Details for: POU3F4

Gene ID: 5456

Symbol: POU3F4

Ensembl ID: ENSG00000196767

Description: POU class 3 homeobox 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 3.6849
    Cell Significance Index: 376.4100
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.5910
    Cell Significance Index: 3.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2084
    Cell Significance Index: 12.8100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1014
    Cell Significance Index: 3.8400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0916
    Cell Significance Index: 4.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0799
    Cell Significance Index: 28.6700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0303
    Cell Significance Index: 0.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0036
    Cell Significance Index: -2.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0037
    Cell Significance Index: -2.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0094
    Cell Significance Index: -1.0700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0158
    Cell Significance Index: -10.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0185
    Cell Significance Index: -3.9000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0219
    Cell Significance Index: -16.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0223
    Cell Significance Index: -6.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0248
    Cell Significance Index: -2.8900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0643
    Cell Significance Index: -0.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0796
    Cell Significance Index: -15.9700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0805
    Cell Significance Index: -36.5500
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1226
    Cell Significance Index: -0.7700
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1518
    Cell Significance Index: -1.3800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1778
    Cell Significance Index: -2.9300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1792
    Cell Significance Index: -3.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2035
    Cell Significance Index: -16.1200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2392
    Cell Significance Index: -2.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2530
    Cell Significance Index: -17.0100
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.2765
    Cell Significance Index: -3.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2937
    Cell Significance Index: -16.4800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2990
    Cell Significance Index: -7.1700
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.3191
    Cell Significance Index: -4.0100
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.3220
    Cell Significance Index: -3.8400
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.3225
    Cell Significance Index: -3.0700
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.3330
    Cell Significance Index: -3.4500
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.3387
    Cell Significance Index: -3.5700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3426
    Cell Significance Index: -3.7300
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.3646
    Cell Significance Index: -3.5000
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.3779
    Cell Significance Index: -3.5000
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.3796
    Cell Significance Index: -2.7600
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.3886
    Cell Significance Index: -3.7700
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.4007
    Cell Significance Index: -3.2500
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.4153
    Cell Significance Index: -2.8800
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.4215
    Cell Significance Index: -3.9800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4286
    Cell Significance Index: -3.6000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4353
    Cell Significance Index: -8.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4698
    Cell Significance Index: -22.0800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4704
    Cell Significance Index: -16.4800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4734
    Cell Significance Index: -16.4500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.4736
    Cell Significance Index: -4.4300
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.4739
    Cell Significance Index: -3.9200
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.4815
    Cell Significance Index: -4.4600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4903
    Cell Significance Index: -16.0500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5045
    Cell Significance Index: -10.9000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5156
    Cell Significance Index: -16.4200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5548
    Cell Significance Index: -16.3400
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.5957
    Cell Significance Index: -4.4400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5999
    Cell Significance Index: -17.1200
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.6154
    Cell Significance Index: -3.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6260
    Cell Significance Index: -16.4600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.6611
    Cell Significance Index: -11.1200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.6739
    Cell Significance Index: -17.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6741
    Cell Significance Index: -31.4300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.6789
    Cell Significance Index: -16.9400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.6849
    Cell Significance Index: -13.4800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.6998
    Cell Significance Index: -12.1000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7284
    Cell Significance Index: -15.9500
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.7304
    Cell Significance Index: -8.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7560
    Cell Significance Index: -21.6700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7632
    Cell Significance Index: -15.0900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7685
    Cell Significance Index: -16.3100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.7757
    Cell Significance Index: -16.1900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.7957
    Cell Significance Index: -16.1900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.8169
    Cell Significance Index: -16.2900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.8190
    Cell Significance Index: -13.2700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.8250
    Cell Significance Index: -7.8200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.8388
    Cell Significance Index: -9.6000
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.8554
    Cell Significance Index: -4.5800
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.8641
    Cell Significance Index: -8.5500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.8800
    Cell Significance Index: -15.0800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.9012
    Cell Significance Index: -17.6200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.9370
    Cell Significance Index: -12.6500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.9413
    Cell Significance Index: -13.4800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.9474
    Cell Significance Index: -15.8600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.9528
    Cell Significance Index: -17.6100
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -1.0158
    Cell Significance Index: -11.9700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.0329
    Cell Significance Index: -17.4000
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -1.0822
    Cell Significance Index: -16.1900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -1.0907
    Cell Significance Index: -14.1500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -1.1256
    Cell Significance Index: -15.7400
  • Cell Name: glial cell (CL0000125)
    Fold Change: -1.1300
    Cell Significance Index: -12.3800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.1630
    Cell Significance Index: -17.1700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -1.1788
    Cell Significance Index: -15.7300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.1815
    Cell Significance Index: -32.1600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -1.2214
    Cell Significance Index: -15.9400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -1.2214
    Cell Significance Index: -16.4700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -1.2291
    Cell Significance Index: -21.0100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -1.2336
    Cell Significance Index: -17.9100
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -1.2399
    Cell Significance Index: -12.4900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -1.2476
    Cell Significance Index: -16.6300
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -1.2541
    Cell Significance Index: -11.4300
  • Cell Name: mural cell (CL0008034)
    Fold Change: -1.2552
    Cell Significance Index: -15.2800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -1.2719
    Cell Significance Index: -15.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **POU domain structure**: POU3F4 contains a characteristic POU domain, a conserved structural motif found in transcription factors of the POU class. This domain is essential for protein-protein interactions, DNA binding, and transcriptional regulation. 2. **Tissue-specific expression**: POU3F4 is expressed in various cell types, including T cells, endothelial cells, plasma cells, B cells, goblet cells, and neurons. This widespread expression suggests a role in multiple cellular processes. 3. **DNA binding specificity**: POU3F4 exhibits sequence-specific DNA binding activity, targeting specific regulatory regions of genes involved in transcriptional regulation. **Pathways and Functions:** 1. **Brain development**: POU3F4 is involved in the development of the brain, particularly in the formation of the cerebral cortex and cochlea. Its expression in GABAergic interneurons and forebrain radial glial cells suggests a role in neuronal differentiation and migration. 2. **Chromatin regulation**: POU3F4 modulates chromatin structure and function, influencing gene expression and transcriptional regulation. Its ability to bind to specific DNA sequences allows it to interact with other transcription factors and co-regulators. 3. **Transcriptional regulation**: POU3F4 regulates transcription by interacting with RNA polymerase II and other transcriptional regulators, influencing the expression of target genes involved in cellular differentiation and development. 4. **Apoptosis regulation**: POU3F4 negatively regulates mesenchymal cell apoptosis, suggesting a role in maintaining tissue homeostasis and preventing excessive cell death. **Clinical Significance:** 1. **Neurological disorders**: Dysregulation of POU3F4 expression has been implicated in various neurological disorders, including autism spectrum disorder, schizophrenia, and hearing loss. Its role in brain development and function highlights the importance of this gene in neurological health. 2. **Immune system dysfunction**: Abnormal expression of POU3F4 in immune cells may contribute to immune system dysfunction, leading to autoimmune diseases or impaired immune responses. 3. **Cancer development**: POU3F4's role in regulating transcription and chromatin structure may also contribute to cancer development, as aberrant expression of this gene can lead to uncontrolled cell growth and tumorigenesis. In conclusion, the POU3F4 gene plays a multifaceted role in regulating developmental and cellular processes, influencing transcriptional regulation, chromatin structure, and immune responses. Further research is necessary to fully elucidate the mechanisms of POU3F4 function and its clinical significance in human health and disease.

