Details for: PRKCH
Gene ID: 5583
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PRKCH
Ensembl ID: ENSG00000027075
Description: protein kinase C eta
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 54.65rCSI 94.52%PRS 45.26
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CSI 15.86rCSI 39.25%PRS 53.1
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CSI 14.21rCSI 22.44%PRS 56.7
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CSI 11.43rCSI 7.62%PRS 77.1
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CSI 11.17rCSI 22.27%PRS 73.46
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CSI 11.11rCSI 7.73%PRS 69.65
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CSI 10.62rCSI 26.93%PRS 44.82
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CSI 10.34rCSI 8.35%PRS 64.87
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CSI 9.89rCSI 48.76%PRS 66.61
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CSI 9.8rCSI 17.68%PRS 78.82
-
CSI 9.69rCSI 6.53%PRS 67.57
-
CSI 8.92rCSI 13.46%PRS 58.33
-
CSI 8.53rCSI 28.26%PRS 57.98
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CSI 8.3rCSI 12.83%PRS 53.15
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CSI 8.1rCSI 24.96%PRS 65.27
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CSI 7.63rCSI 41.74%PRS 55.01
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CSI 7.57rCSI 53.56%PRS 46.94
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CSI 7.12rCSI 7%PRS 71
-
CSI 7.04rCSI 5.29%PRS 59.87
-
CSI 6.88rCSI 6.4%PRS 55.06
-
CSI 6.76rCSI 30.06%PRS 54.25
-
CSI 6.73rCSI 4.83%PRS 69.18
-
CSI 6.5rCSI 4.32%PRS 58.63
-
CSI 6.49rCSI 5.2%PRS 76.27
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CSI 6.21rCSI 7.73%PRS 35.93
-
CSI 5.7rCSI 9.39%PRS 60.37
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CSI 5.54rCSI 10.56%PRS 70.92
-
CSI 5.4rCSI 21.81%PRS 53.68
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CSI 5.34rCSI 5.54%PRS 60.76
-
CSI 5.32rCSI 13.77%PRS 82.61
-
CSI 5.23rCSI 6.14%PRS 84.65
-
CSI 5.21rCSI 28.91%PRS 72.41
-
CSI 5.08rCSI 3.87%PRS 67.77
-
CSI 5.03rCSI 3.53%PRS 74.54
-
CSI 4.98rCSI 3.73%PRS 83.65
-
CSI 4.95rCSI 10.27%PRS 52.4
-
CSI 4.52rCSI 7.18%PRS 47.55
-
CSI 4rCSI 9.15%PRS 54.59
-
CSI 3.98rCSI 3.62%PRS 69.49
-
CSI 3.93rCSI 18.84%PRS 54.28
-
CSI 3.89rCSI 5.29%PRS 67.42
-
CSI 3.85rCSI 3.56%PRS 75.14
