Details for: PRB3

Gene ID: 5544

Symbol: PRB3

Ensembl ID: ENSG00000197870

Description: proline rich protein BstNI subfamily 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 12.4187
    Cell Significance Index: 259.0000
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 11.4030
    Cell Significance Index: 63.4700
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 3.4188
    Cell Significance Index: 34.2100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.3884
    Cell Significance Index: 33.6300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.2528
    Cell Significance Index: 8.0000
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.2036
    Cell Significance Index: 2.2800
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.1046
    Cell Significance Index: 1.1200
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.0776
    Cell Significance Index: 0.7200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0511
    Cell Significance Index: 1.3700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0461
    Cell Significance Index: 0.6800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0414
    Cell Significance Index: 8.2200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0307
    Cell Significance Index: 0.4400
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.0306
    Cell Significance Index: 0.3900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.0280
    Cell Significance Index: 0.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0197
    Cell Significance Index: 0.9200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0168
    Cell Significance Index: 0.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0133
    Cell Significance Index: 1.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0107
    Cell Significance Index: 1.9300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0101
    Cell Significance Index: 0.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0081
    Cell Significance Index: 1.6300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0070
    Cell Significance Index: 0.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0067
    Cell Significance Index: 0.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0058
    Cell Significance Index: 0.7100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0048
    Cell Significance Index: 6.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0025
    Cell Significance Index: 1.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0015
    Cell Significance Index: 2.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0013
    Cell Significance Index: 0.0700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0012
    Cell Significance Index: 0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0008
    Cell Significance Index: 1.5400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0006
    Cell Significance Index: 1.1700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0005
    Cell Significance Index: 0.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0004
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0011
    Cell Significance Index: -0.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0011
    Cell Significance Index: -0.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0013
    Cell Significance Index: -0.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0015
    Cell Significance Index: -0.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0016
    Cell Significance Index: -0.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0016
    Cell Significance Index: -0.4700
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0018
    Cell Significance Index: -0.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0018
    Cell Significance Index: -0.2600
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: -0.0023
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0031
    Cell Significance Index: -0.3500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0032
    Cell Significance Index: -0.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0034
    Cell Significance Index: -0.4700
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: -0.0040
    Cell Significance Index: -0.0300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0042
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0043
    Cell Significance Index: -0.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0059
    Cell Significance Index: -0.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0059
    Cell Significance Index: -0.4600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0076
    Cell Significance Index: -0.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0077
    Cell Significance Index: -0.8000
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.0080
    Cell Significance Index: -0.0700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0086
    Cell Significance Index: -0.1400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0086
    Cell Significance Index: -0.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0089
    Cell Significance Index: -0.5000
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.0100
    Cell Significance Index: -0.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0102
    Cell Significance Index: -0.7600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0105
    Cell Significance Index: -0.0700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0107
    Cell Significance Index: -0.3400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0110
    Cell Significance Index: -0.3600
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0115
    Cell Significance Index: -0.1400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0140
    Cell Significance Index: -0.2400
  • Cell Name: serous cell of epithelium of bronchus (CL1000331)
    Fold Change: -0.0144
    Cell Significance Index: -0.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0150
    Cell Significance Index: -0.9700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0156
    Cell Significance Index: -0.3900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0156
    Cell Significance Index: -0.6400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0167
