Details for: PLA2G4A

Gene ID: 5321

Symbol: PLA2G4A

Ensembl ID: ENSG00000116711

Description: phospholipase A2 group IVA

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 143.6881
    Cell Significance Index: -22.3500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 86.8739
    Cell Significance Index: -22.0400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 36.5286
    Cell Significance Index: -14.8400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 29.5370
    Cell Significance Index: -19.8200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.1758
    Cell Significance Index: -22.4100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 15.6063
    Cell Significance Index: -14.9000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.7374
    Cell Significance Index: -22.6400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.6064
    Cell Significance Index: -12.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.5958
    Cell Significance Index: 494.0000
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 2.1422
    Cell Significance Index: 21.6100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.7123
    Cell Significance Index: 88.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6517
    Cell Significance Index: 163.3900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 1.6341
    Cell Significance Index: 23.2200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.4999
    Cell Significance Index: 32.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 1.3911
    Cell Significance Index: 48.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1581
    Cell Significance Index: 25.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9072
    Cell Significance Index: 98.6800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.8371
    Cell Significance Index: 19.3400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7574
    Cell Significance Index: 45.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7464
    Cell Significance Index: 20.8600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.6953
    Cell Significance Index: 13.5700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.5543
    Cell Significance Index: 7.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4337
    Cell Significance Index: 78.1800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3669
    Cell Significance Index: 200.3900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3312
    Cell Significance Index: 8.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2994
    Cell Significance Index: 36.8200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2881
    Cell Significance Index: 8.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2825
    Cell Significance Index: 56.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2514
    Cell Significance Index: 29.3000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2462
    Cell Significance Index: 12.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1211
    Cell Significance Index: 2.5800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0939
    Cell Significance Index: 0.8700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0519
    Cell Significance Index: 0.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0516
    Cell Significance Index: 22.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0472
    Cell Significance Index: 2.1400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0262
    Cell Significance Index: 18.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0052
    Cell Significance Index: 9.8200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0039
    Cell Significance Index: -2.5000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0125
    Cell Significance Index: -23.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0163
    Cell Significance Index: -10.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0165
    Cell Significance Index: -7.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0166
    Cell Significance Index: -12.2900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0182
    Cell Significance Index: -28.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0214
    Cell Significance Index: -15.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0229
    Cell Significance Index: -12.9100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0260
    Cell Significance Index: -19.7000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0267
    Cell Significance Index: -36.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0276
    Cell Significance Index: -5.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0373
    Cell Significance Index: -1.0200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0377
    Cell Significance Index: -1.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0384
    Cell Significance Index: -5.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0453
    Cell Significance Index: -9.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0454
    Cell Significance Index: -16.2800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0570
    Cell Significance Index: -4.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0656
    Cell Significance Index: -18.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0697
    Cell Significance Index: -11.9100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0778
    Cell Significance Index: -1.0800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0852
    Cell Significance Index: -8.7000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0855
    Cell Significance Index: -1.2000
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0881
    Cell Significance Index: -1.3400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1004
    Cell Significance Index: -1.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1066
    Cell Significance Index: -13.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1159
    Cell Significance Index: -13.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1259
    Cell Significance Index: -16.2700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1349
    Cell Significance Index: -1.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1553
    Cell Significance Index: -7.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1575
    Cell Significance Index: -18.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1601
    Cell Significance Index: -21.9900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1662
    Cell Significance Index: -18.9800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1723
    Cell Significance Index: -5.5200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2044
    Cell Significance Index: -21.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2069
    Cell Significance Index: -16.3900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2093
    Cell Significance Index: -13.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2123
    Cell Significance Index: -11.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2497
    Cell Significance Index: -11.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2528
    Cell Significance Index: -18.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2805
    Cell Significance Index: -21.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2931
    Cell Significance Index: -17.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3315
    Cell Significance Index: -22.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3338
    Cell Significance Index: -18.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3560
    Cell Significance Index: -21.8800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3740
    Cell Significance Index: -6.2600
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.3881
    Cell Significance Index: -4.4700
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.3918
    Cell Significance Index: -4.5500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4439
    Cell Significance Index: -6.6900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4536
    Cell Significance Index: -9.4100
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.4625
    Cell Significance Index: -5.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4849
    Cell Significance Index: -25.4600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4892
    Cell Significance Index: -17.0000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.4958
    Cell Significance Index: -21.5600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.5094
    Cell Significance Index: -7.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5112
    Cell Significance Index: -22.6100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5418
    Cell Significance Index: -18.9800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5605
    Cell Significance Index: -18.3500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5881
    Cell Significance Index: -15.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5915
    Cell Significance Index: -22.4000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6072
    Cell Significance Index: -8.7000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6074
    Cell Significance Index: -17.8900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6096
    Cell Significance Index: -15.6700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6139
    Cell Significance Index: -18.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PLA2G4A shares structural and functional similarities with other phospholipase A2 enzymes, including the ability to hydrolyze phospholipids to produce arachidonic acid and lysophospholipids. The enzyme is characterized by its calcium-dependent activity, which regulates its substrate specificity and enzymatic activity. PLA2G4A has been shown to interact with various cellular components, including membrane-bound organelles, cytoskeletal proteins, and signaling molecules, indicating its role in modulating cellular processes. **Pathways and Functions** PLA2G4A is involved in several cellular pathways, including: 1. **Acyl chain remodeling**: PLA2G4A participates in the remodeling of phospholipid acyl chains, which is essential for maintaining cellular membrane structure and function. 2. **Arachidonic acid metabolism**: The enzyme is involved in the production of arachidonic acid, a key lipid mediator involved in inflammation, immune responses, and cell signaling. 3. **Cell signaling**: PLA2G4A interacts with various signaling molecules, including G-proteins, to modulate cellular responses to stimuli. 4. **Immune responses**: The enzyme is expressed in immune cells, such as macrophages and microglia, and is involved in the regulation of immune responses, including the production of pro-inflammatory mediators. **Clinical Significance** PLA2G4A has been implicated in various diseases, including: 1. **Atherosclerosis**: Elevated PLA2G4A activity has been linked to the development of atherosclerosis, a condition characterized by the buildup of lipid-rich plaques in blood vessels. 2. **Inflammatory disorders**: PLA2G4A has been shown to contribute to the pathogenesis of inflammatory disorders, such as arthritis and asthma, by regulating the production of pro-inflammatory mediators. 3. **Neurological disorders**: The enzyme has been implicated in the regulation of neuronal function and the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, PLA2G4A is a multifunctional enzyme involved in various cellular processes, including cell signaling, membrane trafficking, and immune responses. Its dysregulation has been implicated in several diseases, highlighting the importance of understanding the mechanisms underlying its function and regulation.

