POLR2E | ENSG00000099817 | NCBI 5434

Details for: POLR2E

Gene ID: 5434

Symbol: POLR2E

Ensembl ID: ENSG00000099817

Description: RNA polymerase II, I and III subunit E

Associated with

Abortive elongation of hiv-1 transcript in the absence of tat
(R-HSA-167242)
Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Cell cycle
(R-HSA-1640170)
Chromosome maintenance
(R-HSA-73886)
Cytosolic sensors of pathogen-associated dna
(R-HSA-1834949)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Dna repair
(R-HSA-73894)
Dual incision in tc-ner
(R-HSA-6782135)
Epigenetic regulation of gene expression
(R-HSA-212165)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Fgfr2 alternative splicing
(R-HSA-6803529)
Fgfr2 mutant receptor activation
(R-HSA-1839126)
Formation of hiv-1 elongation complex containing hiv-1 tat
(R-HSA-167200)
Formation of hiv elongation complex in the absence of hiv tat
(R-HSA-167152)
Formation of rna pol ii elongation complex
(R-HSA-112382)
Formation of tc-ner pre-incision complex
(R-HSA-6781823)
Formation of the early elongation complex
(R-HSA-113418)
Formation of the hiv-1 early elongation complex
(R-HSA-167158)
Gap-filling dna repair synthesis and ligation in tc-ner
(R-HSA-6782210)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hiv elongation arrest and recovery
(R-HSA-167287)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Hiv transcription elongation
(R-HSA-167169)
Hiv transcription initiation
(R-HSA-167161)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Innate immune system
(R-HSA-168249)
Late phase of hiv life cycle
(R-HSA-162599)
Metabolism of rna
(R-HSA-8953854)
Microrna (mirna) biogenesis
(R-HSA-203927)
Mrna capping
(R-HSA-72086)
Mrna splicing
(R-HSA-72172)
Mrna splicing - major pathway
(R-HSA-72163)
Mrna splicing - minor pathway
(R-HSA-72165)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleotide excision repair
(R-HSA-5696398)
Pausing and recovery of hiv elongation
(R-HSA-167290)
Pausing and recovery of tat-mediated hiv elongation
(R-HSA-167238)
Piwi-interacting rna (pirna) biogenesis
(R-HSA-5601884)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Processing of capped intron-containing pre-mrna
(R-HSA-72203)
Rna pol ii ctd phosphorylation and interaction with ce
(R-HSA-77075)
Rna pol ii ctd phosphorylation and interaction with ce during hiv infection
(R-HSA-167160)
Rna polymerase ii hiv promoter escape
(R-HSA-167162)
Rna polymerase iii abortive and retractive initiation
(R-HSA-749476)
Rna polymerase iii chain elongation
(R-HSA-73780)
Rna polymerase iii transcription
(R-HSA-74158)
Rna polymerase iii transcription initiation
(R-HSA-76046)
Rna polymerase iii transcription initiation from type 1 promoter
(R-HSA-76061)
Rna polymerase iii transcription initiation from type 2 promoter
(R-HSA-76066)
Rna polymerase iii transcription initiation from type 3 promoter
(R-HSA-76071)
Rna polymerase iii transcription termination
(R-HSA-73980)
Rna polymerase ii pre-transcription events
(R-HSA-674695)
Rna polymerase ii promoter escape
(R-HSA-73776)
Rna polymerase ii transcribes snrna genes
(R-HSA-6807505)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase ii transcription elongation
(R-HSA-75955)
Rna polymerase ii transcription initiation
(R-HSA-75953)
Rna polymerase ii transcription initiation and promoter clearance
(R-HSA-76042)
Rna polymerase ii transcription pre-initiation and promoter opening
(R-HSA-73779)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i transcription
(R-HSA-73864)
Rna polymerase i transcription initiation
(R-HSA-73762)
Rna polymerase i transcription termination
(R-HSA-73863)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 iiia tm
(R-HSA-8851708)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Tat-mediated elongation of the hiv-1 transcript
(R-HSA-167246)
Tat-mediated hiv elongation arrest and recovery
(R-HSA-167243)
Telomere maintenance
(R-HSA-157579)
Tp53 regulates transcription of dna repair genes
(R-HSA-6796648)
Transcription-coupled nucleotide excision repair (tc-ner)
(R-HSA-6781827)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcription of the hiv genome
(R-HSA-167172)
Viral infection pathways
(R-HSA-9824446)
Viral messenger rna synthesis
(R-HSA-168325)
Dna-directed 5'-3' rna polymerase activity
(GO:0003899)
Dna binding
(GO:0003677)
Rna polymerase i activity
(GO:0001054)
Rna polymerase ii activity
(GO:0001055)
Rna polymerase iii activity
(GO:0001056)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 281.1401
Cell Significance Index: -43.7300
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 164.5815
Cell Significance Index: -41.7500
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 133.4150
Cell Significance Index: -54.9600
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 117.7333
Cell Significance Index: -47.8300
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 114.4406
Cell Significance Index: -54.0300
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 104.5909
Cell Significance Index: -53.8000
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 80.6531
Cell Significance Index: -54.1200
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 50.5581
Cell Significance Index: -48.2700
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 41.9155
Cell Significance Index: -51.6800
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 13.7986
Cell Significance Index: -54.4500
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 11.6980
Cell Significance Index: -35.9300
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 11.5086
Cell Significance Index: -30.8300
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 5.4510
Cell Significance Index: -11.9300
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 4.0013
Cell Significance Index: 43.5000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 3.2783
Cell Significance Index: 68.6200
Cell Name: kidney cell (CL1000497)
Fold Change: 2.7016
Cell Significance Index: 21.5700
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.9240
Cell Significance Index: 24.6400
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.8386
Cell Significance Index: 110.3800
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.6573
Cell Significance Index: 57.5900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.6059
Cell Significance Index: 189.3900
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.5714
Cell Significance Index: 41.3200
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.4521
Cell Significance Index: 793.0400
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.3871
Cell Significance Index: 72.8300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.3652
Cell Significance Index: 63.6500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.3058
Cell Significance Index: 179.3200
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.2541
Cell Significance Index: 80.9100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.1057
Cell Significance Index: 51.9700
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.1033
Cell Significance Index: 198.8900
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.0860
Cell Significance Index: 133.5300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.0700
Cell Significance Index: 79.7500
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.9965
Cell Significance Index: 70.4800
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9501
Cell Significance Index: 154.5300
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.9085
Cell Significance Index: 62.8300
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.9057
Cell Significance Index: 400.4500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.9026
Cell Significance Index: 12.3200
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.8644
Cell Significance Index: 7.9600
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.8638
Cell Significance Index: 25.3700
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.8609
Cell Significance Index: 9.7800
Cell Name: lactocyte (CL0002325)
Fold Change: 0.7780
Cell Significance Index: 100.5200
