Details for: PPP1R3C

Gene ID: 5507

Symbol: PPP1R3C

Ensembl ID: ENSG00000119938

Description: protein phosphatase 1 regulatory subunit 3C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 34.8850
    Cell Significance Index: -16.4700
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 7.6640
    Cell Significance Index: 47.4200
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 2.4208
    Cell Significance Index: 27.8800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.2135
    Cell Significance Index: 31.5100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 2.0378
    Cell Significance Index: 49.7200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.9525
    Cell Significance Index: 17.9800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 1.6870
    Cell Significance Index: 27.2200
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.2457
    Cell Significance Index: 3.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.0353
    Cell Significance Index: 79.4500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.0060
    Cell Significance Index: 8.4500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.7866
    Cell Significance Index: 11.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7730
    Cell Significance Index: 139.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3998
    Cell Significance Index: 20.7700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3947
    Cell Significance Index: 356.3600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.3915
    Cell Significance Index: 5.7800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3890
    Cell Significance Index: 10.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3865
    Cell Significance Index: 38.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3198
    Cell Significance Index: 41.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2851
    Cell Significance Index: 14.9700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2580
    Cell Significance Index: 3.5200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2382
    Cell Significance Index: 25.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2297
    Cell Significance Index: 37.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2118
    Cell Significance Index: 42.0300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2104
    Cell Significance Index: 12.6300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2061
    Cell Significance Index: 39.2200
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.2005
    Cell Significance Index: 1.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1132
    Cell Significance Index: 13.1900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1129
    Cell Significance Index: 7.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1094
    Cell Significance Index: 148.7600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1053
    Cell Significance Index: 198.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0906
    Cell Significance Index: 2.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0748
    Cell Significance Index: 1.6200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.0701
    Cell Significance Index: 0.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0490
    Cell Significance Index: 6.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0417
    Cell Significance Index: 18.9300
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.0407
    Cell Significance Index: 0.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0381
    Cell Significance Index: 1.3400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0343
    Cell Significance Index: 2.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0326
    Cell Significance Index: 50.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0254
    Cell Significance Index: 1.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0240
    Cell Significance Index: 4.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0240
    Cell Significance Index: 44.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0062
    Cell Significance Index: -4.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0063
    Cell Significance Index: -2.8000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0066
    Cell Significance Index: -3.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0067
    Cell Significance Index: -2.3900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0069
    Cell Significance Index: -4.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0074
    Cell Significance Index: -2.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0099
    Cell Significance Index: -1.9900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0113
    Cell Significance Index: -7.1900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0124
    Cell Significance Index: -0.2600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0143
    Cell Significance Index: -0.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0178
    Cell Significance Index: -10.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0196
    Cell Significance Index: -14.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0200
    Cell Significance Index: -2.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0215
    Cell Significance Index: -16.2400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0260
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0409
    Cell Significance Index: -8.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0431
    Cell Significance Index: -4.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0462
    Cell Significance Index: -2.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0540
    Cell Significance Index: -1.5100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0562
    Cell Significance Index: -0.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0624
    Cell Significance Index: -9.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0651
    Cell Significance Index: -7.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0654
    Cell Significance Index: -3.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0762
    Cell Significance Index: -2.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0840
    Cell Significance Index: -11.5300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0966
    Cell Significance Index: -1.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1158
    Cell Significance Index: -14.9600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1226
    Cell Significance Index: -13.9900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1320
    Cell Significance Index: -1.5000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1364
    Cell Significance Index: -2.8300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1447
    Cell Significance Index: -5.9300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1499
    Cell Significance Index: -2.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1510
    Cell Significance Index: -10.6800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1531
    Cell Significance Index: -3.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1541
    Cell Significance Index: -8.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1885
    Cell Significance Index: -5.1300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1915
    Cell Significance Index: -9.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2039
    Cell Significance Index: -12.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2066
    Cell Significance Index: -16.3600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2101
    Cell Significance Index: -15.6600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2212
    Cell Significance Index: -5.5300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.2308
    Cell Significance Index: -2.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2417
    Cell Significance Index: -16.2500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2489
    Cell Significance Index: -12.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2781
    Cell Significance Index: -13.0700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2811
    Cell Significance Index: -3.9400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3001
    Cell Significance Index: -7.8900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3145
    Cell Significance Index: -13.6700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3259
    Cell Significance Index: -9.6000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3401
    Cell Significance Index: -5.0200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3412
    Cell Significance Index: -4.8900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3523
    Cell Significance Index: -3.8300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.3687
    Cell Significance Index: -4.2200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3792
    Cell Significance Index: -10.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3839
    Cell Significance Index: -16.9800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3849
    Cell Significance Index: -14.1300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4020
    Cell Significance Index: -13.9700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4073
    Cell Significance Index: -14.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PPP1R3C is a highly conserved protein phosphatase 1 regulatory subunit, characterized by its ability to bind to PP1 and modulate its activity. The protein exhibits high specificity for PP1, with a binding affinity that is several orders of magnitude higher than that of other protein phosphatase 1 regulatory subunits. PPP1R3C is also unique in its ability to bind to a wide range of substrates, including proteins involved in glycogen metabolism, signaling pathways, and protein homeostasis. **Pathways and Functions:** PPP1R3C is integral to several key cellular pathways, including: 1. **Glycogen Metabolism:** PPP1R3C regulates glycogen synthesis and breakdown by modulating the activity of PP1, which in turn phosphorylates and dephosphorylates key enzymes involved in glycogen metabolism. 2. **Cellular Signaling:** PPP1R3C interacts with various signaling proteins, influencing the activity of PP1 and modulating the response to external stimuli. 3. **Protein Homeostasis:** PPP1R3C regulates protein degradation and turnover by modulating the activity of PP1, which dephosphorylates and activates protein degradation pathways. **Clinical Significance:** Dysregulation of PPP1R3C has been implicated in various disease states, including: 1. **Glycogen Storage Diseases:** Mutations in PPP1R3C have been identified as a cause of glycogen storage diseases, characterized by abnormal glycogen accumulation and metabolic disturbances. 2. **Myoclonic Epilepsy of Lafora:** PPP1R3C is also implicated in myoclonic epilepsy of Lafora, a rare genetic disorder characterized by seizures and glycogen accumulation. 3. **Cardiac Disease:** PPP1R3C has been linked to cardiac disease, with alterations in its expression and activity contributing to cardiac dysfunction and arrhythmias. In conclusion, PPP1R3C is a critical regulatory subunit of protein phosphatase 1, playing a vital role in regulating glycogen metabolism, cellular signaling, and protein homeostasis. Its dysregulation has been implicated in various disease states, highlighting the importance of PPP1R3C in maintaining normal physiology and preventing disease. Further research into the mechanisms of PPP1R3C will provide valuable insights into the development of novel therapeutic strategies for these diseases.

