Details for: PLP2

Gene ID: 5355

Symbol: PLP2

Ensembl ID: ENSG00000102007

Description: proteolipid protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 233.6298
    Cell Significance Index: -36.3400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 107.1189
    Cell Significance Index: -27.1700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 103.1367
    Cell Significance Index: -41.9000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 95.5896
    Cell Significance Index: -45.1300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 89.9909
    Cell Significance Index: -46.2900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 67.4270
    Cell Significance Index: -45.2500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 44.3784
    Cell Significance Index: -42.3700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.4569
    Cell Significance Index: -38.7900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.2483
    Cell Significance Index: -37.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.3116
    Cell Significance Index: -40.6900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.5946
    Cell Significance Index: -18.8100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 7.0549
    Cell Significance Index: 59.2600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 5.6989
    Cell Significance Index: 91.4300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.2373
    Cell Significance Index: -14.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.0360
    Cell Significance Index: 137.0800
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 4.3981
    Cell Significance Index: 13.0800
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 4.3220
    Cell Significance Index: 21.0200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.3209
    Cell Significance Index: 126.9000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.1419
    Cell Significance Index: 58.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.0232
    Cell Significance Index: 1336.6300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.8254
    Cell Significance Index: 182.2800
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.4374
    Cell Significance Index: 16.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.1616
    Cell Significance Index: 112.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.1556
    Cell Significance Index: 152.4500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.8946
    Cell Significance Index: 16.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.7019
    Cell Significance Index: 209.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.6810
    Cell Significance Index: 79.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.5960
    Cell Significance Index: 1441.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3615
    Cell Significance Index: 245.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1514
    Cell Significance Index: 628.8200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1404
    Cell Significance Index: 84.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9597
    Cell Significance Index: 131.7900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.9572
    Cell Significance Index: 16.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9045
    Cell Significance Index: 116.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7640
    Cell Significance Index: 34.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.6593
    Cell Significance Index: 75.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.6575
    Cell Significance Index: 112.2700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.6499
    Cell Significance Index: 9.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5698
    Cell Significance Index: 56.3700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.5653
    Cell Significance Index: 7.2400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4357
    Cell Significance Index: 4.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4076
    Cell Significance Index: 11.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3656
    Cell Significance Index: 11.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2991
    Cell Significance Index: 56.9200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1942
    Cell Significance Index: 24.8900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1665
    Cell Significance Index: 126.0100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0485
    Cell Significance Index: 5.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0298
    Cell Significance Index: 1.3900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0065
    Cell Significance Index: 0.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0089
    Cell Significance Index: -1.7700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0098
    Cell Significance Index: -7.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0130
    Cell Significance Index: -1.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0134
    Cell Significance Index: -25.1800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0204
    Cell Significance Index: -12.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0239
    Cell Significance Index: -44.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0266
    Cell Significance Index: -41.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0290
    Cell Significance Index: -21.2900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0312
    Cell Significance Index: -0.8400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0334
    Cell Significance Index: -0.5000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0377
    Cell Significance Index: -51.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0423
    Cell Significance Index: -23.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0538
    Cell Significance Index: -34.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0632
    Cell Significance Index: -13.3100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0704
    Cell Significance Index: -8.0400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0953
    Cell Significance Index: -2.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0969
    Cell Significance Index: -44.0000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1143
    Cell Significance Index: -1.9700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1144
    Cell Significance Index: -41.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1150