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.7407
Cell Significance Index: 13.6900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.7171
Cell Significance Index: 19.5200
Cell Name: odontoblast (CL0000060)
Fold Change: 0.6929
Cell Significance Index: 88.8200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.5591
Cell Significance Index: 14.9300
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.5105
Cell Significance Index: 101.3100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.4403
Cell Significance Index: 9.5400
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4336
Cell Significance Index: 19.6600
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.4287
Cell Significance Index: 22.3300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.4087
Cell Significance Index: 81.9800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.3069
Cell Significance Index: 52.4100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2990
Cell Significance Index: 15.5300
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.2387
Cell Significance Index: 6.3900
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1414
Cell Significance Index: 13.9900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1294
Cell Significance Index: 46.4100
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1107
Cell Significance Index: 76.5400
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0957
Cell Significance Index: 86.4300
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0771
Cell Significance Index: 58.3900
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0606
Cell Significance Index: 1.0200
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0476
Cell Significance Index: 9.0600
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0254
Cell Significance Index: 0.7100
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0025
Cell Significance Index: -0.2600
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0040
Cell Significance Index: -0.2600
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0072
Cell Significance Index: -5.3000
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0110
Cell Significance Index: -20.7800
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0112
Cell Significance Index: -7.0200
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0164
Cell Significance Index: -11.9900
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0292
Cell Significance Index: -53.8600
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0350
Cell Significance Index: -1.2300
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0384
Cell Significance Index: -59.1200
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0470
Cell Significance Index: -1.0000
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0486
Cell Significance Index: -66.0900
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0598
Cell Significance Index: -37.9900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0621
Cell Significance Index: -35.0200
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.0854
Cell Significance Index: -1.5100
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1039
Cell Significance Index: -47.1700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1173
Cell Significance Index: -24.7100
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1513
Cell Significance Index: -43.5200
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1554
Cell Significance Index: -18.1100
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1624
Cell Significance Index: -4.1500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2250
Cell Significance Index: -25.7800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2846
Cell Significance Index: -41.3800
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2972
Cell Significance Index: -9.5200
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: -0.3330
Cell Significance Index: -2.0600
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.4204
Cell Significance Index: -11.2700
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4241
Cell Significance Index: -48.4100
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.4719
Cell Significance Index: -31.7300
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.4751
Cell Significance Index: -13.6200
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5159
Cell Significance Index: -53.7200
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5178
Cell Significance Index: -41.0100
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.5288
Cell Significance Index: -32.5100
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.5576
Cell Significance Index: -8.3600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.5753
Cell Significance Index: -44.1500
Cell Name: peg cell (CL4033014)
Fold Change: -0.5852
Cell Significance Index: -13.5200
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.6166
Cell Significance Index: -7.3500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.6697
Cell Significance Index: -37.5800
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.7371
Cell Significance Index: -7.6300
Cell Name: mesodermal cell (CL0000222)
Fold Change: -0.7460
Cell Significance Index: -4.6700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.7615
Cell Significance Index: -46.6900
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.8762
Cell Significance Index: -7.3600
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.8873
Cell Significance Index: -22.1800
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.9074
Cell Significance Index: -15.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** * POLR2E is a subunit of the RNA polymerase II complex, which is composed of five subunits (α, β, β', τ, and ε). * The ε subunit (POLR2E) is responsible for the 5' to 3' direction of RNA synthesis. * POLR2E is required for the transcription of protein-coding genes, microRNAs, and small RNAs. * The gene is highly expressed in hematopoietic cells, epithelial cells, and trophoblast cells. * POLR2E is involved in the regulation of gene expression, including the transcriptional regulation of HIV-1 and other viral genomes. **Pathways and Functions** * **Transcriptional Regulation**: POLR2E plays a central role in the transcriptional regulation of gene expression, including the transcription of protein-coding genes, microRNAs, and small RNAs. * **HIV-1 Transcription**: POLR2E is required for the transcription of HIV-1, and its dysregulation can lead to the aberrant transcription of HIV-1. * **Cell Cycle Regulation**: POLR2E is involved in the regulation of cell cycle progression, particularly during the G1 phase. * **DNA Repair**: POLR2E is involved in the repair of DNA damage, particularly in the context of chromosomal instability. * **Epigenetic Regulation**: POLR2E is involved in the regulation of epigenetic marks, including DNA methylation and histone modification. **Clinical Significance** * **Cancer**: Dysregulation of POLR2E has been implicated in various types of cancer, including breast cancer, lung cancer, and leukemia. * **HIV Infection**: POLR2E is required for the transcription of HIV-1, and its dysregulation can lead to the aberrant transcription of HIV-1. * **Developmental Disorders**: Dysregulation of POLR2E has been implicated in various developmental disorders, including autism spectrum disorder and schizophrenia. * **Telomere Maintenance**: POLR2E is involved in the maintenance of telomeres, and its dysregulation can lead to telomere shortening and cellular aging. In conclusion, the POLR2E gene plays a critical role in the regulation of gene expression, including the transcription of protein-coding genes, microRNAs, and small RNAs. Its dysregulation has been implicated in various diseases, including cancer, HIV infection, and developmental disorders. Further research is needed to fully understand the mechanisms by which POLR2E regulates gene expression and its implications for human health.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

