PRKAR1B | ENSG00000188191 | NCBI 5575

Details for: PRKAR1B

Gene ID: 5575

Symbol: PRKAR1B

Ensembl ID: ENSG00000188191

Description: protein kinase cAMP-dependent type I regulatory subunit beta

Associated with

Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Adora2b mediated anti-inflammatory cytokines production
(R-HSA-9660821)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Aquaporin-mediated transport
(R-HSA-445717)
Ca-dependent events
(R-HSA-111996)
Calmodulin induced events
(R-HSA-111933)
Cam pathway
(R-HSA-111997)
Cellular responses to mechanical stimuli
(R-HSA-9855142)
Cellular responses to stimuli
(R-HSA-8953897)
Creb1 phosphorylation through the activation of adenylate cyclase
(R-HSA-442720)
Dag and ip3 signaling
(R-HSA-1489509)
Darpp-32 events
(R-HSA-180024)
Disease
(R-HSA-1643685)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
G-protein mediated events
(R-HSA-112040)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (s) signalling events
(R-HSA-418555)
Glucagon-like peptide-1 (glp1) regulates insulin secretion
(R-HSA-381676)
Glucagon signaling in metabolic regulation
(R-HSA-163359)
Gpcr downstream signalling
(R-HSA-388396)
Gper1 signaling
(R-HSA-9634597)
Hedgehog 'off' state
(R-HSA-5610787)
Hemostasis
(R-HSA-109582)
High laminar flow shear stress activates signaling by piezo1 and pecam1:cdh5:kdr in endothelial cells
(R-HSA-9856530)
Infectious disease
(R-HSA-5663205)
Integration of energy metabolism
(R-HSA-163685)
Intracellular signaling by second messengers
(R-HSA-9006925)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Metabolism
(R-HSA-1430728)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Opioid signalling
(R-HSA-111885)
Parasitic infection pathways
(R-HSA-9824443)
Pka-mediated phosphorylation of creb
(R-HSA-111931)
Pka activation
(R-HSA-163615)
Pka activation in glucagon signalling
(R-HSA-164378)
Plc beta mediated events
(R-HSA-112043)
Post nmda receptor activation events
(R-HSA-438064)
Regulation of insulin secretion
(R-HSA-422356)
Response of endothelial cells to shear stress
(R-HSA-9860931)
Signaling by gpcr
(R-HSA-372790)
Signaling by hedgehog
(R-HSA-5358351)
Signal transduction
(R-HSA-162582)
Transmission across chemical synapses
(R-HSA-112315)
Transport of small molecules
(R-HSA-382551)
Vasopressin regulates renal water homeostasis via aquaporins
(R-HSA-432040)
Adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0007189)
Camp-dependent protein kinase complex
(GO:0005952)
Camp-dependent protein kinase inhibitor activity
(GO:0004862)
Camp-dependent protein kinase regulator activity
(GO:0008603)
Camp binding
(GO:0030552)
Ciliary base
(GO:0097546)
Cytosol
(GO:0005829)
Glutamatergic synapse
(GO:0098978)
Hippocampal mossy fiber to ca3 synapse
(GO:0098686)
Learning or memory
(GO:0007611)
Multivesicular body
(GO:0005771)
Negative regulation of camp/pka signal transduction
(GO:0141162)
Plasma membrane
(GO:0005886)
Positive regulation of excitatory postsynaptic potential
(GO:2000463)
Positive regulation of fear response
(GO:1903367)
Positive regulation of long-term synaptic potentiation
(GO:1900273)
Postsynapse
(GO:0098794)
Protein binding
(GO:0005515)
Protein kinase a catalytic subunit binding
(GO:0034236)
Regulation of protein phosphorylation
(GO:0001932)
Regulation of synaptic vesicle cycle
(GO:0098693)
Schaffer collateral - ca1 synapse
(GO:0098685)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 142.2737
Cell Significance Index: -22.1300
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 94.9759
Cell Significance Index: -24.0900
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 20.0169
Cell Significance Index: -24.6800
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 8.7776
Cell Significance Index: -26.9600
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 7.9138
Cell Significance Index: -21.2000
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 5.8577
Cell Significance Index: -12.8200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.4424
Cell Significance Index: 489.9500
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 2.4400
Cell Significance Index: 69.6300
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 1.9910
Cell Significance Index: 26.5600
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.5980
Cell Significance Index: 19.8200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.5686
Cell Significance Index: 562.6200
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.4524
Cell Significance Index: 1004.5200
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 1.3498
Cell Significance Index: 90.7600
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.3201
Cell Significance Index: 69.3100
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.2662
Cell Significance Index: 251.2900
Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.2043
Cell Significance Index: 26.3700
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.0899
Cell Significance Index: 65.4300
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 1.0646
Cell Significance Index: 18.2500
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.9308
Cell Significance Index: 57.2100
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.8623
Cell Significance Index: 32.6600
Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.8610
Cell Significance Index: 20.6500
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.8537
Cell Significance Index: 37.7600
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.7678
Cell Significance Index: 34.8000
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7621
Cell Significance Index: 123.9500
Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 0.7009
Cell Significance Index: 9.0900
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.5417
Cell Significance Index: 15.1400
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5263
Cell Significance Index: 15.1700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.5091
Cell Significance Index: 35.2100
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.4948
Cell Significance Index: 13.0100
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.3541
Cell Significance Index: 4.5400
Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
Fold Change: 0.3345
Cell Significance Index: 3.6900
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.3242
Cell Significance Index: 6.9300
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.2757
Cell Significance Index: 21.1600
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.2592
Cell Significance Index: 30.2100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2244
Cell Significance Index: 40.4500
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2160
Cell Significance Index: 4.6800
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1668
Cell Significance Index: 31.7500
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1364
Cell Significance Index: 123.1300
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1137
Cell Significance Index: 11.2500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.1108
Cell Significance Index: 2.3600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0921
Cell Significance Index: 4.7900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0736
Cell Significance Index: 32.5400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0729
Cell Significance Index: 4.0900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0711
Cell Significance Index: 9.7700
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0553
Cell Significance Index: 104.2000
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0499
