Details for: PPP3CA

Gene ID: 5530

Symbol: PPP3CA

Ensembl ID: ENSG00000138814

Description: protein phosphatase 3 catalytic subunit alpha

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 7.54
    Marker Score: 40519
  • Cell Name: granule cell (CL0000120)
    Fold Change: 7.5
    Marker Score: 56534
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 6.63
    Marker Score: 34793
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 6.18
    Marker Score: 14205
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 5.78
    Marker Score: 195073
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 5.74
    Marker Score: 101972.5
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 3.79
    Marker Score: 17546
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 3.54
    Marker Score: 2330
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 3.52
    Marker Score: 14661
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 3.29
    Marker Score: 2921
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 3.2
    Marker Score: 10726
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 3.17
    Marker Score: 1658
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 3.05
    Marker Score: 4290
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 3.01
    Marker Score: 2088
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.92
    Marker Score: 62317
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.91
    Marker Score: 8310
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 2.84
    Marker Score: 1040
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.81
    Marker Score: 1630
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 2.79
    Marker Score: 710
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2.75
    Marker Score: 2069
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.73
    Marker Score: 986
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.72
    Marker Score: 40739
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.72
    Marker Score: 20817.5
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.71
    Marker Score: 4549
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.71
    Marker Score: 53865
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.62
    Marker Score: 1528
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.58
    Marker Score: 98122
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.57
    Marker Score: 1277
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.53
    Marker Score: 3679
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.52
    Marker Score: 1503
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.49
    Marker Score: 10338
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.47
    Marker Score: 39655
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.44
    Marker Score: 634
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.42
    Marker Score: 2782
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 2.41
    Marker Score: 2905.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.4
    Marker Score: 88569.5
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.26
    Marker Score: 1264
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.26
    Marker Score: 8738
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.25
    Marker Score: 1183
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.23
    Marker Score: 4896
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.22
    Marker Score: 1237
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 2.21
    Marker Score: 2759
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.2
    Marker Score: 1087
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.18
    Marker Score: 2720
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.18
    Marker Score: 1886
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.17
    Marker Score: 4173
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.15
    Marker Score: 2664
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.14
    Marker Score: 616
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.13
    Marker Score: 20048
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.11
    Marker Score: 813
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.09
    Marker Score: 2370
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.08
    Marker Score: 872
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.08
    Marker Score: 127630.5
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.06
    Marker Score: 4925
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.99
    Marker Score: 8102
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.98
    Marker Score: 953
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.96
    Marker Score: 1099
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.96
    Marker Score: 990
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.94
    Marker Score: 20052
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.94
    Marker Score: 567
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.9
    Marker Score: 18053
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.86
    Marker Score: 16347.5
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.85
    Marker Score: 612.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.85
    Marker Score: 15863
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.83
    Marker Score: 6003
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.83
    Marker Score: 2021
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.8
    Marker Score: 1895
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.8
    Marker Score: 931
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.79
    Marker Score: 1548
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.77
    Marker Score: 663
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.75
    Marker Score: 1025
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.75
    Marker Score: 754
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.75
    Marker Score: 561
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.71
    Marker Score: 965
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.7
    Marker Score: 1121
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.68
    Marker Score: 10950
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.67
    Marker Score: 455
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.65
    Marker Score: 3293
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.65
    Marker Score: 598
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.64
    Marker Score: 559
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.64
    Marker Score: 497
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.63
    Marker Score: 616
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.63
    Marker Score: 517.5
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.63
    Marker Score: 790
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.62
    Marker Score: 1742
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.6
    Marker Score: 508
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.6
    Marker Score: 576
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.6
    Marker Score: 595
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.6
    Marker Score: 961
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.6
    Marker Score: 2059
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.59
    Marker Score: 2823
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.58
    Marker Score: 1680.5
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.58
    Marker Score: 640
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.58
    Marker Score: 498
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.57
    Marker Score: 3926
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.57
    Marker Score: 374.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.56
    Marker Score: 2408
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.56
    Marker Score: 4306.5
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.55
    Marker Score: 355.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.54
    Marker Score: 569