-
CSI 3.83rCSI 9.98%PRS 60.63
-
CSI 3.75rCSI 4.71%PRS 84.64
-
CSI 3.72rCSI 7.38%PRS 72.31
-
CSI 3.72rCSI 14.07%PRS 38.49
-
CSI 3.69rCSI 4.32%PRS 71.63
-
CSI 3.68rCSI 8.35%PRS 60.12
-
CSI 3.61rCSI 5.11%PRS 61.64
-
CSI 3.56rCSI 3.72%PRS 79.61
-
CSI 3.52rCSI 6.17%PRS 47.31
-
CSI 3.14rCSI 5.75%PRS 71.2
-
CSI 3.07rCSI 6.76%PRS 58.99
-
CSI 3.04rCSI 2.41%PRS 77.25
-
CSI 3.01rCSI 11.28%PRS 47.39
-
CSI 2.99rCSI 9.73%PRS 56.22
-
CSI 2.97rCSI 8.82%PRS 65.51
-
CSI 2.89rCSI 69.14%PRS 37.03
-
CSI 2.81rCSI 2.47%PRS 60.33
-
CSI 2.81rCSI 67.75%PRS 37.92
-
CSI 2.81rCSI 4.8%PRS 74.3
-
CSI 2.8rCSI 2.94%PRS 58.37
-
CSI 2.75rCSI 2.04%PRS 47.84
-
CSI 2.69rCSI 7.01%PRS 54.45
-
CSI 2.58rCSI 3.94%PRS 55.75
-
CSI 2.56rCSI 1.51%PRS 72.06
-
CSI 2.51rCSI 2.47%PRS 78.61
-
CSI 2.5rCSI 2.74%PRS 58.92
-
CSI 2.5rCSI 3.58%PRS 45.32
-
CSI 2.43rCSI 2.01%PRS 56.81
-
CSI 2.42rCSI 2.99%PRS 51.11
-
CSI 2.38rCSI 2.89%PRS 45.03
-
CSI 2.35rCSI 2.16%PRS 63.52
-
CSI 2.33rCSI 2.15%PRS 56.23
-
CSI 2.32rCSI 2.69%PRS 69.36
-
CSI 2.31rCSI 3.15%PRS 80.66
-
CSI 2.31rCSI 1.79%PRS 56.36
-
CSI 2.28rCSI 3.05%PRS 55.97
-
CSI 2.24rCSI 1.69%PRS 68.71
-
CSI 2.23rCSI 2.51%PRS 71.69
-
CSI 2.22rCSI 2.85%PRS 48.56
-
CSI 2.2rCSI 3.42%PRS 63.21
-
CSI 2.18rCSI 1.63%PRS 70.37
-
CSI 2.12rCSI 4.84%PRS 47.39
-
CSI 2.06rCSI 2.46%PRS 75.22
-
CSI 2rCSI 1.39%PRS 65.56
-
CSI 1.99rCSI 4.83%PRS 36.44
-
CSI 1.87rCSI 4.56%PRS 49.15
-
CSI 1.85rCSI 2.89%PRS 80.42
-
CSI 1.81rCSI 2.9%PRS 59.07
-
CSI 1.78rCSI 1.6%PRS 51.91
-
CSI 1.76rCSI 3.89%PRS 41.92
-
CSI 1.72rCSI 1.34%PRS 72.96
-
CSI 1.67rCSI 4.6%PRS 50.98
-
CSI 1.65rCSI 2.34%PRS 51.45
-
CSI 1.65rCSI 4.72%PRS 69.64
-
CSI 1.61rCSI 3.75%PRS 76.01
-
CSI 1.6rCSI 2.2%PRS 75.1
-
CSI 1.6rCSI 4.13%PRS 50.27
-
CSI 1.58rCSI 1.97%PRS 65.88
-
CSI 0.2rCSI 5.4%PRS 90.6%
-
CSI 0.2rCSI 1.4%PRS 42.2%
-
CSI 0.2rCSI 4.4%PRS 73.8%
-
CSI 0.3rCSI 3.9%PRS 84.6%
-
CSI 0.3rCSI 1.8%PRS 65.6%
-
CSI 0.3rCSI 6.5%PRS 46.3%
-
CSI 0.4rCSI 2.8%PRS 69.9%
-
CSI 0.4rCSI 1.0%PRS 52.9%
-
CSI 0.5rCSI 4.7%PRS 76.3%
-
CSI 0.6rCSI 2.2%PRS 46.7%
-
CSI 0.6rCSI 2.1%PRS 36.3%
-
CSI 0.6rCSI 2.3%PRS 75.7%
-
CSI 0.6rCSI 2.8%PRS 84.9%
-
CSI 0.6rCSI 3.6%PRS 73.8%
-
CSI 0.6rCSI 6.6%PRS 54.2%
-
CSI 0.6rCSI 1.4%PRS 62.6%
-
CSI 0.7rCSI 3.4%PRS 67.7%
-
CSI 0.7rCSI 2.4%PRS 65.6%
-
CSI 0.7rCSI 1.0%PRS 71.2%
-
CSI 0.7rCSI 2.3%PRS 53.7%
-
CSI 0.8rCSI 3.4%PRS 75.5%
-
