PPP2CB | ENSG00000104695 | NCBI 5516

Details for: PPP2CB

Gene ID: 5516

Symbol: PPP2CB

Ensembl ID: ENSG00000104695

Description: protein phosphatase 2 catalytic subunit beta

Associated with

Adaptive immune system
(R-HSA-1280218)
Amplification of signal from the kinetochores
(R-HSA-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-HSA-141444)
Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Apc truncation mutants have impaired axin binding
(R-HSA-5467337)
Axin missense mutants destabilize the destruction complex
(R-HSA-5467340)
Beta-catenin phosphorylation cascade
(R-HSA-196299)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Costimulation by the cd28 family
(R-HSA-388841)
Ctla4 inhibitory signaling
(R-HSA-389513)
Ctnnb1 s33 mutants aren't phosphorylated
(R-HSA-5358747)
Ctnnb1 s37 mutants aren't phosphorylated
(R-HSA-5358749)
Ctnnb1 s45 mutants aren't phosphorylated
(R-HSA-5358751)
Ctnnb1 t41 mutants aren't phosphorylated
(R-HSA-5358752)
Cytokine signaling in immune system
(R-HSA-1280215)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Disassembly of the destruction complex and recruitment of axin to the membrane
(R-HSA-4641262)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
E2f mediated regulation of dna replication
(R-HSA-113510)
G1 phase
(R-HSA-69236)
G1/s transition
(R-HSA-69206)
G2/m transition
(R-HSA-69275)
G alpha (i) signalling events
(R-HSA-418594)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Glucose metabolism
(R-HSA-70326)
Glycolysis
(R-HSA-70171)
Gpcr downstream signalling
(R-HSA-388396)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Integration of energy metabolism
(R-HSA-163685)
Interferon signaling
(R-HSA-913531)
Interleukin-17 signaling
(R-HSA-448424)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Mastl facilitates mitotic progression
(R-HSA-2465910)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic prophase
(R-HSA-68875)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Negative regulation of fgfr1 signaling
(R-HSA-5654726)
Negative regulation of fgfr2 signaling
(R-HSA-5654727)
Negative regulation of fgfr3 signaling
(R-HSA-5654732)
Negative regulation of fgfr4 signaling
(R-HSA-5654733)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Opioid signalling
(R-HSA-111885)
Pip3 activates akt signaling
(R-HSA-1257604)
Platelet homeostasis
(R-HSA-418346)
Platelet sensitization by ldl
(R-HSA-432142)
Pp2a-mediated dephosphorylation of key metabolic factors
(R-HSA-163767)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of tp53 activity
(R-HSA-5633007)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rho gtpase effectors
(R-HSA-195258)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by amer1 mutants
(R-HSA-4839748)
Signaling by apc mutants
(R-HSA-4839744)
Signaling by axin mutants
(R-HSA-4839735)
Signaling by ctnnb1 phospho-site mutants
(R-HSA-4839743)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by gpcr
(R-HSA-372790)
Signaling by gsk3beta mutants
(R-HSA-5339716)
Signaling by interleukins
(R-HSA-449147)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signaling by wnt in cancer
(R-HSA-4791275)
Signal transduction
(R-HSA-162582)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Transcriptional regulation by tp53
(R-HSA-3700989)
Truncations of amer1 destabilize the destruction complex
(R-HSA-5467348)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 434.7289
Cell Significance Index: -67.6200
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 266.4765
Cell Significance Index: -67.5900
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 145.0788
Cell Significance Index: -68.5000
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 133.0931
Cell Significance Index: -54.0700
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 124.3815
Cell Significance Index: -63.9800
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 102.1352
Cell Significance Index: -68.5400
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 56.9211
Cell Significance Index: -54.3500
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 55.3548
Cell Significance Index: -68.2500
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 24.3089
Cell Significance Index: -65.1200
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 17.3921
Cell Significance Index: -68.6300
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 15.4715
Cell Significance Index: -47.5200
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 10.9066
Cell Significance Index: -23.8700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 3.6151
Cell Significance Index: 250.0100
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.9567
Cell Significance Index: 80.4800
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.6403
Cell Significance Index: 47.0200
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.5004
Cell Significance Index: 297.7600
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.4804
Cell Significance Index: 161.0200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.4613
Cell Significance Index: 293.1400
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.4165
Cell Significance Index: 194.5300
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.2917
Cell Significance Index: 99.1300
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.1999
Cell Significance Index: 32.0400
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.1414
Cell Significance Index: 32.8900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.0799
Cell Significance Index: 387.3400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.0719
Cell Significance Index: 131.8100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.8995
Cell Significance Index: 162.1600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.7545
Cell Significance Index: 35.1800
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.7200
Cell Significance Index: 48.4100
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.6811
Cell Significance Index: 371.9700
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.6639
Cell Significance Index: 293.5300
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.6453
Cell Significance Index: 33.6200
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.5664
Cell Significance Index: 14.5600
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.5134
Cell Significance Index: 28.8100
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.4608
Cell Significance Index: 318.6900
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.4512
Cell Significance Index: 7.6000
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.4102
Cell Significance Index: 25.2100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3860
Cell Significance Index: 20.0500
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.3854
Cell Significance Index: 10.7700
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3695
Cell Significance Index: 16.7500
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.3431
Cell Significance Index: 9.7900
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3084
Cell Significance Index: 30.5100
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3011
Cell Significance Index: 271.9100
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.2954
Cell Significance Index: 134.0500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.2852
Cell Significance Index: 13.4100
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.2778
Cell Significance Index: 19.6500
Cell Name: lactocyte (CL0002325)
Fold Change: 0.2545