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Other Information

**Key Characteristics:** PPP3CA is a catalytic subunit of the protein phosphatase 3 (PP3) complex, which is a heterodimeric enzyme composed of PPP3CA and PPP3R1. PPP3CA is a 40 kDa protein with a high degree of homology to other phosphatase catalytic subunits. Its primary function is to dephosphorylate a wide range of protein substrates, including transcription factors, kinases, and other phosphoproteins. **Pathways and Functions:** PPP3CA plays a pivotal role in various cellular signaling pathways, including: 1. **Calcineurin-mediated signaling:** PPP3CA dephosphorylates and activates calcineurin, a key regulator of T-cell activation and immune responses. 2. **Adaptive immune system:** PPP3CA modulates the activity of immune cells, such as T-cells and B-cells, by dephosphorylating and activating key transcription factors, such as NFAT and NF-κB. 3. **C-type lectin receptors (CLRs):** PPP3CA interacts with CLR signaling pathways, influencing the activation of immune cells and the regulation of inflammatory responses. 4. **Calmodulin-dependent protein phosphatase activity:** PPP3CA is involved in the regulation of calcium-dependent signaling pathways, which are critical for immune cell activation and function. **Clinical Significance:** Dysregulation of PPP3CA has been implicated in various diseases, including: 1. **Autoimmune disorders:** Altered PPP3CA expression and activity have been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer:** Aberrant PPP3CA expression has been observed in various types of cancer, including breast cancer and lymphoma. 3. **Neurological disorders:** PPP3CA dysfunction has been implicated in neurological conditions, such as Alzheimer's disease and Parkinson's disease. 4. **Infectious diseases:** PPP3CA plays a critical role in the regulation of immune responses to infections, and its dysregulation can contribute to the development of sepsis and other immunocompromised states. **Significantly Expressed Cells:** PPP3CA is widely expressed in various cell types, including: 1. **Immune cells:** T-cells, B-cells, macrophages, and dendritic cells. 2. **Neuronal cells:** Neurons, astrocytes, and oligodendrocytes. 3. **Epithelial cells:** Epithelial cells of the skin, lung, and gut. **Proteins:** PPP3CA interacts with various proteins, including: 1. **PP2BA_HUMAN (CAM-PRP catalytic subunit):** A homologous protein that shares similar catalytic activity with PPP3CA. 2. **A0A0S2Z4B5_HUMAN:** A protein that interacts with PPP3CA in the regulation of immune responses. In conclusion, PPP3CA is a multifaceted enzyme that plays a critical role in immune regulation, cellular signaling, and protein dephosphorylation. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding PPP3CA's complex biology and its implications in human health and disease.

Genular Protein ID: 3003412150

Symbol: PP2BA_HUMAN

Name: CAM-PRP catalytic subunit

UniProtKB Accession Codes:

Q08209 A1A441 A8K3B7 A8W6Z7 A8W6Z8 B5BUA2 Q8TAW9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 ComplexPortal 4 DEPOD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 DrugCentral 1 EC 2 ELM 1 EMBL 15 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 70 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 33 PDBsum 17 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 5 RefSeq 3 Rhea 6 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8392375

Title: Molecular cloning of a full-length cDNA encoding the catalytic subunit of human calmodulin-dependent protein phosphatase (calcineurin A alpha).

PubMed ID: 8392375

DOI: 10.1016/0167-4889(93)90117-8

PubMed ID: 20590401

Title: Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative splicing patterns, association of 5'UTR trinucleotide repeat with addiction vulnerability, and differential isoform expression in Alzheimer's disease.

PubMed ID: 20590401

DOI: 10.3109/10826084.2010.482449

PubMed ID: 21647268

Title: Identification of differentially expressed genes in uveal melanoma using suppressive subtractive hybridization.

PubMed ID: 21647268

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11114196

Title: Calsarcins, a novel family of sarcomeric calcineurin-binding proteins.

PubMed ID: 11114196

DOI: 10.1073/pnas.260501097

PubMed ID: 11842093

Title: Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins.

PubMed ID: 11842093

DOI: 10.1074/jbc.m200712200

PubMed ID: 12809556

Title: Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life.

PubMed ID: 12809556

DOI: 10.1042/bj20030267

PubMed ID: 15454081

Title: The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.

