index: 29.9700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1650
    Cell Significance Index: 4.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1509
    Cell Significance Index: 9.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1491
    Cell Significance Index: 6.9500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1247
    Cell Significance Index: 1.7300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1247
    Cell Significance Index: 2.8800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1217
    Cell Significance Index: 3.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1179
    Cell Significance Index: 14.5000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1165
    Cell Significance Index: 3.3400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0966
    Cell Significance Index: 1.0000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0789
    Cell Significance Index: 10.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0725
    Cell Significance Index: 14.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0526
    Cell Significance Index: 2.4700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.0431
    Cell Significance Index: 0.4500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0385
    Cell Significance Index: 1.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0282
    Cell Significance Index: 10.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0169
    Cell Significance Index: 7.4900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0147
    Cell Significance Index: 1.4500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0138
    Cell Significance Index: 0.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0085
    Cell Significance Index: 5.9100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0016
    Cell Significance Index: 0.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0005
    Cell Significance Index: 0.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0012
    Cell Significance Index: -0.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0023
    Cell Significance Index: -4.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0038
    Cell Significance Index: -2.8100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0038
    Cell Significance Index: -6.9400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0044
    Cell Significance Index: -6.8000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0048
    Cell Significance Index: -3.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0053
    Cell Significance Index: -7.1600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0088
    Cell Significance Index: -1.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0090
    Cell Significance Index: -6.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0091
    Cell Significance Index: -6.7700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0093
    Cell Significance Index: -1.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0095
    Cell Significance Index: -1.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0103
    Cell Significance Index: -1.2000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0107
    Cell Significance Index: -0.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0111
    Cell Significance Index: -6.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0121
    Cell Significance Index: -7.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0141
    Cell Significance Index: -4.0600
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.0145
    Cell Significance Index: -0.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0218
    Cell Significance Index: -2.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0227
    Cell Significance Index: -0.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0244
    Cell Significance Index: -3.5400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0244
    Cell Significance Index: -1.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0353
    Cell Significance Index: -7.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0420
    Cell Significance Index: -0.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0461
    Cell Significance Index: -3.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0468
    Cell Significance Index: -5.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0474
    Cell Significance Index: -3.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0490
    Cell Significance Index: -2.2200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0667
    Cell Significance Index: -6.9500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0718
    Cell Significance Index: -1.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0731
    Cell Significance Index: -5.6100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0780
    Cell Significance Index: -1.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0859
    Cell Significance Index: -6.8000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0920
    Cell Significance Index: -2.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0936
    Cell Significance Index: -5.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0967
    Cell Significance Index: -6.5000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1026
    Cell Significance Index: -4.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1119
    Cell Significance Index: -6.2800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1148
    Cell Significance Index: -5.9800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1216
    Cell Significance Index: -2.5800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1326
    Cell Significance Index: -2.8400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1340
    Cell Significance Index: -4.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1409
    Cell Significance Index: -7.4000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1410
    Cell Significance Index: -4.9400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1427
    Cell Significance Index: -3.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1458
    Cell Significance Index: -2.4400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1495
    Cell Significance Index: -3.1300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1603
    Cell Significance Index: -2.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1637
    Cell Significance Index: -7.2400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1647
    Cell Significance Index: -4.7000
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1741
    Cell Significance Index: -1.8900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1775
    Cell Significance Index: -5.8100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1883
    Cell Significance Index: -7.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1888
    Cell Significance Index: -4.7200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1953
    Cell Significance Index: -6.2200
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.2009
    Cell Significance Index: -2.0100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2019
    Cell Significance Index: -3.4600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2023
    Cell Significance Index: -5.3200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2039
    Cell Significance Index: -2.9200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2059
    Cell Significance Index: -1.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2083
    Cell Significance Index: -7.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The SIX4 gene is a transcription factor that belongs to the SIX family of homeobox genes. It encodes a protein that binds to specific DNA sequences, regulating the expression of target genes involved in developmental processes. The SIX4 protein exhibits a unique ability to bind to both single-stranded and double-stranded DNA, making it a versatile transcriptional regulator. Its expression is tightly regulated during embryonic development, and its dysregulation has been implicated in various developmental abnormalities and diseases. **Pathways and Functions:** The SIX4 gene is involved in multiple signaling pathways, including: 1. **Embryonic development:** SIX4 regulates the expression of genes involved in cranial skeleton morphogenesis, inner ear development, and gonad formation. 2. **Immune regulation:** SIX4 is expressed in thymic epithelial cells and regulates the development of immune cells, including T cells and mast cells. 3. **Cell proliferation and differentiation:** SIX4 regulates the expression of genes involved in cell proliferation, differentiation, and apoptosis. 4. **Transcriptional regulation:** SIX4 interacts with other transcription factors to regulate the expression of target genes involved in various developmental processes. **Clinical Significance:** Dysregulation of the SIX4 gene has been implicated in various diseases, including: 1. **Developmental abnormalities:** SIX4 mutations have been associated with craniosynostosis, inner ear abnormalities, and gonadal dysgenesis. 2. **Immune disorders:** SIX4 is involved in the regulation of immune cell development and function, and its dysregulation has been implicated in autoimmune diseases, such as allergies and autoimmune disorders. 3. **Cancer:** SIX4 has been shown to be a tumor suppressor gene, and its dysregulation has been implicated in various types of cancer, including breast and lung cancer. In conclusion, the SIX4 gene plays a crucial role in developmental morphogenesis and immune regulation, and its dysregulation has significant clinical implications. Further research is needed to fully elucidate the mechanisms by which SIX4 regulates developmental processes and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 1350987809

