Details for: PHKG1

Gene ID: 5260

Symbol: PHKG1

Ensembl ID: ENSG00000164776

Description: phosphorylase kinase catalytic subunit gamma 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 111.8646
    Cell Significance Index: -17.4000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 69.0734
    Cell Significance Index: -17.5200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 37.1937
    Cell Significance Index: -17.5600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 33.2824
    Cell Significance Index: -17.1200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.6072
    Cell Significance Index: -18.0100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.6477
    Cell Significance Index: -18.3400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.4041
    Cell Significance Index: 38.5700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.3684
    Cell Significance Index: 60.8800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.7554
    Cell Significance Index: 42.8300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 1.3021
    Cell Significance Index: 21.0100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6861
    Cell Significance Index: 111.5900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6703
    Cell Significance Index: 72.9100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5643
    Cell Significance Index: 43.3000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5139
    Cell Significance Index: 30.8500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4752
    Cell Significance Index: 33.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4094
    Cell Significance Index: 19.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3970
    Cell Significance Index: 175.5300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3420
    Cell Significance Index: 67.8800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3022
    Cell Significance Index: 20.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2737
    Cell Significance Index: 52.0900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2360
    Cell Significance Index: 3.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1906
    Cell Significance Index: 26.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1869
    Cell Significance Index: 9.7100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1800
    Cell Significance Index: 162.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1798
    Cell Significance Index: 5.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1579
    Cell Significance Index: 11.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1461
    Cell Significance Index: 17.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1412
    Cell Significance Index: 28.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1403
    Cell Significance Index: 3.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1372
    Cell Significance Index: 3.7400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.1306
    Cell Significance Index: 1.1100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1123
    Cell Significance Index: 20.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1031
    Cell Significance Index: 4.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0944
    Cell Significance Index: 12.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0832
    Cell Significance Index: 8.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0749
    Cell Significance Index: 40.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0656
    Cell Significance Index: 8.4700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0542
    Cell Significance Index: 37.4600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0522
    Cell Significance Index: 3.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0496
    Cell Significance Index: 17.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0302
    Cell Significance Index: 1.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0045
    Cell Significance Index: 8.5100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0037
    Cell Significance Index: 0.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0021
    Cell Significance Index: 2.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0015
    Cell Significance Index: 2.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0013
    Cell Significance Index: 2.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0081
    Cell Significance Index: -6.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0125
    Cell Significance Index: -7.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0175
    Cell Significance Index: -7.9600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0178
    Cell Significance Index: -13.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0184
    Cell Significance Index: -13.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0251
    Cell Significance Index: -1.1800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0260
    Cell Significance Index: -0.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0264
    Cell Significance Index: -14.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0301
    Cell Significance Index: -3.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0367
    Cell Significance Index: -5.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0377
    Cell Significance Index: -6.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0488
    Cell Significance Index: -1.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0562
    Cell Significance Index: -16.1800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0635
    Cell Significance Index: -0.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0656
    Cell Significance Index: -4.0400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0682
    Cell Significance Index: -1.9100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0716
    Cell Significance Index: -8.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0740
    Cell Significance Index: -7.5600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0887
    Cell Significance Index: -1.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0936
    Cell Significance Index: -19.7100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0996
    Cell Significance Index: -6.2800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1095
    Cell Significance Index: -0.9200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1132
    Cell Significance Index: -2.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1327
    Cell Significance Index: -15.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1495
    Cell Significance Index: -7.8500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1533
    Cell Significance Index: -4.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1644
    Cell Significance Index: -17.1200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1693
    Cell Significance Index: -2.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1767
    Cell Significance Index: -4.7400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1954
    Cell Significance Index: -13.1400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1980
    Cell Significance Index: -15.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2042
    Cell Significance Index: -11.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2135
    Cell Significance Index: -13.0900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.2443
    Cell Significance Index: -2.5500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2770
    Cell Significance Index: -14.4300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2776
    Cell Significance Index: -5.8100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2857
    Cell Significance Index: -6.6000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2991
    Cell Significance Index: -15.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3026
    Cell Significance Index: -10.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3090
    Cell Significance Index: -13.6700
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.3103
    Cell Significance Index: -2.0600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3136
    Cell Significance Index: -8.9900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3316
    Cell Significance Index: -8.8700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3450
    Cell Significance Index: -5.9700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3497
    Cell Significance Index: -3.2200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3550
    Cell Significance Index: -6.1200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3619
    Cell Significance Index: -13.7100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3776
    Cell Significance Index: -4.2900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3781
    Cell Significance Index: -9.6600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3974
    Cell Significance Index: -5.8700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4093
    Cell Significance Index: -14.3400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4108
    Cell Significance Index: -12.1000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.4164
    Cell Significance Index: -5.3400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.4204
    Cell Significance Index: -6.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PHKG1 is a catalytic subunit of the phosphorylase kinase complex, which is composed of three subunits: alpha, beta, and gamma. The gamma subunit is responsible for the kinase activity and is the primary target of calcium/calmodulin-dependent phosphorylation. PHKG1 is a serine/threonine kinase that exhibits high specificity for phosphorylating the gamma subunit of glycogen phosphorylase, thereby regulating glycogen breakdown. The enzyme is activated by calcium/calmodulin and is subject to regulation by various signaling pathways, including the PI3K/Akt and MAPK/ERK pathways. **Pathways and Functions:** PHKG1 plays a central role in glycogen metabolism, particularly in the breakdown of glycogen to glucose-1-phosphate. This process is essential for maintaining energy homeostasis in the body, particularly in skeletal muscle and cardiac muscle. Beyond glycogen metabolism, PHKG1 has been implicated in various cellular processes, including: 1. **Cell Signaling:** PHKG1 is involved in the regulation of cell signaling pathways, including the PI3K/Akt and MAPK/ERK pathways. These pathways are crucial for regulating cell growth, differentiation, and survival. 2. **Protein Regulation:** PHKG1 phosphorylates and regulates various proteins, including glycogen phosphorylase, tau protein, and other serine/threonine kinases. 3. **Metabolic Regulation:** PHKG1 is involved in the regulation of carbohydrate metabolism, including the breakdown of glycogen, glucose-6-phosphate, and other carbohydrates. 4. **Disease Pathogenesis:** PHKG1 has been implicated in various diseases, including glycogen storage diseases, diabetes, and cancer. **Clinical Significance:** The PHKG1 gene has significant clinical implications, particularly in the diagnosis and treatment of glycogen storage diseases. Mutations in the PHKG1 gene have been identified in patients with glycogen storage disease type VII, a rare genetic disorder characterized by impaired glycogen breakdown. Additionally, PHKG1 has been implicated in the pathogenesis of diabetes and cancer, highlighting the need for further research into the regulatory mechanisms of this gene. In conclusion, the PHKG1 gene plays a critical role in glycogen metabolism and beyond, regulating various cellular processes, including cell signaling, protein regulation, and metabolic regulation. Further research into the functions and regulation of PHKG1 is essential for understanding its clinical significance and developing novel therapeutic strategies for diseases associated with impaired glycogen metabolism.

