Details for: PPP3CA

Gene ID: 5530

Symbol: PPP3CA

Ensembl ID: ENSG00000138814

Description: protein phosphatase 3 catalytic subunit alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 655.5007
    Cell Significance Index: -101.9600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 390.8637
    Cell Significance Index: -99.1400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 224.8568
    Cell Significance Index: -106.1600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 209.9963
    Cell Significance Index: -85.3100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 191.4518
    Cell Significance Index: -98.4800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 158.1617
    Cell Significance Index: -106.1300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 89.7938
    Cell Significance Index: -85.7300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 84.1717
    Cell Significance Index: -103.7800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 36.8291
    Cell Significance Index: -98.6600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 34.1532
    Cell Significance Index: -104.9000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 33.6701
    Cell Significance Index: -73.6900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 26.4860
    Cell Significance Index: -104.5200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 12.9409
    Cell Significance Index: 221.7700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 7.3442
    Cell Significance Index: 324.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 7.0517
    Cell Significance Index: 267.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 6.6655
    Cell Significance Index: 448.1900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 6.2969
    Cell Significance Index: 179.7000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 4.1096
    Cell Significance Index: 230.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.9926
    Cell Significance Index: 1432.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 3.9068
    Cell Significance Index: 240.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.4646
    Cell Significance Index: 694.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.4620
    Cell Significance Index: 403.4600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 3.4334
    Cell Significance Index: 67.0100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 3.1148
    Cell Significance Index: 74.7000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.6379
    Cell Significance Index: 57.7600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.3848
    Cell Significance Index: 1649.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5262
    Cell Significance Index: 302.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.3742
    Cell Significance Index: 176.1700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.3429
    Cell Significance Index: 69.9500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2911
    Cell Significance Index: 140.4400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.2010
    Cell Significance Index: 32.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1840
    Cell Significance Index: 145.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.1029
    Cell Significance Index: 28.3500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0898
    Cell Significance Index: 30.4600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.0809
    Cell Significance Index: 82.9500
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.9046
    Cell Significance Index: 8.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8324
    Cell Significance Index: 368.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6915
    Cell Significance Index: 124.6600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5086
    Cell Significance Index: 32.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4532
    Cell Significance Index: 62.2400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.4012
    Cell Significance Index: 5.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4008
    Cell Significance Index: 218.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3945
    Cell Significance Index: 39.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3678
    Cell Significance Index: 233.5800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.3532
    Cell Significance Index: 4.2100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2751
    Cell Significance Index: 52.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2643
    Cell Significance Index: 11.9800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2527
    Cell Significance Index: 11.8800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.2451
    Cell Significance Index: 3.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1888
    Cell Significance Index: 85.6900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1741
    Cell Significance Index: 327.7400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1604
    Cell Significance Index: 4.6200
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.1198
    Cell Significance Index: 1.6800
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.0864
    Cell Significance Index: 0.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0713
    Cell Significance Index: 96.9700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0433
    Cell Significance Index: 79.9300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0056
    Cell Significance Index: 8.5700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0019
    Cell Significance Index: -0.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0196
    Cell Significance Index: -0.6900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0417
    Cell Significance Index: -26.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0550
    Cell Significance Index: -7.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0575
    Cell Significance Index: -2.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0829
    Cell Significance Index: -61.3900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0949
    Cell Significance Index: -71.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0977
