Details for: PLSCR1

Gene ID: 5359

Symbol: PLSCR1

Ensembl ID: ENSG00000188313

Description: phospholipid scramblase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 264.5533
    Cell Significance Index: -41.1500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 152.7341
    Cell Significance Index: -38.7400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 111.7739
    Cell Significance Index: -46.0500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 103.2147
    Cell Significance Index: -48.7300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 92.4988
    Cell Significance Index: -47.5800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 72.8739
    Cell Significance Index: -48.9000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.5950
    Cell Significance Index: -45.1200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.5108
    Cell Significance Index: -44.2300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.8831
    Cell Significance Index: -39.5700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.5597
    Cell Significance Index: -45.6200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.8517
    Cell Significance Index: -23.7500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 3.7264
    Cell Significance Index: 53.6000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.5645
    Cell Significance Index: 62.9900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.5505
    Cell Significance Index: 47.1400
  • Cell Name: reticulocyte (CL0000558)
    Fold Change: 2.0891
    Cell Significance Index: 10.9900
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.0477
    Cell Significance Index: 12.0300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.8001
    Cell Significance Index: 20.4500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.7804
    Cell Significance Index: 48.4600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.5862
    Cell Significance Index: 41.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4340
    Cell Significance Index: 74.4900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.1643
    Cell Significance Index: 26.9000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.1489
    Cell Significance Index: 10.5800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.0753
    Cell Significance Index: 309.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9119
    Cell Significance Index: 42.8600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8564
    Cell Significance Index: 109.7800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6743
    Cell Significance Index: 9.2000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6702
    Cell Significance Index: 66.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6684
    Cell Significance Index: 365.0500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6133
    Cell Significance Index: 553.7200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6032
    Cell Significance Index: 17.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5621
    Cell Significance Index: 25.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5561
    Cell Significance Index: 68.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5463
    Cell Significance Index: 98.4800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.5150
    Cell Significance Index: 13.7800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.4909
    Cell Significance Index: 9.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4481
    Cell Significance Index: 12.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4437
    Cell Significance Index: 57.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4399
    Cell Significance Index: 60.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4230
    Cell Significance Index: 151.7100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3400
    Cell Significance Index: 17.1800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3399
    Cell Significance Index: 64.6800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3284
    Cell Significance Index: 65.1700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2790
    Cell Significance Index: 4.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2760
    Cell Significance Index: 122.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2496
    Cell Significance Index: 6.2400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2456
    Cell Significance Index: 3.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1996
    Cell Significance Index: 40.0500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1854
    Cell Significance Index: 1.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1302
    Cell Significance Index: 9.7000
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0805
    Cell Significance Index: 0.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0526
    Cell Significance Index: 8.9800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0521
    Cell Significance Index: 98.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0308
    Cell Significance Index: 19.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0127
    Cell Significance Index: 0.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0072
    Cell Significance Index: 0.7400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0089
    Cell Significance Index: -16.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0105
    Cell Significance Index: -7.7700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0137
    Cell Significance Index: -9.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0166
    Cell Significance Index: -25.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0198
    Cell Significance Index: -14.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0210
    Cell Significance Index: -1.3600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0222
    Cell Significance Index: -3.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0292
    Cell Significance Index: -21.4400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0322
    Cell Significance Index: -20.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0344
    Cell Significance Index: -19.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0344
    Cell Significance Index: -46.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0463
    Cell Significance Index: -5.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0561
    Cell Significance Index: -25.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0676
    Cell Significance Index: -1.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0789
    Cell Significance Index: -3.6800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1254
    Cell Significance Index: -26.4100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1606
    Cell Significance Index: -2.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1766
    Cell Significance Index: -20.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1905
    Cell Significance Index: -6.1000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2128
    Cell Significance Index: -15.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2307
    Cell Significance Index: -26.8900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2873
    Cell Significance Index: -32.8000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3056
    Cell Significance Index: -6.6200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3158
    Cell Significance Index: -4.5400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4133
    Cell Significance Index: -43.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4158
    Cell Significance Index: -23.3300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.4329
    Cell Significance Index: -2.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4350
    Cell Significance Index: -33.3800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4621
    Cell Significance Index: -6.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4990
    Cell Significance Index: -13.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5081
    Cell Significance Index: -40.2400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6126
    Cell Significance Index: -15.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6313
    Cell Significance Index: -38.8000
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.6990
    Cell Significance Index: -5.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7272
    Cell Significance Index: -38.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7316
    Cell Significance Index: -49.1900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7527
    Cell Significance Index: -47.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7528
    Cell Significance Index: -33.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7739
    Cell Significance Index: -47.4500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.8578
    Cell Significance Index: -8.8800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.8652
    Cell Significance Index: -25.4100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.9354
    Cell Significance Index: -35.4200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.9504
    Cell Significance Index: -7.7500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.9730
    Cell Significance Index: -33.8100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.9881
    Cell Significance Index: -40.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Phospholipid Scramblase Activity:** PLSCR1 is a phospholipid scramblase, an enzyme that rapidly redistributes phosphatidylserine (PS) across the plasma membrane, a process essential for various cellular functions. 2. **Cell-Type Specificity:** PLSCR1 expression is highly regulated, with its levels varying across different cell types, including endothelial cells, monocytes, macrophages, and epithelial cells. 3. **Tissue Distribution:** PLSCR1 is widely expressed in various tissues, including the cerebral cortex, lung, kidney, and reproductive organs. 4. **Regulation of Immune Responses:** PLSCR1 is involved in the regulation of immune responses, including the negative regulation of phagocytosis and the positive regulation of innate immune response. **Pathways and Functions:** 1. **Apoptosis:** PLSCR1 regulates apoptosis by redistributing phosphatidylserine (PS) across the plasma membrane, making cells more susceptible to phagocytosis. 2. **Phagocytosis:** PLSCR1 negatively regulates phagocytosis by preventing the efficient clearance of apoptotic cells. 3. **Cell Signaling:** PLSCR1 is involved in various cell signaling pathways, including the regulation of gene expression, transcriptional activation, and protein binding. 4. **Viral Infection:** PLSCR1 is involved in the regulation of viral infection, including the negative regulation of viral genome replication. 5. **Cardiovascular Diseases:** PLSCR1 has been implicated in the pathogenesis of cardiovascular diseases, including atherosclerosis and cardiac hypertrophy. **Clinical Significance:** 1. **Autoimmune Disorders:** PLSCR1 has been implicated in the pathogenesis of autoimmune disorders, including rheumatoid arthritis and lupus. 2. **Cancer:** PLSCR1 has been found to be overexpressed in various types of cancer, including breast, lung, and colon cancer. 3. **Cardiovascular Diseases:** PLSCR1 has been implicated in the pathogenesis of cardiovascular diseases, including atherosclerosis and cardiac hypertrophy. 4. **Infectious Diseases:** PLSCR1 has been implicated in the regulation of viral infection, including the negative regulation of viral genome replication. In conclusion, PLSCR1 plays a crucial role in the regulation of immune responses, cellular homeostasis, and cellular signaling pathways. Its dysregulation has been implicated in various diseases, including autoimmune disorders, cancer, and cardiovascular diseases. Further research is needed to fully understand the role of PLSCR1 in human health and disease.

