Details for: PPOX
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 49.8337
Cell Significance Index: -12.6400 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 37.6990
Cell Significance Index: -15.5300 - Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 33.5594
Cell Significance Index: -5.2200 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 29.5872
Cell Significance Index: -12.0200 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 12.5898
Cell Significance Index: -12.0200 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 9.4326
Cell Significance Index: -11.6300 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 4.7707
Cell Significance Index: -12.7800 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 3.7227
Cell Significance Index: -14.6900 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 2.7837
Cell Significance Index: -8.5500 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 2.2891
Cell Significance Index: -5.0100 - Cell Name: decidual cell (CL2000002)
Fold Change: 1.4564
Cell Significance Index: 23.3700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.0819
Cell Significance Index: 107.0200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8487
Cell Significance Index: 766.3400 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6344
Cell Significance Index: 69.0100 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5315
Cell Significance Index: 86.4400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.4793
Cell Significance Index: 30.2100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3765
Cell Significance Index: 19.5600 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3682
Cell Significance Index: 16.6900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3398
Cell Significance Index: 9.7900 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3177
Cell Significance Index: 21.9700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.2785
Cell Significance Index: 55.8600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2666
Cell Significance Index: 50.7400 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.2646
Cell Significance Index: 3.6100 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2483
Cell Significance Index: 5.3800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2476
Cell Significance Index: 49.1300 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2326
Cell Significance Index: 127.0300 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2320
Cell Significance Index: 160.4700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2312
Cell Significance Index: 6.4600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.2271
Cell Significance Index: 26.4700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2198
Cell Significance Index: 10.2500 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.1838
Cell Significance Index: 9.6500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1776
Cell Significance Index: 63.6900 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.1537
Cell Significance Index: 19.7000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1502
Cell Significance Index: 20.6300 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.1436
Cell Significance Index: 4.9900 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.1317
Cell Significance Index: 3.5900 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.1224
Cell Significance Index: 2.6800 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.1189
Cell Significance Index: 7.3100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0975
Cell Significance Index: 43.0900 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0863
Cell Significance Index: 2.2700 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.0849
Cell Significance Index: 4.4200 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.0730
Cell Significance Index: 9.4400 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0718
Cell Significance Index: 1.9300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0694
Cell Significance Index: 8.5300 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0670
Cell Significance Index: 7.9000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0643
Cell Significance Index: 1.3700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0633
Cell Significance Index: 11.4200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0518
Cell Significance Index: 3.6600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0496
Cell Significance Index: 1.2400 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0386
Cell Significance Index: 2.8800 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.0333
Cell Significance Index: 0.7000 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0215
Cell Significance Index: 1.3900 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0187
Cell Significance Index: 0.3200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0137
Cell Significance Index: 25.7600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0054
Cell Significance Index: 8.3700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0050
Cell Significance Index: 9.2100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0029
Cell Significance Index: 0.2200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0005
Cell Significance Index: 0.7100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0001
Cell Significance Index: 0.0700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0027
Cell Significance Index: -0.1000 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0034
Cell Significance Index: -0.0700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0088
Cell Significance Index: -6.4700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0162
Cell Significance Index: -12.2900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0179
Cell Significance Index: -13.2400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0186
Cell Significance Index: -8.4200 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.0231
Cell Significance Index: -0.2700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0238
Cell Significance Index: -13.4100 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0253
Cell Significance Index: -3.6800 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0258
Cell Significance Index: -16.1000 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0277
Cell Significance Index: -0.7400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0306
Cell Significance Index: -3.1300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0346
Cell Significance Index: -5.9000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0353
Cell Significance Index: -1.9800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0357
Cell Significance Index: -1.6800 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0431
Cell Significance Index: -12.4100 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0454
Cell Significance Index: -0.7600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0596
Cell Significance Index: -1.9100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0649
Cell Significance Index: -7.4300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0740
Cell Significance Index: -15.5900 - Cell Name: peg cell (CL4033014)
Fold Change: -0.0827
Cell Significance Index: -1.9100 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0869
Cell Significance Index: -2.2200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0889
Cell Significance Index: -5.9800 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.0961
Cell Significance Index: -1.4400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1030
Cell Significance Index: -2.7500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1309
Cell Significance Index: -13.6300 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.1359
Cell Significance Index: -3.2600 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.1382
Cell Significance Index: -4.0600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1470
Cell Significance Index: -11.6400 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1483
Cell Significance Index: -6.5600 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.1587
Cell Significance Index: -2.4100 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.1619
Cell Significance Index: -1.7600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1760
Cell Significance Index: -10.7900 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.1853
Cell Significance Index: -2.6000 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1860
Cell Significance Index: -4.7800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1975
Cell Significance Index: -7.4800 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.2061
Cell Significance Index: -4.4100 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.2104
Cell Significance Index: -6.2000 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2268
Cell Significance Index: -6.5000 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.2347
Cell Significance Index: -4.5800 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.2549
Cell Significance Index: -3.6500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 602988283
Symbol: PPOX_HUMAN
Name: Protoporphyrinogen oxidase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7713909
Title: Cloning of a human cDNA for protoporphyrinogen oxidase by complementation in vivo of a hemG mutant of Escherichia coli.
