Details for: CTSA

Gene ID: 5476

Symbol: CTSA

Ensembl ID: ENSG00000064601

Description: cathepsin A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 236.7800
    Cell Significance Index: -36.8300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 137.4371
    Cell Significance Index: -34.8600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 100.7410
    Cell Significance Index: -41.5000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 95.2353
    Cell Significance Index: -38.6900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 89.3094
    Cell Significance Index: -42.1700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 81.7092
    Cell Significance Index: -42.0300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 40.8277
    Cell Significance Index: -38.9800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.8665
    Cell Significance Index: -39.2900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.2701
    Cell Significance Index: -32.8700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.5911
    Cell Significance Index: -32.5300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.1291
    Cell Significance Index: -39.9700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.9588
    Cell Significance Index: -15.2300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 5.6863
    Cell Significance Index: 152.3700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.1826
    Cell Significance Index: 370.9000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.4079
    Cell Significance Index: 44.5100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.2685
    Cell Significance Index: 19.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.2571
    Cell Significance Index: 66.0000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9867
    Cell Significance Index: 135.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8399
    Cell Significance Index: 166.6800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6969
    Cell Significance Index: 31.5900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6750
    Cell Significance Index: 9.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6569
    Cell Significance Index: 131.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6061
    Cell Significance Index: 331.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5802
    Cell Significance Index: 12.5700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5683
    Cell Significance Index: 16.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5670
    Cell Significance Index: 72.6900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4579
    Cell Significance Index: 23.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4559
    Cell Significance Index: 31.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4055
    Cell Significance Index: 73.1000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3988
    Cell Significance Index: 4.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3947
    Cell Significance Index: 10.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3273
    Cell Significance Index: 15.3900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3069
    Cell Significance Index: 8.2100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3048
    Cell Significance Index: 14.2100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3013
    Cell Significance Index: 49.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2828
    Cell Significance Index: 101.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2728
    Cell Significance Index: 51.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2682
    Cell Significance Index: 13.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2594
    Cell Significance Index: 31.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2324
    Cell Significance Index: 102.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2191
    Cell Significance Index: 5.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1669
    Cell Significance Index: 10.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0743
    Cell Significance Index: 9.6000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0570
    Cell Significance Index: 39.4100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0551
    Cell Significance Index: 0.8200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0163
    Cell Significance Index: 12.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0095
    Cell Significance Index: 6.9500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0075
    Cell Significance Index: 0.7700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0044
    Cell Significance Index: 8.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0088
    Cell Significance Index: -0.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0131
    Cell Significance Index: -24.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0263
    Cell Significance Index: -40.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0325
    Cell Significance Index: -44.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0331
    Cell Significance Index: -3.9000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0351
    Cell Significance Index: -22.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0451
    Cell Significance Index: -33.3800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0489
    Cell Significance Index: -3.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0538
    Cell Significance Index: -5.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0654
    Cell Significance Index: -36.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0657
    Cell Significance Index: -4.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0727
    Cell Significance Index: -12.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0728
    Cell Significance Index: -33.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0735
    Cell Significance Index: -45.8700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0887
    Cell Significance Index: -2.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1141
    Cell Significance Index: -32.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1227