PubMed ID: 15454081

DOI: 10.1016/j.cell.2004.09.015

PubMed ID: 15671020

Title: Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin.

PubMed ID: 15671020

DOI: 10.1074/jbc.m411494200

PubMed ID: 17923693

Title: Protein kinase A, Ca2+/calmodulin-dependent kinase II, and calcineurin regulate the intracellular trafficking of myopodin between the Z-disc and the nucleus of cardiac myocytes.

PubMed ID: 17923693

DOI: 10.1128/mcb.00950-07

PubMed ID: 18838687

Title: Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria.

PubMed ID: 18838687

DOI: 10.1073/pnas.0808249105

PubMed ID: 19154138

Title: The proline-rich N-terminal sequence of calcineurin Abeta determines substrate binding.

PubMed ID: 19154138

DOI: 10.1021/bi8019355

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28942967

Title: De Novo Mutations in PPP3CA Cause Severe Neurodevelopmental Disease with Seizures.

PubMed ID: 28942967

DOI: 10.1016/j.ajhg.2017.08.013

PubMed ID: 29043977

Title: A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis.

PubMed ID: 29043977

DOI: 10.7554/elife.27356

PubMed ID: 28881575

Title: Overexpression of C16orf74 is involved in aggressive pancreatic cancers.

PubMed ID: 28881575

DOI: 10.18632/oncotarget.10912

PubMed ID: 30611118

Title: Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment.

PubMed ID: 30611118

DOI: 10.1016/j.isci.2018.12.012

PubMed ID: 30718414

Title: Calcineurin dephosphorylates Kelch-like 3, reversing phosphorylation by angiotensin II and regulating renal electrolyte handling.

PubMed ID: 30718414

DOI: 10.1073/pnas.1817281116

PubMed ID: 33691586

Title: Coxsackievirus B3 targets TFEB to disrupt lysosomal function.

PubMed ID: 33691586

DOI: 10.1080/15548627.2021.1896925

PubMed ID: 34446558

Title: SPATA33 localizes calcineurin to the mitochondria and regulates sperm motility in mice.

PubMed ID: 34446558

DOI: 10.1073/pnas.2106673118

PubMed ID: 8524402

Title: Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex.

PubMed ID: 8524402

DOI: 10.1038/378641a0

PubMed ID: 12218175

Title: Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes.

PubMed ID: 12218175

DOI: 10.1073/pnas.192206699

PubMed ID: 12357034

Title: Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin.

PubMed ID: 12357034

DOI: 10.1073/pnas.212504399

PubMed ID: 17498738

Title: Structure of calcineurin in complex with PVIVIT peptide: portrait of a low-affinity signalling interaction.

PubMed ID: 17498738

DOI: 10.1016/j.jmb.2007.04.032

PubMed ID: 17502104

Title: Structure of the calcineurin-NFAT complex: defining a T cell activation switch using solution NMR and crystal coordinates.

PubMed ID: 17502104

DOI: 10.1016/j.str.2007.03.015

PubMed ID: 18384083

Title: The complex structure of calmodulin bound to a calcineurin peptide.

PubMed ID: 18384083

DOI: 10.1002/prot.22032

PubMed ID: 19404396

Title: Domain swapping and different oligomeric States for the complex between calmodulin and the calmodulin-binding domain of calcineurin a.

PubMed ID: 19404396

DOI: 10.1371/journal.pone.0005402

PubMed ID: 22343722

Title: Balanced interactions of calcineurin with AKAP79 regulate Ca2+-calcineurin-NFAT signaling.

PubMed ID: 22343722

DOI: 10.1038/nsmb.2238

PubMed ID: 23468591

Title: The molecular mechanism of substrate engagement and immunosuppressant inhibition of calcineurin.

PubMed ID: 23468591

DOI: 10.1371/journal.pbio.1001492

PubMed ID: 25144868

Title: Stoichiometry of the calcineurin regulatory domain-calmodulin complex.

PubMed ID: 25144868

DOI: 10.1021/bi5004734

PubMed ID: 26248042

Title: Calcineurin Undergoes a Conformational Switch Evoked via Peptidyl-Prolyl Isomerization.