    Cell Significance Index: -4.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1409
    Cell Significance Index: -16.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1513
    Cell Significance Index: -43.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1658
    Cell Significance Index: -33.2500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1879
    Cell Significance Index: -4.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2215
    Cell Significance Index: -6.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2574
    Cell Significance Index: -37.4200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3863
    Cell Significance Index: -40.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3905
    Cell Significance Index: -29.9700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4368
    Cell Significance Index: -5.9600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5032
    Cell Significance Index: -26.2100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5486
    Cell Significance Index: -43.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5577
    Cell Significance Index: -34.1900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5837
    Cell Significance Index: -5.3800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6460
    Cell Significance Index: -32.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6605
    Cell Significance Index: -44.4100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7010
    Cell Significance Index: -43.0900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7089
    Cell Significance Index: -17.7200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.7285
    Cell Significance Index: -10.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7302
    Cell Significance Index: -15.8200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.7511
    Cell Significance Index: -30.7800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.7735
    Cell Significance Index: -19.3200
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.7837
    Cell Significance Index: -4.8500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.7978
    Cell Significance Index: -11.1900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8008
    Cell Significance Index: -50.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.8272
    Cell Significance Index: -46.4200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8410
    Cell Significance Index: -19.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8430
    Cell Significance Index: -44.2600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.8583
    Cell Significance Index: -4.6800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.8742
    Cell Significance Index: -5.3800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8868
    Cell Significance Index: -32.5600
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.9007
    Cell Significance Index: -4.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PLP2 exhibits a unique combination of characteristics that distinguish it from other genes. Its broad expression profile across different cell types, including myeloid dendritic cells, classical monocytes, and mature T cells, underscores its importance in immune cell function. The gene's involvement in chemokine binding and cytokine-mediated signaling pathways suggests a role in modulating immune responses. Additionally, PLP2's participation in monoatomic ion transport and transmembrane transport activities highlights its potential role in maintaining cellular homeostasis. **Pathways and Functions:** PLP2 is implicated in several key pathways, including: 1. **Chemokine binding:** PLP2 interacts with chemokines, which are small cytokines that play a crucial role in immune cell migration and homing. 2. **Cytokine-mediated signaling pathway:** PLP2 is involved in the regulation of cytokine-mediated signaling pathways, which are essential for the proper functioning of immune cells. 3. **Endoplasmic reticulum and membrane functions:** PLP2 is localized to the endoplasmic reticulum and membrane, suggesting a role in maintaining cellular homeostasis and regulating protein folding. 4. **Monoatomic ion transport:** PLP2 participates in the transport of monoatomic ions, which are essential for maintaining cellular pH and regulating ion homeostasis. 5. **Monoatomic ion transmembrane transport:** PLP2 also exhibits transmembrane transport activity, allowing for the movement of monoatomic ions across cell membranes. **Clinical Significance:** The dysfunction of PLP2 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases:** PLP2's role in regulating immune responses suggests that its dysfunction may contribute to the development of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer:** PLP2's involvement in cytokine-mediated signaling pathways and monoatomic ion transport activities may also contribute to cancer progression and metastasis. 3. **Infectious diseases:** PLP2's role in chemokine binding and cytokine-mediated signaling pathways may also be relevant to the regulation of immune responses during infectious diseases. In conclusion, PLP2 is a multifunctional gene that plays a critical role in regulating immune responses and maintaining cellular homeostasis. Further research is needed to fully elucidate the mechanisms by which PLP2 regulates immune cell function and its clinical significance in various immune-related disorders.

Genular Protein ID: 1883343417

Symbol: PLP2_HUMAN

Name: Proteolipid protein 2

UniProtKB Accession Codes:

Q04941 A6NDT7 Q32MM8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8470895

Title: Isolation and characterization of a differentiation-dependent gene in the human colonic cell line HT29-18.

PubMed ID: 8470895

DOI: 10.1006/abbi.1993.1197

PubMed ID: 9344658

Title: Sequence-based exon prediction around the synaptophysin locus reveals a gene-rich area containing novel genes in human proximal Xp.

PubMed ID: 9344658

DOI: 10.1006/geno.1997.4941

PubMed ID: 16344560

Title: Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.

PubMed ID: 16344560

DOI: 10.1101/gr.4039406

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 152
  • Mass: 16691
  • Checksum: 689378A8C326206C
  • Sequence:
    • MADSERLSAP GCWAACTNFS RTRKGILLFA EIILCLVILI CFSASTPGYS SLSVIEMILA 
AIFFVVYMCD LHTKIPFINW PWSDFFRTLI AAILYLITSI VVLVERGNHS KIVAGVLGLI 
ATCLFGYDAY VTFPVRQPRH TAAPTDPADG PV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.