PGR | ENSG00000082175 | NCBI 5241

Details for: PGR

Gene ID: 5241

Symbol: PGR

Ensembl ID: ENSG00000082175

Description: progesterone receptor

Associated with

Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hsp90 chaperone cycle for steroid hormone receptors (shr) in the presence of ligand
(R-HSA-3371497)
Metabolism of proteins
(R-HSA-392499)
Nuclear receptor transcription pathway
(R-HSA-383280)
Nuclear signaling by erbb4
(R-HSA-1251985)
Post-translational protein modification
(R-HSA-597592)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by erbb4
(R-HSA-1236394)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of intracellular receptors
(R-HSA-4090294)
Atpase binding
(GO:0051117)
Cell-cell signaling
(GO:0007267)
Chromatin
(GO:0000785)
Cytosol
(GO:0005829)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Enzyme binding
(GO:0019899)
Estrogen response element binding
(GO:0034056)
Glandular epithelial cell maturation
(GO:0002071)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Identical protein binding
(GO:0042802)
Lung alveolus development
(GO:0048286)
Maintenance of protein location in nucleus
(GO:0051457)
Mitochondrial outer membrane
(GO:0005741)
Negative regulation of gene expression
(GO:0010629)
Nuclear receptor-mediated steroid hormone signaling pathway
(GO:0030518)
Nuclear receptor activity
(GO:0004879)
Nuclear steroid receptor activity
(GO:0003707)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Ovulation from ovarian follicle
(GO:0001542)
Paracrine signaling
(GO:0038001)
Plasma membrane
(GO:0005886)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Progesterone receptor signaling pathway
(GO:0050847)
Protein binding
(GO:0005515)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of epithelial cell proliferation
(GO:0050678)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Steroid binding
(GO:0005496)
Tertiary branching involved in mammary gland duct morphogenesis
(GO:0060748)
Transcription coactivator binding
(GO:0001223)
Zinc ion binding
(GO:0008270)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: peg cell (CL4033014)
Fold Change: 10.7408
Cell Significance Index: 248.1500
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 1.7021
Cell Significance Index: 10.4800
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 1.3876
Cell Significance Index: 866.4900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.9693
Cell Significance Index: 133.1100
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.8736
Cell Significance Index: 21.1600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.7355
Cell Significance Index: 56.4400
Cell Name: theca cell (CL0000503)
Fold Change: 0.7068
Cell Significance Index: 4.1500
Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.6415
Cell Significance Index: 20.2900
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.6195
Cell Significance Index: 12.0900
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.5003
Cell Significance Index: 7.7400
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.4022
Cell Significance Index: 20.3300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.3578
Cell Significance Index: 26.6700
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.2757
Cell Significance Index: 3.5500
Cell Name: keratocyte (CL0002363)
Fold Change: 0.2376
Cell Significance Index: 3.7700
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.1630
Cell Significance Index: 2.3400
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1280
Cell Significance Index: 69.9300
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.0797
Cell Significance Index: 11.5900
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.0526
Cell Significance Index: 0.7300
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0334
Cell Significance Index: 23.1200
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0286
Cell Significance Index: 3.6700
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.0107
Cell Significance Index: 0.0900
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.0106
Cell Significance Index: 1.2200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0100
Cell Significance Index: 18.7800
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.0020
Cell Significance Index: 1.1500
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.0020
Cell Significance Index: 1.4500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0037
Cell Significance Index: -2.3600
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0040
Cell Significance Index: -0.1000
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0057
Cell Significance Index: -10.4800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0071
Cell Significance Index: -10.9900
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0086
Cell Significance Index: -11.7000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0113
Cell Significance Index: -5.1100
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0122
Cell Significance Index: -8.9400
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0173
Cell Significance Index: -13.0800
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0181
Cell Significance Index: -3.8100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0191
Cell Significance Index: -0.8900
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0192
Cell Significance Index: -5.5200
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0238
Cell Significance Index: -4.2900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0280
Cell Significance Index: -10.0300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0289
Cell Significance Index: -4.9300
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0470
Cell Significance Index: -4.8000
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0510
Cell Significance Index: -6.2700
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0521
Cell Significance Index: -10.3400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0530
Cell Significance Index: -10.6300
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0560
Cell Significance Index: -1.4400
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.0732
Cell Significance Index: -1.0800
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0824
Cell Significance Index: -10.6400
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0951
Cell Significance Index: -11.0800
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1072
Cell Significance Index: -11.1700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1081
Cell Significance Index: -12.3900
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1174
Cell Significance Index: -9.3000
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.1196
Cell Significance Index: -1.8200
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1639
Cell Significance Index: -3.4300
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1730
Cell Significance Index: -4.5500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1756
Cell Significance Index: -8.2600
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1777
Cell Significance Index: -11.9500
