POLR2B | ENSG00000047315 | NCBI 5431

Details for: POLR2B

Gene ID: 5431

Symbol: POLR2B

Ensembl ID: ENSG00000047315

Description: RNA polymerase II subunit B

Associated with

Abortive elongation of hiv-1 transcript in the absence of tat
(R-HSA-167242)
Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Cell cycle
(R-HSA-1640170)
Chromosome maintenance
(R-HSA-73886)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Dna repair
(R-HSA-73894)
Dual incision in tc-ner
(R-HSA-6782135)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Fgfr2 alternative splicing
(R-HSA-6803529)
Fgfr2 mutant receptor activation
(R-HSA-1839126)
Formation of hiv-1 elongation complex containing hiv-1 tat
(R-HSA-167200)
Formation of hiv elongation complex in the absence of hiv tat
(R-HSA-167152)
Formation of rna pol ii elongation complex
(R-HSA-112382)
Formation of tc-ner pre-incision complex
(R-HSA-6781823)
Formation of the early elongation complex
(R-HSA-113418)
Formation of the hiv-1 early elongation complex
(R-HSA-167158)
Gap-filling dna repair synthesis and ligation in tc-ner
(R-HSA-6782210)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hiv elongation arrest and recovery
(R-HSA-167287)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Hiv transcription elongation
(R-HSA-167169)
Hiv transcription initiation
(R-HSA-167161)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Late phase of hiv life cycle
(R-HSA-162599)
Metabolism of rna
(R-HSA-8953854)
Microrna (mirna) biogenesis
(R-HSA-203927)
Mrna capping
(R-HSA-72086)
Mrna splicing
(R-HSA-72172)
Mrna splicing - major pathway
(R-HSA-72163)
Mrna splicing - minor pathway
(R-HSA-72165)
Nucleotide excision repair
(R-HSA-5696398)
Pausing and recovery of hiv elongation
(R-HSA-167290)
Pausing and recovery of tat-mediated hiv elongation
(R-HSA-167238)
Piwi-interacting rna (pirna) biogenesis
(R-HSA-5601884)
Processing of capped intron-containing pre-mrna
(R-HSA-72203)
Rna pol ii ctd phosphorylation and interaction with ce
(R-HSA-77075)
Rna pol ii ctd phosphorylation and interaction with ce during hiv infection
(R-HSA-167160)
Rna polymerase ii hiv promoter escape
(R-HSA-167162)
Rna polymerase ii pre-transcription events
(R-HSA-674695)
Rna polymerase ii promoter escape
(R-HSA-73776)
Rna polymerase ii transcribes snrna genes
(R-HSA-6807505)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase ii transcription elongation
(R-HSA-75955)
Rna polymerase ii transcription initiation
(R-HSA-75953)
Rna polymerase ii transcription initiation and promoter clearance
(R-HSA-76042)
Rna polymerase ii transcription pre-initiation and promoter opening
(R-HSA-73779)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 iiia tm
(R-HSA-8851708)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Tat-mediated elongation of the hiv-1 transcript
(R-HSA-167246)
Tat-mediated hiv elongation arrest and recovery
(R-HSA-167243)
Telomere maintenance
(R-HSA-157579)
Tp53 regulates transcription of dna repair genes
(R-HSA-6796648)
Transcription-coupled nucleotide excision repair (tc-ner)
(R-HSA-6781827)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcription of the hiv genome
(R-HSA-167172)
Viral infection pathways
(R-HSA-9824446)
Viral messenger rna synthesis
(R-HSA-168325)
Chromatin binding
(GO:0003682)
Chromosome, telomeric region
(GO:0000781)
Dna-directed 5'-3' rna polymerase activity
(GO:0003899)
Dna binding
(GO:0003677)
Hydrolase activity
(GO:0016787)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Ribonucleoside binding
(GO:0032549)
Rna-dependent rna polymerase activity
(GO:0003968)
Rna-templated transcription
(GO:0001172)
Rna binding
(GO:0003723)
Rna polymerase ii, core complex
(GO:0005665)
Rna polymerase ii activity
(GO:0001055)
Transcription by rna polymerase ii
(GO:0006366)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 287.8905
Cell Significance Index: -44.7800
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 171.9343
Cell Significance Index: -43.6100
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 124.7003
Cell Significance Index: -51.3700
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 107.4297
Cell Significance Index: -50.7200
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 101.7828
Cell Significance Index: -41.3500
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 93.0139
Cell Significance Index: -47.8500
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 43.5091
Cell Significance Index: -41.5400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 39.9122
Cell Significance Index: -49.2100
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 17.1528
Cell Significance Index: -45.9500
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 12.7938
Cell Significance Index: -50.4900
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 11.5385
Cell Significance Index: -35.4400
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 9.8694
Cell Significance Index: -21.6000
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 3.2903
Cell Significance Index: 227.5400
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 2.7599
Cell Significance Index: 2491.9500
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.8711
Cell Significance Index: 203.5200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.4315
Cell Significance Index: 232.8300
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.2917
Cell Significance Index: 34.4900
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.2646
Cell Significance Index: 35.3400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.1367
Cell Significance Index: 228.0300
Cell Name: decidual cell (CL2000002)
Fold Change: 1.1257
Cell Significance Index: 18.0600
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.0924
Cell Significance Index: 216.8000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.0031
Cell Significance Index: 180.8400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.8257
Cell Significance Index: 101.5300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.7457
Cell Significance Index: 102.4000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7342
Cell Significance Index: 21.1600
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.7319
Cell Significance Index: 399.7300
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.6946
Cell Significance Index: 36.1800
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.6663
Cell Significance Index: 239.0000
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.6454
Cell Significance Index: 41.6400
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.6418
Cell Significance Index: 29.0900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.5810
Cell Significance Index: 256.8900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.5194
Cell Significance Index: 61.2500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.5004
Cell Significance Index: 26.2800
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.4912
Cell Significance Index: 13.3700
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.4205
Cell Significance Index: 19.7700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4013
Cell Significance Index: 39.7000
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.3794
Cell Significance Index: 23.3200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.3597
Cell Significance Index: 16.7700
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.3380
Cell Significance Index: 25.9400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.3373
Cell Significance Index: 18.9300
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3188
Cell Significance Index: 220.5200
Cell Name: odontoblast (CL0000060)
Fold Change: 0.3075
Cell Significance Index: 39.4200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.2631