DNA-directed RNA polymerases I, II, and III subunit RPABC1
B4DJ89_HUMAN

Genular Protein ID: 3255455578

Symbol: RPAB1_HUMAN

Name: DNA-directed RNA polymerases I, II, and III subunit RPABC1

UniProtKB Accession Codes:

P19388 B2R6L4 D6W5Y1 O43380 Q6PIH5 Q9BT06

Database IDs:

Citations:

PubMed ID: 2753903

Title: Isolation and molecular characterization of a cDNA encoding the 23-kDa subunit of human RNA polymerase II.

PubMed ID: 2753903

DOI: 10.1016/s0021-9258(18)51603-3

PubMed ID: 2071613

Title:

PubMed ID: 2071613

DOI: 10.1016/s0021-9258(18)98863-0

PubMed ID: 7828586

Title: Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation.

PubMed ID: 7828586

DOI: 10.1002/j.1460-2075.1995.tb06984.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9852112

Title: Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes.

PubMed ID: 9852112

DOI: 10.1074/jbc.273.51.34444

PubMed ID: 9819440

Title: RMP, a novel RNA polymerase II subunit 5-interacting protein, counteracts transactivation by hepatitis B virus X protein.

PubMed ID: 9819440

DOI: 10.1128/mcb.18.12.7546

PubMed ID: 16809778

Title: RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor.

PubMed ID: 16809778

DOI: 10.1128/mcb.00230-06

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20413673

Title: Defining the RNA polymerase III transcriptome: Genome-wide localization of the RNA polymerase III transcription machinery in human cells.

PubMed ID: 20413673

DOI: 10.1101/gr.101337.109

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31738558

Title: Upstream ORF-Encoded ASDURF Is a Novel Prefoldin-like Subunit of the PAQosome.

