Details for: PRCC

Gene ID: 5546

Symbol: PRCC

Ensembl ID: ENSG00000143294

Description: proline rich mitotic checkpoint control factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 181.8121
    Cell Significance Index: -28.2800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 101.4416
    Cell Significance Index: -25.7300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 68.0727
    Cell Significance Index: -27.6600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 61.6075
    Cell Significance Index: -31.6900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 48.2771
    Cell Significance Index: -32.4000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.1597
    Cell Significance Index: -27.8400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.2483
    Cell Significance Index: -31.1300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.7775
    Cell Significance Index: -26.1900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.1030
    Cell Significance Index: -31.9800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.0874
    Cell Significance Index: -24.8400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.9810
    Cell Significance Index: -13.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.7563
    Cell Significance Index: 204.6800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.6469
    Cell Significance Index: 1487.0300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2237
    Cell Significance Index: 133.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1956
    Cell Significance Index: 71.7800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8483
    Cell Significance Index: 22.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8035
    Cell Significance Index: 159.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7597
    Cell Significance Index: 152.3900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6937
    Cell Significance Index: 18.2400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6541
    Cell Significance Index: 22.7300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6382
    Cell Significance Index: 17.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6137
    Cell Significance Index: 60.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5358
    Cell Significance Index: 65.8800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5108
    Cell Significance Index: 92.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5053
    Cell Significance Index: 26.2500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5035
    Cell Significance Index: 10.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4897
    Cell Significance Index: 14.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4828
    Cell Significance Index: 56.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4629
    Cell Significance Index: 21.7600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4419
    Cell Significance Index: 57.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4097
    Cell Significance Index: 223.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3945
    Cell Significance Index: 54.1800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3873
    Cell Significance Index: 24.4100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3781
    Cell Significance Index: 19.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3697
    Cell Significance Index: 132.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3637
    Cell Significance Index: 7.8800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3564
    Cell Significance Index: 24.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3170
    Cell Significance Index: 8.8600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3115
    Cell Significance Index: 137.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2575
    Cell Significance Index: 33.0100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2547
    Cell Significance Index: 18.9800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2473
    Cell Significance Index: 11.5300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2427
    Cell Significance Index: 15.6600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2248
    Cell Significance Index: 11.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2056
    Cell Significance Index: 39.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1946
    Cell Significance Index: 134.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1932
    Cell Significance Index: 14.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1626
    Cell Significance Index: 7.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1009
    Cell Significance Index: 5.6600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0590
    Cell Significance Index: 4.1700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0545
    Cell Significance Index: 1.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0374
    Cell Significance Index: 70.5100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0097
    Cell Significance Index: 0.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0082
    Cell Significance Index: 15.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0069
    Cell Significance Index: 10.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0067
    Cell Significance Index: 0.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0036
    Cell Significance Index: 0.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0002
    Cell Significance Index: 0.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0007
    Cell Significance Index: -0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0068
    Cell Significance Index: -9.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0089
    Cell Significance Index: -0.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0121
    Cell Significance Index: -5.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0161
    Cell Significance Index: -12.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0165
    Cell Significance Index: -2.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0210
    Cell Significance Index: -15.4200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0269
    Cell Significance Index: -0.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0288
    Cell Significance Index: -21.3000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0338
    Cell Significance Index: -0.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0368
    Cell Significance Index: -3.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0516
    Cell Significance Index: -29.0900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0531
    Cell Significance Index: -0.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0559
    Cell Significance Index: -34.9100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0587
    Cell Significance Index: -0.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0723
    Cell Significance Index: -4.8600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0797
    Cell Significance Index: -2.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0859
    Cell Significance Index: -24.7100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1076
    Cell Significance Index: -1.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1080
    Cell Significance Index: -2.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1135
    Cell Significance Index: -16.5000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1141
    Cell Significance Index: -3.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1141
    Cell Significance Index: -4.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1381
    Cell Significance Index: -6.1100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1632
    Cell Significance Index: -34.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1831
    Cell Significance Index: -20.9800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2020
    Cell Significance Index: -7.6500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2140
    Cell Significance Index: -2.9200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2161
    Cell Significance Index: -5.5200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2725
    Cell Significance Index: -28.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3449
    Cell Significance Index: -27.3200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3632
    Cell Significance Index: -3.3500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4787
    Cell Significance Index: -14.1000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4911
    Cell Significance Index: -7.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5227
    Cell Significance Index: -32.0500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5275
    Cell Significance Index: -10.3000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5425
    Cell Significance Index: -13.5600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5439
    Cell Significance Index: -11.9100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5726
    Cell Significance Index: -13.2300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5911
    Cell Significance Index: -10.4500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.6267
    Cell Significance Index: -8.7900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6283
    Cell Significance Index: -17.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PRCC is a proline-rich protein that exhibits a high degree of sequence similarity across species, suggesting its evolutionary conservation. Its expression is restricted to specific cell types, indicating a specialized function. The gene's involvement in multiple cellular pathways, including cell cycle regulation, mRNA splicing, and protein binding, underscores its multifaceted role in cellular homeostasis. **Pathways and Functions:** PRCC is intricately linked to various cellular processes, including: 1. **Cell Cycle Regulation:** PRCC acts as a mitotic checkpoint control factor, ensuring that cells progress through the cell cycle in an ordered and error-free manner. Its dysregulation can lead to genomic instability, resulting in cancer or other developmental abnormalities. 2. **mRNA Splicing:** PRCC interacts with other splicing factors to regulate mRNA splicing, a critical process in gene expression. Dysregulation of PRCC can lead to aberrant splicing patterns, affecting protein production and cellular function. 3. **Protein Binding:** PRCC binds to specific proteins, modulating their activity and regulating cellular processes. This protein-protein interaction network is essential for maintaining cellular homeostasis. 4. **Nuclear Speck and Processing of Capped Intron-Containing Pre-mRNA:** PRCC is involved in the formation and maintenance of nuclear specks, a type of nuclear structure that regulates gene expression. Additionally, PRCC participates in the processing of capped intron-containing pre-mRNAs, further highlighting its role in mRNA splicing and gene expression. **Clinical Significance:** Dysregulation of PRCC has been implicated in various diseases, including: 1. **Cancer:** Mutations in PRCC can lead to genomic instability, resulting in cancer. For example, alterations in PRCC expression have been observed in breast cancer and other malignancies. 2. **Neurological Disorders:** PRCC's role in regulating mRNA splicing and protein binding suggests that its dysregulation could contribute to neurological disorders, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). 3. **Developmental Abnormalities:** PRCC's involvement in cell cycle regulation and mRNA splicing suggests that its dysregulation could contribute to developmental abnormalities, such as birth defects and miscarriages. In conclusion, PRCC is a critical regulator of cellular processes, including cell cycle control, mRNA splicing, and protein binding. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms underlying PRCC's function and its role in human disease.