Cell Significance Index: 18.6100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1720
Cell Significance Index: 10.8400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.1699
Cell Significance Index: 12.6600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1488
Cell Significance Index: 7.7300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1393
Cell Significance Index: 23.7800
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.1354
Cell Significance Index: 2.3200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0765
Cell Significance Index: 144.0100
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.0534
Cell Significance Index: 1.5300
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0491
Cell Significance Index: 75.6100
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0448
Cell Significance Index: 82.6800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0374
Cell Significance Index: 23.7300
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.0277
Cell Significance Index: 0.5400
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0276
Cell Significance Index: 12.5200
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0197
Cell Significance Index: 3.7500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0055
Cell Significance Index: 7.5200
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0068
Cell Significance Index: -0.8800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0213
Cell Significance Index: -15.7900
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0235
Cell Significance Index: -17.2600
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0280
Cell Significance Index: -17.5000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0319
Cell Significance Index: -24.1800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0391
Cell Significance Index: -5.6800
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0551
Cell Significance Index: -31.0800
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0608
Cell Significance Index: -4.0900
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0985
Cell Significance Index: -20.7400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1017
Cell Significance Index: -3.5800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1146
Cell Significance Index: -11.7100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1303
Cell Significance Index: -14.9300
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1410
Cell Significance Index: -2.3600
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1411
Cell Significance Index: -40.5900
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1451
Cell Significance Index: -3.0900
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.2036
Cell Significance Index: -1.8800
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2294
Cell Significance Index: -26.7300
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2334
Cell Significance Index: -26.6400
Cell Name: peg cell (CL4033014)
Fold Change: -0.3043
Cell Significance Index: -7.0300
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3473
Cell Significance Index: -12.0700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.3508
Cell Significance Index: -7.6000
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3819
Cell Significance Index: -39.7600
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.4368
Cell Significance Index: -5.9600
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.4567
Cell Significance Index: -12.0100
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.4607
Cell Significance Index: -13.5300
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.4658
Cell Significance Index: -9.7500
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.4741
Cell Significance Index: -5.8800
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.4754
Cell Significance Index: -15.2300
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4888
Cell Significance Index: -21.6200
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5162
Cell Significance Index: -40.8800
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.5175
Cell Significance Index: -12.4100
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.5297
Cell Significance Index: -7.8200
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.5723
Cell Significance Index: -15.3400
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.5909
Cell Significance Index: -15.1900
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.5924
Cell Significance Index: -15.1400
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.6250
Cell Significance Index: -8.9800
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.6417
Cell Significance Index: -24.3000
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.6937
Cell Significance Index: -4.7000
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.7543
Cell Significance Index: -4.5600
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.8137
Cell Significance Index: -49.8900
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.8182
Cell Significance Index: -23.3500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.8207
Cell Significance Index: -49.2700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.8339
Cell Significance Index: -22.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Subunit of RNAP II:** POLR2B is a conserved subunit of the RNAP II complex, which is composed of five subunits (RPB1, RPB2, RPB3, RPB4, and RPB5). 2. **Transcriptional Regulation:** POLR2B is involved in the regulation of gene expression, including transcription initiation, elongation, and termination. 3. **Viral Infections:** POLR2B plays a critical role in the transcription of viral genomes, particularly in the context of HIV-1 and influenza viruses. 4. **Immune Response:** POLR2B is significantly expressed in immune cells, suggesting its involvement in regulating immune responses and gene expression in these cells. **Pathways and Functions:** 1. **Transcriptional Regulation:** POLR2B is involved in the regulation of gene expression through the recruitment of transcription factors, RNA polymerase II, and other transcriptional regulators. 2. **Viral Transcription:** POLR2B is essential for the transcription of viral genomes, including HIV-1 and influenza viruses. 3. **Immune Response:** POLR2B is involved in regulating immune responses, including the transcription of genes involved in inflammation, immune cell development, and cytokine production. 4. **Telomere Maintenance:** POLR2B is involved in the maintenance of telomeres, which are essential for the stability of chromosomes. **Clinical Significance:** 1. **HIV-1 Infection:** POLR2B is a critical component of the HIV-1 transcription complex, and its dysregulation can lead to impaired transcriptional regulation and viral replication. 2. **Cancer:** POLR2B is overexpressed in various types of cancer, suggesting its potential role in tumorigenesis and cancer progression. 3. **Autoimmune Diseases:** POLR2B is involved in the regulation of immune responses, and its dysregulation can contribute to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 4. **Neurological Disorders:** POLR2B is expressed in neural cells, and its dysregulation has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, POLR2B is a critical component of the RNAP II complex, playing a pivotal role in regulating gene expression, particularly in the context of immune response and viral infections. Its dysregulation can contribute to various diseases, highlighting the importance of understanding its function and regulation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 354198557