    Cell Significance Index: -71.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1442
    Cell Significance Index: -81.3400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1717
    Cell Significance Index: -3.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1768
    Cell Significance Index: -30.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2195
    Cell Significance Index: -16.3600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.2534
    Cell Significance Index: -41.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3133
    Cell Significance Index: -21.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3171
    Cell Significance Index: -91.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3205
    Cell Significance Index: -46.5900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3764
    Cell Significance Index: -79.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3993
    Cell Significance Index: -40.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3998
    Cell Significance Index: -47.1500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.5000
    Cell Significance Index: -7.1800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5558
    Cell Significance Index: -35.0300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6494
    Cell Significance Index: -14.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7148
    Cell Significance Index: -74.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7514
    Cell Significance Index: -39.0400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.7544
    Cell Significance Index: -86.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.7689
    Cell Significance Index: -54.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.7711
    Cell Significance Index: -88.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8719
    Cell Significance Index: -45.7800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.9169
    Cell Significance Index: -5.5400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.1170
    Cell Significance Index: -88.4700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.1541
    Cell Significance Index: -19.4400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.3592
    Cell Significance Index: -43.2900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.3609
    Cell Significance Index: -26.9100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.3848
    Cell Significance Index: -45.3400
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -1.4840
    Cell Significance Index: -14.1200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.5869
    Cell Significance Index: -33.6800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.6255
    Cell Significance Index: -39.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.6527
    Cell Significance Index: -27.6600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.6798
    Cell Significance Index: -102.9900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.6858
    Cell Significance Index: -23.0000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -1.6978
    Cell Significance Index: -17.5700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.7146
    Cell Significance Index: -18.6800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.7695
    Cell Significance Index: -61.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PPP3CA is a catalytic subunit of the protein phosphatase 3 (PP3) complex, which is a heterodimeric enzyme composed of PPP3CA and PPP3R1. PPP3CA is a 40 kDa protein with a high degree of homology to other phosphatase catalytic subunits. Its primary function is to dephosphorylate a wide range of protein substrates, including transcription factors, kinases, and other phosphoproteins. **Pathways and Functions:** PPP3CA plays a pivotal role in various cellular signaling pathways, including: 1. **Calcineurin-mediated signaling:** PPP3CA dephosphorylates and activates calcineurin, a key regulator of T-cell activation and immune responses. 2. **Adaptive immune system:** PPP3CA modulates the activity of immune cells, such as T-cells and B-cells, by dephosphorylating and activating key transcription factors, such as NFAT and NF-κB. 3. **C-type lectin receptors (CLRs):** PPP3CA interacts with CLR signaling pathways, influencing the activation of immune cells and the regulation of inflammatory responses. 4. **Calmodulin-dependent protein phosphatase activity:** PPP3CA is involved in the regulation of calcium-dependent signaling pathways, which are critical for immune cell activation and function. **Clinical Significance:** Dysregulation of PPP3CA has been implicated in various diseases, including: 1. **Autoimmune disorders:** Altered PPP3CA expression and activity have been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer:** Aberrant PPP3CA expression has been observed in various types of cancer, including breast cancer and lymphoma. 3. **Neurological disorders:** PPP3CA dysfunction has been implicated in neurological conditions, such as Alzheimer's disease and Parkinson's disease. 4. **Infectious diseases:** PPP3CA plays a critical role in the regulation of immune responses to infections, and its dysregulation can contribute to the development of sepsis and other immunocompromised states. **Significantly Expressed Cells:** PPP3CA is widely expressed in various cell types, including: 1. **Immune cells:** T-cells, B-cells, macrophages, and dendritic cells. 2. **Neuronal cells:** Neurons, astrocytes, and oligodendrocytes. 3. **Epithelial cells:** Epithelial cells of the skin, lung, and gut. **Proteins:** PPP3CA interacts with various proteins, including: 1. **PP2BA_HUMAN (CAM-PRP catalytic subunit):** A homologous protein that shares similar catalytic activity with PPP3CA. 2. **A0A0S2Z4B5_HUMAN:** A protein that interacts with PPP3CA in the regulation of immune responses. In conclusion, PPP3CA is a multifaceted enzyme that plays a critical role in immune regulation, cellular signaling, and protein dephosphorylation. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding PPP3CA's complex biology and its implications in human health and disease.

