POLR2C | ENSG00000102978 | NCBI 5432

Details for: POLR2C

Gene ID: 5432

Symbol: POLR2C

Ensembl ID: ENSG00000102978

Description: RNA polymerase II subunit C

Associated with

Abortive elongation of hiv-1 transcript in the absence of tat
(R-HSA-167242)
Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Cell cycle
(R-HSA-1640170)
Chromosome maintenance
(R-HSA-73886)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Dna repair
(R-HSA-73894)
Dual incision in tc-ner
(R-HSA-6782135)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Fgfr2 alternative splicing
(R-HSA-6803529)
Fgfr2 mutant receptor activation
(R-HSA-1839126)
Formation of hiv-1 elongation complex containing hiv-1 tat
(R-HSA-167200)
Formation of hiv elongation complex in the absence of hiv tat
(R-HSA-167152)
Formation of rna pol ii elongation complex
(R-HSA-112382)
Formation of tc-ner pre-incision complex
(R-HSA-6781823)
Formation of the early elongation complex
(R-HSA-113418)
Formation of the hiv-1 early elongation complex
(R-HSA-167158)
Gap-filling dna repair synthesis and ligation in tc-ner
(R-HSA-6782210)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hiv elongation arrest and recovery
(R-HSA-167287)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Hiv transcription elongation
(R-HSA-167169)
Hiv transcription initiation
(R-HSA-167161)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Late phase of hiv life cycle
(R-HSA-162599)
Metabolism of rna
(R-HSA-8953854)
Microrna (mirna) biogenesis
(R-HSA-203927)
Mrna capping
(R-HSA-72086)
Mrna splicing
(R-HSA-72172)
Mrna splicing - major pathway
(R-HSA-72163)
Mrna splicing - minor pathway
(R-HSA-72165)
Nucleotide excision repair
(R-HSA-5696398)
Pausing and recovery of hiv elongation
(R-HSA-167290)
Pausing and recovery of tat-mediated hiv elongation
(R-HSA-167238)
Piwi-interacting rna (pirna) biogenesis
(R-HSA-5601884)
Processing of capped intron-containing pre-mrna
(R-HSA-72203)
Rna pol ii ctd phosphorylation and interaction with ce
(R-HSA-77075)
Rna pol ii ctd phosphorylation and interaction with ce during hiv infection
(R-HSA-167160)
Rna polymerase ii hiv promoter escape
(R-HSA-167162)
Rna polymerase ii pre-transcription events
(R-HSA-674695)
Rna polymerase ii promoter escape
(R-HSA-73776)
Rna polymerase ii transcribes snrna genes
(R-HSA-6807505)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase ii transcription elongation
(R-HSA-75955)
Rna polymerase ii transcription initiation
(R-HSA-75953)
Rna polymerase ii transcription initiation and promoter clearance
(R-HSA-76042)
Rna polymerase ii transcription pre-initiation and promoter opening
(R-HSA-73779)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 iiia tm
(R-HSA-8851708)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Tat-mediated elongation of the hiv-1 transcript
(R-HSA-167246)
Tat-mediated hiv elongation arrest and recovery
(R-HSA-167243)
Telomere maintenance
(R-HSA-157579)
Tp53 regulates transcription of dna repair genes
(R-HSA-6796648)
Transcription-coupled nucleotide excision repair (tc-ner)
(R-HSA-6781827)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcription of the hiv genome
(R-HSA-167172)
Viral infection pathways
(R-HSA-9824446)
Viral messenger rna synthesis
(R-HSA-168325)
Cytosol
(GO:0005829)
Dna binding
(GO:0003677)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Rna polymerase ii, core complex
(GO:0005665)
Rna polymerase ii activity
(GO:0001055)
Transcription by rna polymerase ii
(GO:0006366)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 205.3422
Cell Significance Index: -31.9400
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 120.1293
Cell Significance Index: -30.4700
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 100.2130
Cell Significance Index: -41.2800
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 82.1155
Cell Significance Index: -33.3600
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 81.3772
Cell Significance Index: -38.4200
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 74.0010
Cell Significance Index: -38.0700
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 30.1755
Cell Significance Index: -37.2100
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 9.7840
Cell Significance Index: -26.2100
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 9.7591
Cell Significance Index: -38.5100
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 7.5762
Cell Significance Index: -23.2700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 2.1407
Cell Significance Index: 348.1700
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.7698
Cell Significance Index: 19.2400
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.7275
Cell Significance Index: 36.1600
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 1.6643
Cell Significance Index: 13.9800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.5725
Cell Significance Index: 82.5600
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.5684
Cell Significance Index: 54.5000
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.5588
Cell Significance Index: 93.5800
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.4926
Cell Significance Index: 162.3500
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.9419
Cell Significance Index: 7.2600
Cell Name: kidney cell (CL1000497)
Fold Change: 0.9218
Cell Significance Index: 7.3600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.8467
Cell Significance Index: 116.2700
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.8097
Cell Significance Index: 21.2900
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.7773
Cell Significance Index: 53.7600
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.7698
Cell Significance Index: 48.5200
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.7198
Cell Significance Index: 8.5800
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.6929
Cell Significance Index: 44.7100
Cell Name: odontoblast (CL0000060)
Fold Change: 0.6924
Cell Significance Index: 88.7700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.6572
Cell Significance Index: 30.6400
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.6334
Cell Significance Index: 280.0500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.5811
Cell Significance Index: 71.4600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.5683
Cell Significance Index: 26.7100
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.5652
Cell Significance Index: 16.6000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.5604
Cell Significance Index: 101.0200
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.5524
Cell Significance Index: 41.1700
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.5492
Cell Significance Index: 14.9500
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.5312
Cell Significance Index: 290.1000
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.5186
Cell Significance Index: 36.6800
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.4880
Cell Significance Index: 57.5500
Cell Name: lactocyte (CL0002325)
Fold Change: 0.4070
Cell Significance Index: 52.5900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.4057
Cell Significance Index: 81.3800
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3841
Cell Significance Index: 38.0000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3812
Cell Significance Index: 19.8000
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.3309
Cell Significance Index: 4.2400
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3171
Cell Significance Index: 62.9200
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.2974
Cell Significance Index: 8.7600
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2829
Cell Significance Index: 6.1300
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2479