Genular Protein ID: 189629877

Symbol: PHKG1_HUMAN

Name: Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform

UniProtKB Accession Codes:

Q16816 B7Z1D0 F5H2S1 Q75LP5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 2 CTD 1 ChEBI 22 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 8 EMBL 13 EMDB 2 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 12 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8530014

Title: Human cDNA encoding the muscle isoform of the phosphorylase kinase gamma subunit (PHKG1).

PubMed ID: 8530014

DOI: 10.1007/bf00197422

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 387
  • Mass: 45024
  • Checksum: 9CB416CB683920AA
  • Sequence:
    • MTRDEALPDS HSAQDFYENY EPKEILGRGV SSVVRRCIHK PTSQEYAVKV IDVTGGGSFS 
PEEVRELREA TLKEVDILRK VSGHPNIIQL KDTYETNTFF FLVFDLMKRG ELFDYLTEKV 
TLSEKETRKI MRALLEVICT LHKLNIVHRD LKPENILLDD NMNIKLTDFG FSCQLEPGER 
LREVCGTPSY LAPEIIECSM NEDHPGYGKE VDMWSTGVIM YTLLAGSPPF WHRKQMLMLR 
MIMSGNYQFG SPEWDDYSDT VKDLVSRFLV VQPQNRYTAE EALAHPFFQQ YLVEEVRHFS 
PRGKFKVIAL TVLASVRIYY QYRRVKPVTR EIVIRDPYAL RPLRRLIDAY AFRIYGHWVK 
KGQQQNRAAL FENTPKAVLL SLAEEDY

Genular Protein ID: 3210073246

Symbol: B7Z6U2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z6U2

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 5 Gene3D 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 378
  • Mass: 44051
  • Checksum: DB396822873C5B84
  • Sequence:
    • MTRDEALPDS HSAQDFYENY EPKEILGRGV SSVVRRCIHK PTSQEYAVKV IDVTGGGSFS 
PEEVRELREA TLKEVDILRK LKDTYETNTF FFLVFDLMKR GELFDYLTEK VTLSEKETRK 
IMRALLEVIC TLHKLNIVHR DLKPENILLD DNMNIKLTDF GFSCQLEPGE RLREVCGTPS 
YLAPEIIECS MNEDHPGYGK EVDMWSTGVI MYTLLAGSPP FWHRKQMLML RMIMSGSYQF 
GSPEWDDYSD TVKDLVSRFL VVQPQNRYTA EEALAHPFFQ QYLVEEVRHF SPRGKFKVIA 
LTVLASVRIY YQYRRVKPVT REIVIRDPYA LRPLRRLIDA YAFRIYGHWV KKGQQQNRAA 
LFENTPKAVL LSLAEEDY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.