PubMed ID: 7713909
PubMed ID: 8771201
Title: Human protoporphyrinogen oxidase: expression, purification, and characterization of the cloned enzyme.
PubMed ID: 8771201
PubMed ID: 8806618
Title: Protoporphyrinogen oxidase: complete genomic sequence and polymorphisms in the human gene.
PubMed ID: 8806618
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 21048046
Title: Structural insight into human variegate porphyria disease.
PubMed ID: 21048046
DOI: 10.1096/fj.10-170811
PubMed ID: 23467411
Title: Quantitative structural insight into human variegate porphyria disease.
PubMed ID: 23467411
PubMed ID: 8852667
Title: Mutations in the protoporphyrinogen oxidase gene in patients with variegate porphyria.
PubMed ID: 8852667
DOI: 10.1093/hmg/5.3.407
PubMed ID: 8817334
Title: Identification of three mutations and associated haplotypes in the protoporphyrinogen oxidase gene in South African families with variegate porphyria.
PubMed ID: 8817334
DOI: 10.1093/hmg/5.7.981
PubMed ID: 8673113
Title: A R59W mutation in human protoporphyrinogen oxidase results in decreased enzyme activity and is prevalent in South Africans with variegate porphyria.
PubMed ID: 8673113
DOI: 10.1038/ng0596-95
PubMed ID: 9763307
Title: The genetic basis of 'Scarsdale Gourmet Diet' variegate porphyria: a missense mutation in the protoporphyrinogen oxidase gene.
PubMed ID: 9763307
PubMed ID: 9541112
Title: Molecular basis of variegate porphyria: a missense mutation in the protoporphyrinogen oxidase gene.
PubMed ID: 9541112
DOI: 10.1136/jmg.35.3.244
PubMed ID: 9811936
Title: Molecular characterization of homozygous variegate porphyria.
PubMed ID: 9811936
PubMed ID: 10486317
Title: Variegate porphyria in Western Europe: identification of PPOX gene mutations in 104 families, extent of allelic heterogeneity, and absence of correlation between phenotype and type of mutation.
PubMed ID: 10486317
DOI: 10.1086/302586
PubMed ID: 11074242
Title: Three novel mutations in the protoporphyrinogen oxidase gene in Japanese patients with variegate porphyria.
PubMed ID: 11074242
PubMed ID: 11102990
Title: Two new mutations (H106P and L178V) in the protoporphyrinogen oxidase gene in Argentinean patients with variegate porphyria.
PubMed ID: 11102990
DOI: 10.1002/1098-1004(200012)16:6<532::aid-humu18>3.0.co;2-s
PubMed ID: 10870850
Title: Homozygous variegate porphyria in South Africa: genotypic analysis in two cases.
PubMed ID: 10870850
PubMed ID: 11286631
Title: Homozygous variegate porphyria: 20 y follow-up and characterization of molecular defect.
PubMed ID: 11286631
PubMed ID: 11348478
Title: A spectrum of novel mutations in the protoporphyrinogen oxidase gene in 13 families with variegate porphyria.
PubMed ID: 11348478
PubMed ID: 11350188
Title: Identification of the first variegate porphyria mutation in an indigenous black South African and further evidence for heterogeneity in variegate porphyria.
PubMed ID: 11350188
PubMed ID: 11474578
Title: Expression and characterization of six mutations in the protoporphyrinogen oxidase gene among Finnish variegate porphyria patients.
PubMed ID: 11474578
PubMed ID: 12380696
Title: Variegate porphyria in Western Australian Aboriginal patients.
PubMed ID: 12380696
PubMed ID: 12922165
Title: Kinetic and physical characterisation of recombinant wild-type and mutant human protoporphyrinogen oxidases.
PubMed ID: 12922165
PubMed ID: 12859407
Title: Nine novel mutations in the protoporphyrinogen oxidase gene in Swedish families with variegate porphyria.