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1817
Cell Significance Index: -11.4500
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1866
Cell Significance Index: -8.1200
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1914
Cell Significance Index: -11.7700
Cell Name: adipocyte of breast (CL0002617)
Fold Change: -0.2287
Cell Significance Index: -2.8800
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2310
Cell Significance Index: -8.4800
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: -0.2323
Cell Significance Index: -2.3000
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.2332
Cell Significance Index: -2.9900
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2345
Cell Significance Index: -13.1600
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2347
Cell Significance Index: -6.5600
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2404
Cell Significance Index: -6.8900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.2641
Cell Significance Index: -11.9700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2735
Cell Significance Index: -14.2100
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2784
Cell Significance Index: -14.6200
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2855
Cell Significance Index: -7.6500
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2901
Cell Significance Index: -12.8300
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.2901
Cell Significance Index: -4.1600
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: -0.2937
Cell Significance Index: -3.9600
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.3146
Cell Significance Index: -3.4200
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.3230
Cell Significance Index: -4.6500
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.3239
Cell Significance Index: -9.5400
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3314
Cell Significance Index: -10.8500
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: -0.3315
Cell Significance Index: -3.8500
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3353
Cell Significance Index: -10.6800
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3383
Cell Significance Index: -12.8100
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3491
Cell Significance Index: -12.2300
Cell Name: myoblast (CL0000056)
Fold Change: -0.3491
Cell Significance Index: -3.4300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.3630
Cell Significance Index: -9.8800
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.3686
Cell Significance Index: -7.5000
Cell Name: connective tissue cell (CL0002320)
Fold Change: -0.3703
Cell Significance Index: -3.5700
Cell Name: helper T cell (CL0000912)
Fold Change: -0.3744
Cell Significance Index: -5.3200
Cell Name: IgG plasma cell (CL0000985)
Fold Change: -0.3827
Cell Significance Index: -3.5000
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.3985
Cell Significance Index: -2.7000
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.4007
Cell Significance Index: -14.0800
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.4068
Cell Significance Index: -5.2100
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.4079
Cell Significance Index: -16.7100
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.4153
Cell Significance Index: -11.0900
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.4171
Cell Significance Index: -8.9200
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.4212
Cell Significance Index: -12.0200
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.4276
Cell Significance Index: -10.6800
Cell Name: Schwann cell precursor (CL0002375)
Fold Change: -0.4306
Cell Significance Index: -3.4200
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.4326
Cell Significance Index: -7.2400
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: -0.4526
Cell Significance Index: -2.8000
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: -0.4596
Cell Significance Index: -4.4000
Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -0.4680
Cell Significance Index: -9.7600
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.4757
Cell Significance Index: -12.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** The PGR gene is located on chromosome 19q13.3 and spans approximately 53.6 kilobases. It consists of 8 exons and 7 introns, with a predicted protein sequence of 561 amino acids. The receptor is a member of the nuclear receptor superfamily, characterized by the presence of a ligand-binding domain and a DNA-binding domain. The PGR protein is highly expressed in tissues such as the uterus, ovary, and mammary gland, where it plays a critical role in regulating gene expression in response to progesterone (P4) and other steroid hormones. **Pathways and Functions:** The PGR gene is involved in several signaling pathways, including: 1. **Cell-cell signaling**: PGR regulates cell-cell interactions and adhesion, influencing the development and maintenance of tissues such as the uterus and mammary gland. 2. **Cellular responses to stimuli**: PGR mediates cellular responses to various stimuli, including hormone binding, growth factors, and stress signals. 3. **Chromatin remodeling**: PGR regulates chromatin structure and transcriptional activity, influencing gene expression in response to hormonal signals. 4. **Gene expression (transcription)**: PGR acts as a transcriptional regulator, modulating the expression of target genes involved in reproductive functions, cell proliferation, and differentiation. PGR's functions include: 1. **Reproductive regulation**: PGR regulates gene expression in the uterus, ovary, and other reproductive tissues, influencing implantation, embryogenesis, and fetal development. 2. **Cell proliferation and differentiation**: PGR modulates cell proliferation and differentiation in various tissues, including the mammary gland and cardiac muscle. 3. **Stress response**: PGR regulates cellular responses to stress signals, influencing cell survival and adaptation. **Clinical Significance:** Dysregulation of the PGR gene has been implicated in various diseases and disorders, including: 1. **Reproductive disorders**: Abnormalities in PGR expression and function have been linked to infertility, miscarriage, and gestational trophoblastic disease. 2. **Cancer**: PGR overexpression has been observed in various cancers, including breast, endometrial, and ovarian cancer. 3. **Cardiovascular disease**: PGR has been linked to cardiac muscle hypertrophy and fibrosis, highlighting its role in cardiovascular disease. 4. **Neurological disorders**: PGR has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. In conclusion, the PGR gene plays a critical role in regulating various physiological processes, including reproductive functions, cell proliferation, and differentiation. Its dysregulation has been implicated in various diseases and disorders, emphasizing the importance of understanding its functions and clinical significance.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Progesterone receptor

