Details for: PPP4C

Gene ID: 5531

Symbol: PPP4C

Ensembl ID: ENSG00000149923

Description: protein phosphatase 4 catalytic subunit

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 272.1395
    Cell Significance Index: -42.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 172.7622
    Cell Significance Index: -43.8200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 144.0717
    Cell Significance Index: -59.3500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 125.6593
    Cell Significance Index: -51.0500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 121.9704
    Cell Significance Index: -57.5900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 110.6758
    Cell Significance Index: -56.9300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 85.9249
    Cell Significance Index: -57.6600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 54.3549
    Cell Significance Index: -51.9000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 43.6593
    Cell Significance Index: -53.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.3739
    Cell Significance Index: -56.7200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.1994
    Cell Significance Index: -37.4700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.4933
    Cell Significance Index: -28.1100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.8903
    Cell Significance Index: -15.0800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.5037
    Cell Significance Index: 73.5300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.2217
    Cell Significance Index: 58.4200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.9088
    Cell Significance Index: 15.2400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.7853
    Cell Significance Index: 16.4400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.6589
    Cell Significance Index: 30.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.6254
    Cell Significance Index: 191.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5926
    Cell Significance Index: 82.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.5721
    Cell Significance Index: 117.1700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.5609
    Cell Significance Index: 54.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.4989
    Cell Significance Index: 70.4500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.4203
    Cell Significance Index: 29.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3503
    Cell Significance Index: 737.4300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.2997
    Cell Significance Index: 14.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2789
    Cell Significance Index: 230.5400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.2520
    Cell Significance Index: 80.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1923
    Cell Significance Index: 146.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0699
    Cell Significance Index: 138.2300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0411
    Cell Significance Index: 113.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.0326
    Cell Significance Index: 73.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9849
    Cell Significance Index: 135.2500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.9825
    Cell Significance Index: 51.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9229
    Cell Significance Index: 408.0300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.8815
    Cell Significance Index: 5.4300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8579
    Cell Significance Index: 59.3300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7531
    Cell Significance Index: 74.5000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7487
    Cell Significance Index: 20.3800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7475
    Cell Significance Index: 19.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6126
    Cell Significance Index: 27.7700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.6030
    Cell Significance Index: 6.8500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5728
    Cell Significance Index: 16.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5640
    Cell Significance Index: 72.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5019
    Cell Significance Index: 23.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3804
    Cell Significance Index: 10.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3715
    Cell Significance Index: 73.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2281
    Cell Significance Index: 45.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2220
    Cell Significance Index: 42.2400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2049
    Cell Significance Index: 3.0700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1824
    Cell Significance Index: 10.9500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1168
    Cell Significance Index: 80.8000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1027
    Cell Significance Index: 3.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0402
    Cell Significance Index: 14.4200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0257
    Cell Significance Index: 0.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0248
    Cell Significance Index: 4.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0205
    Cell Significance Index: 15.5000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0173
    Cell Significance Index: 0.1400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0024
    Cell Significance Index: 0.0300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0078
    Cell Significance Index: -0.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0137
    Cell Significance Index: -25.7600
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0146
    Cell Significance Index: -0.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0231
    Cell Significance Index: -2.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0276
    Cell Significance Index: -50.9700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0324
    Cell Significance Index: -49.8900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0326
    Cell Significance Index: -23.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0412
    Cell Significance Index: -56.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0658
    Cell Significance Index: -41.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0736
    Cell Significance Index: -54.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0761
    Cell Significance Index: -12.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0976
    Cell Significance Index: -55.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1017
    Cell Significance Index: -63.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1034
    Cell Significance Index: -6.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1104
    Cell Significance Index: -50.1200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1357
    Cell Significance Index: -0.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1572
    Cell Significance Index: -45.2400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1720
    Cell Significance Index: -5.5100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1957
    Cell Significance Index: -5.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2282
    Cell Significance Index: -11.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2681
    Cell Significance Index: -31.2400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2962
    Cell Significance Index: -5.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3140
    Cell Significance Index: -45.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3156
    Cell Significance Index: -36.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3184
    Cell Significance Index: -67.0600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4251
    Cell Significance Index: -11.3700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4324
    Cell Significance Index: -9.9900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4581
    Cell Significance Index: -6.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5343
    Cell Significance Index: -32.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5388
    Cell Significance Index: -56.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5519
    Cell Significance Index: -42.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5907
    Cell Significance Index: -33.1500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5975
    Cell Significance Index: -47.3200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7147
    Cell Significance Index: -8.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7154
    Cell Significance Index: -48.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7226
    Cell Significance Index: -19.3600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.7443
    Cell Significance Index: -10.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8737
    Cell Significance Index: -53.5700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9370
    Cell Significance Index: -27.6000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.9989
    Cell Significance Index: -12.7900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.1185
    Cell Significance Index: -28.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** PPP4C is expressed in a wide range of cell types, including myeloid leukocytes, pancreatic acinar cells, epithelial cells of the esophagus, and immune cells such as CD14-positive and CD8-alpha-alpha-positive T cells. 2. **Protein Phosphatase Activity:** PPP4C is a catalytic subunit of protein phosphatase 4, which possesses serine/threonine protein phosphatase activity, enabling it to dephosphorylate and regulate various proteins. 3. **DNA Repair:** PPP4C is involved in the regulation of double-strand break repair via homologous recombination, a critical process for maintaining genomic integrity. 4. **Cell Signaling:** PPP4C modulates various cell signaling pathways, including those involved in the regulation of cytoskeleton dynamics, cell migration, and cell survival. **Pathways and Functions:** 1. **DNA Double-Strand Break Repair:** PPP4C plays a crucial role in the regulation of double-strand break repair via homologous recombination, a process essential for maintaining genomic stability. 2. **Cell Signaling:** PPP4C modulates various cell signaling pathways, including those involved in the regulation of cytoskeleton dynamics, cell migration, and cell survival. 3. **Metal Ion Binding:** PPP4C binds to metal ions, which are essential for its catalytic activity and protein-protein interactions. 4. **Regulation of Double-Strand Break Repair:** PPP4C regulates the processing of DNA double-strand break ends, a critical step in the repair process. 5. **Regulation of Homologous Recombination:** PPP4C modulates the regulation of homologous recombination, a process essential for maintaining genomic integrity. **Clinical Significance:** 1. **Cancer:** Dysregulation of PPP4C has been implicated in various cancers, including breast, lung, and colon cancer, highlighting its potential as a therapeutic target. 2. **Immunodeficiency:** PPP4C plays a crucial role in the regulation of immune cell function, and its dysfunction may contribute to immunodeficiency disorders. 3. **Neurodegenerative Diseases:** PPP4C may be involved in the regulation of protein phosphatase activity in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 4. **Infectious Diseases:** PPP4C may play a role in the regulation of immune responses to infections, highlighting its potential as a therapeutic target for infectious diseases. In conclusion, PPP4C is a multifaceted gene that plays a crucial role in maintaining genomic stability, regulating cell signaling pathways, and modulating the immune response. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target. Further research is needed to fully understand the mechanisms of PPP4C and its role in human disease.

