PRKAA1 | ENSG00000132356 | NCBI 5562

Details for: PRKAA1

Gene ID: 5562

Symbol: PRKAA1

Ensembl ID: ENSG00000132356

Description: protein kinase AMP-activated catalytic subunit alpha 1

Associated with

Activation of ampk downstream of nmdars
(R-HSA-9619483)
Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Energy dependent regulation of mtor by lkb1-ampk
(R-HSA-380972)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Macroautophagy
(R-HSA-1632852)
Mtor signalling
(R-HSA-165159)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Post nmda receptor activation events
(R-HSA-438064)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through phosphorylation
(R-HSA-6804756)
Rna polymerase ii transcription
(R-HSA-73857)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transmission across chemical synapses
(R-HSA-112315)
Amp-activated protein kinase activity
(GO:0004679)
Atp binding
(GO:0005524)
Autophagy
(GO:0006914)
Camkk-ampk signaling cascade
(GO:0061762)
Camp-dependent protein kinase activity
(GO:0004691)
Cellular response to calcium ion
(GO:0071277)
Cellular response to ethanol
(GO:0071361)
Cellular response to glucose starvation
(GO:0042149)
Cellular response to glucose stimulus
(GO:0071333)
Cellular response to hydrogen peroxide
(GO:0070301)
Cellular response to hypoxia
(GO:0071456)
Cellular response to nutrient levels
(GO:0031669)
Cellular response to oxidative stress
(GO:0034599)
Cellular response to prostaglandin e stimulus
(GO:0071380)
Cellular response to stress
(GO:0033554)
Cellular response to xenobiotic stimulus
(GO:0071466)
Cholesterol biosynthetic process
(GO:0006695)
Chromatin binding
(GO:0003682)
Chromatin remodeling
(GO:0006338)
Cold acclimation
(GO:0009631)
Energy homeostasis
(GO:0097009)
Fatty acid biosynthetic process
(GO:0006633)
Fatty acid homeostasis
(GO:0055089)
Fatty acid oxidation
(GO:0019395)
Glucose homeostasis
(GO:0042593)
Glucose metabolic process
(GO:0006006)
Histone h2as1 kinase activity
(GO:0044024)
Histone h2bs36 kinase activity
(GO:0140823)
Lipid biosynthetic process
(GO:0008610)
Metal ion binding
(GO:0046872)
Motor behavior
(GO:0061744)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of glucosylceramide biosynthetic process
(GO:0046318)
Negative regulation of hepatocyte apoptotic process
(GO:1903944)
Negative regulation of insulin receptor signaling pathway
(GO:0046627)
Negative regulation of lipid catabolic process
(GO:0050995)
Negative regulation of tor signaling
(GO:0032007)
Neuron cellular homeostasis
(GO:0070050)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cholesterol biosynthetic process
(GO:0045542)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of glycolytic process
(GO:0045821)
Positive regulation of mitochondrial transcription
(GO:1903109)
Positive regulation of protein localization
(GO:1903829)
Positive regulation of skeletal muscle tissue development
(GO:0048643)
Positive regulation of t cell activation
(GO:0050870)
Positive regulation of t cell mediated immune response to tumor cell
(GO:0002842)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Regulation of circadian rhythm
(GO:0042752)
Regulation of microtubule cytoskeleton organization
(GO:0070507)
Regulation of stress granule assembly
(GO:0062028)
Regulation of vesicle-mediated transport
(GO:0060627)
Response to activity
(GO:0014823)
Response to caffeine
(GO:0031000)
Response to estrogen
(GO:0043627)
Response to gamma radiation
(GO:0010332)
Response to hypoxia
(GO:0001666)
Response to uv
(GO:0009411)
Rhythmic process
(GO:0048511)
Signal transduction
(GO:0007165)
Tau-protein kinase activity
(GO:0050321)
Tau protein binding
(GO:0048156)
Wnt signaling pathway
(GO:0016055)
[hydroxymethylglutaryl-coa reductase (nadph)] kinase activity
(GO:0047322)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 219.7432
Cell Significance Index: -34.1800
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 133.2580
Cell Significance Index: -33.8000
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 79.5662
Cell Significance Index: -37.5700
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 78.2017
Cell Significance Index: -31.7700
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 70.1225
Cell Significance Index: -36.0700
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 56.2053
Cell Significance Index: -37.7200
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 33.3702
Cell Significance Index: -31.8600
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 29.7010
Cell Significance Index: -36.6200
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 12.8226
Cell Significance Index: -34.3500
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 9.4145
Cell Significance Index: -37.1500
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 9.2845
Cell Significance Index: -20.3200
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 9.0153
Cell Significance Index: -27.6900
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.5303
Cell Significance Index: 91.8700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.4862
Cell Significance Index: 161.6600
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.1439
Cell Significance Index: 227.0100
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.9005
Cell Significance Index: 813.0400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.7650
Cell Significance Index: 153.4500
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.7598
Cell Significance Index: 52.5500
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.7247
Cell Significance Index: 4.9100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.6540
Cell Significance Index: 117.8900
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.6456
Cell Significance Index: 12.6000
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.5740
Cell Significance Index: 70.5800
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.5526
Cell Significance Index: 75.8900
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.5276
Cell Significance Index: 364.9100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.4414
Cell Significance Index: 20.5800
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.4267
Cell Significance Index: 153.0600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.4029
Cell Significance Index: 20.9300
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.3765
Cell Significance Index: 205.6400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.3744
Cell Significance Index: 28.7300
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.3513
Cell Significance Index: 9.0300
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.3053
Cell Significance Index: 19.2400
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2990
Cell Significance Index: 8.3600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2926
Cell Significance Index: 8.4300
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.2725
Cell Significance Index: 15.2900
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.2584
Cell Significance Index: 6.4600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.2521
Cell Significance Index: 11.8500
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.2102
Cell Significance Index: 3.5400
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.1661
Cell Significance Index: 4.5200
Cell Name: odontoblast (CL0000060)
Fold Change: 0.1597
Cell Significance Index: 20.4700
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1572
Cell Significance Index: 7.1300
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.1531
Cell Significance Index: 9.8800
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1512
Cell Significance Index: 28.7800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.1418
Cell Significance Index: 10.5700
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.1401
Cell Significance Index: 3.7600
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.1140
Cell Significance Index: 5.9400
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1114
Cell Significance Index: 49.2600