Genular Protein ID: 3659778833

Symbol: PRGR_HUMAN

Name: Progesterone receptor

UniProtKB Accession Codes:

P06401 A7LQ08 A7X8B0 B4E3T0 Q8TDS3 Q9UPF7

Database IDs:

Citations:

PubMed ID: 2328727

Title: Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B.

PubMed ID: 2328727

DOI: 10.1002/j.1460-2075.1990.tb08280.x

PubMed ID: 3551956

Title: Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA.

PubMed ID: 3551956

DOI: 10.1016/0006-291x(87)91416-1

PubMed ID: 18375150

Title: The human progesterone receptor shows evidence of adaptive evolution associated with its ability to act as a transcription factor.

PubMed ID: 18375150

DOI: 10.1016/j.ympev.2007.12.026

PubMed ID: 12644308

Title: Cloning and expression of a novel, truncated, progesterone receptor.

PubMed ID: 12644308

DOI: 10.1016/s0303-7207(02)00380-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 11110801

Title: Identification of a phosphorylation site in the hinge region of the human progesterone receptor and additional amino-terminal phosphorylation sites.

PubMed ID: 11110801

DOI: 10.1074/jbc.m009805200

PubMed ID: 23518922

Title: A truncated progesterone receptor (PR-M) localizes to the mitochondrion and controls cellular respiration.

PubMed ID: 23518922

DOI: 10.1210/me.2012-1292

PubMed ID: 1587864

Title: A limiting factor mediates the differential activation of promoters by the human progesterone receptor isoforms.

PubMed ID: 1587864

DOI: 10.1016/s0021-9258(19)50100-4

PubMed ID: 1517211

Title: Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II).

PubMed ID: 1517211

DOI: 10.1016/s0021-9258(19)37087-5

PubMed ID: 8264658

Title: Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function.

PubMed ID: 8264658

DOI: 10.1210/mend.7.10.8264658

PubMed ID: 8180103

Title: The human progesterone receptor A-form functions as a transcriptional modulator of mineralocorticoid receptor transcriptional activity.

PubMed ID: 8180103

DOI: 10.1016/0960-0760(94)90190-2

PubMed ID: 7969170

Title: The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells.

PubMed ID: 7969170

DOI: 10.1128/mcb.14.12.8356-8364.1994

PubMed ID: 7476977

Title: Identification of a group of Ser-Pro motif hormone-inducible phosphorylation sites in the human progesterone receptor.

PubMed ID: 7476977

DOI: 10.1210/mend.9.8.7476977

PubMed ID: 8702648

Title: Stoichiometry and site-specific phosphorylation of human progesterone receptor in native target cells and in the baculovirus expression system.

PubMed ID: 8702648

DOI: 10.1074/jbc.271.32.19546

PubMed ID: 9407067

Title: Mapping and characterization of the functional domains responsible for the differential activity of the A and B isoforms of the human progesterone receptor.

PubMed ID: 9407067

DOI: 10.1074/jbc.272.52.32889

PubMed ID: 9171245

Title: Phosphorylation of human progesterone receptor by cyclin-dependent kinase 2 on three sites that are authentic basal phosphorylation sites in vivo.

PubMed ID: 9171245

DOI: 10.1210/mend.11.6.0006

PubMed ID: 11041221

Title: Heterogeneity of progesterone receptors A and B expression in human endometrial glands and stroma.

PubMed ID: 11041221

DOI: 10.1093/humrep/15.suppl_3.48

PubMed ID: 10757795

Title: The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding.

PubMed ID: 10757795

DOI: 10.1128/mcb.20.9.3102-3115.2000

PubMed ID: 10628747

Title: Differential hormone-dependent phosphorylation of progesterone receptor A and B forms revealed by a phosphoserine site-specific monoclonal antibody.