Symbol: RPB2_HUMAN

Name: DNA-directed RNA polymerase II subunit RPB2

UniProtKB Accession Codes:

P30876 A8K1A8 Q8IZ61

Database IDs:

Citations:

PubMed ID: 1518060

Title: Primary structure of the second largest subunit of human RNA polymerase II (or B).

PubMed ID: 1518060

DOI: 10.1016/0022-2836(92)91071-v

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

DOI: 10.1101/gr.7.4.353

PubMed ID: 8381534

Title: Identification of a 3'-->5' exonuclease activity associated with human RNA polymerase II.

PubMed ID: 8381534

DOI: 10.1073/pnas.90.3.843

PubMed ID: 9852112

Title: Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes.

PubMed ID: 9852112

DOI: 10.1074/jbc.273.51.34444

PubMed ID: 14992727

Title: Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus.

PubMed ID: 14992727

DOI: 10.1016/s1097-2765(04)00081-4

PubMed ID: 17998332

Title: Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes.

PubMed ID: 17998332

DOI: 10.1128/mcb.01356-07

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23395899

Title: RNA polymerase II acts as an RNA-dependent RNA polymerase to extend and destabilize a non-coding RNA.

PubMed ID: 23395899

DOI: 10.1038/emboj.2013.18

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 27193682

Title: Near-atomic resolution visualization of human transcription promoter opening.

PubMed ID: 27193682

DOI: 10.1038/nature17970

PubMed ID: 30190596

Title: Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1.

