Details for: PEX10

Gene ID: 5192

Symbol: PEX10

Ensembl ID: ENSG00000157911

Description: peroxisomal biogenesis factor 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 93.5419
    Cell Significance Index: -14.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 52.7907
    Cell Significance Index: -13.3900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 41.2674
    Cell Significance Index: -17.0000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 32.8940
    Cell Significance Index: -15.5300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 32.2456
    Cell Significance Index: -13.1000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.7524
    Cell Significance Index: -13.1300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.4660
    Cell Significance Index: -15.3700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.0320
    Cell Significance Index: -13.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.9761
    Cell Significance Index: -15.6900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.1353
    Cell Significance Index: -9.6300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.5359
    Cell Significance Index: -5.5500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1844
    Cell Significance Index: 16.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0376
    Cell Significance Index: 62.2900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0306
    Cell Significance Index: 930.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9383
    Cell Significance Index: 48.7400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8811
    Cell Significance Index: 23.6100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7210
    Cell Significance Index: 71.3200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6804
    Cell Significance Index: 110.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4927
    Cell Significance Index: 88.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4862
    Cell Significance Index: 33.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4470
    Cell Significance Index: 20.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4190
    Cell Significance Index: 51.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3865
    Cell Significance Index: 76.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3540
    Cell Significance Index: 67.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3537
    Cell Significance Index: 22.3000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3203
    Cell Significance Index: 8.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2606
    Cell Significance Index: 11.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2490
    Cell Significance Index: 136.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2371
    Cell Significance Index: 30.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2335
    Cell Significance Index: 32.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2332
    Cell Significance Index: 6.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2295
    Cell Significance Index: 16.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2254
    Cell Significance Index: 6.3000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2231
    Cell Significance Index: 98.6600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.2167
    Cell Significance Index: 1.7300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2135
    Cell Significance Index: 7.4200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2020
    Cell Significance Index: 1.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1918
    Cell Significance Index: 4.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1877
    Cell Significance Index: 24.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1773
    Cell Significance Index: 4.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1623
    Cell Significance Index: 12.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1580
    Cell Significance Index: 31.6900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1196
    Cell Significance Index: 82.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0973
    Cell Significance Index: 6.2800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0957
    Cell Significance Index: 1.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0781
    Cell Significance Index: 28.0200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0664
    Cell Significance Index: 1.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0643
    Cell Significance Index: 3.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0562
    Cell Significance Index: 6.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0346
    Cell Significance Index: 5.9000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0337
    Cell Significance Index: 1.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0334
    Cell Significance Index: 2.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0182
    Cell Significance Index: 1.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0090
    Cell Significance Index: 16.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0060
    Cell Significance Index: 0.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0028
    Cell Significance Index: 0.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0015
    Cell Significance Index: 2.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0006
    Cell Significance Index: 1.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0011
    Cell Significance Index: -0.7900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0014
    Cell Significance Index: -0.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0048
    Cell Significance Index: -6.5500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0058
    Cell Significance Index: -4.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0109
    Cell Significance Index: -0.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0118
    Cell Significance Index: -7.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0152
    Cell Significance Index: -0.2600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0167
    Cell Significance Index: -1.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0181
    Cell Significance Index: -13.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0238
    Cell Significance Index: -10.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0246
    Cell Significance Index: -13.8700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0296
    Cell Significance Index: -18.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0394
    Cell Significance Index: -5.7300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0409
    Cell Significance Index: -11.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0512
    Cell Significance Index: -5.9700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0554
    Cell Significance Index: -0.6600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0712
    Cell Significance Index: -1.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0715
    Cell Significance Index: -8.1900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0868
    Cell Significance Index: -2.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0875
    Cell Significance Index: -18.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1331
    Cell Significance Index: -10.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1370
    Cell Significance Index: -14.2700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1479
    Cell Significance Index: -1.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1502
    Cell Significance Index: -10.1000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1590
    Cell Significance Index: -4.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1648
    Cell Significance Index: -3.5700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1773
    Cell Significance Index: -2.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1830
    Cell Significance Index: -9.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1892
    Cell Significance Index: -5.0600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2023
    Cell Significance Index: -5.9600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2112
    Cell Significance Index: -9.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2160
    Cell Significance Index: -13.2400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2164
    Cell Significance Index: -5.0000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2377
    Cell Significance Index: -9.0000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2386
    Cell Significance Index: -2.4700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2389
    Cell Significance Index: -3.7900
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2553
    Cell Significance Index: -1.5200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2687
    Cell Significance Index: -3.8500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2827
    Cell Significance Index: -6.1900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2952
    Cell Significance Index: -2.4800
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.2994
    Cell Significance Index: -1.8800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3163
    Cell Significance Index: -8.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PEX10 is a protein-coding gene that belongs to the PEX family of genes, which are essential for peroxisomal biogenesis and function. The PEX10 protein is specifically involved in the organization and import of peroxisomal proteins into the peroxisomal matrix. It is also implicated in the regulation of protein quality control and the ubiquitination of misfolded or incompletely synthesized proteins. PEX10 is highly expressed in various cell types, including pulmonary interstitial fibroblasts, cerebral cortex GABAergic interneurons, and intestinal epithelial cells. **Pathways and Functions:** PEX10 is involved in several critical cellular pathways, including: 1. **Peroxisomal Biogenesis:** PEX10 plays a crucial role in the formation of peroxisomes by regulating the import of peroxisomal proteins and the assembly of peroxisomal membranes. 2. **Protein Import:** PEX10 is responsible for the import of peroxisomal proteins into the peroxisomal matrix, ensuring the proper functioning of peroxisomal enzymes. 3. **Protein Quality Control:** PEX10 is involved in the ubiquitination of misfolded or incompletely synthesized proteins, which helps maintain protein homeostasis and prevent protein aggregation. 4. **Reactive Oxygen Species (ROS) Detoxification:** PEX10 is also implicated in the regulation of ROS detoxification, which is essential for maintaining cellular redox balance. **Clinical Significance:** Dysregulation of PEX10 has been linked to various human diseases, including: 1. **Peroxisomal Biogenesis Disorders (PBDs):** Mutations in PEX10 can lead to PBDs, a group of rare genetic disorders characterized by impaired peroxisomal function and accumulation of toxic substances. 2. **Neurodegenerative Diseases:** PEX10 dysfunction has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where impaired peroxisomal function contributes to oxidative stress and protein aggregation. 3. **Cancer:** PEX10 dysregulation has been observed in various types of cancer, including colorectal cancer, where it contributes to tumor progression and metastasis. In conclusion, PEX10 is a critical gene that plays a vital role in peroxisomal biogenesis, protein import, and quality control. Its dysregulation has been linked to various human diseases, highlighting the importance of PEX10 in maintaining cellular homeostasis and preventing disease. Further research is needed to elucidate the mechanisms underlying PEX10 dysfunction and to develop therapeutic strategies for the treatment of PEX10-related disorders.

