Details for: PLTP

Gene ID: 5360

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: PLTP

Ensembl ID: ENSG00000100979

Description: phospholipid transfer protein

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • Hofbauer cell CL3000001
    CSI 31.11
    rCSI 58.73%
    PRS 90.71
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 23.87
    rCSI 28.93%
    PRS 64.51
  • regulatory T cell CL0000815
    CSI 21.66
    rCSI 25.11%
    PRS 82.38
  • ciliated epithelial cell CL0000067
    CSI 19.33
    rCSI 17%
    PRS 73.87
  • helper T cell CL0000912
    CSI 17.83
    rCSI 25.22%
    PRS 82.07
  • myeloid leukocyte CL0000766
    CSI 16.14
    rCSI 14.89%
    PRS 85.3
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 15.81
    rCSI 14.27%
    PRS 82.54
  • multi-ciliated epithelial cell CL0005012
    CSI 15.18
    rCSI 15.15%
    PRS 78.06
  • vascular associated smooth muscle cell CL0000359
    CSI 14.37
    rCSI 46.61%
    PRS 82.09
  • common myeloid progenitor CL0000049
    CSI 13.83
    rCSI 11.18%
    PRS 86.01
  • bronchus fibroblast of lung CL2000093
    CSI 13.46
    rCSI 10.94%
    PRS 83.36
  • respiratory basal cell CL0002633
    CSI 13.13
    rCSI 13.6%
    PRS 87.07
  • ependymal cell CL0000065
    CSI 13.11
    rCSI 26.61%
    PRS 63.55
  • skin fibroblast CL0002620
    CSI 13.01
    rCSI 11.22%
    PRS 83.98
  • suprabasal keratinocyte CL4033013
    CSI 12.15
    rCSI 19.83%
    PRS 51.96
  • lung macrophage CL1001603
    CSI 12.12
    rCSI 27.07%
    PRS 90.25
  • keratocyte CL0002363
    CSI 12.08
    rCSI 29.05%
    PRS 86.11
  • Kupffer cell CL0000091
    CSI 11.85
    rCSI 27.09%
    PRS 84.81
  • myofibroblast cell CL0000186
    CSI 10.93
    rCSI 15.14%
    PRS 80.61
  • basal cell of epidermis CL0002187
    CSI 10.64
    rCSI 18.86%
    PRS 53.22
  • melanocyte of skin CL1000458
    CSI 10.38
    rCSI 14.14%
    PRS 51.76
  • macrophage CL0000235
    CSI 10.24
    rCSI 18.62%
    PRS 88.39
  • innate lymphoid cell CL0001065
    CSI 10.24
    rCSI 21.13%
    PRS 80.09
  • alveolar adventitial fibroblast CL4028006
    CSI 10.14
    rCSI 16.02%
    PRS 85.2
  • vascular leptomeningeal cell CL4023051
    CSI 8.79
    rCSI 15.41%
    PRS 78.44
  • fallopian tube secretory epithelial cell CL4030006
    CSI 8.62
    rCSI 8.3%
    PRS 83.31
  • adventitial cell CL0002503
    CSI 8.29
    rCSI 19.81%
    PRS 87.24
  • stromal cell of ovary CL0002132
    CSI 8.17
    rCSI 22.44%
    PRS 89.33
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 7.99
    rCSI 20.84%
    PRS 84.94
  • fibroblast of lung CL0002553
    CSI 7.97
    rCSI 7.41%
    PRS 84.76
  • mononuclear phagocyte CL0000113
    CSI 7.68
    rCSI 16.91%
    PRS 87.21