Genular Protein ID: 484453326

Symbol: PLS1_HUMAN

Name: Phospholipid scramblase 1

UniProtKB Accession Codes:

O15162 B2R8H8 B4DTE8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 6 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 44 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 6 Rhea 8 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9218461

Title: Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids.

PubMed ID: 9218461

DOI: 10.1074/jbc.272.29.18240

PubMed ID: 9712717

Title: Identity of human normal counterpart (MmTRA1b) of mouse leukemogenesis-associated gene (MmTRA1a) product as plasma membrane phospholipid scramblase and chromosome mapping of the human MmTRA1b/phospholipid scramblase gene.

PubMed ID: 9712717

DOI: 10.1006/bbrc.1998.9190

PubMed ID: 10930526

Title: Identification of three new members of the phospholipid scramblase gene family.

PubMed ID: 10930526

DOI: 10.1016/s0005-2736(00)00236-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8663431

Title: Isolation of an erythrocyte membrane protein that mediates Ca2+-dependent transbilayer movement of phospholipid.

PubMed ID: 8663431

DOI: 10.1074/jbc.271.29.17205

PubMed ID: 10770950

Title: Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta.

PubMed ID: 10770950

DOI: 10.1074/jbc.m003116200

PubMed ID: 11390389

Title: c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1.

PubMed ID: 11390389

DOI: 10.1074/jbc.m102505200

PubMed ID: 9572851

Title: Palmitoylation of phospholipid scramblase is required for normal function in promoting Ca2+-activated transbilayer movement of membrane phospholipids.

PubMed ID: 9572851

DOI: 10.1021/bi980218m

PubMed ID: 9485382

Title: Identity of a conserved motif in phospholipid scramblase that is required for Ca2+-accelerated transbilayer movement of membrane phospholipids.

PubMed ID: 9485382

DOI: 10.1021/bi972625o

PubMed ID: 12564925

Title: Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane.

PubMed ID: 12564925

DOI: 10.1021/bi026679w

PubMed ID: 15308695

Title: Phospholipid scramblase 1 potentiates the antiviral activity of interferon.

PubMed ID: 15308695

DOI: 10.1128/jvi.78.17.8983-8993.2004

PubMed ID: 16091359

Title: Phospholipid scramblase 1 binds to the promoter region of the inositol 1,4,5-triphosphate receptor type 1 gene to enhance its expression.

PubMed ID: 16091359

DOI: 10.1074/jbc.m504821200

PubMed ID: 17567603

Title: Nuclear interactions of topoisomerase II alpha and beta with phospholipid scramblase 1.

PubMed ID: 17567603

DOI: 10.1093/nar/gkm434

PubMed ID: 18629440

Title: Over-expression of recombinant human phospholipid scramblase 1 in E. coli and its purification from inclusion bodies.