Genular Protein ID: 2769193111

Symbol: PA24A_HUMAN

Name: Cytosolic phospholipase A2

UniProtKB Accession Codes:

P47712 B1AKG4 Q29R80

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 100 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 15 DrugCentral 1 EC 2 EMBL 6 Ensembl 1 EvolutionaryTrace 1 GO 40 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 3 Rhea 40 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 4 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1904318

Title: A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP.

PubMed ID: 1904318

DOI: 10.1016/0092-8674(91)90556-e

PubMed ID: 1869522

Title: Molecular cloning and expression of human Ca(2+)-sensitive cytosolic phospholipase A2.

PubMed ID: 1869522

DOI: 10.1016/s0021-9258(18)98550-9

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8381049

Title: cPLA2 is phosphorylated and activated by MAP kinase.

PubMed ID: 8381049

DOI: 10.1016/0092-8674(93)90666-e

PubMed ID: 8083230

Title: Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2.

PubMed ID: 8083230

DOI: 10.1016/s0021-9258(17)31645-9

PubMed ID: 7794891

Title: Multiple enzymatic activities of the human cytosolic 85-kDa phospholipase A2: hydrolytic reactions and acyl transfer to glycerol.

PubMed ID: 7794891

DOI: 10.1021/bi00024a004

PubMed ID: 8619991

Title: Functional identification of the active-site nucleophile of the human 85-kDa cytosolic phospholipase A2.

PubMed ID: 8619991

DOI: 10.1021/bi952541k

PubMed ID: 8702602

Title: Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginine.

PubMed ID: 8702602

DOI: 10.1074/jbc.271.32.19225

PubMed ID: 9425121

Title: Inhibition of human cytosolic phospholipase A2 by human annexin V.

PubMed ID: 9425121

DOI: 10.1042/bj3290369

PubMed ID: 9468497

Title: Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells.

PubMed ID: 9468497

DOI: 10.1074/jbc.273.8.4449

PubMed ID: 10358058

Title: Molecular characterization of cytosolic phospholipase A2-beta.

PubMed ID: 10358058

DOI: 10.1074/jbc.274.24.17063

PubMed ID: 11375391

Title: Intracellular calcium signals regulating cytosolic phospholipase A2 translocation to internal membranes.

PubMed ID: 11375391

DOI: 10.1074/jbc.m100943200

PubMed ID: 11416127

Title: PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production.

PubMed ID: 11416127

DOI: 10.1128/mcb.21.14.4470-4481.2001

PubMed ID: 12672805

Title: Essential Ca(2+)-independent role of the group IVA cytosolic phospholipase A(2) C2 domain for interfacial activity.

PubMed ID: 12672805

DOI: 10.1074/jbc.m301386200

PubMed ID: 14709560

Title: Cloning of a gene for a novel epithelium-specific cytosolic phospholipase A2, cPLA2delta, induced in psoriatic skin.

PubMed ID: 14709560

DOI: 10.1074/jbc.m305801200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16617059

Title: Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes.

PubMed ID: 16617059

DOI: 10.1074/jbc.m601770200

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17472963

Title: Ceramide-1-phosphate binds group IVA cytosolic phospholipase a2 via a novel site in the C2 domain.

PubMed ID: 17472963

DOI: 10.1074/jbc.m701396200

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 27642067

Title: Cyclooxygenase-2 Mediated Oxidation of 2-Arachidonoyl-Lysophospholipids Identifies Unknown Lipid Signaling Pathways.