  • choroid plexus epithelial cell CL0000706
    CSI 7.59
    rCSI 12.44%
    PRS 74.36
  • colon macrophage CL0009038
    CSI 7.52
    rCSI 34.73%
    PRS 93.65
  • lung pericyte CL0009089
    CSI 7.17
    rCSI 18.93%
    PRS 89.43
  • neural cell CL0002319
    CSI 7.14
    rCSI 26.96%
    PRS 67.01
  • melanocyte CL0000148
    CSI 6.83
    rCSI 5.06%
    PRS 78.21
  • monocyte CL0000576
    CSI 6.8
    rCSI 12.29%
    PRS 87.35
  • interstitial cell of Cajal CL0002088
    CSI 6.78
    rCSI 8.63%
    PRS 88.5
  • radial glial cell CL0000681
    CSI 6.43
    rCSI 8.93%
    PRS 82.41
  • elicited macrophage CL0000861
    CSI 6.38
    rCSI 5.86%
    PRS 90.63
  • mesodermal cell CL0000222
    CSI 6.29
    rCSI 7.55%
    PRS 82.11
  • endothelial cell of pericentral hepatic sinusoid CL0019022
    CSI 6.14
    rCSI 18.92%
    PRS 87.29
  • retinal pigment epithelial cell CL0002586
    CSI 6.13
    rCSI 12.18%
    PRS 79.83
  • alveolar type 1 fibroblast cell CL4028004
    CSI 6.05
    rCSI 6.62%
    PRS 85.68
  • stromal cell CL0000499
    CSI 5.99
    rCSI 16.86%
    PRS 79.16
  • glioblast CL0000030
    CSI 5.92
    rCSI 9.45%
    PRS 75.77
  • chondrocyte CL0000138
    CSI 5.67
    rCSI 9.02%
    PRS 77.51
  • microglial cell CL0000129
    CSI 5.52
    rCSI 22.22%
    PRS 84.44
  • lung interstitial macrophage CL4033043
    CSI 5.48
    rCSI 12.31%
    PRS 93.43
  • respiratory suprabasal cell CL4033048
    CSI 5.07
    rCSI 6.5%
    PRS 86.6
  • hepatic stellate cell CL0000632
    CSI 5.01
    rCSI 18.78%
    PRS 77
  • astrocyte of the cerebral cortex CL0002605
    CSI 4.98
    rCSI 11.18%
    PRS 68.16
  • podocyte CL0000653
    CSI 4.92
    rCSI 21.88%
    PRS 84.62
  • lung ciliated cell CL1000271
    CSI 4.86
    rCSI 5.62%
    PRS 76.99
  • stem cell CL0000034
    CSI 4.83
    rCSI 4.66%
    PRS 78.31
  • intermediate monocyte CL0002393
    CSI 4.82
    rCSI 7.28%
    PRS 88.85
  • acinar cell CL0000622
    CSI 4.82
    rCSI 7.07%
    PRS 91.72
  • enteric smooth muscle cell CL0002504
    CSI 4.57
    rCSI 6.53%
    PRS 84.58
  • neural crest cell CL0011012
    CSI 4.44
    rCSI 3.51%
    PRS 74.18
  • ciliated cell CL0000064
    CSI 4.41
    rCSI 7.15%
    PRS 78.91
  • cytotoxic T cell CL0000910
    CSI 4.36
    rCSI 25.02%
    PRS 86.03
  • mesenchymal cell CL0008019
    CSI 4.07
    rCSI 10.34%
    PRS 77.66
  • pulmonary artery endothelial cell CL1001568
    CSI 4.04
    rCSI 5.49%
    PRS 90.87
  • tracheobronchial serous cell CL0019001
    CSI 3.93
    rCSI 16.96%
    PRS 89.14
  • myoepithelial cell CL0000185
    CSI 3.77
    rCSI 9.53%
    PRS 87.84
  • pancreatic acinar cell CL0002064
    CSI 3.51
    rCSI 4.67%
    PRS 88.6