CSI 0.8rCSI 3.6%PRS 71.9%
-
CSI 0.8rCSI 2.8%PRS 75.0%
-
CSI 0.8rCSI 9.0%PRS 84.1%
-
CSI 0.8rCSI 1.8%PRS 52.2%
-
CSI 0.9rCSI 2.2%PRS 82.0%
-
CSI 0.9rCSI 6.6%PRS 74.7%
-
CSI 0.9rCSI 5.4%PRS 39.1%
-
CSI 1.0rCSI 2.3%PRS 63.4%
-
CSI 1.0rCSI 2.0%PRS 58.2%
-
CSI 1.0rCSI 16.4%PRS 80.3%
-
CSI 1.0rCSI 3.5%PRS 86.7%
-
CSI 1.0rCSI 1.2%PRS 63.5%
-
CSI 1.0rCSI 2.0%PRS 82.4%
-
CSI 1.0rCSI 1.7%PRS 66.2%
-
CSI 1.1rCSI 3.1%PRS 53.2%
-
CSI 1.1rCSI 6.8%PRS 74.6%
-
CSI 1.1rCSI 1.8%PRS 37.7%
-
CSI 1.1rCSI 2.6%PRS 59.8%
-
CSI 1.1rCSI 11.4%PRS 48.2%
-
CSI 1.1rCSI 3.3%PRS 74.5%
-
CSI 1.2rCSI 5.3%PRS 68.8%
-
CSI 1.2rCSI 3.3%PRS 86.0%
-
CSI 1.2rCSI 10.1%PRS 48.3%
-
CSI 1.3rCSI 1.5%PRS 45.0%
-
CSI 1.3rCSI 7.3%PRS 67.7%
-
CSI 1.3rCSI 2.5%PRS 85.7%
-
CSI 1.4rCSI 3.1%PRS 63.7%
-
CSI 1.4rCSI 1.8%PRS 57.2%
-
CSI 1.5rCSI 2.6%PRS 54.0%
-
CSI 1.5rCSI 3.8%PRS 59.0%
-
CSI 1.5rCSI 5.9%PRS 61.7%
-
CSI 1.6rCSI 2.0%PRS 65.9%
-
CSI 1.6rCSI 4.1%PRS 50.3%
-
CSI 1.6rCSI 2.2%PRS 75.1%
-
CSI 1.6rCSI 3.8%PRS 76.0%
-
CSI 1.7rCSI 4.7%PRS 69.6%
-
CSI 1.7rCSI 2.3%PRS 51.5%
-
CSI 1.7rCSI 4.6%PRS 51.0%
-
CSI 1.7rCSI 1.3%PRS 73.0%
-
CSI 1.8rCSI 3.9%PRS 41.9%
-
CSI 1.8rCSI 1.6%PRS 51.9%
-
CSI 1.8rCSI 2.9%PRS 59.1%
-
CSI 1.9rCSI 2.9%PRS 80.4%
-
CSI 1.9rCSI 4.6%PRS 49.2%
-
CSI 2.0rCSI 4.8%PRS 36.4%
-
CSI 2.0rCSI 1.4%PRS 65.6%
-
CSI 2.1rCSI 2.5%PRS 75.2%
-
CSI 2.1rCSI 4.8%PRS 47.4%
-
CSI 2.2rCSI 1.6%PRS 70.4%
-
CSI 2.2rCSI 3.4%PRS 63.2%
-
CSI 2.2rCSI 2.9%PRS 48.6%
-
CSI 2.2rCSI 2.5%PRS 71.7%
-
CSI 2.2rCSI 1.7%PRS 68.7%
-
CSI 2.3rCSI 3.1%PRS 56.0%
-
CSI 2.3rCSI 1.8%PRS 56.4%
-
CSI 2.3rCSI 3.2%PRS 80.7%
-
CSI 2.3rCSI 2.7%PRS 69.4%
-
CSI 2.3rCSI 2.2%PRS 56.2%
-
CSI 2.4rCSI 2.2%PRS 63.5%
-
CSI 2.4rCSI 2.9%PRS 45.0%
-
CSI 2.4rCSI 3.0%PRS 51.1%
-
CSI 2.4rCSI 2.0%PRS 56.8%
-
CSI 2.5rCSI 3.6%PRS 45.3%
-
CSI 2.5rCSI 2.7%PRS 58.9%
-
CSI 2.5rCSI 2.5%PRS 78.6%
-
CSI 2.6rCSI 1.5%PRS 72.1%
-
CSI 2.6rCSI 3.9%PRS 55.8%
-
CSI 2.7rCSI 7.0%PRS 54.5%
-
CSI 2.8rCSI 2.0%PRS 47.8%
-
CSI 2.8rCSI 2.9%PRS 58.4%
-
CSI 2.8rCSI 4.8%PRS 74.3%
-
CSI 2.8rCSI 67.8%PRS 37.9%
-
CSI 2.8rCSI 2.5%PRS 60.3%
-
CSI 2.9rCSI 69.1%PRS 37.0%
-
CSI 3.0rCSI 8.8%PRS 65.5%
-
CSI 3.0rCSI 9.7%PRS 56.2%
-
CSI 3.0rCSI 11.3%PRS 47.4%
-
CSI 3.0rCSI 2.4%PRS 77.3%
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CSI 3.1rCSI 6.8%PRS 59.0%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2925223137