Genular Protein ID: 1914187420

Symbol: PRCC_HUMAN

Name: Proline-rich protein PRCC

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8872474

Title: The t(X;1)(p11.2;q21.2) translocation in papillary renal cell carcinoma fuses a novel gene PRCC to the TFE3 transcription factor gene.

PubMed ID: 8872474

DOI: 10.1093/hmg/5.9.1333

PubMed ID: 8986805

Title: Fusion of the transcription factor TFE3 gene to a novel gene, PRCC, in t(X;1)(p11;q21)-positive papillary renal cell carcinomas.

PubMed ID: 8986805

DOI: 10.1073/pnas.93.26.15294

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11717438

Title: Impairment of MAD2B-PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomas.

PubMed ID: 11717438

DOI: 10.1073/pnas.241304198

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 491
  • Mass: 52418
  • Checksum: F99CFD9D42725D57
  • Sequence:
  • MSLVAYASSD ESEPDEAEPE PEEEEAVAPT SGPALGGLFA SLPAPKGPAL LPPPPQMLAP 
    AFPPPLLLPP PTGDPRLQPP PPLPFGLGGF PPPPGVSPAE AAGVGEGLGL GLPSPRGPGL 
    NLPPPIGGAG PPLGLPKPKK RKEPVKIAAP ELHKGDSDSE EDEPTKKKTI LQGSSEGTGL 
    SALLPQPKNL TVKETNRLLL PHAFSRKPSD GSPDTKPSRL ASKTKTSSLA PVVGTTTTTP 
    SPSAIKAAAK SAALQVTKQI TQEEDDSDEE VAPENFFSLP EKAEPPGVEP YPYPIPTVPE 
    ELPPGTEPEP AFQDDAANAP LEFKMAAGSS GAPWMPKPGD DYSYNQFSTY GDANAAGAYY 
    QDYYSGGYYP AQDPALVPPQ EIAPDASFID DEAFKRLQGK RNRGREEINF VEIKGDDQLS 
    GAQQWMTKSL TEEKTMKSFS KKKGEQPTGQ QRRKHQITYL IHQAKERELE LKNTWSENKL 
    SRRQTQAKYG F

Genular Protein ID: 3336304909

Symbol: Q96FT4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 491
  • Mass: 52422
  • Checksum: 4A808B462FC48126
  • Sequence:
  • MSLVAYASSD ESEPDEAEPE PEEEEAVAPT SGPALGGLFA SLPAPKGPAL LPPPPQMLAP 
    AFPPPLLLPP PTGDPRLQPP PPLPFGLGGF PPPPGVSPAE AAGVGEGLGL GLPSPRGPGL 
    NLPPPIGGAG PPLGLPKPKK RKEPVKIAAP ELHKGDSDSE EDEPTKKKTI LQGSSEGTGL 
    SALLPQPKNL TVKETNRLLL PHAFSRKPSD GSPDTKPSRL ASKTKTSSLA PVVGTTTTTP 
    SPSAIKAAAK SAALQVTKQI TQEEDDSDEE VAPENFFSLP EKAEPPGVEP YPYPIPTVPE 
    ELPPGTEPEP AFQDDAANAP LEFKMAAGSS GAPWMPKPGD DYSYNQFSTY GDANAAGAYY 
    QDYYSGGYYP AQDPALVPTQ EIAPDASFID DEAFKRLQGK RNRGREEINF VEIKGDDQLS 
    GAQQWMTKSL TEEKTMKSFS KKKGEQPTGQ QRRKHQITYL IHQAKERELE LKNTWSENKL 
    SRRQTQAKYG F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.