Genular Protein ID: 3948917135

Symbol: PPR3C_HUMAN

Name: Protein phosphatase 1 regulatory subunit 3C

UniProtKB Accession Codes:

Q9UQK1 B2R7X0 O95686

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIRSF 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8985175

Title: Amino acid sequence of a novel protein phosphatase 1 binding protein (R5) which is related to the liver- and muscle-specific glycogen binding subunits of protein phosphatase 1.

PubMed ID: 8985175

DOI: 10.1016/s0014-5793(96)01357-9

PubMed ID: 10222257

Title: Protein targeting to glycogen/PPP1R5: screening of coding and flanking genomic regions for polymorphisms and association analysis with insulin action in Pima Indians.

PubMed ID: 10222257

DOI: 10.1006/bbrc.1999.0614

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14532330

Title: Laforin, the dual-phosphatase responsible for Lafora disease, interacts with R5 (PTG), a regulatory subunit of protein phosphatase-1 that enhances glycogen accumulation.

PubMed ID: 14532330

DOI: 10.1093/hmg/ddg340

PubMed ID: 18070875

Title: Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG).

PubMed ID: 18070875

DOI: 10.1074/jbc.m708712200

PubMed ID: 21738631

Title: A PTG variant contributes to a milder phenotype in Lafora disease.

PubMed ID: 21738631

DOI: 10.1371/journal.pone.0021294

Sequence Information:

  • Length: 317
  • Mass: 36445
  • Checksum: FBFD6DE015F9AB2D
  • Sequence:
    • MSCTRMIQVL DPRPLTSSVM PVDVAMRLCL AHSPPVKSFL GPYDEFQRRH FVNKLKPLKS 
CLNIKHKAKS QNDWKCSHNQ AKKRVVFADS KGLSLTAIHV FSDLPEEPAW DLQFDLLDLN 
DISSALKHHE EKNLILDFPQ PSTDYLSFRS HFQKNFVCLE NCSLQERTVT GTVKVKNVSF 
EKKVQIRITF DSWKNYTDVD CVYMKNVYGG TDSDTFSFAI DLPPVIPTEQ KIEFCISYHA 
NGQVFWDNND GQNYRIVHVQ WKPDGVQTQM APQDCAFHQT SPKTELESTI FGSPRLASGL 
FPEWQSWGRM ENLASYR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.