Genular Protein ID: 3429189517

Symbol: PO3F4_HUMAN

Name: POU domain, class 3, transcription factor 4

UniProtKB Accession Codes:

P49335 B2RC71 Q5H9G9 Q99410

Database IDs:

AGR 1 AlphaFoldDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 GO 11 Gene3D 2 GeneCards 1 GeneReviews 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InParanoid 1 InterPro 8 KEGG 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7839145

Title: Association between X-linked mixed deafness and mutations in the POU domain gene POU3F4.

PubMed ID: 7839145

DOI: 10.1126/science.7839145

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 9105675

Title: The class III POU factor Brn-4 interacts with other class III POU factors and the heterogeneous nuclear ribonucleoprotein U.

PubMed ID: 9105675

DOI: 10.1016/s0169-328x(96)00238-0

PubMed ID: 7581392

Title: Further mutations in Brain 4 (POU3F4) clarify the phenotype in the X-linked deafness, DFN3.

PubMed ID: 7581392

DOI: 10.1093/hmg/4.8.1467

PubMed ID: 9298820

Title: The molecular basis of X-linked deafness type 3 (DFN3) in two sporadic cases: identification of a somatic mosaicism for a POU3F4 missense mutation.

PubMed ID: 9298820

DOI: 10.1002/(sici)1098-1004(1997)10:3<207::aid-humu5>3.0.co;2-f

PubMed ID: 9778298

Title: A new mutation in the POU3F4 gene in a Japanese family with X-linked mixed deafness (DFN3).

PubMed ID: 9778298

DOI: 10.1097/00005537-199810000-00022

Sequence Information:

  • Length: 361
  • Mass: 39427
  • Checksum: DE30602CFAC4683A
  • Sequence:
    • MATAASNPYS ILSSTSLVHA DSAGMQQGSP FRNPQKLLQS DYLQGVPSNG HPLGHHWVTS 
LSDGGPWSST LATSPLDQQD VKPGREDLQL GAIIHHRSPH VAHHSPHTNH PNAWGASPAP 
NPSITSSGQP LNVYSQPGFT VSGMLEHGGL TPPPAAASAQ SLHPVLREPP DHGELGSHHC 
QDHSDEETPT SDELEQFAKQ FKQRRIKLGF TQADVGLALG TLYGNVFSQT TICRFEGLQL 
SFKNMCKLKP LLNKWLEEAD SSTGSPTSID KIAAQGRKRK KRTSIEVSVK GVLETHFLKC 
PKPAAQEISS LADSLQLEKE VVRVWFCNRR QKEKRMTPPG DQQPHEVYSH TVKTDTSCHD 
L

Genular Protein ID: 2061667775

Symbol: A0A2R8Y739_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A2R8Y739

Database IDs:

ARBA 7 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 GO 9 Gene3D 2 GeneTree 1 HGNC 1 InterPro 8 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PROSITE 7 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 2 SAM 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

Sequence Information:

  • Length: 361
  • Mass: 39441
  • Checksum: DE30658CF9646E3A
  • Sequence:
    • MATAASNPYS ILSSTSLVHA DSAGMQQGSP FRNPQKLLQS DYLQGVPSNG HPLGHHWVTS 
LSDGGPWSST LATSPLDQQD VKPGREDLQL GAIIHHRSPH VAHHSPHTNH PNAWGASPAP 
NPSITSSGQP LNVYSQPGFT VSGMLEHGGL TPPPAAASAQ SLHPVLREPP DHGELGSHHC 
QDHSDEETPT SDELEQFAKQ FKQRRIKLGF TQADVGLALG TLYGNVFSQT TICRFEALQL 
SFKNMCKLKP LLNKWLEEAD SSTGSPTSID KIAAQGRKRK KRTSIEVSVK GVLETHFLKC 
PKPAAQEISS LADSLQLEKE VVRVWFCNRR QKEKRMTPPG DQQPHEVYSH TVKTDTSCHD 
L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.