Details for: PLTP

Gene ID: 5360

Symbol: PLTP

Ensembl ID: ENSG00000100979

Description: phospholipid transfer protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 273.6825
    Cell Significance Index: -42.5700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 160.8163
    Cell Significance Index: -40.7900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 127.4191
    Cell Significance Index: -52.4900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 83.0928
    Cell Significance Index: -39.2300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 75.2848
    Cell Significance Index: -30.5900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.7296
    Cell Significance Index: -42.8200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 31.5216
    Cell Significance Index: -30.1000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.1744
    Cell Significance Index: -40.6500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.8919
    Cell Significance Index: -42.9800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.8387
    Cell Significance Index: -10.5900
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 3.5669
    Cell Significance Index: 29.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.9761
    Cell Significance Index: 79.7500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.1915
    Cell Significance Index: 17.8700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.8956
    Cell Significance Index: 15.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.7969
    Cell Significance Index: 93.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.5884
    Cell Significance Index: 218.1300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.3466
    Cell Significance Index: 38.6000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.3016
    Cell Significance Index: 16.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.2533
    Cell Significance Index: 214.0000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.1260
    Cell Significance Index: 14.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.0973
    Cell Significance Index: 140.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.0742
    Cell Significance Index: 125.1900
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.0349
    Cell Significance Index: 6.0800
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.0005
    Cell Significance Index: 6.1900
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.9515
    Cell Significance Index: 2.5100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6799
    Cell Significance Index: 371.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5971
    Cell Significance Index: 263.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5734
    Cell Significance Index: 109.1300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5493
    Cell Significance Index: 10.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4884
    Cell Significance Index: 22.7700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4630
    Cell Significance Index: 91.8900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3721
    Cell Significance Index: 26.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2553
    Cell Significance Index: 25.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2306
    Cell Significance Index: 208.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1416
    Cell Significance Index: 23.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0903
    Cell Significance Index: 11.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0764
    Cell Significance Index: 9.8800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0454
    Cell Significance Index: 8.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0071
    Cell Significance Index: 13.4100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0053
    Cell Significance Index: 3.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0050
    Cell Significance Index: -0.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0156
    Cell Significance Index: -28.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0248
    Cell Significance Index: -0.8700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0304
    Cell Significance Index: -22.5200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0335
    Cell Significance Index: -0.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0371
    Cell Significance Index: -57.1100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0421
    Cell Significance Index: -29.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0436
    Cell Significance Index: -27.6800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0464
    Cell Significance Index: -34.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0483
    Cell Significance Index: -65.7000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0514
    Cell Significance Index: -1.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0548
    Cell Significance Index: -41.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0570
    Cell Significance Index: -20.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0619
    Cell Significance Index: -34.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0899
    Cell Significance Index: -40.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0911
    Cell Significance Index: -4.2800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1112
    Cell Significance Index: -2.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1223
    Cell Significance Index: -24.5300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1289
    Cell Significance Index: -37.1000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1442
    Cell Significance Index: -7.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1800
    Cell Significance Index: -37.9100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2062
    Cell Significance Index: -3.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2133
    Cell Significance Index: -5.9600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2209
    Cell Significance Index: -13.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2262
    Cell Significance Index: -32.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2446
    Cell Significance Index: -5.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2465
    Cell Significance Index: -17.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2662
    Cell Significance Index: -16.3200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2877
    Cell Significance Index: -4.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2929
    Cell Significance Index: -34.5400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3021
    Cell Significance Index: -34.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3382
    Cell Significance Index: -38.7500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3795
    Cell Significance Index: -24.4900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3852
    Cell Significance Index: -2.6100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4034
    Cell Significance Index: -10.7900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4132
    Cell Significance Index: -43.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4330
    Cell Significance Index: -34.2900
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.4641
    Cell Significance Index: -2.2200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4663
    Cell Significance Index: -9.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4871
    Cell Significance Index: -36.3100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4941
    Cell Significance Index: -4.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5181
    Cell Significance Index: -39.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5450
    Cell Significance Index: -33.5000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5790
    Cell Significance Index: -12.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5962
    Cell Significance Index: -30.9700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.6137
    Cell Significance Index: -8.7200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6281
    Cell Significance Index: -42.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.6336
    Cell Significance Index: -28.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6421
    Cell Significance Index: -36.0300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6425
    Cell Significance Index: -26.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6591
    Cell Significance Index: -41.5400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7393
    Cell Significance Index: -25.6900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.7445
    Cell Significance Index: -19.8800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7560
    Cell Significance Index: -19.8800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7735
    Cell Significance Index: -19.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8174
    Cell Significance Index: -26.1800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8796
    Cell Significance Index: -46.1800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.9254
    Cell Significance Index: -33.9700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9265
    Cell Significance Index: -23.8200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9394
    Cell Significance Index: -27.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Phospholipid transfer activity**: PLTP exhibits high affinity for phospholipids, including phosphatidylcholine, phosphatidylethanolamine, and phosphatidylglycerol, and can transfer these lipids between lipoproteins. 2. **Lipid metabolic process**: PLTP is involved in various lipid metabolic processes, including cholesterol efflux, lipoprotein remodeling, and sphingomyelin transfer. 3. **Cell surface localization**: PLTP is primarily expressed on the surface of cells, where it can interact with lipoproteins and other cellular components. 4. **Immune cell function**: PLTP is expressed on the surface of immune cells, including T cells, B cells, and dendritic cells, and plays a role in immune cell function and signaling. **Pathways and Functions:** 1. **Cholesterol efflux**: PLTP facilitates the transfer of phospholipids from high-density lipoprotein (HDL) to apolipoprotein A-I (apoA-I), promoting cholesterol efflux and reducing the risk of atherosclerosis. 2. **Lipoprotein remodeling**: PLTP is involved in the remodeling of lipoproteins, including the transfer of phospholipids and cholesterol esters between lipoproteins. 3. **Immune cell signaling**: PLTP interacts with various signaling molecules, including nuclear receptors, to regulate immune cell function and response. 4. **Ceramide and sphingomyelin transfer**: PLTP facilitates the transfer of ceramides and sphingomyelins between lipoproteins, which is important for lipid metabolism and immune function. **Clinical Significance:** 1. **Atherosclerosis**: PLTP has been implicated in the development of atherosclerosis, as increased PLTP activity is associated with increased risk of cardiovascular disease. 2. **Cholesterol efflux**: PLTP plays a critical role in cholesterol efflux, and alterations in PLTP activity may contribute to the development of atherosclerosis. 3. **Immune-mediated diseases**: PLTP is involved in immune cell function and signaling, and alterations in PLTP activity may contribute to the development of immune-mediated diseases, such as multiple sclerosis and rheumatoid arthritis. 4. **Cancer**: PLTP has been implicated in the development and progression of certain cancers, including breast and lung cancer. In conclusion, the phospholipid transfer protein (PLTP) is a multifunctional protein that plays a critical role in lipid metabolism, immune response, and cell signaling. Understanding the characteristics, pathways, and functions of PLTP is essential for elucidating its clinical significance and potential therapeutic applications.