    Cell Significance Index: -3.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1909
    Cell Significance Index: -21.8700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1972
    Cell Significance Index: -3.4800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2060
    Cell Significance Index: -12.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2110
    Cell Significance Index: -44.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2148
    Cell Significance Index: -3.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2190
    Cell Significance Index: -31.8400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.2646
    Cell Significance Index: -1.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3036
    Cell Significance Index: -7.5900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3236
    Cell Significance Index: -2.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3511
    Cell Significance Index: -23.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3709
    Cell Significance Index: -38.6200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3742
    Cell Significance Index: -9.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3903
    Cell Significance Index: -29.9500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4473
    Cell Significance Index: -4.6300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.4589
    Cell Significance Index: -27.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4707
    Cell Significance Index: -37.2800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4861
    Cell Significance Index: -5.8000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5065
    Cell Significance Index: -17.6000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5667
    Cell Significance Index: -34.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5719
    Cell Significance Index: -35.0600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5835
    Cell Significance Index: -29.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5843
    Cell Significance Index: -32.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.6047
    Cell Significance Index: -16.4600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.6200
    Cell Significance Index: -12.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7318
    Cell Significance Index: -32.3700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7593
    Cell Significance Index: -22.3700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.7630
    Cell Significance Index: -15.9700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8598
    Cell Significance Index: -32.5600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8929
    Cell Significance Index: -18.9500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.9011
    Cell Significance Index: -36.9200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.9153
    Cell Significance Index: -26.1200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9189
    Cell Significance Index: -32.1900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9330
    Cell Significance Index: -29.7200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.9425
    Cell Significance Index: -34.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Lysosomal Protease:** CTSA is a lysosomal protease that operates in the acidic environment of the lysosome, where it degrades a wide range of proteins, including antigens, peptides, and chaperone proteins. 2. **Antigen Presentation:** CTSA has been implicated in the processing and presentation of antigens to T-cells, thereby modulating immune responses. 3. **Regulation of Immune Responses:** CTSA interacts with various signaling molecules, including MHC class II molecules, to regulate immune responses and prevent excessive or autoimmune reactions. 4. **Cell Type-Specific Expression:** CTSA is expressed in diverse cell types, including myeloid leukocytes, decidual natural killer cells, and megakaryocyte-erythroid progenitor cells, highlighting its role in regulating immune responses in different tissues. 5. **Disease Association:** CTSA has been linked to various diseases, including sialidosis, amyloidosis, and autoimmune disorders, underscoring its potential as a therapeutic target. **Pathways and Functions:** 1. **Adaptive Immune System:** CTSA participates in the processing and presentation of antigens to T-cells, thereby regulating adaptive immune responses. 2. **Asparagine N-Linked Glycosylation:** CTSA is involved in the regulation of asparagine N-linked glycosylation, a critical process in protein modification and function. 3. **Azurophil Granule Lumen:** CTSA is present in the azurophil granule lumen, where it participates in the degradation of antimicrobial peptides and proteins. 4. **Biosynthesis of n-Glycan Precursor:** CTSA is involved in the biosynthesis of the n-glycan precursor (dolichol lipid-linked oligosaccharide, llo), a critical step in protein glycosylation. 5. **Regulation of Chaperone-Mediated Autophagy:** CTSA negatively regulates chaperone-mediated autophagy, a process essential for maintaining protein homeostasis. **Clinical Significance:** 1. **Autoimmune Disorders:** CTSA has been implicated in the pathogenesis of autoimmune disorders, such as rheumatoid arthritis and lupus, highlighting its potential as a therapeutic target. 2. **Cancer:** CTSA has been associated with cancer progression and metastasis, suggesting its role in tumor immune evasion and evasion of immune surveillance. 3. **Infectious Diseases:** CTSA has been linked to the pathogenesis of infectious diseases, including tuberculosis and HIV-1 infection, underscoring its potential as a therapeutic target. 4. **Neurological Disorders:** CTSA has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease, highlighting its role in protein degradation and immune regulation. In conclusion, CTSA is a multifaceted protein that plays a critical role in regulating immune responses, protein degradation, and glycosylation processes. Its involvement in various diseases highlights its potential as a therapeutic target, and further research is necessary to elucidate its regulatory mechanisms and clinical implications.