PubMed ID: 12859407
PubMed ID: 12655566
Title: Genetic analysis of variegate porphyria (VP) in Italy: identification of six novel mutations in the protoporphyrinogen oxidase (PPOX) gene.
PubMed ID: 12655566
DOI: 10.1002/humu.9125
PubMed ID: 14669009
Title: Modulation of penetrance by the wild-type allele in dominantly inherited erythropoietic protoporphyria and acute hepatic porphyrias.
PubMed ID: 14669009
PubMed ID: 16433813
Title: A Chilean boy with severe photosensitivity and finger shortening: the first case of homozygous variegate porphyria in South America.
PubMed ID: 16433813
PubMed ID: 16621625
Title: Mitochondrial targeting of human protoporphyrinogen oxidase.
PubMed ID: 16621625
PubMed ID: 16922948
Title: Genetic studies in variegate porphyria in Spain. Identification of gene mutations and family study for carrier detection.
PubMed ID: 16922948
PubMed ID: 16947091
Title: Swiss patients with variegate porphyria have unique mutations.
PubMed ID: 16947091
PubMed ID: 18350656
Title: Novel human pathological mutations. Gene symbol: PPOX. Disease: porphyria, variegate.
PubMed ID: 18350656
PubMed ID: 18570668
Title: Genetic and biochemical studies in Argentinean patients with variegate porphyria.
PubMed ID: 18570668
PubMed ID: 19320019
Title: Novel human pathological mutations. Gene symbol: PPOX. Disease: porphyria, variegate.
PubMed ID: 19320019
PubMed ID: 23430901
Title: Functional characterization of five protoporphyrinogen oxidase missense mutations found in Argentinean variegate porphyria patients.
PubMed ID: 23430901
DOI: 10.1007/8904_2011_77
PubMed ID: 24073655
Title: Homozygous variegate porphyria presenting with developmental and language delay in childhood.
PubMed ID: 24073655
DOI: 10.1111/ced.12071
PubMed ID: 33159949
Title: Novel PPOX exonic mutation inducing aberrant splicing in a patient with homozygous variegate porphyria.
PubMed ID: 33159949
Sequence Information:
- Length: 477
- Mass: 50765
- Checksum: 2444DEAC2E6C33EE
- Sequence:
MGRTVVVLGG GISGLAASYH LSRAPCPPKV VLVESSERLG GWIRSVRGPN GAIFELGPRG IRPAGALGAR TLLLVSELGL DSEVLPVRGD HPAAQNRFLY VGGALHALPT GLRGLLRPSP PFSKPLFWAG LRELTKPRGK EPDETVHSFA QRRLGPEVAS LAMDSLCRGV FAGNSRELSI RSCFPSLFQA EQTHRSILLG LLLGAGRTPQ PDSALIRQAL AERWSQWSLR GGLEMLPQAL ETHLTSRGVS VLRGQPVCGL SLQAEGRWKV SLRDSSLEAD HVISAIPASV LSELLPAEAA PLARALSAIT AVSVAVVNLQ YQGAHLPVQG FGHLVPSSED PGVLGIVYDS VAFPEQDGSP PGLRVTVMLG GSWLQTLEAS GCVLSQELFQ QRAQEAAATQ LGLKEMPSHC LVHLHKNCIP QYTLGHWQKL ESARQFLTAH RLPLTLAGAS YEGVAVNDCI ESGRQAAVSV LGTEPNS
Genular Protein ID: 1562724230
Symbol: B4DY76_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 444
- Mass: 46843
- Checksum: 5E77D9E07EFB7B9D
- Sequence:
MGRTVVVLGG GISGLAASYH LSRAPCPPKV VLVESSERLG GWIRSVRGPN GAIFELGPRG IRPAGALGAR TLLLACGEQV SELGLDSEVL PVRGDHPAAQ NRFLYVGGAL HALPTGLSPS LTLKVASLAM DSLCRGVFAG NSRELSIRSC FPSLFQAEQT HRSILLGLLL GAGRTPQPDS ALIRQALAER WSQWSLRGGL EMLPQALETH LTSRGVSVLR GQPVCGLSLQ AEGRWKVSLR DSSLEADHVI SAIPASVLSE LLPAEAAPLA RALSAITAVS VAVVNLQYQG AHLPVQGFGH LVPSSEDPGV LGIVYDSVAF PEQDGSPPGL RVTVMLGGSW LQTLEASGCV LSQELFQQRA QEAAATQLGL KEMPSHCLVH LHKNCIPQYT LGHWQKLESA RQFLTAHRLP LTLAGASYEG VAVNDCIESG RQAAVSVLGT EPNS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.