Details for: PI4KA

Gene ID: 5297

Symbol: PI4KA

Ensembl ID: ENSG00000241973

Description: phosphatidylinositol 4-kinase alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 335.5294
    Cell Significance Index: -52.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 201.4640
    Cell Significance Index: -51.1000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 113.4451
    Cell Significance Index: -53.5600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 103.8751
    Cell Significance Index: -42.2000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 44.3575
    Cell Significance Index: -42.3500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 43.0672
    Cell Significance Index: -53.1000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.5807
    Cell Significance Index: -49.7800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.5933
    Cell Significance Index: -53.6400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.1866
    Cell Significance Index: -28.8600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.5483
    Cell Significance Index: 44.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.0409
    Cell Significance Index: 134.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.9945
    Cell Significance Index: 600.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.8452
    Cell Significance Index: 107.7400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.4218
    Cell Significance Index: 868.6500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.3853
    Cell Significance Index: 68.0700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.2752
    Cell Significance Index: 1573.6100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.1437
    Cell Significance Index: 144.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.9029
    Cell Significance Index: 377.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.4996
    Cell Significance Index: 84.1500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.3490
    Cell Significance Index: 28.8400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.2801
    Cell Significance Index: 30.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.1856
    Cell Significance Index: 72.8700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.0934
    Cell Significance Index: 14.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0243
    Cell Significance Index: 28.6300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9935
    Cell Significance Index: 76.2400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8606
    Cell Significance Index: 139.9800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7803
    Cell Significance Index: 84.8800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.7467
    Cell Significance Index: 16.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4768
    Cell Significance Index: 897.8000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4378
    Cell Significance Index: 12.6200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3988
    Cell Significance Index: 8.6400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3625
    Cell Significance Index: 327.3300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2964
    Cell Significance Index: 20.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2809
    Cell Significance Index: 50.6400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2684
    Cell Significance Index: 4.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2308
    Cell Significance Index: 10.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2281
    Cell Significance Index: 420.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2216
    Cell Significance Index: 140.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2116
    Cell Significance Index: 325.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1869
    Cell Significance Index: 84.8500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1861
    Cell Significance Index: 22.8800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1371
    Cell Significance Index: 2.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1290
    Cell Significance Index: 12.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1219
    Cell Significance Index: 66.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1192
    Cell Significance Index: 4.1900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0989
    Cell Significance Index: 1.9300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0873
    Cell Significance Index: 118.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0489
    Cell Significance Index: 9.3000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0052
    Cell Significance Index: 0.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0042
    Cell Significance Index: 0.5800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0109
    Cell Significance Index: -4.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0162
    Cell Significance Index: -2.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0300
    Cell Significance Index: -22.2500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0360
    Cell Significance Index: -4.2400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0388
    Cell Significance Index: -24.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0435
    Cell Significance Index: -31.8900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0498
    Cell Significance Index: -1.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0590
    Cell Significance Index: -44.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0627
    Cell Significance Index: -35.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0742
    Cell Significance Index: -12.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1078
    Cell Significance Index: -11.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1365
    Cell Significance Index: -28.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1455
    Cell Significance Index: -6.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1564