Cell Significance Index: 27.2400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0403
Cell Significance Index: 4.9600
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0304
Cell Significance Index: 19.3000
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.0296
Cell Significance Index: 0.8700
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0178
Cell Significance Index: 27.3500
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0168
Cell Significance Index: 31.0500
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0162
Cell Significance Index: 1.9100
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0039
Cell Significance Index: 5.3200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0020
Cell Significance Index: -0.0700
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0113
Cell Significance Index: -8.3200
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0248
Cell Significance Index: -11.2500
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0269
Cell Significance Index: -20.3300
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0274
Cell Significance Index: -20.2700
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0382
Cell Significance Index: -21.5700
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0428
Cell Significance Index: -26.7500
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0598
Cell Significance Index: -7.7200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0696
Cell Significance Index: -20.0300
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.0786
Cell Significance Index: -0.9800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0837
Cell Significance Index: -14.3000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0839
Cell Significance Index: -8.5700
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.0841
Cell Significance Index: -1.2600
Cell Name: kidney cell (CL1000497)
Fold Change: -0.0870
Cell Significance Index: -0.7000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0950
Cell Significance Index: -13.8100
Cell Name: odontoblast (CL0000060)
Fold Change: -0.1073
Cell Significance Index: -13.7500
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1093
Cell Significance Index: -1.5700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1224
Cell Significance Index: -25.7900
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.1333
Cell Significance Index: -2.8300
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1374
Cell Significance Index: -4.4000
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.1381
Cell Significance Index: -2.7300
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -0.1387
Cell Significance Index: -1.3200
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.1474
Cell Significance Index: -3.6900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1592
Cell Significance Index: -7.4800
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.1606
Cell Significance Index: -3.2300
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1628
Cell Significance Index: -2.7300
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1702
Cell Significance Index: -10.9800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1748
Cell Significance Index: -20.0300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1755
Cell Significance Index: -13.0800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1892
Cell Significance Index: -8.8200
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2047
Cell Significance Index: -6.5200
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.2050
Cell Significance Index: -4.2900
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2139
Cell Significance Index: -22.2700
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2187
Cell Significance Index: -7.1600
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2307
Cell Significance Index: -18.2700
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.2341
Cell Significance Index: -6.2500
Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.2472
Cell Significance Index: -3.1200
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.2601
Cell Significance Index: -3.8400
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.2906
Cell Significance Index: -3.9700
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.2907
Cell Significance Index: -20.5600
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.3069
Cell Significance Index: -6.6300
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3180
Cell Significance Index: -11.0500
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.3249
Cell Significance Index: -3.5400
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3265
Cell Significance Index: -20.5800
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.3468
Cell Significance Index: -8.6500
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3866
Cell Significance Index: -23.7000
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4016
Cell Significance Index: -11.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** PRKAR1B is a member of the protein kinase A (PKA) complex, which is a heterotrimeric complex consisting of a catalytic subunit (PRKAC), a regulatory subunit (PRKAR1A), and an inhibitory subunit (PRKAR1B). PRKAR1B is specifically involved in the regulation of PKA activity, modulating its binding to its regulatory subunits. It is a phosphoprotein, meaning it can be phosphorylated by PKA, which regulates its activity. PRKAR1B is highly expressed in the brain, particularly in neurons, where it plays a crucial role in regulating synaptic transmission and plasticity. **Pathways and Functions** PRKAR1B is involved in numerous signaling pathways, including: 1. **Adenylate Cyclase Signaling**: PRKAR1B regulates the activity of adenylate cyclase, an enzyme involved in the production of cyclic AMP (cAMP), a secondary messenger molecule that activates PKA. 2. **Ca-dependent Events**: PRKAR1B modulates the activity of Ca-dependent enzymes, such as calmodulin, which regulates various cellular processes, including muscle contraction and neurotransmission. 3. **Cam Pathway**: PRKAR1B is involved in the regulation of the cAMP-dependent protein kinase complex, which phosphorylates and regulates numerous downstream targets. 4. **Neurotransmitter Signaling**: PRKAR1B regulates the activity of neurotransmitter receptors, including the NMDA receptor, which is involved in synaptic plasticity and learning. 5. **Hemostasis**: PRKAR1B plays a role in regulating blood clotting, particularly in the context of platelet production and activation. **Clinical Significance** PRKAR1B mutations have been associated with several neurological disorders, including: 1. **Seizures**: Mutations in PRKAR1B have been linked to an increased risk of seizures, particularly in individuals with a history of epilepsy. 2. **Autoimmune Disorders**: PRKAR1B mutations have been associated with autoimmune disorders, such as lupus and multiple sclerosis. 3. **Cancer**: PRKAR1B mutations have been implicated in the development of certain cancers, including glioblastoma and breast cancer. 4. **Neurodevelopmental Disorders**: PRKAR1B mutations have been linked to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. In conclusion, PRKAR1B is a critical component of the PKA complex, playing a central role in regulating various cellular processes, including signal transduction, gene regulation, and protein modification. Its dysregulation has been implicated in several neurological and autoimmune disorders, highlighting the importance of PRKAR1B in maintaining normal cellular function.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