Symbol: SIX4_HUMAN

Name: Homeobox protein SIX4

UniProtKB Accession Codes:

Q9UIU6 Q4QQH5 Q4V764

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 40 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10640827

Title: Structure and chromosome mapping of the human SIX4 and murine Six4 genes.

PubMed ID: 10640827

DOI: 10.1159/000015407

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14966291

Title: Quantitative proteomic identification of six4 as the trex-binding factor in the muscle creatine kinase enhancer.

PubMed ID: 14966291

DOI: 10.1128/mcb.24.5.2132-2143.2004

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 781
  • Mass: 82933
  • Checksum: 0054080AFF7BFF7E
  • Sequence:
    • MSSSSPTGQI ASAADIKQEN GMESASEGQE AHREVAGGAA VGLSPPAPAP FPLEPGDAAT 
AAARVSGEEG AVAAAAAGAA ADQVQLHSEL LGRHHHAAAA AAQTPLAFSP DHVACVCEAL 
QQGGNLDRLA RFLWSLPQSD LLRGNESLLK ARALVAFHQG IYPELYSILE SHSFESANHP 
LLQQLWYKAR YTEAERARGR PLGAVDKYRL RRKFPLPRTI WDGEETVYCF KEKSRNALKE 
LYKQNRYPSP AEKRHLAKIT GLSLTQVSNW FKNRRQRDRN PSETQSKSES DGNPSTEDES 
SKGHEDLSPH PLSSSSDGIT NLSLSSHMEP VYMQQIGNAK ISLSSSGVLL NGSLVPASTS 
PVFLNGNSFI QGPSGVILNG LNVGNTQAVA LNPPKMSSNI VSNGISMTDI LGSTSQDVKE 
FKVLQSSANS ATTTSYSPSV PVSFPGLIPS TEVKREGIQT VASQDGGSVV TFTTPVQINQ 
YGIVQIPNSG ANSQFLNGSI GFSPLQLPPV SVAASQGNIS VSSSTSDGST FTSESTTVQQ 
GKVFLSSLAP SAVVYTVPNT GQTIGSVKQE GLERSLVFSQ LMPVNQNAQV NANLSSENIS 
GSGLHPLASS LVNVSPTHNF SLSPSTLLNP TELNRDIADS QPMSAPVASK STVTSVSNTN 
YATLQNCSLI TGQDLLSVPM TQAALGEIVP TAEDQVGHPS PAVHQDFVQE HRLVLQSVAN 
MKENFLSNSE SKATSSLMML DSKSKYVLDG MVDTVCEDLE TDKKELAKLQ TVQLDEDMQD 
L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.