    Cell Significance Index: -45.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1577
    Cell Significance Index: -16.1100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1612
    Cell Significance Index: -10.1600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1700
    Cell Significance Index: -2.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1829
    Cell Significance Index: -21.3200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1906
    Cell Significance Index: -24.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1915
    Cell Significance Index: -9.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2441
    Cell Significance Index: -12.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2450
    Cell Significance Index: -15.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2722
    Cell Significance Index: -35.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2868
    Cell Significance Index: -32.8600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3029
    Cell Significance Index: -34.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3430
    Cell Significance Index: -15.9900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3844
    Cell Significance Index: -3.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3910
    Cell Significance Index: -20.5300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4090
    Cell Significance Index: -5.5800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4137
    Cell Significance Index: -8.8100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4459
    Cell Significance Index: -9.2500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4499
    Cell Significance Index: -6.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4545
    Cell Significance Index: -33.8700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4619
    Cell Significance Index: -5.8300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5154
    Cell Significance Index: -13.8100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5169
    Cell Significance Index: -10.2200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.5191
    Cell Significance Index: -5.6600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5361
    Cell Significance Index: -7.7100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5453
    Cell Significance Index: -43.1900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5985
    Cell Significance Index: -19.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6124
    Cell Significance Index: -43.3100
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.6173
    Cell Significance Index: -6.4300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6288
    Cell Significance Index: -9.0100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6297
    Cell Significance Index: -20.6200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6446
    Cell Significance Index: -13.6800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.7009
    Cell Significance Index: -9.0900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.7107
    Cell Significance Index: -10.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7119
    Cell Significance Index: -22.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7202
    Cell Significance Index: -44.1600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7606
    Cell Significance Index: -15.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PI4KA is a type II transmembrane protein, anchored to the plasma membrane, and exhibits kinase activity, phosphorylating inositol phosphates to produce PIP2. The enzyme is characterized by its ability to interact with various cellular components, including cadherins, ATP, and phosphatidylinositol (PI) metabolites. PI4KA's activity is tightly regulated by post-translational modifications, including phosphorylation and ubiquitination, which modulate its activity and localization. **Pathways and Functions:** PI4KA is involved in various cellular signaling pathways, including: 1. **Phosphatidylinositol-mediated signaling:** PI4KA's activity is crucial for the production of PIP2, a key phospholipid component of cellular membranes, which plays a central role in regulating various signaling pathways, including those involved in cellular proliferation, differentiation, and survival. 2. **Golgi-associated vesicle membrane formation:** PI4KA is involved in the synthesis of PIP2 at the Golgi membrane, which is essential for the formation of Golgi-associated vesicles, a process critical for cellular membrane dynamics and lipid metabolism. 3. **Reorganization of cellular membranes to establish viral sites of replication:** PI4KA's activity is also required for the reorganization of cellular membranes to establish viral sites of replication, a process critical for viral infection and replication. 4. **Metabolism of lipids:** PI4KA is involved in the regulation of lipid metabolism, including the synthesis and degradation of PIP2, which plays a crucial role in maintaining cellular membrane fluidity and structure. **Clinical Significance:** Dysregulation of PI4KA's activity has been implicated in various diseases, including: 1. **Neurodegenerative disorders:** PI4KA's activity has been linked to the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, where dysregulation of PI4KA's activity contributes to the disruption of cellular signaling pathways and membrane dynamics. 2. **Cancer:** PI4KA's activity has been implicated in the regulation of cancer cell growth, survival, and metastasis, highlighting its potential as a therapeutic target for cancer treatment. 3. **Infectious diseases:** PI4KA's activity is required for the reorganization of cellular membranes to establish viral sites of replication, making it a potential target for the development of antiviral therapies. In conclusion, PI4KA is a critical enzyme in the regulation of cellular signaling, membrane dynamics, and lipid metabolism. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target for the treatment of neurodegenerative disorders, cancer, and infectious diseases.