Genular Protein ID: 359006559

Symbol: PP4C_HUMAN

Name: Serine/threonine-protein phosphatase 4 catalytic subunit

UniProtKB Accession Codes:

P60510 P33172

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 16 ChiTaRS 1 ComplexPortal 5 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1336397

Title: Protein phosphatase X has been highly conserved during mammalian evolution.

PubMed ID: 1336397

DOI: 10.1016/0167-4781(92)90129-n

PubMed ID: 9837938

Title: Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity.

PubMed ID: 9837938

DOI: 10.1074/jbc.273.50.33561

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11698396

Title: Protein phosphatase 4 is involved in tumor necrosis factor-alpha-induced activation of c-Jun N-terminal kinase.

PubMed ID: 11698396

DOI: 10.1074/jbc.m107014200

PubMed ID: 12934076

Title: Functional expression cloning reveals proapoptotic role for protein phosphatase 4.

PubMed ID: 12934076

DOI: 10.1038/sj.cdd.4401274

PubMed ID: 12668731

Title: Protein phosphatase 4 interacts with the survival of motor neurons complex and enhances the temporal localisation of snRNPs.

PubMed ID: 12668731

DOI: 10.1242/jcs.00409

PubMed ID: 15331607

Title: Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation.

PubMed ID: 15331607

DOI: 10.1074/jbc.m408067200

PubMed ID: 15805470

Title: Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4.

PubMed ID: 15805470

DOI: 10.1101/gad.1286005

PubMed ID: 16085932

Title: A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity.

PubMed ID: 16085932

DOI: 10.1074/mcp.m500231-mcp200

PubMed ID: 18758438

Title: PP4 is a gammaH2AX phosphatase required for recovery from the DNA damage checkpoint.

PubMed ID: 18758438

DOI: 10.1038/embor.2008.162

PubMed ID: 18487071

Title: Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases.

PubMed ID: 18487071

DOI: 10.1016/j.biocel.2008.03.021

PubMed ID: 18715871

Title: PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4.

PubMed ID: 18715871

DOI: 10.1074/jbc.m803443200

PubMed ID: 18347064

Title: Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation.

PubMed ID: 18347064

DOI: 10.1083/jcb.200705148

PubMed ID: 18614045

Title: A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication.

PubMed ID: 18614045

DOI: 10.1016/j.molcel.2008.05.016

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20154705

Title: A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination.

PubMed ID: 20154705

DOI: 10.1038/nsmb.1769

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25130464

Title: Leucine methylation of protein phosphatase PP4C at C-terminal is critical for its cellular functions.

PubMed ID: 25130464

DOI: 10.1016/j.bbrc.2014.08.045

Sequence Information:

  • Length: 307
  • Mass: 35080
  • Checksum: D6FE470A5C6CBCAC
  • Sequence:
    • MAEISDLDRQ IEQLRRCELI KESEVKALCA KAREILVEES NVQRVDSPVT VCGDIHGQFY 
DLKELFRVGG DVPETNYLFM GDFVDRGFYS VETFLLLLAL KVRYPDRITL IRGNHESRQI 
TQVYGFYDEC LRKYGSVTVW RYCTEIFDYL SLSAIIDGKI FCVHGGLSPS IQTLDQIRTI 
DRKQEVPHDG PMCDLLWSDP EDTTGWGVSP RGAGYLFGSD VVAQFNAAND IDMICRAHQL 
VMEGYKWHFN ETVLTVWSAP NYCYRCGNVA AILELDEHLQ KDFIIFEAAP QETRGIPSKK 
PVADYFL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.