Cell Name: lactocyte (CL0002325)
Fold Change: 0.0528
Cell Significance Index: 6.8300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0518
Cell Significance Index: 97.5400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0428
Cell Significance Index: 7.3100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0298
Cell Significance Index: 18.9300
Cell Name: slow muscle cell (CL0000189)
Fold Change: 0.0100
Cell Significance Index: 0.1500
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0087
Cell Significance Index: 3.9700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0015
Cell Significance Index: 0.1500
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0047
Cell Significance Index: -7.1900
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0055
Cell Significance Index: -10.1400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0077
Cell Significance Index: -0.2700
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0095
Cell Significance Index: -6.9400
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0137
Cell Significance Index: -0.3600
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.0174
Cell Significance Index: -0.2500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0206
Cell Significance Index: -27.9700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0255
Cell Significance Index: -19.2800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0322
Cell Significance Index: -23.8800
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.0514
Cell Significance Index: -8.3600
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0546
Cell Significance Index: -3.8600
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.0570
Cell Significance Index: -0.5200
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0570
Cell Significance Index: -32.1200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0594
Cell Significance Index: -7.0100
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0666
Cell Significance Index: -41.6200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0670
Cell Significance Index: -6.8400
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0852
Cell Significance Index: -4.3100
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1119
Cell Significance Index: -32.1900
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1146
Cell Significance Index: -13.3500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1255
Cell Significance Index: -18.2400
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1507
Cell Significance Index: -9.2600
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1571
Cell Significance Index: -6.9500
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.1734
Cell Significance Index: -2.4900
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1881
Cell Significance Index: -21.5500
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1909
Cell Significance Index: -40.2100
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2006
Cell Significance Index: -13.4900
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2163
Cell Significance Index: -8.1900
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.2206
Cell Significance Index: -2.6300
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.2263
Cell Significance Index: -1.3700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.2869
Cell Significance Index: -6.2200
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2995
Cell Significance Index: -31.1900
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3370
Cell Significance Index: -9.6600
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.3717
Cell Significance Index: -6.3700
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.3892
Cell Significance Index: -8.3200
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.3914
Cell Significance Index: -6.5500
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3956
Cell Significance Index: -31.3300
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.3984
Cell Significance Index: -5.8800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4045
Cell Significance Index: -21.2400
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.4097
Cell Significance Index: -5.5900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4531
Cell Significance Index: -27.7800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.4541
Cell Significance Index: -9.6700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.5149
Cell Significance Index: -16.4900
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.5506
Cell Significance Index: -16.1700
Cell Name: hepatoblast (CL0005026)
Fold Change: -0.5535
Cell Significance Index: -9.3100
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.6255
Cell Significance Index: -21.7400
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.6670
Cell Significance Index: -19.0400
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.6951
Cell Significance Index: -7.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Energy-sensing function**: PRKAA1 is activated by low energy states, allowing it to sense changes in energy levels and respond accordingly. 2. **Regulation of glucose and lipid metabolism**: PRKAA1 regulates glucose uptake, glycogen synthesis, and lipid metabolism to maintain energy homeostasis. 3. **Autophagy regulation**: PRKAA1 promotes autophagy, a process by which cells recycle damaged or dysfunctional components, to maintain cellular homeostasis. 4. **Cellular response to various stimuli**: PRKAA1 is activated by various stimuli, including glucose starvation, exercise, and ethanol, allowing it to respond to changes in energy levels and maintain cellular homeostasis. 5. **Expression in various cell types**: PRKAA1 is expressed in neurons, muscle cells, pancreatic cells, and other cell types, highlighting its importance in various physiological processes. **Pathways and Functions** 1. **AMPK signaling pathway**: PRKAA1 is the catalytic subunit of the AMPK complex, which is activated by low energy states and regulates glucose and lipid metabolism. 2. **Autophagy pathway**: PRKAA1 promotes autophagy by regulating the activity of autophagy-related proteins. 3. **Glucose metabolism pathway**: PRKAA1 regulates glucose uptake, glycogen synthesis, and gluconeogenesis to maintain energy homeostasis. 4. **Lipid metabolism pathway**: PRKAA1 regulates lipid synthesis, breakdown, and uptake to maintain energy homeostasis. 5. **Neurotransmitter signaling pathway**: PRKAA1 is involved in neurotransmitter signaling, including the regulation of neuronal excitability and synaptic plasticity. **Clinical Significance** 1. **Diabetes**: PRKAA1 is involved in glucose metabolism, and alterations in PRKAA1 expression or activity have been implicated in diabetes. 2. **Metabolic disorders**: PRKAA1 plays a role in energy homeostasis, and alterations in PRKAA1 expression or activity have been implicated in metabolic disorders, such as obesity and fatty liver disease. 3. **Cancer**: PRKAA1 is involved in autophagy and glucose metabolism, and alterations in PRKAA1 expression or activity have been implicated in cancer. 4. **Neurological disorders**: PRKAA1 is involved in neuronal function, and alterations in PRKAA1 expression or activity have been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 5. **Cardiovascular disease**: PRKAA1 is involved in energy homeostasis, and alterations in PRKAA1 expression or activity have been implicated in cardiovascular disease. In conclusion, PRKAA1 is a crucial gene that plays a central role in energy homeostasis, glucose metabolism, and cellular response to various stimuli. Its dysregulation has been implicated in various diseases, including diabetes, metabolic disorders, cancer, neurological disorders, and cardiovascular disease. Further research is needed to fully understand the mechanisms by which PRKAA1 regulates cellular processes and to develop therapeutic strategies to target PRKAA1 in disease prevention and treatment.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