Genular Protein ID: 3003412150

Symbol: PP2BA_HUMAN

Name: CAM-PRP catalytic subunit

UniProtKB Accession Codes:

Q08209 A1A441 A8K3B7 A8W6Z7 A8W6Z8 B5BUA2 Q8TAW9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 ComplexPortal 4 DEPOD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 DrugCentral 1 EC 2 ELM 1 EMBL 15 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 70 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 17 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 5 RefSeq 3 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8392375

Title: Molecular cloning of a full-length cDNA encoding the catalytic subunit of human calmodulin-dependent protein phosphatase (calcineurin A alpha).

PubMed ID: 8392375

DOI: 10.1016/0167-4889(93)90117-8

PubMed ID: 20590401

Title: Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative splicing patterns, association of 5'UTR trinucleotide repeat with addiction vulnerability, and differential isoform expression in Alzheimer's disease.

PubMed ID: 20590401

DOI: 10.3109/10826084.2010.482449

PubMed ID: 21647268

Title: Identification of differentially expressed genes in uveal melanoma using suppressive subtractive hybridization.

PubMed ID: 21647268

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11114196

Title: Calsarcins, a novel family of sarcomeric calcineurin-binding proteins.

PubMed ID: 11114196

DOI: 10.1073/pnas.260501097

PubMed ID: 11842093

Title: Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins.

PubMed ID: 11842093

DOI: 10.1074/jbc.m200712200

PubMed ID: 12809556

Title: Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life.

PubMed ID: 12809556

DOI: 10.1042/bj20030267

PubMed ID: 15454081

Title: The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.

PubMed ID: 15454081

DOI: 10.1016/j.cell.2004.09.015

PubMed ID: 15671020

Title: Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin.

PubMed ID: 15671020

DOI: 10.1074/jbc.m411494200

PubMed ID: 17923693

Title: Protein kinase A, Ca2+/calmodulin-dependent kinase II, and calcineurin regulate the intracellular trafficking of myopodin between the Z-disc and the nucleus of cardiac myocytes.

PubMed ID: 17923693

DOI: 10.1128/mcb.00950-07

PubMed ID: 18838687

Title: Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria.

PubMed ID: 18838687

DOI: 10.1073/pnas.0808249105

PubMed ID: 19154138

Title: The proline-rich N-terminal sequence of calcineurin Abeta determines substrate binding.

PubMed ID: 19154138

DOI: 10.1021/bi8019355

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28942967

Title: De Novo Mutations in PPP3CA Cause Severe Neurodevelopmental Disease with Seizures.

PubMed ID: 28942967

DOI: 10.1016/j.ajhg.2017.08.013

PubMed ID: 29043977

Title: A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis.

PubMed ID: 29043977

DOI: 10.7554/elife.27356

PubMed ID: 28881575

Title: Overexpression of C16orf74 is involved in aggressive pancreatic cancers.

PubMed ID: 28881575

DOI: 10.18632/oncotarget.10912

PubMed ID: 30611118

Title: Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment.

PubMed ID: 30611118

DOI: 10.1016/j.isci.2018.12.012

PubMed ID: 30718414

Title: Calcineurin dephosphorylates Kelch-like 3, reversing phosphorylation by angiotensin II and regulating renal electrolyte handling.

PubMed ID: 30718414

DOI: 10.1073/pnas.1817281116

PubMed ID: 33691586

Title: Coxsackievirus B3 targets TFEB to disrupt lysosomal function.

PubMed ID: 33691586

DOI: 10.1080/15548627.2021.1896925

PubMed ID: 34446558

Title: SPATA33 localizes calcineurin to the mitochondria and regulates sperm motility in mice.

PubMed ID: 34446558

DOI: 10.1073/pnas.2106673118

PubMed ID: 8524402

Title: Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex.

PubMed ID: 8524402

DOI: 10.1038/378641a0

PubMed ID: 12218175

Title: Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes.

PubMed ID: 12218175

DOI: 10.1073/pnas.192206699

PubMed ID: 12357034

Title: Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin.

PubMed ID: 12357034

DOI: 10.1073/pnas.212504399

PubMed ID: 17498738

Title: Structure of calcineurin in complex with PVIVIT peptide: portrait of a low-affinity signalling interaction.

PubMed ID: 17498738

DOI: 10.1016/j.jmb.2007.04.032

PubMed ID: 17502104

Title: Structure of the calcineurin-NFAT complex: defining a T cell activation switch using solution NMR and crystal coordinates.

PubMed ID: 17502104

DOI: 10.1016/j.str.2007.03.015

PubMed ID: 18384083

Title: The complex structure of calmodulin bound to a calcineurin peptide.

PubMed ID: 18384083

DOI: 10.1002/prot.22032

PubMed ID: 19404396

Title: Domain swapping and different oligomeric States for the complex between calmodulin and the calmodulin-binding domain of calcineurin a.

PubMed ID: 19404396

DOI: 10.1371/journal.pone.0005402

PubMed ID: 22343722

Title: Balanced interactions of calcineurin with AKAP79 regulate Ca2+-calcineurin-NFAT signaling.

PubMed ID: 22343722

DOI: 10.1038/nsmb.2238

PubMed ID: 23468591

Title: The molecular mechanism of substrate engagement and immunosuppressant inhibition of calcineurin.

PubMed ID: 23468591

DOI: 10.1371/journal.pbio.1001492

PubMed ID: 25144868

Title: Stoichiometry of the calcineurin regulatory domain-calmodulin complex.