PubMed ID: 26248042

DOI: 10.1371/journal.pone.0134569

PubMed ID: 27974827

Title: Investigating the human Calcineurin Interaction Network using the piLxVP SLiM.

PubMed ID: 27974827

DOI: 10.1038/srep38920

PubMed ID: 31375679

Title: Molecular basis for the binding and selective dephosphorylation of Na+/H+ exchanger 1 by calcineurin.

PubMed ID: 31375679

DOI: 10.1038/s41467-019-11391-7

PubMed ID: 29432562

Title: Loss-of-function and gain-of-function mutations in PPP3CA cause two distinct disorders.

PubMed ID: 29432562

DOI: 10.1093/hmg/ddy052

PubMed ID: 30254215

Title: Novel calcineurin A (PPP3CA) variant associated with epilepsy, constitutive enzyme activation and downregulation of protein expression.

PubMed ID: 30254215

DOI: 10.1038/s41431-018-0254-8

Sequence Information:

  • Length: 521
  • Mass: 58688
  • Checksum: 16480D62DDBF1F40
  • Sequence:
    • MSEPKAIDPK LSTTDRVVKA VPFPPSHRLT AKEVFDNDGK PRVDILKAHL MKEGRLEESV 
ALRIITEGAS ILRQEKNLLD IDAPVTVCGD IHGQFFDLMK LFEVGGSPAN TRYLFLGDYV 
DRGYFSIECV LYLWALKILY PKTLFLLRGN HECRHLTEYF TFKQECKIKY SERVYDACMD 
AFDCLPLAAL MNQQFLCVHG GLSPEINTLD DIRKLDRFKE PPAYGPMCDI LWSDPLEDFG 
NEKTQEHFTH NTVRGCSYFY SYPAVCEFLQ HNNLLSILRA HEAQDAGYRM YRKSQTTGFP 
SLITIFSAPN YLDVYNNKAA VLKYENNVMN IRQFNCSPHP YWLPNFMDVF TWSLPFVGEK 
VTEMLVNVLN ICSDDELGSE EDGFDGATAA ARKEVIRNKI RAIGKMARVF SVLREESESV 
LTLKGLTPTG MLPSGVLSGG KQTLQSATVE AIEADEAIKG FSPQHKITSF EEAKGLDRIN 
ERMPPRRDAM PSDANLNSIN KALTSETNGT DSNGSNSSNI Q

Genular Protein ID: 1340068074

Symbol: A0A0S2Z4B5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z4B5

Database IDs:

ARBA 9 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 10 ChiTaRS 1 DNASU 1 EC 2 EMBL 2 ExpressionAtlas 1 GO 4 Gene3D 1 GenomeRNAi 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 Pfam 1 RefSeq 1 Rhea 6 RuleBase 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 511
  • Mass: 57659
  • Checksum: B1E98CC0D6034CCC
  • Sequence:
    • MSEPKAIDPK LSTTDRVVKA VPFPPSHRLT AKEVFDNDGK PRVDILKAHL MKEGRLEESV 
ALRIITEGAS ILRQEKNLLD IDAPVTVCGD IHGQFFDLMK LFEVGGSPAN TRYLFLGDYV 
DRGYFSIECV LYLWALKILY PKTLFLLRGN HECRHLTEYF TFKQECKIKY SERVYDACMD 
AFDCLPLAAL MNQQFLCVHG GLSPEINTLD DIRKLDRFKE PPAYGPMCDI LWSDPLEDFG 
NEKTQEHFTH NTVRGCSYFY SYPAVCEFLQ HNNLLSILRA HEAQDAGYRM YRKSQTTGFP 
SLITIFSAPN YLDVYNNKAA VLKYENNVMN IRQFNCSPHP YWLPNFMDVF TWSLPFVGEK 
VTEMLVNVLN ICSDDELGSE EDGFDGATAA ARKEVIRNKI RAIGKMARVF SVLREESESV 
LTLKGLTPTG MLPSGVLSGG KQTLQSAIKG FSPQHKITSF EEAKGLDRIN ERMPPRRDAM 
PSDANLNSIN KALTSETNGT DSNGSNSSNI Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.