Details for: POU3F4

Gene ID: 5456

Symbol: POU3F4

Ensembl ID: ENSG00000196767

Description: POU class 3 homeobox 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: T cell (CL0000084)
    Fold Change: 2.45
    Marker Score: 4227.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.19
    Marker Score: 2203
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.94
    Marker Score: 2167
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.25
    Marker Score: 1187
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7692
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71795
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48013
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5328
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.87
    Marker Score: 11682
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.87
    Marker Score: 506
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 492
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.73
    Marker Score: 1391
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.73
    Marker Score: 1171
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.69
    Marker Score: 10257
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.64
    Marker Score: 1018
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.64
    Marker Score: 507
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.58
    Marker Score: 324
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.58
    Marker Score: 1173
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.57
    Marker Score: 21802
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.56
    Marker Score: 334
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.51
    Marker Score: 207
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.47
    Marker Score: 407
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.47
    Marker Score: 1174
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.43
    Marker Score: 257
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.37
    Marker Score: 336
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.37
    Marker Score: 73
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.35
    Marker Score: 92
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.35
    Marker Score: 2667
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.32
    Marker Score: 113
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.32
    Marker Score: 312
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.3
    Marker Score: 61
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.3
    Marker Score: 70
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.3
    Marker Score: 1793
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3
    Marker Score: 4667
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.3
    Marker Score: 367
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.28
    Marker Score: 385
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.28
    Marker Score: 462
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.27
    Marker Score: 104
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.25
    Marker Score: 132
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.25
    Marker Score: 265
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.24
    Marker Score: 129
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.22
    Marker Score: 457
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.22
    Marker Score: 54.5
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.21
    Marker Score: 60
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.21
    Marker Score: 100
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.21
    Marker Score: 801
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.19
    Marker Score: 59
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.18
    Marker Score: 101
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.17
    Marker Score: 55
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.17
    Marker Score: 58
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.17
    Marker Score: 52
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.16
    Marker Score: 3461
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.16
    Marker Score: 59.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.16
    Marker Score: 71
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.16
    Marker Score: 639
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.15
    Marker Score: 988
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.15
    Marker Score: 59
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.15
    Marker Score: 130
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.14
    Marker Score: 59
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.14
    Marker Score: 51
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.14
    Marker Score: 55
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.13
    Marker Score: 61
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.13
    Marker Score: 48
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.13
    Marker Score: 591
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.13
    Marker Score: 48
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.13
    Marker Score: 62
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.12
    Marker Score: 57
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.12
    Marker Score: 59
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.12
    Marker Score: 79
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.12
    Marker Score: 62
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.12
    Marker Score: 480
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.11
    Marker Score: 63.5
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.11
    Marker Score: 54
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.11
    Marker Score: 119
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.11
    Marker Score: 58
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.11
    Marker Score: 71
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.11
    Marker Score: 55
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.11
    Marker Score: 62
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.1
    Marker Score: 117
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.1
    Marker Score: 137
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.1
    Marker Score: 56
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.1
    Marker Score: 97
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.09
    Marker Score: 59.5
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.09
    Marker Score: 59
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.09
    Marker Score: 976
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.09
    Marker Score: 102
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.09
    Marker Score: 51
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.09
    Marker Score: 41
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.09
    Marker Score: 60
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.09
    Marker Score: 42
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.08
    Marker Score: 57.5
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.08
    Marker Score: 60
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.08
    Marker Score: 51

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Other Information

**Key Characteristics:** 1. **POU domain structure**: POU3F4 contains a characteristic POU domain, a conserved structural motif found in transcription factors of the POU class. This domain is essential for protein-protein interactions, DNA binding, and transcriptional regulation. 2. **Tissue-specific expression**: POU3F4 is expressed in various cell types, including T cells, endothelial cells, plasma cells, B cells, goblet cells, and neurons. This widespread expression suggests a role in multiple cellular processes. 3. **DNA binding specificity**: POU3F4 exhibits sequence-specific DNA binding activity, targeting specific regulatory regions of genes involved in transcriptional regulation. **Pathways and Functions:** 1. **Brain development**: POU3F4 is involved in the development of the brain, particularly in the formation of the cerebral cortex and cochlea. Its expression in GABAergic interneurons and forebrain radial glial cells suggests a role in neuronal differentiation and migration. 2. **Chromatin regulation**: POU3F4 modulates chromatin structure and function, influencing gene expression and transcriptional regulation. Its ability to bind to specific DNA sequences allows it to interact with other transcription factors and co-regulators. 3. **Transcriptional regulation**: POU3F4 regulates transcription by interacting with RNA polymerase II and other transcriptional regulators, influencing the expression of target genes involved in cellular differentiation and development. 4. **Apoptosis regulation**: POU3F4 negatively regulates mesenchymal cell apoptosis, suggesting a role in maintaining tissue homeostasis and preventing excessive cell death. **Clinical Significance:** 1. **Neurological disorders**: Dysregulation of POU3F4 expression has been implicated in various neurological disorders, including autism spectrum disorder, schizophrenia, and hearing loss. Its role in brain development and function highlights the importance of this gene in neurological health. 2. **Immune system dysfunction**: Abnormal expression of POU3F4 in immune cells may contribute to immune system dysfunction, leading to autoimmune diseases or impaired immune responses. 3. **Cancer development**: POU3F4's role in regulating transcription and chromatin structure may also contribute to cancer development, as aberrant expression of this gene can lead to uncontrolled cell growth and tumorigenesis. In conclusion, the POU3F4 gene plays a multifaceted role in regulating developmental and cellular processes, influencing transcriptional regulation, chromatin structure, and immune responses. Further research is necessary to fully elucidate the mechanisms of POU3F4 function and its clinical significance in human health and disease.