PubMed ID: 10628747

DOI: 10.1210/mend.14.1.0413

PubMed ID: 10655479

Title: Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome.

PubMed ID: 10655479

DOI: 10.1073/pnas.97.3.1032

PubMed ID: 11546784

Title: Mapping the unique activation function 3 in the progesterone B-receptor upstream segment. Two LXXLL motifs and a tryptophan residue are required for activity.

PubMed ID: 11546784

DOI: 10.1074/jbc.m106843200

PubMed ID: 12039952

Title: Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha.

PubMed ID: 12039952

DOI: 10.1074/jbc.m201053200

PubMed ID: 12917342

Title: BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation.

PubMed ID: 12917342

DOI: 10.1128/mcb.23.17.6210-6220.2003

PubMed ID: 15572662

Title: Phosphorylation of progesterone receptor serine 400 mediates ligand-independent transcriptional activity in response to activation of cyclin-dependent protein kinase 2.

PubMed ID: 15572662

DOI: 10.1128/mcb.24.24.10542-10557.2004

PubMed ID: 15798179

Title: Human progesterone receptor displays cell cycle-dependent changes in transcriptional activity.

PubMed ID: 15798179

DOI: 10.1128/mcb.25.8.2885-2898.2005

PubMed ID: 16478993

Title: GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway.

PubMed ID: 16478993

DOI: 10.1128/mcb.26.5.1722-1730.2006

PubMed ID: 17020914

Title: PIAS3 induction of PRB sumoylation represses PRB transactivation by destabilizing its retention in the nucleus.

PubMed ID: 17020914

DOI: 10.1093/nar/gkl691

PubMed ID: 17347654

Title: CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin-proteasome.

PubMed ID: 17347654

DOI: 10.1038/sj.emboj.7601602

PubMed ID: 17717077

Title: Phosphorylation-dependent antagonism of sumoylation derepresses progesterone receptor action in breast cancer cells.

PubMed ID: 17717077

DOI: 10.1210/me.2007-0248

PubMed ID: 17173941

Title: Linkage of progestin and epidermal growth factor signaling: phosphorylation of progesterone receptors mediates transcriptional hypersensitivity and increased ligand-independent breast cancer cell growth.

PubMed ID: 17173941

DOI: 10.1016/j.steroids.2006.11.009

PubMed ID: 18202149

Title: Progesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factors.

PubMed ID: 18202149

DOI: 10.1210/me.2007-0437

PubMed ID: 22031296

Title: DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors.

PubMed ID: 22031296

DOI: 10.1091/mbc.e11-07-0638

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 37478846

Title: UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability.

PubMed ID: 37478846

DOI: 10.1016/j.molcel.2023.06.028

PubMed ID: 9620806

Title: Atomic structure of progesterone complexed with its receptor.

PubMed ID: 9620806

DOI: 10.1038/30775

PubMed ID: 15937332

Title: Molecular and pharmacological properties of a potent and selective novel nonsteroidal progesterone receptor agonist tanaproget.

PubMed ID: 15937332

DOI: 10.1074/jbc.m504144200

Sequence Information:

Length: 933
Mass: 98981
Checksum: 80452E54FF3A0454
Sequence:

MTELKAKGPR APHVAGGPPS PEVGSPLLCR PAAGPFPGSQ TSDTLPEVSA IPISLDGLLF 
PRPCQGQDPS DEKTQDQQSL SDVEGAYSRA EATRGAGGSS SSPPEKDSGL LDSVLDTLLA 
PSGPGQSQPS PPACEVTSSW CLFGPELPED PPAAPATQRV LSPLMSRSGC KVGDSSGTAA 
AHKVLPRGLS PARQLLLPAS ESPHWSGAPV KPSPQAAAVE VEEEDGSESE ESAGPLLKGK 
PRALGGAAAG GGAAAVPPGA AAGGVALVPK EDSRFSAPRV ALVEQDAPMA PGRSPLATTV 
MDFIHVPILP LNHALLAART RQLLEDESYD GGAGAASAFA PPRSSPCASS TPVAVGDFPD 
CAYPPDAEPK DDAYPLYSDF QPPALKIKEE EEGAEASARS PRSYLVAGAN PAAFPDFPLG 
PPPPLPPRAT PSRPGEAAVT AAPASASVSS ASSSGSTLEC ILYKAEGAPP QQGPFAPPPC 
KAPGASGCLL PRDGLPSTSA SAAAAGAAPA LYPALGLNGL PQLGYQAAVL KEGLPQVYPP 
YLNYLRPDSE ASQSPQYSFE SLPQKICLIC GDEASGCHYG VLTCGSCKVF FKRAMEGQHN 
YLCAGRNDCI VDKIRRKNCP ACRLRKCCQA GMVLGGRKFK KFNKVRVVRA LDAVALPQPV 
GVPNESQALS QRFTFSPGQD IQLIPPLINL LMSIEPDVIY AGHDNTKPDT SSSLLTSLNQ 
LGERQLLSVV KWSKSLPGFR NLHIDDQITL IQYSWMSLMV FGLGWRSYKH VSGQMLYFAP 
DLILNEQRMK ESSFYSLCLT MWQIPQEFVK LQVSQEEFLC MKVLLLLNTI PLEGLRSQTQ 
FEEMRSSYIR ELIKAIGLRQ KGVVSSSQRF YQLTKLLDNL HDLVKQLHLY CLNTFIQSRA 
LSVEFPEMMS EVIAAQLPKI LAGMVKPLLF HKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PGR