Genular Protein ID: 3992186622

Symbol: PI4KA_HUMAN

Name: Phosphatidylinositol 4-kinase alpha

UniProtKB Accession Codes:

P42356 Q7Z625 Q9UPG2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CPTAC 2 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 1 EMBL 6 EMDB 1 Ensembl 1 ExpressionAtlas 1 GO 18 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 2 SABIO-RK 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 2 SwissPalm 1 TreeFam 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7961848

Title: Cloning and characterization of a human phosphatidylinositol 4-kinase.

PubMed ID: 7961848

DOI: 10.1016/s0021-9258(19)61989-7

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 10101268

Title: Functional expression and characterisation of a new human phosphatidylinositol 4-kinase PI4K230.

PubMed ID: 10101268

DOI: 10.1016/s1388-1981(99)00029-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23229899

Title: PtdIns4P synthesis by PI4KIIIalpha at the plasma membrane and its impact on plasma membrane identity.

PubMed ID: 23229899

DOI: 10.1083/jcb.201206095

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24417819

Title: Mutations in tetratricopeptide repeat domain 7A result in a severe form of very early onset inflammatory bowel disease.

PubMed ID: 24417819

DOI: 10.1053/j.gastro.2014.01.015

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25855803

Title: Germline recessive mutations in PI4KA are associated with perisylvian polymicrogyria, cerebellar hypoplasia and arthrogryposis.

PubMed ID: 25855803

DOI: 10.1093/hmg/ddv117

PubMed ID: 25608530

Title: Plasticity of PI4KIIIalpha interactions at the plasma membrane.

PubMed ID: 25608530

DOI: 10.15252/embr.201439151

PubMed ID: 26571211

Title: The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane.