Genular Protein ID: 2612234687

Symbol: PEX10_HUMAN

Name: Peroxisomal biogenesis factor 10

UniProtKB Accession Codes:

O60683 B3KWD8 Q5T095 Q9BW90

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EC 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 6 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9683594

Title: Identification of PEX10, the gene defective in complementation group 7 of the peroxisome-biogenesis disorders.

PubMed ID: 9683594

DOI: 10.1086/301963

PubMed ID: 9700193

Title: Mutations in PEX10 is the cause of Zellweger peroxisome deficiency syndrome of complementation group B.

PubMed ID: 9700193

DOI: 10.1093/hmg/7.9.1399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9922452

Title: Peroxisome synthesis in the absence of preexisting peroxisomes.

PubMed ID: 9922452

DOI: 10.1083/jcb.144.2.255

PubMed ID: 10704444

Title: PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.

PubMed ID: 10704444

DOI: 10.1083/jcb.148.5.931

PubMed ID: 11390669

Title: Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences.

PubMed ID: 11390669

DOI: 10.1128/mcb.21.13.4413-4424.2001

PubMed ID: 24662292

Title: Distinct modes of ubiquitination of peroxisome-targeting signal type 1 (PTS1) receptor Pex5p regulate PTS1 protein import.

PubMed ID: 24662292

DOI: 10.1074/jbc.m113.527937

PubMed ID: 30022445

Title: PEX10-related autosomal recessive cerebellar ataxia with hearing loss.

PubMed ID: 30022445

DOI: 10.1007/s13760-018-0987-8

PubMed ID: 17041890

Title: Identification of novel mutations in PEX2, PEX6, PEX10, PEX12, and PEX13 in Zellweger spectrum patients.

PubMed ID: 17041890

DOI: 10.1002/humu.9462

PubMed ID: 19105186

Title: Identification of novel mutations and sequence variation in the Zellweger syndrome spectrum of peroxisome biogenesis disorders.

PubMed ID: 19105186

DOI: 10.1002/humu.20932

PubMed ID: 20695019

Title: Mutations in PEX10 are a cause of autosomal recessive ataxia.

PubMed ID: 20695019

DOI: 10.1002/ana.22035

PubMed ID: 27230853

Title: Expanding the spectrum of PEX10-related peroxisomal biogenesis disorders: slowly progressive recessive ataxia.

PubMed ID: 27230853

DOI: 10.1007/s00415-016-8167-3

PubMed ID: 28784167

Title: Identification of a novel mutation in PEX10 in a patient with attenuated Zellweger spectrum disorder: a case report.

PubMed ID: 28784167

DOI: 10.1186/s13256-017-1365-5

PubMed ID: 32069232

Title: Two different missense mutations of PEX genes in two similar patients with severe Zellweger syndrome: an argument on the genotype-phenotype correlation.

PubMed ID: 32069232

DOI: 10.1515/jpem-2019-0194

Sequence Information:

  • Length: 326
  • Mass: 37069
  • Checksum: 9CF2CE5E4C797799
  • Sequence:
    • MAPAAASPPE VIRAAQKDEY YRGGLRSAAG GALHSLAGAR KWLEWRKEVE LLSDVAYFGL 
TTLAGYQTLG EEYVSIIQVD PSRIHVPSSL RRGVLVTLHA VLPYLLDKAL LPLEQELQAD 
PDSGRPLQGS LGPGGRGCSG ARRWMRHHTA TLTEQQRRAL LRAVFVLRQG LACLQRLHVA 
WFYIHGVFYH LAKRLTGITY LRVRSLPGED LRARVSYRLL GVISLLHLVL SMGLQLYGFR 
QRQRARKEWR LHRGLSHRRA SLEERAVSRN PLCTLCLEER RHPTATPCGH LFCWECITAW 
CSSKAECPLC REKFPPQKLI YLRHYR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.