  • dendritic cell, human CL0001056
    CSI 3.36
    rCSI 5.17%
    PRS 90.97
  • alternatively activated macrophage CL0000890
    CSI 3.27
    rCSI 4.11%
    PRS 91.73
  • cerebral cortex endothelial cell CL1001602
    CSI 2.97
    rCSI 5.13%
    PRS 76.23
  • tracheobronchial smooth muscle cell CL0019019
    CSI 2.91
    rCSI 5.14%
    PRS 88.25
  • promyelocyte CL0000836
    CSI 2.84
    rCSI 4.09%
    PRS 88.41
  • mucous neck cell CL0000651
    CSI 2.69
    rCSI 3.87%
    PRS 89.29
  • adipocyte CL0000136
    CSI 2.65
    rCSI 3.4%
    PRS 74.55
  • pancreatic stellate cell CL0002410
    CSI 2.64
    rCSI 15.37%
    PRS 86.88
  • alveolar macrophage CL0000583
    CSI 2.52
    rCSI 4.15%
    PRS 87.34
  • mesenchymal stem cell of adipose tissue CL0002570
    CSI 2.42
    rCSI 13.49%
    PRS 85.97
  • keratinocyte CL0000312
    CSI 2.32
    rCSI 1.95%
    PRS 85.89
  • granulocyte monocyte progenitor cell CL0000557
    CSI 2.27
    rCSI 1.96%
    PRS 87.32
  • conjunctival epithelial cell CL1000432
    CSI 2.17
    rCSI 3.32%
    PRS 83.86
  • duct epithelial cell CL0000068
    CSI 2.13
    rCSI 3.11%
    PRS 88.34
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 2.06
    rCSI 4.7%
    PRS 77.53
  • microcirculation associated smooth muscle cell CL0008035
    CSI 2.06
    rCSI 5.97%
    PRS 83.09
  • peptic cell CL0000155
    CSI 2
    rCSI 19.72%
    PRS 91.73
  • Bergmann glial cell CL0000644
    CSI 1.97
    rCSI 2.69%
    PRS 75.4
  • extravillous trophoblast CL0008036
    CSI 1.82
    rCSI 2.25%
    PRS 82.14
  • fibroblast of breast CL4006000
    CSI 1.6
    rCSI 6.74%
    PRS 87.42
  • tissue-resident macrophage CL0000864
    CSI 1.54
    rCSI 7.2%
    PRS 93.22
  • forebrain radial glial cell CL0013000
    CSI 1.49
    rCSI 4.79%
    PRS 84.91
  • mammary gland epithelial cell CL0002327
    CSI 1.49
    rCSI 5.23%
    PRS 90.42
  • endocardial cell CL0002350
    CSI 1.33
    rCSI 6.38%
    PRS 80
  • club cell CL0000158
    CSI 1.18
    rCSI 1.73%
    PRS 78.85
  • endothelial cell of placenta CL0009092
    CSI 0.94
    rCSI 4.65%
    PRS 90.09
  • serous secreting cell of bronchus submucosal gland CL4033005
    CSI 0.91
    rCSI 5.17%
    PRS 89.55
  • metallothionein-positive alveolar macrophage CL4033042
    CSI 0.58
    rCSI 6.26%
    PRS 91.59
  • kidney interstitial cell CL1000500
    CSI 0.55
    rCSI 9.06%
    PRS 86.6
  • erythroid progenitor cell CL0000038
    CSI 0.41
    rCSI 2.38%
    PRS 88.17
  • mesenchymal stem cell CL0000134
    CSI 0.37
    rCSI 4.09%
    PRS 87.96
  • pluripotent stem cell CL0002248
    CSI 0.33
    rCSI 9.96%
    PRS 91.91
  • blood vessel smooth muscle cell CL0019018
    CSI 0.22
    rCSI 1.78%
    PRS 78.92