PubMed ID: 31738558

DOI: 10.1021/acs.jproteome.9b00599

PubMed ID: 27193682

Title: Near-atomic resolution visualization of human transcription promoter opening.

PubMed ID: 27193682

DOI: 10.1038/nature17970

PubMed ID: 30190596

Title: Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1.

PubMed ID: 30190596

DOI: 10.1038/s41594-018-0118-5

PubMed ID: 33335104

Title: Structure of human RNA polymerase III.

PubMed ID: 33335104

DOI: 10.1038/s41467-020-20262-5

PubMed ID: 34671025

Title: Structure of the human RNA polymerase I elongation complex.

PubMed ID: 34671025

DOI: 10.1038/s41421-021-00335-5

PubMed ID: 33674783

Title: Structure of human RNA polymerase III elongation complex.

PubMed ID: 33674783

DOI: 10.1038/s41422-021-00472-2

PubMed ID: 34675218

Title: Structural insights into RNA polymerase III-mediated transcription termination through trapping poly-deoxythymidine.

PubMed ID: 34675218

DOI: 10.1038/s41467-021-26402-9

PubMed ID: 33558764

Title: Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states.

PubMed ID: 33558764

DOI: 10.1038/s41594-020-00555-5

PubMed ID: 34887565

Title: Cryo-EM structures of human RNA polymerase I.

PubMed ID: 34887565

DOI: 10.1038/s41594-021-00693-4

PubMed ID: 33558766

Title: Structural insights into transcriptional regulation of human RNA polymerase III.

PubMed ID: 33558766

DOI: 10.1038/s41594-021-00557-x

PubMed ID: 36271492

Title: The human RNA polymerase I structure reveals an HMG-like docking domain specific to metazoans.

PubMed ID: 36271492

DOI: 10.26508/lsa.202201568

Sequence Information:

Length: 210
Mass: 24551
Checksum: 1E88AFDBCF9C8535
Sequence:

MDDEEETYRL WKIRKTIMQL CHDRGYLVTQ DELDQTLEEF KAQSGDKPSE GRPRRTDLTV 
LVAHNDDPTD QMFVFFPEEP KVGIKTIKVY CQRMQEENIT RALIVVQQGM TPSAKQSLVD 
MAPKYILEQF LQQELLINIT EHELVPEHVV MTKEEVTELL ARYKLRENQL PRIQAGDPVA 
RYFGIKRGQV VKIIRPSETA GRYITYRLVQ

Genular Protein ID: 123653964

Symbol: B4DJ89_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DJ89

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

Length: 117
Mass: 13548
Checksum: B50927667A951F12
Sequence:

MQEENITRAL IVVQQGMTPS AKQSLVDMAP KYILEQFLQQ ELLINITEHE LVPEHVVMTK 
EEVTELLARY KLRENQLPRI QAGDPVARYF GIKRGQVVKI IRPSETAGRY ITYRLVQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: POLR2E

Associated with

Cells (max top 100)

Other Information

Isolation and molecular characterization of a cDNA encoding the 23-kDa subunit of human RNA polymerase II. PubMed ID: 2753903

PubMed ID: 2071613

Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation. PubMed ID: 7828586

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. PubMed ID: 9852112

RMP, a novel RNA polymerase II subunit 5-interacting protein, counteracts transactivation by hepatitis B virus X protein. PubMed ID: 9819440

RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor. PubMed ID: 16809778

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Defining the RNA polymerase III transcriptome: Genome-wide localization of the RNA polymerase III transcription machinery in human cells. PubMed ID: 20413673

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Upstream ORF-Encoded ASDURF Is a Novel Prefoldin-like Subunit of the PAQosome. PubMed ID: 31738558

Near-atomic resolution visualization of human transcription promoter opening. PubMed ID: 27193682

Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1. PubMed ID: 30190596

Structure of human RNA polymerase III. PubMed ID: 33335104

Structure of the human RNA polymerase I elongation complex. PubMed ID: 34671025

Structure of human RNA polymerase III elongation complex. PubMed ID: 33674783

Structural insights into RNA polymerase III-mediated transcription termination through trapping poly-deoxythymidine. PubMed ID: 34675218

Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states. PubMed ID: 33558764

Cryo-EM structures of human RNA polymerase I. PubMed ID: 34887565

Structural insights into transcriptional regulation of human RNA polymerase III. PubMed ID: 33558766

The human RNA polymerase I structure reveals an HMG-like docking domain specific to metazoans. PubMed ID: 36271492

The sequence of the human genome. PubMed ID: 11181995