Cell Significance Index: 32.8800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2239
Cell Significance Index: 38.2400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.2194
Cell Significance Index: 7.7100
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.2008
Cell Significance Index: 3.9200
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.1869
Cell Significance Index: 13.9300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1869
Cell Significance Index: 351.8600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1760
Cell Significance Index: 33.4900
Cell Name: odontoblast (CL0000060)
Fold Change: 0.1518
Cell Significance Index: 19.4600
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1252
Cell Significance Index: 79.5400
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.0712
Cell Significance Index: 0.4300
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0691
Cell Significance Index: 93.9400
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0622
Cell Significance Index: 95.8300
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0488
Cell Significance Index: 89.9400
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.0408
Cell Significance Index: 0.6200
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0031
Cell Significance Index: -2.2400
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0190
Cell Significance Index: -1.0000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0261
Cell Significance Index: -19.7700
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0275
Cell Significance Index: -20.3400
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0310
Cell Significance Index: -4.5000
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.0369
Cell Significance Index: -0.9000
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0380
Cell Significance Index: -23.7600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0787
Cell Significance Index: -44.4000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1282
Cell Significance Index: -13.1000
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1417
Cell Significance Index: -16.1700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1548
Cell Significance Index: -32.6100
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1793
Cell Significance Index: -20.8900
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1942
Cell Significance Index: -55.8800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2243
Cell Significance Index: -25.7000
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.2367
Cell Significance Index: -3.2300
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.2767
Cell Significance Index: -45.0000
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.2777
Cell Significance Index: -4.1000
Cell Name: peg cell (CL4033014)
Fold Change: -0.3614
Cell Significance Index: -8.3500
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3650
Cell Significance Index: -38.0100
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.3863
Cell Significance Index: -3.1500
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4261
Cell Significance Index: -26.8600
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.4865
Cell Significance Index: -57.3700
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4976
Cell Significance Index: -22.0100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.5151
Cell Significance Index: -11.1600
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5470
Cell Significance Index: -43.3200
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.5679
Cell Significance Index: -13.6200
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.6127
Cell Significance Index: -10.5000
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.6173
Cell Significance Index: -15.4300
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.6184
Cell Significance Index: -16.2600
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.6279
Cell Significance Index: -21.8200
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.6859
Cell Significance Index: -25.9800
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.7133
Cell Significance Index: -46.0200
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.7219
Cell Significance Index: -23.1200
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.7514
Cell Significance Index: -12.5800
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.8155
Cell Significance Index: -7.5100
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.8870
Cell Significance Index: -18.8900
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.9011
Cell Significance Index: -13.3000
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.0657
Cell Significance Index: -28.5600
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.0902
Cell Significance Index: -66.8400
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -1.1225
Cell Significance Index: -16.8200
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -1.1364
Cell Significance Index: -24.2900
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -1.2823
Cell Significance Index: -26.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Structure:** PPP2CB is a heterodimeric enzyme consisting of two subunits, PP2A (protein phosphatase 2A) and B (protein phosphatase 2B). The PP2B subunit is responsible for the catalytic activity of the enzyme. 2. **Subcellular Localization:** PPP2CB is primarily localized in the cytosol, where it regulates various signaling pathways. 3. **Substrate specificity:** PPP2CB has a broad substrate specificity, dephosphorylating a wide range of proteins, including transcription factors, kinases, and phosphatases. **Pathways and Functions:** 1. **Calcineurin-NFAT signaling pathway:** PPP2CB is a critical component of this pathway, which regulates immune responses, cell growth, and differentiation. 2. **Adaptive immune system:** PPP2CB plays a key role in the activation of T cells and the regulation of immune responses. 3. **Cell cycle regulation:** PPP2CB regulates the G1/S transition and the G2/M transition, ensuring proper cell cycle progression. 4. **Gene expression regulation:** PPP2CB modulates the activity of transcription factors, influencing the expression of genes involved in various cellular processes. 5. **Cytokine signaling:** PPP2CB regulates the activity of cytokine receptors, influencing the signaling pathways involved in immune responses. **Clinical Significance:** 1. **Autoimmune diseases:** Dysregulation of PPP2CB has been implicated in various autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, and type 1 diabetes. 2. **Cancer:** PPP2CB has been shown to play a role in cancer development and progression, particularly in the regulation of cell cycle and gene expression. 3. **Neurological disorders:** PPP2CB has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 4. **Infectious diseases:** PPP2CB regulates the activity of immune cells, influencing the response to infections. In conclusion, PPP2CB is a critical enzyme involved in various cellular processes, including immune response, cell cycle regulation, and gene expression. Its dysregulation has been implicated in various diseases, highlighting the importance of PPP2CB in maintaining cellular homeostasis. Further research is necessary to fully elucidate the role of PPP2CB in disease pathogenesis and to explore potential therapeutic strategies for the treatment of PPP2CB-related disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