Cell Significance Index: 171.4300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2285
Cell Significance Index: 43.4800
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.2142
Cell Significance Index: 6.1400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1831
Cell Significance Index: 31.2600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1454
Cell Significance Index: 52.1400
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.1373
Cell Significance Index: 103.9300
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.1347
Cell Significance Index: 1.5300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1286
Cell Significance Index: 5.8300
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.1037
Cell Significance Index: 2.7700
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0412
Cell Significance Index: 0.6900
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0175
Cell Significance Index: 0.4700
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0002
Cell Significance Index: 0.4000
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0022
Cell Significance Index: -1.6100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0027
Cell Significance Index: -1.9900
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0102
Cell Significance Index: -6.3800
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0151
Cell Significance Index: -27.8200
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0176
Cell Significance Index: -27.1000
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0219
Cell Significance Index: -13.8900
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0278
Cell Significance Index: -2.8400
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0281
Cell Significance Index: -38.2500
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0299
Cell Significance Index: -0.3100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0430
Cell Significance Index: -24.2700
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0526
Cell Significance Index: -1.5200
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0590
Cell Significance Index: -26.7600
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0626
Cell Significance Index: -1.7500
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0735
Cell Significance Index: -15.4900
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0751
Cell Significance Index: -1.6000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0912
Cell Significance Index: -13.2500
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.0920
Cell Significance Index: -1.6200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0924
Cell Significance Index: -10.5900
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1008
Cell Significance Index: -29.0000
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1114
Cell Significance Index: -12.9800
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1644
Cell Significance Index: -4.2000
Cell Name: theca cell (CL0000503)
Fold Change: -0.2485
Cell Significance Index: -1.4600
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.2610
Cell Significance Index: -9.1700
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2815
Cell Significance Index: -21.6000
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2863
Cell Significance Index: -32.6800
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.3008
Cell Significance Index: -2.7700
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3404
Cell Significance Index: -20.9200
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3423
Cell Significance Index: -27.1100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3631
Cell Significance Index: -37.8100
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3656
Cell Significance Index: -9.7800
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3897
Cell Significance Index: -12.4800
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3925
Cell Significance Index: -26.3900
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.4022
Cell Significance Index: -22.5700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4556
Cell Significance Index: -27.9300
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.4919
Cell Significance Index: -8.4300
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.5035
Cell Significance Index: -6.8700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.5882
Cell Significance Index: -30.6400
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.6595
Cell Significance Index: -29.1700
Cell Name: peg cell (CL4033014)
Fold Change: -0.6618
Cell Significance Index: -15.2900
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.7112
Cell Significance Index: -18.2800
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.7601
Cell Significance Index: -5.1500
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.7888
Cell Significance Index: -29.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** POLR2C is a 33-kDa subunit of the RNAPII complex, which is a heterotrimeric enzyme consisting of RPB1, RPB2, and RPB3 (POLR2C). This subunit is essential for the assembly of the RNAPII complex and the recruitment of other transcription factors to specific genomic regions. POLR2C is also involved in the regulation of transcription elongation, processivity, and the recruitment of transcriptional coactivators. **Pathways and Functions:** POLR2C is involved in numerous biological pathways, including: 1. **Transcriptional regulation:** POLR2C regulates the transcription of approximately 80% of the human genome, including genes involved in cell cycle regulation, developmental biology, and disease pathology. 2. **DNA repair:** POLR2C is involved in the repair of DNA damage, particularly in the context of telomere maintenance and nucleotide excision repair (NER). 3. **Cell cycle regulation:** POLR2C regulates the cell cycle by controlling the expression of genes involved in DNA replication and repair. 4. **Developmental biology:** POLR2C plays a critical role in the development of various tissues and organs, including the nervous system and the kidney. **Clinical Significance:** Dysregulation of POLR2C has been implicated in various diseases, including: 1. **Cancer:** Mutations in POLR2C have been associated with cancer, particularly in the context of telomere maintenance and DNA repair. 2. **Neurological disorders:** POLR2C dysfunction has been linked to neurological disorders, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). 3. **Kidney disease:** POLR2C mutations have been associated with kidney disease, particularly in the context of telomere maintenance and DNA repair. 4. **Infectious diseases:** POLR2C is involved in the regulation of viral transcription, particularly in the context of HIV-1 infection. **Significantly Expressed Cells:** POLR2C is expressed in a wide range of cell types, including: 1. **Pulmonary interstitial fibroblast** 2. **Pneumocyte** 3. **Epithelial cell of nephron** 4. **GABAergic amacrine cell** 5. **Mesenchymal cell** 6. **Glycinergic neuron** 7. **Type II pneumocyte** 8. **Mesodermal cell** 9. **Kidney epithelial cell** 10. **Glycinergic amacrine cell** **Proteins:** RPB3_HUMAN (DNA-directed RNA polymerase II 33 kDa polypeptide) In conclusion, POLR2C is a critical component of the RNAPII complex, playing a pivotal role in various cellular processes, including transcriptional regulation, DNA repair, and cell cycle regulation. Dysregulation of POLR2C has been implicated in various diseases, highlighting the importance of this gene in human health and disease. Further research is needed to fully elucidate the mechanisms of POLR2C and its role in disease pathology.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