PubMed ID: 25144868

DOI: 10.1021/bi5004734

PubMed ID: 26248042

Title: Calcineurin Undergoes a Conformational Switch Evoked via Peptidyl-Prolyl Isomerization.

PubMed ID: 26248042

DOI: 10.1371/journal.pone.0134569

PubMed ID: 27974827

Title: Investigating the human Calcineurin Interaction Network using the piLxVP SLiM.

PubMed ID: 27974827

DOI: 10.1038/srep38920

PubMed ID: 31375679

Title: Molecular basis for the binding and selective dephosphorylation of Na+/H+ exchanger 1 by calcineurin.

PubMed ID: 31375679

DOI: 10.1038/s41467-019-11391-7

PubMed ID: 29432562

Title: Loss-of-function and gain-of-function mutations in PPP3CA cause two distinct disorders.

PubMed ID: 29432562

DOI: 10.1093/hmg/ddy052

PubMed ID: 30254215

Title: Novel calcineurin A (PPP3CA) variant associated with epilepsy, constitutive enzyme activation and downregulation of protein expression.

PubMed ID: 30254215

DOI: 10.1038/s41431-018-0254-8

Sequence Information:

  • Length: 521
  • Mass: 58688
  • Checksum: 16480D62DDBF1F40
  • Sequence:
    • MSEPKAIDPK LSTTDRVVKA VPFPPSHRLT AKEVFDNDGK PRVDILKAHL MKEGRLEESV 
ALRIITEGAS ILRQEKNLLD IDAPVTVCGD IHGQFFDLMK LFEVGGSPAN TRYLFLGDYV 
DRGYFSIECV LYLWALKILY PKTLFLLRGN HECRHLTEYF TFKQECKIKY SERVYDACMD 
AFDCLPLAAL MNQQFLCVHG GLSPEINTLD DIRKLDRFKE PPAYGPMCDI LWSDPLEDFG 
NEKTQEHFTH NTVRGCSYFY SYPAVCEFLQ HNNLLSILRA HEAQDAGYRM YRKSQTTGFP 
SLITIFSAPN YLDVYNNKAA VLKYENNVMN IRQFNCSPHP YWLPNFMDVF TWSLPFVGEK 
VTEMLVNVLN ICSDDELGSE EDGFDGATAA ARKEVIRNKI RAIGKMARVF SVLREESESV 
LTLKGLTPTG MLPSGVLSGG KQTLQSATVE AIEADEAIKG FSPQHKITSF EEAKGLDRIN 
ERMPPRRDAM PSDANLNSIN KALTSETNGT DSNGSNSSNI Q

Genular Protein ID: 1340068074

Symbol: A0A0S2Z4B5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z4B5

Database IDs:

ARBA 9 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 10 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 2 ExpressionAtlas 1 GO 7 Gene3D 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 Pfam 1 RefSeq 1 Rhea 6 RuleBase 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 511
  • Mass: 57659
  • Checksum: B1E98CC0D6034CCC
  • Sequence:
    • MSEPKAIDPK LSTTDRVVKA VPFPPSHRLT AKEVFDNDGK PRVDILKAHL MKEGRLEESV 
ALRIITEGAS ILRQEKNLLD IDAPVTVCGD IHGQFFDLMK LFEVGGSPAN TRYLFLGDYV 
DRGYFSIECV LYLWALKILY PKTLFLLRGN HECRHLTEYF TFKQECKIKY SERVYDACMD 
AFDCLPLAAL MNQQFLCVHG GLSPEINTLD DIRKLDRFKE PPAYGPMCDI LWSDPLEDFG 
NEKTQEHFTH NTVRGCSYFY SYPAVCEFLQ HNNLLSILRA HEAQDAGYRM YRKSQTTGFP 
SLITIFSAPN YLDVYNNKAA VLKYENNVMN IRQFNCSPHP YWLPNFMDVF TWSLPFVGEK 
VTEMLVNVLN ICSDDELGSE EDGFDGATAA ARKEVIRNKI RAIGKMARVF SVLREESESV 
LTLKGLTPTG MLPSGVLSGG KQTLQSAIKG FSPQHKITSF EEAKGLDRIN ERMPPRRDAM 
PSDANLNSIN KALTSETNGT DSNGSNSSNI Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.