Details for: PRB3

Gene ID: 5544

Symbol: PRB3

Ensembl ID: ENSG00000197870

Description: proline rich protein BstNI subfamily 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.53
    Marker Score: 8036
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3180
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.84
    Marker Score: 2145.5
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 1.98
    Marker Score: 724
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.76
    Marker Score: 1215
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.48
    Marker Score: 691
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 876
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.32
    Marker Score: 1180
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.3
    Marker Score: 517
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.19
    Marker Score: 1060
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.05
    Marker Score: 2677
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71839
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48063
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5355
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.9
    Marker Score: 691
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 494
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.54
    Marker Score: 773
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 479
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.49
    Marker Score: 108
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: 0.44
    Marker Score: 123
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.43
    Marker Score: 107
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 376
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.36
    Marker Score: 207
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.31
    Marker Score: 162
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.31
    Marker Score: 97
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.23
    Marker Score: 1557
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.22
    Marker Score: 276
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.2
    Marker Score: 99
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.19
    Marker Score: 100
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.17
    Marker Score: 81
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.16
    Marker Score: 385
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.15
    Marker Score: 89
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.14
    Marker Score: 85
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.14
    Marker Score: 58
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.11
    Marker Score: 75
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.1
    Marker Score: 69
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.1
    Marker Score: 54
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.09
    Marker Score: 55
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.09
    Marker Score: 52
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.08
    Marker Score: 40
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.08
    Marker Score: 71
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.07
    Marker Score: 78
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.07
    Marker Score: 133
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.06
    Marker Score: 57
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.05
    Marker Score: 67
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.05
    Marker Score: 110
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.05
    Marker Score: 461
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.05
    Marker Score: 85
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.05
    Marker Score: 29
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.05
    Marker Score: 72
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.05
    Marker Score: 63.5
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.04
    Marker Score: 31
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.04
    Marker Score: 103
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.04
    Marker Score: 35
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.04
    Marker Score: 38.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.04
    Marker Score: 54
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.04
    Marker Score: 46
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.04
    Marker Score: 110
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.04
    Marker Score: 56
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.03
    Marker Score: 67
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.03
    Marker Score: 36
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.03
    Marker Score: 390
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.03
    Marker Score: 62
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.03
    Marker Score: 29.5
  • Cell Name: serous cell of epithelium of trachea (CL1000330)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.03
    Marker Score: 56
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.03
    Marker Score: 93
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.03
    Marker Score: 35
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.03
    Marker Score: 9

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Other Information

## Summary PRB3 is a protein belonging to the proline-rich protein BstNI subfamily 3. It is a cell surface protein that is highly expressed in various cell types, including acinar cells of the salivary gland, blood vessel endothelial cells, memory B cells, tracheobronchial serous cells, conventional dendritic cells, duct epithelial cells, granulocyte monocyte progenitor cells, lung secretory cells, serous secreting cells, and naive B cells. ## Key characteristics * PRB3 is a cell surface protein with a molecular weight of approximately 130 kDa. * It is a transmembrane protein with a cytoplasmic domain and two extracellular loops. * It is expressed on the surface of cells in various tissues, including the skin, lungs, and gastrointestinal tract. * It is involved in cell adhesion, migration, and signaling. ## Pathways and functions * PRB3 is involved in several cellular processes, including cell adhesion, migration, and signaling. * It is a key protein for the adhesion of cells to extracellular matrix proteins. * It is involved in the migration of cells towards growth factors and other extracellular signals. * It is also involved in cell signaling pathways, such as the PI3K/Akt pathway. ## Clinical significance PRB3 is a promising target for cancer immunotherapy. It is expressed on the surface of cancer cells, and antibodies against PRB3 have been shown to be effective in blocking cancer cell growth in preclinical models. However, further research is needed to develop effective PRB3-targeting therapies for cancer.

Genular Protein ID: 4121101783

Symbol: A0A0G2JNB4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0G2JNB4

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 Ensembl 2 GenomeRNAi 1 HGNC 1 InterPro 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 2 Pfam 1 Proteomes 2 RefSeq 1 SAM 2 SMART 1

Citations:

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 309
  • Mass: 30990
  • Checksum: FAE699EFFFD244E7
  • Sequence:
    • MLLILLSVAL LALSSAQSLN EDVSQEESPS VISGKPEGRR PQGGNQPQRT PPPPGKPEGR 
PPQGGNQSQG PPPRPGKPEG PPPQGGNQSQ GPPPRPGKPE GQPPQGGNQS QGPPPRPGKP 
EGPPPQGGNQ SQGPPPRPGK PEGPPPQGGN QSQGPPPRPG KPEGPPPQGG NQSQGPPPHP 
GKPEGPPPQG GNQSQGPPPR PGKPEGPPPQ GGNQSQGPPP RPGKPEGPPS QGGNKPQGPP 
PHPGKPQGPP PQEGNKPQRP PPPGRPQGPP PPGGNPQQPL PPPAGKPQGP PPPPQGGRPH 
RPPQGQPPQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.