PubMed ID: 26571211

DOI: 10.1038/ncb3271

PubMed ID: 28566381

Title: Hepatitis C Virus Subverts Human Choline Kinase-alpha To Bridge Phosphatidylinositol-4-Kinase IIIalpha (PI4KIIIalpha) and NS5A and Upregulates PI4KIIIalpha Activation, Thereby Promoting the Translocation of the Ternary Complex to the Endoplasmic Reticulum for Viral Replication.

PubMed ID: 28566381

DOI: 10.1128/jvi.00355-17

PubMed ID: 34415322

Title: Biallelic PI4KA variants cause a novel neurodevelopmental syndrome with hypomyelinating leukodystrophy.

PubMed ID: 34415322

DOI: 10.1093/brain/awab124

PubMed ID: 34415310

Title: Biallelic PI4KA variants cause neurological, intestinal and immunological disease.

PubMed ID: 34415310

DOI: 10.1093/brain/awab313

Sequence Information:

  • Length: 2102
  • Mass: 236830
  • Checksum: ED4C3C9EA79E6B5D
  • Sequence:
    • MAAAPARGGG GGGGGGGGCS GSGSSASRGF YFNTVLSLAR SLAVQRPASL EKVQKLLCMC 
PVDFHGIFQL DERRRDAVIA LGIFLIESDL QHKDCVVPYL LRLLKGLPKV YWVEESTARK 
GRGALPVAES FSFCLVTLLS DVAYRDPSLR DEILEVLLQV LHVLLGMCQA LEIQDKEYLC 
KYAIPCLIGI SRAFGRYSNM EESLLSKLFP KIPPHSLRVL EELEGVRRRS FNDFRSILPS 
NLLTVCQEGT LKRKTSSVSS ISQVSPERGM PPPSSPGGSA FHYFEASCLP DGTALEPEYY 
FSTISSSFSV SPLFNGVTYK EFNIPLEMLR ELLNLVKKIV EEAVLKSLDA IVASVMEANP 
SADLYYTSFS DPLYLTMFKM LRDTLYYMKD LPTSFVKEIH DFVLEQFNTS QGELQKILHD 
ADRIHNELSP LKLRCQANAA CVDLMVWAVK DEQGAENLCI KLSEKLQSKT SSKVIIAHLP 
LLICCLQGLG RLCERFPVVV HSVTPSLRDF LVIPSPVLVK LYKYHSQYHT VAGNDIKISV 
TNEHSESTLN VMSGKKSQPS MYEQLRDIAI DNICRCLKAG LTVDPVIVEA FLASLSNRLY 
ISQESDKDAH LIPDHTIRAL GHIAVALRDT PKVMEPILQI LQQKFCQPPS PLDVLIIDQL 
GCLVITGNQY IYQEVWNLFQ QISVKASSVV YSATKDYKDH GYRHCSLAVI NALANIAANI 
QDEHLVDELL MNLLELFVQL GLEGKRASER ASEKGPALKA SSSAGNLGVL IPVIAVLTRR 
LPPIKEAKPR LQKLFRDFWL YSVLMGFAVE GSGLWPEEWY EGVCEIATKS PLLTFPSKEP 
LRSVLQYNSA MKNDTVTPAE LSELRSTIIN LLDPPPEVSA LINKLDFAMS TYLLSVYRLE 
YMRVLRSTDP DRFQVMFCYF EDKAIQKDKS GMMQCVIAVA DKVFDAFLNM MADKAKTKEN 
EEELERHAQF LLVNFNHIHK RIRRVADKYL SGLVDKFPHL LWSGTVLKTM LDILQTLSLS 
LSADIHKDQP YYDIPDAPYR ITVPDTYEAR ESIVKDFAAR CGMILQEAMK WAPTVTKSHL 
QEYLNKHQNW VSGLSQHTGL AMATESILHF AGYNKQNTTL GATQLSERPA CVKKDYSNFM 
ASLNLRNRYA GEVYGMIRFS GTTGQMSDLN KMMVQDLHSA LDRSHPQHYT QAMFKLTAML 
ISSKDCDPQL LHHLCWGPLR MFNEHGMETA LACWEWLLAG KDGVEVPFMR EMAGAWHMTV 
EQKFGLFSAE IKEADPLAAS EASQPKPCPP EVTPHYIWID FLVQRFEIAK YCSSDQVEIF 
SSLLQRSMSL NIGGAKGSMN RHVAAIGPRF KLLTLGLSLL HADVVPNATI RNVLREKIYS 
TAFDYFSCPP KFPTQGEKRL REDISIMIKF WTAMFSDKKY LTASQLVPPD NQDTRSNLDI 
TVGSRQQATQ GWINTYPLSS GMSTISKKSG MSKKTNRGSQ LHKYYMKRRT LLLSLLATEI 
ERLITWYNPL SAPELELDQA GENSVANWRS KYISLSEKQW KDNVNLAWSI SPYLAVQLPA 
RFKNTEAIGN EVTRLVRLDP GAVSDVPEAI KFLVTWHTID ADAPELSHVL CWAPTDPPTG 
LSYFSSMYPP HPLTAQYGVK VLRSFPPDAI LFYIPQIVQA LRYDKMGYVR EYILWAASKS 
QLLAHQFIWN MKTNIYLDEE GHQKDPDIGD LLDQLVEEIT GSLSGPAKDF YQREFDFFNK 
ITNVSAIIKP YPKGDERKKA CLSALSEVKV QPGCYLPSNP EAIVLDIDYK SGTPMQSAAK 
APYLAKFKVK RCGVSELEKE GLRCRSDSED ECSTQEADGQ KISWQAAIFK VGDDCRQDML 
ALQIIDLFKN IFQLVGLDLF VFPYRVVATA PGCGVIECIP DCTSRDQLGR QTDFGMYDYF 
TRQYGDESTL AFQQARYNFI RSMAAYSLLL FLLQIKDRHN GNIMLDKKGH IIHIDFGFMF 
ESSPGGNLGW EPDIKLTDEM VMIMGGKMEA TPFKWFMEMC VRGYLAVRPY MDAVVSLVTL 
MLDTGLPCFR GQTIKLLKHR FSPNMTEREA ANFIMKVIQS CFLSNRSRTY DMIQYYQNDI 
PY