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [PLTP](/details-gene/5360) (phospholipid transfer protein) is a protein-coding gene located on chromosome 20q13.12. As its name implies, [PLTP](/details-gene/5360) is a key secreted enzyme involved in the transport of various lipids, including phospholipids, ceramides, and cholesterol. Its primary function is mediating the transfer of these molecules between lipoproteins, playing a crucial role in [High-density lipoprotein particle remodeling](https://www.ebi.ac.uk/QuickGO/term/GO:0034375) and reverse cholesterol transport. Expression data indicates that **Overall**, [PLTP](/details-gene/5360) is most significant in specialized macrophages like the placental [Hofbauer cell](/details-cell/CL3000001), various T lymphocyte subsets, and ciliated epithelial cells, suggesting functions that extend beyond systemic lipid metabolism into tissue-specific immunity and barrier maintenance. A clinical association with lipid metabolism disorders has been noted ([172425](https://omim.org/entry/172425)). ## Cellular Roles and Expression Landscape The expression profile of [PLTP](/details-gene/5360) highlights its significance in diverse cellular contexts, with prominent roles in immunology, epithelial function, and hematopoiesis. **Overall**, the gene shows the highest significance in [Hofbauer cell](/details-cell/CL3000001)s (CSI: 31.11), a type of macrophage found in the placenta. This suggests a critical role in lipid handling and immune regulation at the maternal-fetal interface. A second major functional cluster is the adaptive immune system. [PLTP](/details-gene/5360) is highly significant in several T lymphocyte populations, including [CD8-positive, alpha-beta memory T cell, CD45RO-positive](/details-cell/CL0001203) (CSI: 23.87), [regulatory T cell](/details-cell/CL0000815) (CSI: 21.66), and [helper T cell](/details-cell/CL0000912) (CSI: 17.83). This pattern indicates a potential role in modulating T cell membrane composition, lipid signaling, or metabolic programming during activation and differentiation. The gene also demonstrates importance in barrier tissues, with high significance in [ciliated epithelial cell](/details-cell/CL0000067)s (CSI: 19.33) and [multi-ciliated epithelial cell](/details-cell/CL0005012)s (CSI: 15.18), particularly in the respiratory system. This may relate to its function in maintaining the lipid composition of mucosal surfaces or in cellular responses to environmental stimuli. Furthermore, its significance in hematopoietic progenitors, such as [megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050) (CSI: 15.81) and [common myeloid progenitor](/details-cell/CL0000049) (CSI: 13.83), suggests an early role in the development of myeloid and erythroid lineages. ## Pathways and Molecular Function The functions of [PLTP](/details-gene/5360) are centered on its ability to bind and transfer a wide array of lipid species. Its molecular activities include [Phospholipid transfer activity](https://www.ebi.ac.uk/QuickGO/term/GO:0120014), [Ceramide transfer activity](https://www.ebi.ac.uk/QuickGO/term/GO:0120017), and [Cholesterol transfer activity](https://www.ebi.ac.uk/QuickGO/term/GO:0120020). It interacts with various lipoprotein particles, including [High-density lipoprotein particle binding](https://www.ebi.ac.uk/QuickGO/term/GO:0008035) and [Low-density lipoprotein particle binding](https://www.ebi.ac.uk/QuickGO/term/GO:0030169). At the process level, [PLTP](/details-gene/5360) is a central component of [Lipid transport](https://www.ebi.ac.uk/QuickGO/term/GO:0006869) and metabolism. It participates extensively in [Plasma lipoprotein assembly, remodeling, and clearance](https://reactome.org/content/detail/R-HSA-174824), particularly [Hdl remodeling](https://reactome.org/content/detail/R-HSA-8964058). This is consistent with its established role in systemic cholesterol homeostasis, contributing to the [Positive regulation of cholesterol efflux](https://www.ebi.ac.uk/QuickGO/term/GO:0010875) from peripheral cells. Research indicates that it exists in both catalytically active and inactive forms in plasma ([Link](https://pubmed.ncbi.nlm.nih.gov/11013307/)). While predominantly known as a secreted protein found in the [Extracellular space](https://www.ebi.ac.uk/QuickGO/term/GO:0005615), studies have also identified [PLTP](/details-gene/5360) within the [Nucleus](https://www.ebi.ac.uk/QuickGO/term/GO:0005634), where its transport is dependent on CRM1, suggesting intracellular functions beyond lipid transport ([Link](https://pubmed.ncbi.nlm.nih.gov/19321130/)). ## Research Directions The expression profile of [PLTP](/details-gene/5360) points to important functions in tissue-specific contexts, particularly in immunity and physiology at barrier sites, which warrant further investigation. **Testable Hypotheses:** 1. Given its exceptionally high significance in [Hofbauer cell](/details-cell/CL3000001)s, [PLTP](/details-gene/5360) may be a critical mediator of lipid transfer from the mother to the fetus and may also regulate the immunotolerant phenotype of these placental macrophages through modulation of membrane lipids. 2. The high significance of [PLTP](/details-gene/5360) across multiple activated and memory T cell subsets suggests it is required for establishing or maintaining the specific plasma membrane composition necessary for T cell receptor signaling, immunological synapse formation, or long-term survival of memory cells. 3. In [ciliated epithelial cell](/details-cell/CL0000067)s, [PLTP](/details-gene/5360) may play a protective role by regulating the composition of surfactant phospholipids or cell membrane integrity, thereby influencing mucociliary clearance and the response to inhaled pathogens or pollutants. **Proposed Experiment:** To test the first hypothesis regarding the role of [PLTP](/details-gene/5360) in [Hofbauer cell](/details-cell/CL3000001) function, primary human monocytes could be cultured with placental-conditioned media to differentiate them into Hofbauer-like cells. Using a CRISPR-Cas9 knockout or siRNA knockdown of [PLTP](/details-gene/5360) in these cells, one could assess the impact on their ability to process lipids by measuring cellular uptake of labeled lipoproteins and quantifying lipid droplet formation via microscopy. Furthermore, the immunomodulatory function could be evaluated by analyzing the cytokine secretion profile (e.g., IL-10, TGF-beta) in both basal and stimulated (e.g., LPS) conditions using multiplex assays. **Therapeutic Potential:** As a secreted protein integral to lipoprotein metabolism, [PLTP](/details-gene/5360) is already a recognized therapeutic target for cardiovascular disease. Inhibition of its transfer activity is a strategy being explored to raise HDL cholesterol levels and promote reverse cholesterol transport. The data presented here suggest that modulating [PLTP](/details-gene/5360) could also have implications for immunometabolism. For instance, in chronic inflammatory diseases characterized by dysfunctional lipid-laden macrophages, targeted inhibition of [PLTP](/details-gene/5360) could potentially reprogram macrophage function. Given its extracellular nature, it is an accessible target for monoclonal antibodies or small molecule inhibitors.