PubMed ID: 18629440

DOI: 10.1007/s10529-008-9797-z

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21806988

Title: Phospholipid scramblase 1 mediates hepatitis C virus entry into host cells.

PubMed ID: 21806988

DOI: 10.1016/j.febslet.2011.07.019

PubMed ID: 22789739

Title: Human phospholipid scramblase 1 interacts with and regulates transactivation of HTLV-1 Tax.

PubMed ID: 22789739

DOI: 10.1016/j.virol.2012.06.019

PubMed ID: 22052202

Title: Identification of PLSCR1 as a protein that interacts with RELT family members.

PubMed ID: 22052202

DOI: 10.1007/s11010-011-1127-4

PubMed ID: 23501106

Title: Interaction of the phospholipid scramblase 1 with HIV-1 Tat results in the repression of Tat-dependent transcription.

PubMed ID: 23501106

DOI: 10.1016/j.bbrc.2013.02.098

PubMed ID: 23659204

Title: Biochemical evidence for lead and mercury induced transbilayer movement of phospholipids mediated by human phospholipid scramblase 1.

PubMed ID: 23659204

DOI: 10.1021/tx400090h

PubMed ID: 23590222

Title: The single C-terminal helix of human phospholipid scramblase 1 is required for membrane insertion and scrambling activity.

PubMed ID: 23590222

DOI: 10.1111/febs.12289

PubMed ID: 24648509

Title: N-terminal proline-rich domain is required for scrambling activity of human phospholipid scramblases.

PubMed ID: 24648509

DOI: 10.1074/jbc.m113.522953

PubMed ID: 24343571

Title: The C-terminal transmembrane domain of human phospholipid scramblase 1 is essential for the protein flip-flop activity and Ca+2-binding.

PubMed ID: 24343571

DOI: 10.1007/s00232-013-9619-7

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25365352

Title: Interactome map reveals phospholipid scramblase 1 as a novel regulator of hepatitis B virus x protein.

PubMed ID: 25365352

DOI: 10.1021/pr500943x

PubMed ID: 27206388

Title: Identification and characterization of the novel nuclease activity of human phospholipid scramblase 1.

PubMed ID: 27206388

DOI: 10.1186/s12858-016-0067-8

PubMed ID: 26745724

Title: Phospholipid Scramblase 1 Modulates FcR-Mediated Phagocytosis in Differentiated Macrophages.

PubMed ID: 26745724

DOI: 10.1371/journal.pone.0145617

PubMed ID: 29748552

Title: Pb(II) Induces Scramblase Activation and Ceramide-Domain Generation in Red Blood Cells.

PubMed ID: 29748552

DOI: 10.1038/s41598-018-25905-8

PubMed ID: 29352288

Title: Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication.

PubMed ID: 29352288

DOI: 10.1371/journal.ppat.1006851

PubMed ID: 31434743

Title: Interaction of phospholipid scramblase 1 with the Epstein-Barr virus protein BZLF1 represses BZLF1-mediated lytic gene transcription.

PubMed ID: 31434743

DOI: 10.1074/jbc.ra119.008193

PubMed ID: 32110987

Title: Transient Receptor Potential Canonical 5-Scramblase Signaling Complex Mediates Neuronal Phosphatidylserine Externalization and Apoptosis.

PubMed ID: 32110987

DOI: 10.3390/cells9030547

PubMed ID: 35138119

Title: The Interferon-Inducible Human PLSCR1 Protein Is a Restriction Factor of Human Cytomegalovirus.

PubMed ID: 35138119

DOI: 10.1128/spectrum.01342-21

PubMed ID: 35595813

Title: ILDR1 promotes influenza A virus replication through binding to PLSCR1.

PubMed ID: 35595813

DOI: 10.1038/s41598-022-12598-3

PubMed ID: 37438530

Title: PLSCR1 is a cell-autonomous defence factor against SARS-CoV-2 infection.

PubMed ID: 37438530

DOI: 10.1038/s41586-023-06322-y

PubMed ID: 15611084

Title: Phospholipid scramblase 1 contains a nonclassical nuclear localization signal with unique binding site in importin alpha.

PubMed ID: 15611084

DOI: 10.1074/jbc.m413194200

Sequence Information:

  • Length: 318
  • Mass: 35049
  • Checksum: 9860744DEC40616E
  • Sequence:
    • MDKQNSQMNA SHPETNLPVG YPPQYPPTAF QGPPGYSGYP GPQVSYPPPP AGHSGPGPAG 
FPVPNQPVYN QPVYNQPVGA AGVPWMPAPQ PPLNCPPGLE YLSQIDQILI HQQIELLEVL 
TGFETNNKYE IKNSFGQRVY FAAEDTDCCT RNCCGPSRPF TLRIIDNMGQ EVITLERPLR 
CSSCCCPCCL QEIEIQAPPG VPIGYVIQTW HPCLPKFTIQ NEKREDVLKI SGPCVVCSCC 
GDVDFEIKSL DEQCVVGKIS KHWTGILREA FTDADNFGIQ FPLDLDVKMK AVMIGACFLI 
DFMFFESTGS QEQKSGVW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.