PubMed ID: 30190596

DOI: 10.1038/s41594-018-0118-5

Sequence Information:

Length: 1174
Mass: 133897
Checksum: 32BEDF7F95E4DE10
Sequence:

MYDADEDMQY DEDDDEITPD LWQEACWIVI SSYFDEKGLV RQQLDSFDEF IQMSVQRIVE 
DAPPIDLQAE AQHASGEVEE PPRYLLKFEQ IYLSKPTHWE RDGAPSPMMP NEARLRNLTY 
SAPLYVDITK TVIKEGEEQL QTQHQKTFIG KIPIMLRSTY CLLNGLTDRD LCELNECPLD 
PGGYFIINGS EKVLIAQEKM ATNTVYVFAK KDSKYAYTGE CRSCLENSSR PTSTIWVSML 
ARGGQGAKKS AIGQRIVATL PYIKQEVPII IVFRALGFVS DRDILEHIIY DFEDPEMMEM 
VKPSLDEAFV IQEQNVALNF IGSRGAKPGV TKEKRIKYAK EVLQKEMLPH VGVSDFCETK 
KAYFLGYMVH RLLLAALGRR ELDDRDHYGN KRLDLAGPLL AFLFRGMFKN LLKEVRIYAQ 
KFIDRGKDFN LELAIKTRII SDGLKYSLAT GNWGDQKKAH QARAGVSQVL NRLTFASTLS 
HLRRLNSPIG RDGKLAKPRQ LHNTLWGMVC PAETPEGHAV GLVKNLALMA YISVGSQPSP 
ILEFLEEWSM ENLEEISPAA IADATKIFVN GCWVGIHKDP EQLMNTLRKL RRQMDIIVSE 
VSMIRDIRER EIRIYTDAGR ICRPLLIVEK QKLLLKKRHI DQLKEREYNN YSWQDLVASG 
VVEYIDTLEE ETVMLAMTPD DLQEKEVAYC STYTHCEIHP SMILGVCASI IPFPDHNQSP 
RNTYQSAMGK QAMGVYITNF HVRMDTLAHV LYYPQKPLVT TRSMEYLRFR ELPAGINSIV 
AIASYTGYNQ EDSVIMNRSA VDRGFFRSVF YRSYKEQESK KGFDQEEVFE KPTRETCQGM 
RHAIYDKLDD DGLIAPGVRV SGDDVIIGKT VTLPENEDEL ESTNRRYTKR DCSTFLRTSE 
TGIVDQVMVT LNQEGYKFCK IRVRSVRIPQ IGDKFASRHG QKGTCGIQYR QEDMPFTCEG 
ITPDIIINPH AIPSRMTIGH LIECLQGKVS ANKGEIGDAT PFNDAVNVQK ISNLLSDYGY 
HLRGNEVLYN GFTGRKITSQ IFIGPTYYQR LKHMVDDKIH SRARGPIQIL NRQPMEGRSR 
DGGLRFGEME RDCQIAHGAA QFLRERLFEA SDPYQVHVCN LCGIMAIANT RTHTYECRGC 
RNKTQISLVR MPYACKLLFQ ELMSMSIAPR MMSV

Genular Protein ID: 1853661889

Symbol: B4DHJ3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DHJ3

Database IDs:

Sequence Information:

Length: 1167
Mass: 133027
Checksum: 79754AB8ABB17D0B
Sequence:

MQYDEDDDEI TPDLWQEACW IVISSYFDEK GLVRQQLDSF DEFIQMSVQR IVEDAPPIDL 
QAEAQHASGE VEEPPRYLLK FEQIYLSKPT HRERDGAPSP MMPNEARLRN LTYSAPLYVD 
ITKTVIKEGE EQLQTQHQKT FIGKIPIMLR STYCLLNGLT DRDLCELNEC PLDPGGYFII 
NGSEKVLIAQ EKMATNTVYV FAKKDSKYAY TGECRSCLEN SSRPTSTIWV SMLARGGQGA 
KKSAIGQRIV ATLPYIKQEV PIIIVFRALG FVSDRDILEH IIYDFEDPEM MEMVKPSLDE 
AFVIQEQNVA LNFIGSRGAK PGVTKEKRIK YAKEVLQKEM LPHVGVSDFC ETKKAYFLGY 
MVHRLLLAAL GRRELDDRDH YGNKRLDLAG PLLAFLFRGM FKNLLKEVRI YAQKFIDRGK 
DFNLELAIKT RIISDGLKYS LATGNWGDQK KAHQARAGVS QVLNRLTFAS TLSHLRRLNS 
PIGRDGKLAK PRQLHNTLWG MVCPAETPEG HAVGLVKNLA LMAYISVGSQ PSPILEFLEE 
WSMENLEEIS PAAIADATKI FVNGCWVGIH KDPEQLMNTL RKLRRQMDII VSEVSMIRDI 
REREIRIYTD AGRICRPLLI VEKQKLLLKK RHIDQLKERE YNNYSWQDLV ASGVVEYIDT 
LEEETVMLAM TPDDLQEKEV AYCSTYTHCE IHPSMILGVC ASIIPFPDHN QSPRNTYQSA 
MGKQAMGVYI TNFHVRMDTL AHVLYYPQKP LVTTRSMEYL RFRELPAGIN SIVAIASYTG 
YNQEDSVIMN RSAVDRGFFR SVFYRSYKEQ ESKKGFDQEE VFEKPTRETC QGMRHAIYDK 
LDDDGLIAPG VRVSGDDVII GKTVTLPENE DELESTNRRY TKRDCSTFLR TSETGIVDQV 
MVTLNQEGYK FCKIRVRSVR IPQIGDKFAS RHGQKGTCGI QYRQEDMPFT CEGITPDIII 
NPHAIPSRMT IGHLIECLQG KVSANKGEIG DATPFNDAVN VQKISNLLSD YGYHLRGNEV 
LYNGFTGRKI TSQIFIGPTY YQRLKHMVDD KIHSRARGPI QILNRQPMEG RSRDGGLRFG 
EMERDCQIAH GAAQFLRERL FEASDPYQVH VCNLCGIMAI ANTRTHTYEC RGCRNKTQIS 
LVRMPYACKL LFQELMSMSI APRMMSV