DNA-directed RNA polymerase II 33 kDa polypeptide

Genular Protein ID: 1746573515

Symbol: RPB3_HUMAN

Name: DNA-directed RNA polymerase II 33 kDa polypeptide

UniProtKB Accession Codes:

P19387 O15161

Database IDs:

Citations:

PubMed ID: 2187864

Title: The amino acid sequence of the human RNA polymerase II 33-kDa subunit hRPB 33 is highly conserved among eukaryotes.

PubMed ID: 2187864

DOI: 10.1016/s0021-9258(19)38900-8

PubMed ID: 9540830

Title: Cloning and characterization of the human RNA polymerase I subunit hRPA40.

PubMed ID: 9540830

DOI: 10.1016/s0167-4781(97)00206-6

PubMed ID: 10493829

Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.

PubMed ID: 10493829

DOI: 10.1006/geno.1999.5927

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9852112

Title: Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes.

PubMed ID: 9852112

DOI: 10.1074/jbc.273.51.34444

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 37595871

Title: SHP-1 phosphatase acts as a coactivator of PCK1 transcription to control gluconeogenesis.

PubMed ID: 37595871

DOI: 10.1016/j.jbc.2023.105164

PubMed ID: 27193682

Title: Near-atomic resolution visualization of human transcription promoter opening.

PubMed ID: 27193682

DOI: 10.1038/nature17970

PubMed ID: 30190596

Title: Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1.

PubMed ID: 30190596

DOI: 10.1038/s41594-018-0118-5

Sequence Information:

Length: 275
Mass: 31441
Checksum: EF663BE096046A4B
Sequence:

MPYANQPTVR ITELTDENVK FIIENTDLAV ANSIRRVFIA EVPIIAIDWV QIDANSSVLH 
DEFIAHRLGL IPLISDDIVD KLQYSRDCTC EEFCPECSVE FTLDVRCNED QTRHVTSRDL 
ISNSPRVIPV TSRNRDNDPN DYVEQDDILI VKLRKGQELR LRAYAKKGFG KEHAKWNPTA 
GVAFEYDPDN ALRHTVYPKP EEWPKSEYSE LDEDESQAPY DPNGKPERFY YNVESCGSLR 
PETIVLSALS GLKKKLSDLQ TQLSHEIQSD VLTIN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: POLR2C

Associated with

Cells (max top 100)

Other Information

The amino acid sequence of the human RNA polymerase II 33-kDa subunit hRPB 33 is highly conserved among eukaryotes. PubMed ID: 2187864

Cloning and characterization of the human RNA polymerase I subunit hRPA40. PubMed ID: 9540830

Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. PubMed ID: 10493829

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. PubMed ID: 9852112

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

SHP-1 phosphatase acts as a coactivator of PCK1 transcription to control gluconeogenesis. PubMed ID: 37595871

Near-atomic resolution visualization of human transcription promoter opening. PubMed ID: 27193682

Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1. PubMed ID: 30190596