Genular Protein ID: 3798974743

Symbol: Q4LE69_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q4LE69

Database IDs:

ARBA 4 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 2 IntAct 1 InterPro 9 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 6 Pfam 3 PharmGKB 1 RefSeq 1 SAM 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 2121
  • Mass: 238697
  • Checksum: 5B3CEC2D4645DFB6
  • Sequence:
    • GRSRARSGEP AGSAAAREVM AAAPARGGGG GGGGGGGCSG SGSSASRGFY FNTVLSLARS 
LAVQRPASLE KVQKLLCMCP VDFHGIFQLD ERRRDAVIAL GIFLIESDLQ HKDCVVPYLL 
RLLKGLPKVY WVEESTARKG RGALPVAESF SFCLVTLLSD VAYRDPSLRD EILEVLLQVL 
HVLLGMCQAL EIQDKEYLCK YAIPCLIGIS RAFGRYSNME ESLLSKLFPK IPPHSLRVLE 
ELEGVRRRSF NDFRSILPSN LLTVCQEGTL KRKTSSVSSI SQVSPERGMP PPSSPGGSAF 
HYFEASCLPD GTALEPEYYF STISSSFSVS PLFNGVTYKE FNIPLEMLRE LLNLVKKIVE 
EAVLKSLDAI VASVMEANPS ADLYYTSFSD PLYLTMFKML RDTLYYMKDL PTSFVKEIHD 
FVLEQFNTSQ GELQKILHDA DRIHNELSPL KLRCQANAAC VDLMVWAVKD EQGAENLCIK 
LSEKLQSKTS SKVIIAHLPL LICCLQGLGR LCERFPVVVH SVTPSLRDFL VIPSPVLVKL 
YKYHSQYHTV AGNDIKISVT NEHSESTLNV MSGKKSQPSM YEQLRDIAID NICRCLKAGL 
TVDPVIVEAF LASLSNRLYI SQESDKDAHL IPDHTIRALG HIAVALRDTP KVMEPILQIL 
QQKFCQPPSP LDVLIIDQLG CLVITGNQYI YQEVWNLFQQ ISVKASSVVY SATKDYKDHG 
YRHCSLAVIN ALANIAANIQ DEHLVDELLM NLLELFVQLG LEGKRASERA SEKGPALKAS 
SSAGNLGVLI PVIAVLTRRL PPIKEAKPRL QKLFRDFWLY SVLMGFAVEG SGLWPEEWYE 
GVCEIATKSP LLTFPSKEPL RSVLQYNSAM KNDTVTPAEL SELRSTIINL LDPPPEVSAL 
INKLDFAMST YLLSVYRLEY MRVLRSTDPD RFQVMFCYFE DKAIQKDKSG MMQCVIAVAD 
KVFDAFLNMM ADKAKTKENE EELERHAQFL LVNFNHIHKR IRRVADKYLS GLVDKFPHLL 
WSGTVLKTML DILQTLSLSL SADIHKDQPY YDIPDAPYRI TVPDTYEARE SIVKDFAARC 
GMILQEAMKW APTVTKSHLQ EYLNKHQNWV SGLSQHTGLA MATESILHFA GYNKQNTTLG 
ATQLSERPAC VKKDYSNFMA SLNLRNRYAG EVYGMIRFSG TTGQMSDLNK MMVQDLHSAL 
DRSHPQHYTQ AMFKLTAMLI SSKDCDPQLL HHLCWGPLRM FNEHGMETAL ACWEWLLAGK 
DGVEVPFMRE MAGAWHMTVE QKFGLFSAEI KEADPLAASE ASQPKPCPPE VTPHYIWIDF 
LVQRFEIAKY CSSDQVEIFS SLLQRSMSLN IGGAKGSMNR HVAAIGPRFK LLTLGLSLLH 
ADVVPNATIR NVLREKIYST AFDYFSCPPK FPTQGEKRLR EDISIMIKFW TAMFSDKKYL 
TASQLVPPDN QDTRSNLDIT VGSRQQATQG WINTYPLSSG MSTISKKSGM SKKTNRGSQL 
HKYYMKRRTL LLSLLATEIE RLITWYNPLS APELELDQAG ENSVANWRSK YISLSEKQWK 
DNVNLAWSIS PYLAVQLPAR FKNTEAIGNE VTRLVRLDPG AVSDVPEAIK FLVTWHTIDA 
DAPELSHVLC WAPTDPPTGL SYFSSMYPPH PLTAQYGVKV LRSFPPDAIL FYIPQIVQAL 
RYDKMGYVRE YILWAASKSQ LLAHQFIWNM KTNIYLDEEG HQKDPDIGDL LDQLVEEITG 
SLSGPAKDFY QREFDFFNKI TNVSAIIKPY PKGDERKKAC LSALSEVKVQ PGCYLPSNPE 
AIVLDIDYKS GTPMQSAAKA PYLAKFKVKR CGVSELEKEG LRCRSDSEDE CSTQEADGQK 
ISWQAAIFKV GDDCRQDMLA LQIIDLFKNI FQLVGLDLFV FPYRVVATAP GCGVIECIPD 
CTSRDQLGRQ TDFGMYDYFT RQYGDESTLA FQQARYNFIR SMAAYSLLLF LLQIKDRHNG 
NIMLDKKGHI IHIDFGFMFE SSPGGNLGWE PDIKLTDEMV MIMGGKMEAT PFKWFMEMCV 
RGYLAVRPYM DAVVSLVTLM LDTGLPCFRG QTIKLLKHRF SPNMTEREAA NFIMKVIQSC 
FLSNRSRTYD MIQYYQNDIP Y

Genular Protein ID: 878130301

Symbol: B4DYG5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DYG5

Database IDs:

ARBA 4 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 2 InterPro 9 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 7 PeptideAtlas 1 Pfam 3 RefSeq 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 2102
  • Mass: 236756
  • Checksum: 366233F024A4E84C
  • Sequence:
    • MAAAPARGGG GGGGGGGGCS GSGSSASRGF YFNTVLSLAR SLAVQRPASL EKVQKLLCMC 
PVDFHGIFQL DERRRDAVIA LGIFLIESDL QHKDCVVPYL LRLLKGLPKV YWVEESTARK 
GRGALPVAES FSFCLVTLLS DVAYRDPSLR DEILEVLLQV LHVLLGMCQA LEIQDKEYLC 
KYAIPCLIGI SRAFGRYSNM EESLLSKLFP KIPPHSLRVL EELEGVRRRS FNDFRSILPS 
NLLTVCQEGT LKRKTSSVSS ISQVSPERGM PPPSSPGGSA FHYFEASCLP DGAALEPEYY 
FSTISSSFSV SPLFNGVTYK EFNIPLEMLR ELLNLVKKIV EEAVLKSLDA IVASVMEANP 
SADLYYTSFS DPLYLTMFKM LRDTLYYMKD LPTSFVKEIH DFVLEQFNTS QGELQKILHD 
ADRIHNELSP LKLRCQANAA CVDLMVWAVK DEQGAENLCI KLSEKLQSKT SSKVIIAHLP 
LLICCLQGLG RLCERFPVVV HSVTPSLRDF LVIPSPVLVK LYKYHSQYHT VAGNDIKISV 
TNEHSESTLN VMSGKKSQPS MYEQLRDIAI DNICRCLKAG LTVDPVIVEA FLASLSNRLY 
ISQESDKDAH LIPDHTIRAL GHIAVALRDT PKVMEPILQI LQQKFCQPPS PLDVLIIDQL 
GCLVITGNQY IYQEVWNLFQ QISVKASSVV YSATKDYKDH GYRHCSLAVI NALANIAANI 
QDEHLVDELL MNLLELFVQL GLEGKRASER ASEKGPALKA SSSAGNLGVL IPVIAVLTRR 
LPPIKEAKPR LQKLFRDFWL YSVLMGFAVE GSGLWPEEWY EGVCEIATKS PLLTFPSKEP 
LRSVLQYNSA MKNDTVTPAE LSELRSTIIN LLDPPPEVSA LINKLDFAMS TYLLSVYRLE 
YMRVLRSTDP DRFQVMFCYF EDKAIQKDKS GMMQCVIAVA DKVFDAFLNM MADKAKTKEN 
EEELERHAQF LLVNFNHIHK RIRRVADKYL SGLVDKFPHL LWSGTVLKTM LDILQTLSLS 
LSADIHKDQP YYDIPDAPYR ITVPDTYEAR ESIVKDFAAR CGMILQEAMK WAPTVTKSHL 
QEYLNKHQNW VSGLSQHTGL AMATESILHF AGYNKQNTTL GATQLSERPA CVKKDYSNFM 
ASLNLRNRYA GEVYGMIRFS GTTGQMSDLN KMMVQDLHSA LDRSHPQHYT QAMFKLTAML 
ISSKDCDPQL LHHLCWGPLR MFNEHGMETA LACWEWLLAG KDGVEVPFMR EMAGAWHMTV 
EQKFGLFSAE IKEADPLAAS EASQPKPCPP EVTPHYIWID FLVQRFEIAK YCSSDQVEIF 
SSLLQRSMSL NIGGAKGSMN RHVAAIGPRF KLLTLGLSLL HADVVPNATI RNVLREKIYS 
TAFDYFSCPP KFPTQGEKRL REDISIMIKF WTAMFSDKKY LTASQLVPPD NQDTRSNLDI 
TVGSRQQATQ GWINTYPLSS GMSTISKKSG MSKKTNRGSQ LHKYYMKRRT LLLSLLATEI 
ERLITWYNPL SAPELELDQA GENSVANWRS KYISLSEKQW KDNVNLAWSI SPYLAVQLPA 
RFKNTEAIGN EVTRLVRLDP GAVSDVPEAI KFLVTWHTID ADAPELSHVL CWAPTDPPTG 
LSYFSSMYPP HPLTAQYGVK VLRSFPPDAI LFYIPQIVQA LRYDKMGYVR EYILWAASKS 
QLLAHQFIWN MKTNIYLDEE GHQKDPDIGD LLDQLVEEIT GSLSGPAKDF YQREFDFFNK 
ITNVSAIIKP YPKGDERKKA CLSALSEVKV QPGCYLPSNP EAIVLDIDYK SGTPMQSAAK 
APYLAKFKVK RCGVSELEKE GLRCRSDSED ECSTQEADGQ KISWQAAIFK VGDDCRQDML 
ALQIIDLFKN IFQLVGLDLF VFPYRVVATA PGCGVIECIP DCTSRDQLGR QTDFGMYDYF 
TRQYGDESTL AFQQARYNFI RSMAAYSLLL FLLQIKDRHN GNIMLAKKGH IIHIDFGFMF 
ESSPGGNLGW EPDIKLTDEM VMIMGGKMEA TPFKWFMEMC VRGYLAVRPY MDAVVSLVTL 
MLDTGLPCFR GQTIKLLKHR FSPNMTEREA ANFIMKVIQS CFLSNRSRTY DMIQYYQNDI 
PY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.