Genular Protein ID: 1590192009

Symbol: B4DH29_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DH29

Database IDs:

Sequence Information:

Length: 1099
Mass: 125219
Checksum: D610267D44614F74
Sequence:

MLDCNQPRYL LKFEQIYLSK PTHWERDGAP SPMMPNEARL RNLTYSAPLY VDITKTVIKE 
GEEQLQTQHQ KTFIGKIPIM LRSTYCLLNG LTDRDLCELN ECPLDPGGYF IINGSEKVLI 
AQEKMATNTV YVFAKKDSKY AYTGECRSCL ENSSRPTSTI WVSMLARGGQ GAKKSAIGQR 
IVATLPYIKQ EVPIIIVFRA LGFVSDRDIL EHIIYDFEDP EMMEMVKPSL DEAFVIQEQN 
VALNFIGSRG AKPGVTKEKR IKYAKEVLQK EMLPHVGVSD FCETKKAYFL GYMVHRLLLA 
ALGRRELDDR DHYGNKRLDL AGPLLAFLFR GMFKNLLKEV RIYAQKFIDR GKDFNLELAI 
KTRIISDGLK YSLATGNWGD QKKAHQARAG VSQVLNRLTF ASTLSHLRRL NSPIGRDGKL 
AKPRQLHNTL WGMVCPAETP EGHAVGLVKN LALMAYISVG SQPSPILEFL EEWSMENLEE 
ISPAAIADAT KIFVNGCWVG IHKDPEQLMN TLRKLRRQMD IIVSEVSMIR DIREREIRIY 
TDAGRICRPL LIVEKQKLLL KKRHIDQLKE REYNNYSWQD LVASGVVEYI DTLEEETVML 
AMTPDDLQEK EVAYCSTYTH CEIHPSMILG VCASIIPFPD HNQSPRNTYQ SAMGKQAMGV 
YITNFHVRMD TLAHVLYYPQ KPLVTTRSME YLRFRELPAG INSIVAIASY TGYNQEDSVI 
MNRSAVDRSF FRSVFYRSYK EQESKKGFDQ EEVFEKPTRE TCQGMRHAIY DKLDDDGLIA 
PGVRVSGDDV IIGKTVTLPE NEDELESTNR RYTKRDCSTF LRTSETGIVD QVMVTLNQEG 
YKFCKIRVRS VRIPQIGDKF ASRHGQKGTC GIQYRQEDMP FTCEGITPDI IINPHAIPSR 
MTIGHLIECL QGKVSANKGE IGDATPFNDA VNVQKISNLL SDYGYHLRGN EVLYNGFTGR 
KITSQIFIGP TYYQRLKHMV DDKIHSRARG PIQILNRQPM EGRSRDGGLR FGEMERDCQI 
AHGAAQFLRE RLFEASDPYQ VHVCNLCGIM AIANTRTHTY ECRGCRNKTQ ISLVRMPYAC 
KLLFQELMSM SIAPRMMSV

Genular Protein ID: 1469814631

Symbol: C9J2Y9_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9J2Y9

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

Sequence Information:

Length: 1167
Mass: 133057
Checksum: DD600BBDDA6BCD0A
Sequence:

MQYDEDDDEI TPDLWQEACW IVISSYFDEK GLVRQQLDSF DEFIQMSVQR IVEDAPPIDL 
QAEAQHASGE VEEPPRYLLK FEQIYLSKPT HWERDGAPSP MMPNEARLRN LTYSAPLYVD 
ITKTVIKEGE EQLQTQHQKT FIGKIPIMLR STYCLLNGLT DRDLCELNEC PLDPGGYFII 
NGSEKVLIAQ EKMATNTVYV FAKKDSKYAY TGECRSCLEN SSRPTSTIWV SMLARGGQGA 
KKSAIGQRIV ATLPYIKQEV PIIIVFRALG FVSDRDILEH IIYDFEDPEM MEMVKPSLDE 
AFVIQEQNVA LNFIGSRGAK PGVTKEKRIK YAKEVLQKEM LPHVGVSDFC ETKKAYFLGY 
MVHRLLLAAL GRRELDDRDH YGNKRLDLAG PLLAFLFRGM FKNLLKEVRI YAQKFIDRGK 
DFNLELAIKT RIISDGLKYS LATGNWGDQK KAHQARAGVS QVLNRLTFAS TLSHLRRLNS 
PIGRDGKLAK PRQLHNTLWG MVCPAETPEG HAVGLVKNLA LMAYISVGSQ PSPILEFLEE 
WSMENLEEIS PAAIADATKI FVNGCWVGIH KDPEQLMNTL RKLRRQMDII VSEVSMIRDI 
REREIRIYTD AGRICRPLLI VEKQKLLLKK RHIDQLKERE YNNYSWQDLV ASGVVEYIDT 
LEEETVMLAM TPDDLQEKEV AYCSTYTHCE IHPSMILGVC ASIIPFPDHN QSPRNTYQSA 
MGKQAMGVYI TNFHVRMDTL AHVLYYPQKP LVTTRSMEYL RFRELPAGIN SIVAIASYTG 
YNQEDSVIMN RSAVDRGFFR SVFYRSYKEQ ESKKGFDQEE VFEKPTRETC QGMRHAIYDK 
LDDDGLIAPG VRVSGDDVII GKTVTLPENE DELESTNRRY TKRDCSTFLR TSETGIVDQV 
MVTLNQEGYK FCKIRVRSVR IPQIGDKFAS RHGQKGTCGI QYRQEDMPFT CEGITPDIII 
NPHAIPSRMT IGHLIECLQG KVSANKGEIG DATPFNDAVN VQKISNLLSD YGYHLRGNEV 
LYNGFTGRKI TSQIFIGPTY YQRLKHMVDD KIHSRARGPI QILNRQPMEG RSRDGGLRFG 
EMERDCQIAH GAAQFLRERL FEASDPYQVH VCNLCGIMAI ANTRTHTYEC RGCRNKTQIS 
LVRMPYACKL LFQELMSMSI APRMMSV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: POLR2B

Associated with

Cells (max top 100)

Other Information

Primary structure of the second largest subunit of human RNA polymerase II (or B). PubMed ID: 1518060

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Large-scale concatenation cDNA sequencing. PubMed ID: 9110174

Identification of a 3'--&gt;5' exonuclease activity associated with human RNA polymerase II. PubMed ID: 8381534

Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. PubMed ID: 9852112

Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. PubMed ID: 14992727

Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes. PubMed ID: 17998332

Initial characterization of the human central proteome. PubMed ID: 21269460

RNA polymerase II acts as an RNA-dependent RNA polymerase to extend and destabilize a non-coding RNA. PubMed ID: 23395899

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

Near-atomic resolution visualization of human transcription promoter opening. PubMed ID: 27193682

Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1. PubMed ID: 30190596

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

Database document:

PubMed ID: 1518060

PubMed ID: 14702039

PubMed ID: 15489334

PubMed ID: 9110174

PubMed ID: 8381534

PubMed ID: 9852112

PubMed ID: 14992727

PubMed ID: 17998332

PubMed ID: 21269460

PubMed ID: 23395899

PubMed ID: 23186163

PubMed ID: 24275569

PubMed ID: 24129315

PubMed ID: 27193682

PubMed ID: 30190596

PubMed ID: 11237011

PubMed ID: 15496913

PubMed ID: 15815621

PubMed ID: 21269460

PubMed ID: 23186163

PubMed ID: 24275569

PubMed ID: 24129315