5'-AMP-activated protein kinase catalytic subunit alpha-1

Genular Protein ID: 3789217713

Symbol: AAPK1_HUMAN

Name: 5'-AMP-activated protein kinase catalytic subunit alpha-1

UniProtKB Accession Codes:

Q13131 A8MTQ6 B2R7E1 O00286 Q5D0E1 Q86VS1 Q9UNQ4

Database IDs:

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 8557660

Title: Mammalian AMP-activated protein kinase subfamily.

PubMed ID: 8557660

DOI: 10.1074/jbc.271.2.611

PubMed ID: 9857077

Title: Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase.

PubMed ID: 9857077

DOI: 10.1074/jbc.273.52.35347

PubMed ID: 11554766

Title: Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line.

PubMed ID: 11554766

DOI: 10.1006/bbrc.2001.5627

PubMed ID: 11518699

Title: Regulation of transcription by AMP-activated protein kinase: phosphorylation of p300 blocks its interaction with nuclear receptors.

PubMed ID: 11518699

DOI: 10.1074/jbc.c100316200

PubMed ID: 11602624

Title: Role of AMP-activated protein kinase in mechanism of metformin action.

PubMed ID: 11602624

DOI: 10.1172/jci13505

PubMed ID: 12519745

Title: Physiological modulation of CFTR activity by AMP-activated protein kinase in polarized T84 cells.

PubMed ID: 12519745

DOI: 10.1152/ajpcell.00227.2002

PubMed ID: 14651849

Title: TSC2 mediates cellular energy response to control cell growth and survival.

PubMed ID: 14651849

DOI: 10.1016/s0092-8674(03)00929-2

PubMed ID: 14976552

Title: LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.