Genular Protein ID: 1049096489

Symbol: PLTP_HUMAN

Name: Phospholipid transfer protein

UniProtKB Accession Codes:

P55058 A8K006 B4DDD5 B4DRB4 E1P5N8 E7EV16 Q8WTT1 Q9BR07 Q9BSH8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 2 CPTAC 2 CTD 1 ChEBI 10 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 16 Ensembl 5 GO 33 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 Rhea 20 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8132678

Title: Complete cDNA encoding human phospholipid transfer protein from human endothelial cells.

PubMed ID: 8132678

DOI: 10.1016/s0021-9258(17)37120-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7654777

Title: Functional expression of human and mouse plasma phospholipid transfer protein: effect of recombinant and plasma PLTP on HDL subspecies.

PubMed ID: 7654777

DOI: 10.1016/0005-2760(95)00091-p

PubMed ID: 9132017

Title: Molecular and macromolecular specificity of human plasma phospholipid transfer protein.

PubMed ID: 9132017

DOI: 10.1021/bi962776b

PubMed ID: 10333293

Title: Role of cysteine residues in human plasma phospholipid transfer protein.

PubMed ID: 10333293

DOI: 10.1023/a:1020628006453

PubMed ID: 11013307

Title: Distribution of phospholipid transfer protein in human plasma: presence of two forms of phospholipid transfer protein, one catalytically active and the other inactive.

PubMed ID: 11013307

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19321130

Title: PLTP is present in the nucleus, and its nuclear export is CRM1-dependent.

PubMed ID: 19321130

DOI: 10.1016/j.bbamcr.2009.01.010

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 21515415

Title: Impact of site-specific N-glycosylation on cellular secretion, activity and specific activity of the plasma phospholipid transfer protein.

PubMed ID: 21515415

DOI: 10.1016/j.bbapap.2011.04.004

PubMed ID: 21736953

Title: Role of plasma phospholipid transfer protein in lipid and lipoprotein metabolism.

PubMed ID: 21736953

DOI: 10.1016/j.bbalip.2011.06.013

PubMed ID: 12966036

Title: Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors.

PubMed ID: 12966036

DOI: 10.1093/hmg/ddg314

PubMed ID: 29883800

Title: Structural basis of the lipid transfer mechanism of phospholipid transfer protein (PLTP).

PubMed ID: 29883800

DOI: 10.1016/j.bbalip.2018.06.001

Sequence Information:

  • Length: 493
  • Mass: 54739
  • Checksum: C6E4852F18E12317
  • Sequence:
    • MALFGALFLA LLAGAHAEFP GCKIRVTSKA LELVKQEGLR FLEQELETIT IPDLRGKEGH 
FYYNISEVKV TELQLTSSEL DFQPQQELML QITNASLGLR FRRQLLYWFF YDGGYINASA 
EGVSIRTGLE LSRDPAGRMK VSNVSCQASV SRMHAAFGGT FKKVYDFLST FITSGMRFLL 
NQQICPVLYH AGTVLLNSLL DTVPVRSSVD ELVGIDYSLM KDPVASTSNL DMDFRGAFFP 
LTERNWSLPN RAVEPQLQEE ERMVYVAFSE FFFDSAMESY FRAGALQLLL VGDKVPHDLD 
MLLRATYFGS IVLLSPAVID SPLKLELRVL APPRCTIKPS GTTISVTASV TIALVPPDQP 
EVQLSSMTMD ARLSAKMALR GKALRTQLDL RRFRIYSNHS ALESLALIPL QAPLKTMLQI 
GVMPMLNERT WRGVQIPLPE GINFVHEVVT NHAGFLTIGA DLHFAKGLRE VIEKNRPADV 
RASTAPTPST AAV