    Cell Significance Index: -0.4300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0168
    Cell Significance Index: -0.2100
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0168
    Cell Significance Index: -0.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0178
    Cell Significance Index: -0.8400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0180
    Cell Significance Index: -0.4500
  • Cell Name: serous cell of epithelium of trachea (CL1000330)
    Fold Change: -0.0182
    Cell Significance Index: -0.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0196
    Cell Significance Index: -0.8900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0201
    Cell Significance Index: -0.5800
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0207
    Cell Significance Index: -0.2600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0212
    Cell Significance Index: -0.4200
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0214
    Cell Significance Index: -0.1700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0214
    Cell Significance Index: -0.2700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0217
    Cell Significance Index: -0.4500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0224
    Cell Significance Index: -0.3100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0228
    Cell Significance Index: -0.6100
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.0236
    Cell Significance Index: -0.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0242
    Cell Significance Index: -0.8500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0245
    Cell Significance Index: -0.8500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0254
    Cell Significance Index: -0.5300
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: -0.0256
    Cell Significance Index: -0.1500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0257
    Cell Significance Index: -0.5600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0267
    Cell Significance Index: -0.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0268
    Cell Significance Index: -0.7300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0279
    Cell Significance Index: -0.3700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0281
    Cell Significance Index: -0.4100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0282
    Cell Significance Index: -0.2600
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -0.0283
    Cell Significance Index: -0.3000
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0286
    Cell Significance Index: -0.3700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0289
    Cell Significance Index: -0.5000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0291
    Cell Significance Index: -0.5900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0292
    Cell Significance Index: -0.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Proline-rich protein**: The PRB3 protein is characterized by its high content of proline residues, which are essential for its structure and function. 2. **BstNI subfamily**: PRB3 is a member of the BstNI subfamily of proline-rich proteins, which are known for their involvement in cell signaling and immune response. 3. **Cell type specificity**: PRB3 is expressed in a wide range of cell types, including acinar cells of the salivary gland, blood vessel endothelial cells, memory B cells, and lung secretory cells. 4. **Protein binding**: PRB3 interacts with various proteins, including those involved in cell signaling, immune response, and tissue homeostasis. **Pathways and Functions:** 1. **Biological process**: PRB3 is involved in various biological processes, including cell growth, differentiation, and survival. 2. **Defense response to gram-negative bacterium**: PRB3 has been implicated in the defense response to gram-negative bacteria, suggesting its role in innate immunity. 3. **Extracellular region**: PRB3 is secreted into the extracellular environment, where it can interact with other proteins and cells. 4. **Protein binding**: PRB3 interacts with various proteins, including those involved in cell signaling, immune response, and tissue homeostasis. **Clinical Significance:** The PRB3 gene has several potential implications for human health and disease: 1. **Immune response**: PRB3's role in the defense response to gram-negative bacteria makes it a potential target for the development of novel immunotherapies. 2. **Innate immunity**: PRB3's involvement in innate immunity suggests its potential role in the prevention and treatment of infectious diseases. 3. **Tissue homeostasis**: PRB3's expression in various cell types and its interaction with other proteins suggest its potential role in maintaining tissue homeostasis and preventing disease. 4. **Cancer**: PRB3's expression in certain cell types, including those involved in cancer, suggests its potential role in cancer development and progression. In conclusion, the PRB3 gene is a multifaceted gene involved in various cellular processes, including immune response, cell signaling, and tissue homeostasis. Further research is needed to fully understand the role of PRB3 in human health and disease, but its potential implications for the development of novel immunotherapies and treatments for infectious diseases and cancer are significant.

Genular Protein ID: 4121101783

Symbol: A0A0G2JNB4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0G2JNB4

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 Ensembl 2 HGNC 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 2 Pfam 1 Proteomes 2 RefSeq 1 SAM 2 SMART 1

Sequence Information:

  • Length: 309
  • Mass: 30990
  • Checksum: FAE699EFFFD244E7
  • Sequence:
    • MLLILLSVAL LALSSAQSLN EDVSQEESPS VISGKPEGRR PQGGNQPQRT PPPPGKPEGR 
PPQGGNQSQG PPPRPGKPEG PPPQGGNQSQ GPPPRPGKPE GQPPQGGNQS QGPPPRPGKP 
EGPPPQGGNQ SQGPPPRPGK PEGPPPQGGN QSQGPPPRPG KPEGPPPQGG NQSQGPPPHP 
GKPEGPPPQG GNQSQGPPPR PGKPEGPPPQ GGNQSQGPPP RPGKPEGPPS QGGNKPQGPP 
PHPGKPQGPP PQEGNKPQRP PPPGRPQGPP PPGGNPQQPL PPPAGKPQGP PPPPQGGRPH 
RPPQGQPPQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.