PubMed ID: 14976552

DOI: 10.1038/sj.emboj.7600110

PubMed ID: 16054095

Title: Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase.

PubMed ID: 16054095

DOI: 10.1016/j.cmet.2005.05.009

PubMed ID: 15980064

Title: The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases.

PubMed ID: 15980064

DOI: 10.1074/jbc.m503824200

PubMed ID: 15866171

Title: AMP-activated protein kinase induces a p53-dependent metabolic checkpoint.

PubMed ID: 15866171

DOI: 10.1016/j.molcel.2005.03.027

PubMed ID: 17028174

Title: Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling.

PubMed ID: 17028174

DOI: 10.1073/pnas.0603781103

PubMed ID: 17088252

Title: Conserved alpha-helix acts as autoinhibitory sequence in AMP-activated protein kinase alpha subunits.

PubMed ID: 17088252

DOI: 10.1074/jbc.m605790200

PubMed ID: 17711846

Title: The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor.

PubMed ID: 17711846

DOI: 10.1074/jbc.m705325200

PubMed ID: 17486097

Title: Energy-dependent regulation of cell structure by AMP-activated protein kinase.

PubMed ID: 17486097

DOI: 10.1038/nature05828

PubMed ID: 18184930

Title: AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5.

PubMed ID: 18184930

DOI: 10.2337/db07-0843

PubMed ID: 18403135

Title: Identification and characterization of a novel folliculin-interacting protein FNIP2.

PubMed ID: 18403135

DOI: 10.1016/j.gene.2008.02.022

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18439900

Title: AMPK phosphorylation of raptor mediates a metabolic checkpoint.

PubMed ID: 18439900

DOI: 10.1016/j.molcel.2008.03.003

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18663353

Title: Interaction of folliculin (Birt-Hogg-Dube gene product) with a novel Fnip1-like (FnipL/Fnip2) protein.

PubMed ID: 18663353

DOI: 10.1038/onc.2008.261

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20074060

Title: Cell-wide analysis of secretory granule dynamics in three dimensions in living pancreatic beta-cells: evidence against a role for AMPK-dependent phosphorylation of KLC1 at Ser517/Ser520 in glucose-stimulated insulin granule movement.

PubMed ID: 20074060

DOI: 10.1042/bst0380205

PubMed ID: 20160076

Title: ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS.

PubMed ID: 20160076

DOI: 10.1073/pnas.0913860107

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21460634

Title: Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop.

PubMed ID: 21460634

DOI: 10.4161/auto.7.7.15451

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21205641

Title: Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.

PubMed ID: 21205641

DOI: 10.1126/science.1196371

PubMed ID: 21680840

Title: AMPK is a direct adenylate charge-regulated protein kinase.

PubMed ID: 21680840

DOI: 10.1126/science.1200094

PubMed ID: 17307971

Title: AMP-activated protein kinase in metabolic control and insulin signaling.

PubMed ID: 17307971

DOI: 10.1161/01.res.0000256090.42690.05

PubMed ID: 17712357

Title: AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.

PubMed ID: 17712357

DOI: 10.1038/nrm2249

PubMed ID: 23088624

Title: N-Myristoylation is essential for protein phosphatases PPM1A and PPM1B to dephosphorylate their physiological substrates in cells.

PubMed ID: 23088624

DOI: 10.1042/bj20121201

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24563466

Title: Cross-talk between two essential nutrient-sensitive enzymes: O-GlcNAc transferase (OGT) and AMP-activated protein kinase (AMPK).

PubMed ID: 24563466

DOI: 10.1074/jbc.m113.523068

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28561066

Title: WIPI3 and WIPI4 beta-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy.

PubMed ID: 28561066

DOI: 10.1038/ncomms15637

PubMed ID: 32029622

Title: An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis.

PubMed ID: 32029622

DOI: 10.1126/science.aay0542

PubMed ID: 34077757

Title: Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets.

PubMed ID: 34077757

DOI: 10.1016/j.molcel.2021.05.005

PubMed ID: 36367943

Title: AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology.

PubMed ID: 36367943

DOI: 10.1126/sciadv.abo7956

PubMed ID: 36732624

Title: AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation.

PubMed ID: 36732624

DOI: 10.1038/s42255-022-00732-4

PubMed ID: 37079666

Title: Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1.

PubMed ID: 37079666

DOI: 10.1126/science.abj5559

PubMed ID: 37821951

Title: DENV-2 NS1 promotes AMPK-LKB1 interaction to activate AMPK/ERK/mTOR signaling pathway to induce autophagy.