cAMP-dependent protein kinase type I-beta regulatory subunit

Genular Protein ID: 3676189592

Symbol: KAP1_HUMAN

Name: cAMP-dependent protein kinase type I-beta regulatory subunit

UniProtKB Accession Codes:

P31321 Q8N422

Database IDs:

Citations:

PubMed ID: 1708242

Title: Molecular cloning, cDNA structure and tissue-specific expression of the human regulatory subunit RI beta of cAMP-dependent protein kinases.

PubMed ID: 1708242

DOI: 10.1016/0006-291x(91)90904-l

PubMed ID: 7925653

Title: Human regulatory subunit RI beta of cAMP-dependent protein kinases: expression, holoenzyme formation and microinjection into living cells.

PubMed ID: 7925653

DOI: 10.1006/excr.1994.1297

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16777052

Title: Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry.

PubMed ID: 16777052

DOI: 10.1016/j.ab.2006.05.024

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20819953

Title: Regulation of cAMP-dependent protein kinases: the human protein kinase X (PrKX) reveals the role of the catalytic subunit alphaH-alphaI loop.

PubMed ID: 20819953

DOI: 10.1074/jbc.m110.155150

PubMed ID: 23115245

Title: A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane.

PubMed ID: 23115245

DOI: 10.1074/jbc.m112.395970

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 33833410

Title: Variants in PRKAR1B cause a neurodevelopmental disorder with autism spectrum disorder, apraxia, and insensitivity to pain.

PubMed ID: 33833410

DOI: 10.1038/s41436-021-01152-7

Sequence Information:

Length: 381
Mass: 43073
Checksum: 1ED7BFEC30897191
Sequence:

MASPPACPSE EDESLKGCEL YVQLHGIQQV LKDCIVHLCI SKPERPMKFL REHFEKLEKE 
ENRQILARQK SNSQSDSHDE EVSPTPPNPV VKARRRRGGV SAEVYTEEDA VSYVRKVIPK 
DYKTMTALAK AISKNVLFAH LDDNERSDIF DAMFPVTHIA GETVIQQGNE GDNFYVVDQG 
EVDVYVNGEW VTNISEGGSF GELALIYGTP RAATVKAKTD LKLWGIDRDS YRRILMGSTL 
RKRKMYEEFL SKVSILESLE KWERLTVADA LEPVQFEDGE KIVVQGEPGD DFYIITEGTA 
SVLQRRSPNE EYVEVGRLGP SDYFGEIALL LNRPRAATVV ARGPLKCVKL DRPRFERVLG 
PCSEILKRNI QRYNSFISLT V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PRKAR1B

Associated with

Cells (max top 100)

Other Information

Molecular cloning, cDNA structure and tissue-specific expression of the human regulatory subunit RI beta of cAMP-dependent protein kinases. PubMed ID: 1708242

Human regulatory subunit RI beta of cAMP-dependent protein kinases: expression, holoenzyme formation and microinjection into living cells. PubMed ID: 7925653

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. PubMed ID: 16777052

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Regulation of cAMP-dependent protein kinases: the human protein kinase X (PrKX) reveals the role of the catalytic subunit alphaH-alphaI loop. PubMed ID: 20819953

A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane. PubMed ID: 23115245

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Variants in PRKAR1B cause a neurodevelopmental disorder with autism spectrum disorder, apraxia, and insensitivity to pain. PubMed ID: 33833410