PubMed ID: 27642067

DOI: 10.1016/j.chembiol.2016.08.009

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 9430701

Title: Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2.

PubMed ID: 9430701

DOI: 10.1074/jbc.273.3.1596

PubMed ID: 9665851

Title: Solution structure and membrane interactions of the C2 domain of cytosolic phospholipase A2.

PubMed ID: 9665851

DOI: 10.1006/jmbi.1998.1874

PubMed ID: 10319815

Title: Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism.

PubMed ID: 10319815

DOI: 10.1016/s0092-8674(00)80744-8

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 18451993

Title: Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction.

PubMed ID: 18451993

DOI: 10.1172/jci30473

PubMed ID: 23268370

Title: Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-alpha.

PubMed ID: 23268370

DOI: 10.1136/gutjnl-2012-303581

PubMed ID: 25102815

Title: Bleeding diathesis and gastro-duodenal ulcers in inherited cytosolic phospholipase-A2 alpha deficiency.

PubMed ID: 25102815

DOI: 10.1160/th14-04-0352

Sequence Information:

  • Length: 749
  • Mass: 85239
  • Checksum: EE71CA0EBE617856
  • Sequence:
    • MSFIDPYQHI IVEHQYSHKF TVVVLRATKV TKGAFGDMLD TPDPYVELFI STTPDSRKRT 
RHFNNDINPV WNETFEFILD PNQENVLEIT LMDANYVMDE TLGTATFTVS SMKVGEKKEV 
PFIFNQVTEM VLEMSLEVCS CPDLRFSMAL CDQEKTFRQQ RKEHIRESMK KLLGPKNSEG 
LHSARDVPVV AILGSGGGFR AMVGFSGVMK ALYESGILDC ATYVAGLSGS TWYMSTLYSH 
PDFPEKGPEE INEELMKNVS HNPLLLLTPQ KVKRYVESLW KKKSSGQPVT FTDIFGMLIG 
ETLIHNRMNT TLSSLKEKVN TAQCPLPLFT CLHVKPDVSE LMFADWVEFS PYEIGMAKYG 
TFMAPDLFGS KFFMGTVVKK YEENPLHFLM GVWGSAFSIL FNRVLGVSGS QSRGSTMEEE 
LENITTKHIV SNDSSDSDDE SHEPKGTENE DAGSDYQSDN QASWIHRMIM ALVSDSALFN 
TREGRAGKVH NFMLGLNLNT SYPLSPLSDF ATQDSFDDDE LDAAVADPDE FERIYEPLDV 
KSKKIHVVDS GLTFNLPYPL ILRPQRGVDL IISFDFSARP SDSSPPFKEL LLAEKWAKMN 
KLPFPKIDPY VFDREGLKEC YVFKPKNPDM EKDCPTIIHF VLANINFRKY RAPGVPRETE 
EEKEIADFDI FDDPESPFST FNFQYPNQAF KRLHDLMHFN TLNNIDVIKE AMVESIEYRR 
QNPSRCSVSL SNVEARRFFN KEFLSKPKA

Genular Protein ID: 2158536380

Symbol: B4DZI4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DZI4

Database IDs:

ARBA 37 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 98 DNASU 1 DisGeNET 1 EC 2 EMBL 2 GO 12 Gene3D 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 40 RuleBase 1 SAM 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 689
  • Mass: 78261
  • Checksum: F85853B0BCEFBB9C
  • Sequence:
    • MSFIDPYQHI IVEHQYSHKF TVVVLRATKV TKGAFGDMLD TPDPYVELFI STTPDSRKRT 
RHFNNDINPV WNETFEFILD PNQENVLEIT LMDANYVMDE TLGTATFTVS SMKVGEKKEV 
PFIFNQVPVV AILGSGGGFR AMVGFSGVMK ALYESGILDC ATYVAGLSGS TWYMSTLYSH 
PDFPEKGPEE INEELMKNVS HNPLLLLTPQ KVKRYVESLW KKKSSGQPVT FTDIFGMLIG 
ETLIHNRMNT TLSSLKEKVN TAQCPLPLFT CLHVKPDVSE LMFADWVEFS PYEIGMAKYG 
TFMAPDLFGS KFFMGTVVKK YEENPLHFLM GVWGSAFSIL FNRVLGVSGS QSRGSTMEEE 
LENITTKHIV SNDSSDSDDE SHEPKGTENE DAGSDYQSDN QASWIHRMIM ALVSDSALFN 
TREGRAGKVH NFMLGLNLNT SYPLSPLSDF ATQDSFDDDE LDAAVADPDE FERIYEPLDV 
KSKKIHVVDS GLTFNLPYPL ILRPQRGVDL IISFDFSARP SDSSPPFKEL LLAEKWAKMN 
KLPFPKIDPY VFDREGLKEC YVFKPKNPDM EKDCPTIIHF VLANINFRKY KAPGVPRETE 
EEKEIADFDI FDDPESPFST FNFQYPNQAF KRLHDLMHFN TLNNIDVIKE AMVESIEYRR 
QNPSRCSVSL SNVEARRFFN KEFLSKPKA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.