PubMed ID: 37821951

DOI: 10.1186/s12985-023-02166-0

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 559
Mass: 64009
Checksum: ABAE71FBF912947A
Sequence:

MRRLSSWRKM ATAEKQKHDG RVKIGHYILG DTLGVGTFGK VKVGKHELTG HKVAVKILNR 
QKIRSLDVVG KIRREIQNLK LFRHPHIIKL YQVISTPSDI FMVMEYVSGG ELFDYICKNG 
RLDEKESRRL FQQILSGVDY CHRHMVVHRD LKPENVLLDA HMNAKIADFG LSNMMSDGEF 
LRTSCGSPNY AAPEVISGRL YAGPEVDIWS SGVILYALLC GTLPFDDDHV PTLFKKICDG 
IFYTPQYLNP SVISLLKHML QVDPMKRATI KDIREHEWFK QDLPKYLFPE DPSYSSTMID 
DEALKEVCEK FECSEEEVLS CLYNRNHQDP LAVAYHLIID NRRIMNEAKD FYLATSPPDS 
FLDDHHLTRP HPERVPFLVA ETPRARHTLD ELNPQKSKHQ GVRKAKWHLG IRSQSRPNDI 
MAEVCRAIKQ LDYEWKVVNP YYLRVRRKNP VTSTYSKMSL QLYQVDSRTY LLDFRSIDDE 
ITEAKSGTAT PQRSGSVSNY RSCQRSDSDA EAQGKSSEVS LTSSVTSLDS SPVDLTPRPG 
SHTIEFFEMC ANLIKILAQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PRKAA1

Associated with

Cells (max top 100)

Other Information

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. PubMed ID: 11042152

Mammalian AMP-activated protein kinase subfamily. PubMed ID: 8557660

Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase. PubMed ID: 9857077

Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line. PubMed ID: 11554766

Regulation of transcription by AMP-activated protein kinase: phosphorylation of p300 blocks its interaction with nuclear receptors. PubMed ID: 11518699

Role of AMP-activated protein kinase in mechanism of metformin action. PubMed ID: 11602624

Physiological modulation of CFTR activity by AMP-activated protein kinase in polarized T84 cells. PubMed ID: 12519745

TSC2 mediates cellular energy response to control cell growth and survival. PubMed ID: 14651849

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. PubMed ID: 14976552

Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. PubMed ID: 16054095

The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases. PubMed ID: 15980064

AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. PubMed ID: 15866171

Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. PubMed ID: 17028174

Conserved alpha-helix acts as autoinhibitory sequence in AMP-activated protein kinase alpha subunits. PubMed ID: 17088252

The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. PubMed ID: 17711846

Energy-dependent regulation of cell structure by AMP-activated protein kinase. PubMed ID: 17486097

AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5. PubMed ID: 18184930

Identification and characterization of a novel folliculin-interacting protein FNIP2. PubMed ID: 18403135

Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. PubMed ID: 18220336

Phosphoproteome of resting human platelets. PubMed ID: 18088087

AMPK phosphorylation of raptor mediates a metabolic checkpoint. PubMed ID: 18439900

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

Interaction of folliculin (Birt-Hogg-Dube gene product) with a novel Fnip1-like (FnipL/Fnip2) protein. PubMed ID: 18663353

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Cell-wide analysis of secretory granule dynamics in three dimensions in living pancreatic beta-cells: evidence against a role for AMPK-dependent phosphorylation of KLC1 at Ser517/Ser520 in glucose-stimulated insulin granule movement. PubMed ID: 20074060

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. PubMed ID: 20160076

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop. PubMed ID: 21460634

Initial characterization of the human central proteome. PubMed ID: 21269460

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. PubMed ID: 21205641

AMPK is a direct adenylate charge-regulated protein kinase. PubMed ID: 21680840

AMP-activated protein kinase in metabolic control and insulin signaling. PubMed ID: 17307971

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. PubMed ID: 17712357

N-Myristoylation is essential for protein phosphatases PPM1A and PPM1B to dephosphorylate their physiological substrates in cells. PubMed ID: 23088624

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Cross-talk between two essential nutrient-sensitive enzymes: O-GlcNAc transferase (OGT) and AMP-activated protein kinase (AMPK). PubMed ID: 24563466

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

WIPI3 and WIPI4 beta-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy. PubMed ID: 28561066

An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis. PubMed ID: 32029622

Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets. PubMed ID: 34077757

AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology. PubMed ID: 36367943

AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation. PubMed ID: 36732624

Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1. PubMed ID: 37079666

DENV-2 NS1 promotes AMPK-LKB1 interaction to activate AMPK/ERK/mTOR signaling pathway to induce autophagy. PubMed ID: 37821951

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974