Genular Protein ID: 1049096489

Symbol: PLTP_HUMAN

Name: Phospholipid transfer protein

UniProtKB Accession Codes:

P55058 A8K006 B4DDD5 B4DRB4 E1P5N8 E7EV16 Q8WTT1 Q9BR07 Q9BSH8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 2 CPTAC 2 CTD 1 ChEBI 10 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 16 Ensembl 5 GO 33 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 Rhea 20 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8132678

Title: Complete cDNA encoding human phospholipid transfer protein from human endothelial cells.

PubMed ID: 8132678

DOI: 10.1016/s0021-9258(17)37120-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7654777

Title: Functional expression of human and mouse plasma phospholipid transfer protein: effect of recombinant and plasma PLTP on HDL subspecies.

PubMed ID: 7654777

DOI: 10.1016/0005-2760(95)00091-p

PubMed ID: 9132017

Title: Molecular and macromolecular specificity of human plasma phospholipid transfer protein.

PubMed ID: 9132017

DOI: 10.1021/bi962776b

PubMed ID: 10333293

Title: Role of cysteine residues in human plasma phospholipid transfer protein.

PubMed ID: 10333293

DOI: 10.1023/a:1020628006453

PubMed ID: 11013307

Title: Distribution of phospholipid transfer protein in human plasma: presence of two forms of phospholipid transfer protein, one catalytically active and the other inactive.

PubMed ID: 11013307

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19321130

Title: PLTP is present in the nucleus, and its nuclear export is CRM1-dependent.

PubMed ID: 19321130

DOI: 10.1016/j.bbamcr.2009.01.010

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 21515415

Title: Impact of site-specific N-glycosylation on cellular secretion, activity and specific activity of the plasma phospholipid transfer protein.

PubMed ID: 21515415

DOI: 10.1016/j.bbapap.2011.04.004

PubMed ID: 21736953

Title: Role of plasma phospholipid transfer protein in lipid and lipoprotein metabolism.

PubMed ID: 21736953

DOI: 10.1016/j.bbalip.2011.06.013

PubMed ID: 12966036

Title: Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors.

PubMed ID: 12966036

DOI: 10.1093/hmg/ddg314

PubMed ID: 29883800

Title: Structural basis of the lipid transfer mechanism of phospholipid transfer protein (PLTP).

PubMed ID: 29883800

DOI: 10.1016/j.bbalip.2018.06.001

Sequence Information:

  • Length: 493
  • Mass: 54739
  • Checksum: C6E4852F18E12317
  • Sequence:
    • MALFGALFLA LLAGAHAEFP GCKIRVTSKA LELVKQEGLR FLEQELETIT IPDLRGKEGH 
FYYNISEVKV TELQLTSSEL DFQPQQELML QITNASLGLR FRRQLLYWFF YDGGYINASA 
EGVSIRTGLE LSRDPAGRMK VSNVSCQASV SRMHAAFGGT FKKVYDFLST FITSGMRFLL 
NQQICPVLYH AGTVLLNSLL DTVPVRSSVD ELVGIDYSLM KDPVASTSNL DMDFRGAFFP 
LTERNWSLPN RAVEPQLQEE ERMVYVAFSE FFFDSAMESY FRAGALQLLL VGDKVPHDLD 
MLLRATYFGS IVLLSPAVID SPLKLELRVL APPRCTIKPS GTTISVTASV TIALVPPDQP 
EVQLSSMTMD ARLSAKMALR GKALRTQLDL RRFRIYSNHS ALESLALIPL QAPLKTMLQI 
GVMPMLNERT WRGVQIPLPE GINFVHEVVT NHAGFLTIGA DLHFAKGLRE VIEKNRPADV 
RASTAPTPST AAV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.