Details for: MBD3

Gene ID: 53615

Symbol: MBD3

Ensembl ID: ENSG00000071655

Description: methyl-CpG binding domain protein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 143.9774
    Cell Significance Index: -22.4000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 88.7861
    Cell Significance Index: -22.5200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 53.8208
    Cell Significance Index: -25.4100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 46.9899
    Cell Significance Index: -19.0900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.2099
    Cell Significance Index: -20.2500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.1248
    Cell Significance Index: -23.5800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 9.8311
    Cell Significance Index: 162.0000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.1438
    Cell Significance Index: -24.5000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.3911
    Cell Significance Index: -19.6300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.0795
    Cell Significance Index: -23.9900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.0489
    Cell Significance Index: -11.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.7051
    Cell Significance Index: 72.2300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.3293
    Cell Significance Index: 230.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.7288
    Cell Significance Index: 119.5600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.7136
    Cell Significance Index: 89.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2511
    Cell Significance Index: 203.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8571
    Cell Significance Index: 24.7000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8314
    Cell Significance Index: 49.9200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8145
    Cell Significance Index: 36.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7189
    Cell Significance Index: 20.0900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.6916
    Cell Significance Index: 18.5000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6513
    Cell Significance Index: 14.1100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6434
    Cell Significance Index: 580.9200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5725
    Cell Significance Index: 15.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5559
    Cell Significance Index: 68.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5218
    Cell Significance Index: 94.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4849
    Cell Significance Index: 25.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4553
    Cell Significance Index: 91.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4544
    Cell Significance Index: 29.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4284
    Cell Significance Index: 10.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4104
    Cell Significance Index: 56.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3760
    Cell Significance Index: 205.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3702
    Cell Significance Index: 73.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3697
    Cell Significance Index: 17.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3445
    Cell Significance Index: 152.2900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2888
    Cell Significance Index: 8.2800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2478
    Cell Significance Index: 6.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2302
    Cell Significance Index: 12.9200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2263
    Cell Significance Index: 156.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2178
    Cell Significance Index: 78.1200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1797
    Cell Significance Index: 8.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1185
    Cell Significance Index: 15.1900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1082
    Cell Significance Index: 7.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1038
    Cell Significance Index: 19.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0725
    Cell Significance Index: 5.5600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0338
    Cell Significance Index: 0.7200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0310
    Cell Significance Index: 1.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0000
    Cell Significance Index: 0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0028
    Cell Significance Index: -5.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0045
    Cell Significance Index: -0.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0107
    Cell Significance Index: -7.8500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0121
    Cell Significance Index: -1.5700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0142
    Cell Significance Index: -26.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0159
    Cell Significance Index: -24.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0194
    Cell Significance Index: -12.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0208
    Cell Significance Index: -28.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0257
    Cell Significance Index: -19.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0411
    Cell Significance Index: -18.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0419
    Cell Significance Index: -23.6100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0467
    Cell Significance Index: -29.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0579
    Cell Significance Index: -5.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0618
    Cell Significance Index: -17.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0688
    Cell Significance Index: -8.0200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0773
    Cell Significance Index: -0.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0904
    Cell Significance Index: -3.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0933
    Cell Significance Index: -6.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1017
    Cell Significance Index: -6.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1241
    Cell Significance Index: -18.0400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1354
    Cell Significance Index: -3.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1367
    Cell Significance Index: -15.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1410
    Cell Significance Index: -29.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1436
    Cell Significance Index: -4.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1882
    Cell Significance Index: -11.8600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1893
    Cell Significance Index: -1.9600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1920
    Cell Significance Index: -2.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2173
    Cell Significance Index: -14.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2224
    Cell Significance Index: -23.1600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2242
    Cell Significance Index: -17.7600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2336
    Cell Significance Index: -3.9100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2823
    Cell Significance Index: -2.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2857
    Cell Significance Index: -12.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2866
    Cell Significance Index: -17.5700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.3374
    Cell Significance Index: -2.2000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3501
    Cell Significance Index: -2.1200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3617
    Cell Significance Index: -9.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3716
    Cell Significance Index: -19.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3856
    Cell Significance Index: -14.6000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4088
    Cell Significance Index: -6.1600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.4136
    Cell Significance Index: -2.5700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4365
    Cell Significance Index: -10.0900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4534
    Cell Significance Index: -8.3800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4884
    Cell Significance Index: -6.8500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5458
    Cell Significance Index: -11.9500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5565
    Cell Significance Index: -28.1300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5666
    Cell Significance Index: -16.1700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5710
    Cell Significance Index: -20.9600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6036
    Cell Significance Index: -17.7800
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.6228
    Cell Significance Index: -5.9200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6286
    Cell Significance Index: -20.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MBD3 is a 28-kDa protein containing a methyl-CpG binding domain (MBD), which allows it to recognize and bind to methylated CpG dinucleotides. This binding event triggers the recruitment of chromatin remodeling complexes, leading to the repression of gene expression. MBD3 is a member of the Methyl-CpG binding protein family, which also includes MBD1, MBD2, and MBD4. While all these proteins share similar binding properties, MBD3 is unique in its ability to interact with specific transcription factors, such as TP53 and Pten, to modulate their activity. **Pathways and Functions** MBD3 plays a critical role in various cellular processes, including: 1. **Epigenetic Regulation of Gene Expression**: MBD3 binds to methylated CpG dinucleotides, recruiting chromatin remodeling complexes to repress gene expression. This process is essential for maintaining tissue homeostasis and responding to environmental cues. 2. **Transcriptional Regulation by TP53**: MBD3 interacts with TP53, a tumor suppressor protein, to modulate its activity. TP53 regulates cell cycle arrest, apoptosis, and DNA repair, and MBD3's interaction with TP53 enhances its transcriptional activity. 3. **Pten Regulation**: MBD3 also interacts with Pten, a phosphatase that regulates cell growth and metabolism. MBD3's interaction with Pten modulates its activity, influencing cell growth and differentiation. 4. **Regulation of Stem Cell Differentiation**: MBD3 plays a role in regulating stem cell differentiation, particularly in the context of hematopoiesis and epithelial development. 5. **Response to Nutrient Levels**: MBD3 is responsive to nutrient levels, influencing gene expression and cellular metabolism. **Clinical Significance** Dysregulation of MBD3 has been implicated in various diseases, including: 1. **Cancer**: MBD3's interaction with TP53 and Pten suggests its role in cancer development and progression. 2. **Inflammatory Disorders**: MBD3's expression in immune cells suggests its role in regulating immune responses and inflammation. 3. **Infectious Diseases**: MBD3's interaction with viral infection pathways suggests its role in regulating host-virus interactions. 4. **Neurological Disorders**: MBD3's expression in neural cells suggests its role in regulating neural development and function. In conclusion, MBD3 is a crucial epigenetic regulator involved in various cellular processes, including gene expression, cell differentiation, and development. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its role in human health and disease.