PP2AB_HUMAN

Genular Protein ID: 2013676719

Symbol: PP2AB_HUMAN

Name: N/A

UniProtKB Accession Codes:

P62714 D3DSV4 P11082 Q6FHK5

Database IDs:

Citations:

PubMed ID: 2849765

Title: The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A beta catalytic subunit.

PubMed ID: 2849765

DOI: 10.1093/nar/16.23.11366

PubMed ID: 2837763

Title: Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes.

PubMed ID: 2837763

DOI: 10.1073/pnas.85.12.4252

PubMed ID: 1846293

Title: Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes.

PubMed ID: 1846293

DOI: 10.1021/bi00215a014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2555176

Title: Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A.

PubMed ID: 2555176

DOI: 10.1002/j.1460-2075.1989.tb08568.x

PubMed ID: 2153055

Title: Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A.

PubMed ID: 2153055

DOI: 10.1016/0092-8674(90)90726-u

PubMed ID: 8206937

Title: The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo.

PubMed ID: 8206937

DOI: 10.1016/s0021-9258(17)34009-7

PubMed ID: 10318862

Title: A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A.

PubMed ID: 10318862

DOI: 10.1074/jbc.274.20.14382

PubMed ID: 12952889

Title: A novel and essential mechanism determining specificity and activity of protein phosphatase 2A (PP2A) in vivo.

PubMed ID: 12952889

DOI: 10.1101/gad.259903

PubMed ID: 16541025

Title: Shugoshin collaborates with protein phosphatase 2A to protect cohesin.

PubMed ID: 16541025

DOI: 10.1038/nature04663

PubMed ID: 18782753

Title: A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein.

PubMed ID: 18782753

DOI: 10.1074/mcp.m800266-mcp200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

Length: 309
Mass: 35575
Checksum: 51DA9EB0633FC191
Sequence:

MDDKAFTKEL DQWVEQLNEC KQLNENQVRT LCEKAKEILT KESNVQEVRC PVTVCGDVHG 
QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYPER ITILRGNHES 
RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL SPSIDTLDHI 
RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH ANGLTLVSRA 
HQLVMEGYNW CHDRNVVTIF SAPNYCYRCG NQAAIMELDD TLKYSFLQFD PAPRRGEPHV 
TRRTPDYFL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PPP2CB

Associated with

Cells (max top 100)

Other Information

The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A beta catalytic subunit. PubMed ID: 2849765

Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes. PubMed ID: 2837763

Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes. PubMed ID: 1846293

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A. PubMed ID: 2555176

Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A. PubMed ID: 2153055

The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo. PubMed ID: 8206937

A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A. PubMed ID: 10318862

A novel and essential mechanism determining specificity and activity of protein phosphatase 2A (PP2A) in vivo. PubMed ID: 12952889

Shugoshin collaborates with protein phosphatase 2A to protect cohesin. PubMed ID: 16541025

A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. PubMed ID: 18782753

Initial characterization of the human central proteome. PubMed ID: 21269460