Genular Protein ID: 1390708138

Symbol: PPGB_HUMAN

Name: Lysosomal protective protein

UniProtKB Accession Codes:

P10619 B2R798 Q561W6 Q5JZH1 Q96KJ2 Q9BR08 Q9BW68

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EC 2 EMBL 5 ESTHER 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 3 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3136930

Title: Expression of cDNA encoding the human 'protective protein' associated with lysosomal beta-galactosidase and neuraminidase: homology to yeast proteases.

PubMed ID: 3136930

DOI: 10.1016/s0092-8674(88)90999-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1694176

Title: A peptidase in human platelets that deamidates tachykinins. Probable identity with the lysosomal 'protective protein'.

PubMed ID: 1694176

DOI: 10.1016/s0021-9258(19)38586-2

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 1907282

Title: Human lysosomal protective protein has cathepsin A-like activity distinct from its protective function.

PubMed ID: 1907282

DOI: 10.1016/s0021-9258(18)98751-x

PubMed ID: 16263699

Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.

PubMed ID: 16263699

DOI: 10.1074/mcp.m500324-mcp200

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 8591035

Title: Three-dimensional structure of the human 'protective protein': structure of the precursor form suggests a complex activation mechanism.

PubMed ID: 8591035

DOI: 10.1016/s0969-2126(01)00260-x

PubMed ID: 1756715

Title: A mutation in a mild form of galactosialidosis impairs dimerization of the protective protein and renders it unstable.

PubMed ID: 1756715

DOI: 10.1002/j.1460-2075.1991.tb04980.x

PubMed ID: 8514852

Title: Protective protein gene mutations in galactosialidosis.

PubMed ID: 8514852

DOI: 10.1172/jci116472

PubMed ID: 8968752

Title: Molecular and biochemical analysis of protective protein/cathepsin A mutations: correlation with clinical severity in galactosialidosis.

PubMed ID: 8968752

DOI: 10.1093/hmg/5.12.1977

PubMed ID: 10944848

Title: Structural and functional study of K453E mutant protective protein/cathepsin A causing the late infantile form of galactosialidosis.

PubMed ID: 10944848

DOI: 10.1007/s100380070027

Sequence Information:

  • Length: 480
  • Mass: 54466
  • Checksum: 46B737DEE775C508
  • Sequence:
    • MIRAAPPPLF LLLLLLLLLV SWASRGEAAP DQDEIQRLPG LAKQPSFRQY SGYLKGSGSK 
HLHYWFVESQ KDPENSPVVL WLNGGPGCSS LDGLLTEHGP FLVQPDGVTL EYNPYSWNLI 
ANVLYLESPA GVGFSYSDDK FYATNDTEVA QSNFEALQDF FRLFPEYKNN KLFLTGESYA 
GIYIPTLAVL VMQDPSMNLQ GLAVGNGLSS YEQNDNSLVY FAYYHGLLGN RLWSSLQTHC 
CSQNKCNFYD NKDLECVTNL QEVARIVGNS GLNIYNLYAP CAGGVPSHFR YEKDTVVVQD 
LGNIFTRLPL KRMWHQALLR SGDKVRMDPP CTNTTAASTY LNNPYVRKAL NIPEQLPQWD 
MCNFLVNLQY RRLYRSMNSQ YLKLLSSQKY QILLYNGDVD MACNFMGDEW FVDSLNQKME 
VQRRPWLVKY GDSGEQIAGF VKEFSHIAFL TIKGAGHMVP TDKPLAAFTM FSRFLNKQPY

Genular Protein ID: 1463634917

Symbol: X6R5C5_HUMAN

Name: N/A

UniProtKB Accession Codes:

X6R5C5

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 481
  • Mass: 54256
  • Checksum: 926D2DCDAFFE9D5C
  • Sequence:
    • MTSSPRAPPG EQGRGGAEMI RAAPPPLFLL LLLLLLLVSW ASRGEAAPDQ DEIQRLPGLA 
KQPSFRQYSG YLKGSGSKHL HYWFVESQKD PENSPVVLWL NGGPGCSSLD GLLTEHGPFL 
IANVLYLESP AGVGFSYSDD KFYATNDTEV AQSNFEALQD FFRLFPEYKN NKLFLTGESY 
AGIYIPTLAV LVMQDPSMNL QGLAVGNGLS SYEQNDNSLV YFAYYHGLLG NRLWSSLQTH 
CCSQNKCNFY DNKDLECVTN LQEVARIVGN SGLNIYNLYA PCAGGVPSHF RYEKDTVVVQ 
DLGNIFTRLP LKRMWHQALL RSGDKVRMDP PCTNTTAAST YLNNPYVRKA LNIPEQLPQW 
DMCNFLVNLQ YRRLYRSMNS QYLKLLSSQK YQILLYNGDV DMACNFMGDE WFVDSLNQKM 
EVQRRPWLVK YGDSGEQIAG FVKEFSHIAF LTIKGAGHMV PTDKPLAAFT MFSRFLNKQP 
Y

Genular Protein ID: 1469725344

Symbol: X6R8A1_HUMAN

Name: N/A

UniProtKB Accession Codes:

X6R8A1

Database IDs:

ARBA 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 3 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 498
  • Mass: 56233
  • Checksum: E775B6274A921B45
  • Sequence:
    • MTSSPRAPPG EQGRGGAEMI RAAPPPLFLL LLLLLLLVSW ASRGEAAPDQ DEIQRLPGLA 
KQPSFRQYSG YLKGSGSKHL HYWFVESQKD PENSPVVLWL NGGPGCSSLD GLLTEHGPFL 
VQPDGVTLEY NPYSWNLIAN VLYLESPAGV GFSYSDDKFY ATNDTEVAQS NFEALQDFFR 
LFPEYKNNKL FLTGESYAGI YIPTLAVLVM QDPSMNLQGL AVGNGLSSYE QNDNSLVYFA 
YYHGLLGNRL WSSLQTHCCS QNKCNFYDNK DLECVTNLQE VARIVGNSGL NIYNLYAPCA 
GGVPSHFRYE KDTVVVQDLG NIFTRLPLKR MWHQALLRSG DKVRMDPPCT NTTAASTYLN 
NPYVRKALNI PEQLPQWDMC NFLVNLQYRR LYRSMNSQYL KLLSSQKYQI LLYNGDVDMA 
CNFMGDEWFV DSLNQKMEVQ RRPWLVKYGD SGEQIAGFVK EFSHIAFLTI KGAGHMVPTD 
KPLAAFTMFS RFLNKQPY

Genular Protein ID: 2531079638

Symbol: B4E324_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E324

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 ESTHER 1 GO 2 Gene3D 1 InterPro 3 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 480
  • Mass: 54270
  • Checksum: E7A3B6E6876970C6
  • Sequence:
    • MTSSPRAPPG EQGRGGAEMI RAAPPPLFLL LLPLLLVSWA SRGEAAPDQD EIQRLPGLAK 
QPSFRQYSGY LKGSGSKHLH YWFVESQKDP ENSPVVLWLN GGPGCSSLDG LLTEHGPFLI 
ANVLYLESPA GVGFSYSDDK FYATNDTEVA QSNFEALQDF FRLFPEYKNN KLFLTWESYA 
GIYIPTLAVL VMQDPSMNLQ GLAVGNGLSS YEQNDNSLVY FAYYHGLLGN RLWSSLQTHC 
CSQNKCNFYD NKDLECVTNL QEVARIVGNS GLNIYNLYAP CAGGVPSHFR YEKDTVVVQD 
LGNIFTRLPL KRMWHQALLR SGDKVRMEPP CTNTTAASTY LNNPYVRKAL NIPEQLPQWD 
MCNFLVNLQY RRLYRSMNSQ YLKLLSSQKY QILLYNGDVD MACNFMGDEW FVDSLNQKME 
VQRRPWLVKY GDSGEQIAGF VKEFSHIAFL TIKGAGHMVP TDKPLAAFTM FSRFLNKQPY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.