Associated with

Cells (max top 100)

Other Information

Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. PubMed ID: 2328727

Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA. PubMed ID: 3551956

The human progesterone receptor shows evidence of adaptive evolution associated with its ability to act as a transcription factor. PubMed ID: 18375150

Cloning and expression of a novel, truncated, progesterone receptor. PubMed ID: 12644308

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

Identification of a phosphorylation site in the hinge region of the human progesterone receptor and additional amino-terminal phosphorylation sites. PubMed ID: 11110801

A truncated progesterone receptor (PR-M) localizes to the mitochondrion and controls cellular respiration. PubMed ID: 23518922

A limiting factor mediates the differential activation of promoters by the human progesterone receptor isoforms. PubMed ID: 1587864

Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II). PubMed ID: 1517211

Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function. PubMed ID: 8264658

The human progesterone receptor A-form functions as a transcriptional modulator of mineralocorticoid receptor transcriptional activity. PubMed ID: 8180103

The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells. PubMed ID: 7969170

Identification of a group of Ser-Pro motif hormone-inducible phosphorylation sites in the human progesterone receptor. PubMed ID: 7476977

Stoichiometry and site-specific phosphorylation of human progesterone receptor in native target cells and in the baculovirus expression system. PubMed ID: 8702648

Mapping and characterization of the functional domains responsible for the differential activity of the A and B isoforms of the human progesterone receptor. PubMed ID: 9407067

Phosphorylation of human progesterone receptor by cyclin-dependent kinase 2 on three sites that are authentic basal phosphorylation sites in vivo. PubMed ID: 9171245

Heterogeneity of progesterone receptors A and B expression in human endometrial glands and stroma. PubMed ID: 11041221

The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding. PubMed ID: 10757795

Differential hormone-dependent phosphorylation of progesterone receptor A and B forms revealed by a phosphoserine site-specific monoclonal antibody. PubMed ID: 10628747

Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome. PubMed ID: 10655479

Mapping the unique activation function 3 in the progesterone B-receptor upstream segment. Two LXXLL motifs and a tryptophan residue are required for activity. PubMed ID: 11546784

Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha. PubMed ID: 12039952

BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation. PubMed ID: 12917342

Phosphorylation of progesterone receptor serine 400 mediates ligand-independent transcriptional activity in response to activation of cyclin-dependent protein kinase 2. PubMed ID: 15572662

Human progesterone receptor displays cell cycle-dependent changes in transcriptional activity. PubMed ID: 15798179

GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway. PubMed ID: 16478993

PIAS3 induction of PRB sumoylation represses PRB transactivation by destabilizing its retention in the nucleus. PubMed ID: 17020914

CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin-proteasome. PubMed ID: 17347654

Phosphorylation-dependent antagonism of sumoylation derepresses progesterone receptor action in breast cancer cells. PubMed ID: 17717077

Linkage of progestin and epidermal growth factor signaling: phosphorylation of progesterone receptors mediates transcriptional hypersensitivity and increased ligand-independent breast cancer cell growth. PubMed ID: 17173941

Progesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factors. PubMed ID: 18202149

DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors. PubMed ID: 22031296

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability. PubMed ID: 37478846

Atomic structure of progesterone complexed with its receptor. PubMed ID: 9620806

Molecular and pharmacological properties of a potent and selective novel nonsteroidal progesterone receptor agonist tanaproget. PubMed ID: 15937332