Genular Protein ID: 4069414789

Symbol: MBD3_HUMAN

Name: Methyl-CpG-binding domain protein 3

UniProtKB Accession Codes:

O95983 A8K4B7 D6W5Z2 Q6PIL9 Q6PJZ9 Q86XF4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 9 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9774669

Title: Identification and characterization of a family of mammalian methyl-CpG binding proteins.

PubMed ID: 9774669

DOI: 10.1128/mcb.18.11.6538

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10947852

Title: MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase.

PubMed ID: 10947852

DOI: 10.1046/j.1365-2443.2000.00359.x

PubMed ID: 11102443

Title: Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1.

PubMed ID: 11102443

DOI: 10.1074/jbc.m007372200

PubMed ID: 12124384

Title: The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2.

PubMed ID: 12124384

DOI: 10.1074/jbc.m203455200

PubMed ID: 12183469

Title: Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3.

PubMed ID: 12183469

DOI: 10.1074/jbc.m207467200

PubMed ID: 11756549

Title: Identification and functional characterization of the p66/p68 components of the MeCP1 complex.

PubMed ID: 11756549

DOI: 10.1128/mcb.22.2.536-546.2002

PubMed ID: 15454082

Title: MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation.

PubMed ID: 15454082

DOI: 10.1016/j.cell.2004.09.014

PubMed ID: 15701600

Title: MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing.

PubMed ID: 15701600

DOI: 10.1074/jbc.m413492200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16428440

Title: MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.

PubMed ID: 16428440

DOI: 10.1128/mcb.26.3.843-851.2006

PubMed ID: 18644863

Title: MBD3, a component of the NuRD complex, facilitates chromatin alteration and deposition of epigenetic marks.

PubMed ID: 18644863

DOI: 10.1128/mcb.00467-08

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20523938

Title: CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex.

PubMed ID: 20523938

DOI: 10.1039/c004108d

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23361464

Title: Differential roles for MBD2 and MBD3 at methylated CpG islands, active promoters and binding to exon sequences.

PubMed ID: 23361464

DOI: 10.1093/nar/gkt035

PubMed ID: 24385926

Title: MBD3 localizes at promoters, gene bodies and enhancers of active genes.

PubMed ID: 24385926

DOI: 10.1371/journal.pgen.1004028

PubMed ID: 27732854

Title: ZMYND8 Co-localizes with NuRD on Target Genes and Regulates Poly(ADP-Ribose)-Dependent Recruitment of GATAD2A/NuRD to Sites of DNA Damage.

PubMed ID: 27732854

DOI: 10.1016/j.celrep.2016.09.037

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28977666

Title: CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

PubMed ID: 28977666

DOI: 10.1093/nar/gkx711

PubMed ID: 33283408

Title: Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.

PubMed ID: 33283408

DOI: 10.1111/febs.15650

PubMed ID: 24307175

Title: Probing the dynamic distribution of bound states for methylcytosine-binding domains on DNA.

PubMed ID: 24307175

DOI: 10.1074/jbc.m113.512236

Sequence Information:

  • Length: 291
  • Mass: 32844
  • Checksum: B62134DD1BEB636B
  • Sequence:
    • MERKRWECPA LPQGWEREEV PRRSGLSAGH RDVFYYSPSG KKFRSKPQLA RYLGGSMDLS 
TFDFRTGKML MSKMNKSRQR VRYDSSNQVK GKPDLNTALP VRQTASIFKQ PVTKITNHPS 
NKVKSDPQKA VDQPRQLFWE KKLSGLNAFD IAEELVKTMD LPKGLQGVGP GCTDETLLSA 
IASALHTSTM PITGQLSAAV EKNPGVWLNT TQPLCKAFMV TDEDIRKQEE LVQQVRKRLE 
EALMADMLAH VEELARDGEA PLDKACAEDD DEEDEEEEEE EPDPDPEMEH V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.