Genular Protein ID: 3429189517

Symbol: PO3F4_HUMAN

Name: POU domain, class 3, transcription factor 4

UniProtKB Accession Codes:

P49335 B2RC71 Q5H9G9 Q99410

Database IDs:

AGR 1 AlphaFoldDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 GO 11 Gene3D 2 GeneCards 1 GeneReviews 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InParanoid 1 InterPro 7 KEGG 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 5 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7839145

Title: Association between X-linked mixed deafness and mutations in the POU domain gene POU3F4.

PubMed ID: 7839145

DOI: 10.1126/science.7839145

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 9105675

Title: The class III POU factor Brn-4 interacts with other class III POU factors and the heterogeneous nuclear ribonucleoprotein U.

PubMed ID: 9105675

DOI: 10.1016/s0169-328x(96)00238-0

PubMed ID: 7581392

Title: Further mutations in Brain 4 (POU3F4) clarify the phenotype in the X-linked deafness, DFN3.

PubMed ID: 7581392

DOI: 10.1093/hmg/4.8.1467

PubMed ID: 9298820

Title: The molecular basis of X-linked deafness type 3 (DFN3) in two sporadic cases: identification of a somatic mosaicism for a POU3F4 missense mutation.

PubMed ID: 9298820

DOI: 10.1002/(sici)1098-1004(1997)10:3<207::aid-humu5>3.0.co;2-f

PubMed ID: 9778298

Title: A new mutation in the POU3F4 gene in a Japanese family with X-linked mixed deafness (DFN3).

PubMed ID: 9778298

DOI: 10.1097/00005537-199810000-00022

Sequence Information:

  • Length: 361
  • Mass: 39427
  • Checksum: DE30602CFAC4683A
  • Sequence:
    • MATAASNPYS ILSSTSLVHA DSAGMQQGSP FRNPQKLLQS DYLQGVPSNG HPLGHHWVTS 
LSDGGPWSST LATSPLDQQD VKPGREDLQL GAIIHHRSPH VAHHSPHTNH PNAWGASPAP 
NPSITSSGQP LNVYSQPGFT VSGMLEHGGL TPPPAAASAQ SLHPVLREPP DHGELGSHHC 
QDHSDEETPT SDELEQFAKQ FKQRRIKLGF TQADVGLALG TLYGNVFSQT TICRFEGLQL 
SFKNMCKLKP LLNKWLEEAD SSTGSPTSID KIAAQGRKRK KRTSIEVSVK GVLETHFLKC 
PKPAAQEISS LADSLQLEKE VVRVWFCNRR QKEKRMTPPG DQQPHEVYSH TVKTDTSCHD 
L

Genular Protein ID: 2061667775

Symbol: A0A2R8Y739_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A2R8Y739

Database IDs:

ARBA 7 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 Ensembl 2 GO 9 Gene3D 2 GeneTree 1 HGNC 1 InterPro 7 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PROSITE 7 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 2 SAM 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

Sequence Information:

  • Length: 361
  • Mass: 39441
  • Checksum: DE30658CF9646E3A
  • Sequence:
    • MATAASNPYS ILSSTSLVHA DSAGMQQGSP FRNPQKLLQS DYLQGVPSNG HPLGHHWVTS 
LSDGGPWSST LATSPLDQQD VKPGREDLQL GAIIHHRSPH VAHHSPHTNH PNAWGASPAP 
NPSITSSGQP LNVYSQPGFT VSGMLEHGGL TPPPAAASAQ SLHPVLREPP DHGELGSHHC 
QDHSDEETPT SDELEQFAKQ FKQRRIKLGF TQADVGLALG TLYGNVFSQT TICRFEALQL 
SFKNMCKLKP LLNKWLEEAD SSTGSPTSID KIAAQGRKRK KRTSIEVSVK GVLETHFLKC 
PKPAAQEISS LADSLQLEKE VVRVWFCNRR QKEKRMTPPG DQQPHEVYSH TVKTDTSCHD 
L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.