Symbol: KPCL_HUMAN
Name: Protein kinase C eta type
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1986216
Title: Isolation and characterization of PKC-L, a new member of the protein kinase C-related gene family specifically expressed in lung, skin, and heart.
PubMed ID: 1986216
PubMed ID: 1545821
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12508121
Title: The DNA sequence and analysis of human chromosome 14.
PubMed ID: 12508121
DOI: 10.1038/nature01348
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7988719
Title: Identification of multiple, novel, protein kinase C-related gene products.
PubMed ID: 7988719
PubMed ID: 11112424
Title: Overexpression of protein kinase C-eta attenuates caspase activation and tumor necrosis factor-alpha-induced cell death.
PubMed ID: 11112424
PubMed ID: 10806212
Title: Phorbol 12-myristate 13-acetate induces protein kinase ceta-specific proliferative response in astrocytic tumor cells.
PubMed ID: 10806212
PubMed ID: 11772428
Title: Protein kinase C-eta regulates resistance to UV- and gamma-irradiation-induced apoptosis in glioblastoma cells by preventing caspase-9 activation.
PubMed ID: 11772428
DOI: 10.1093/neuonc/4.1.9
PubMed ID: 15489897
Title: PKC-eta mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways.
PubMed ID: 15489897
PubMed ID: 15632189
Title: Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C.
PubMed ID: 15632189
PubMed ID: 17146445
Title: The protein kinase C-eta isoform induces proliferation in glioblastoma cell lines through an ERK/Elk-1 pathway.
PubMed ID: 17146445
PubMed ID: 18780722
Title: PKC eta directs induction of IRF-4 expression and Ig kappa gene rearrangement in pre-BCR signaling pathway.
PubMed ID: 18780722
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19797084
Title: Translational control of protein kinase Ceta by two upstream open reading frames.
PubMed ID: 19797084
DOI: 10.1128/mcb.01044-09
PubMed ID: 19114660
Title: PKC eta regulates occludin phosphorylation and epithelial tight junction integrity.
PubMed ID: 19114660
PubMed ID: 20558593
Title: Protein kinase C-eta and phospholipase D2 pathway regulates foam cell formation via regulator of G protein signaling 2.
PubMed ID: 20558593
PubMed ID: 21820409
Title: Protein kinase C? activates NF-?B in response to camptothecin-induced DNA damage.
PubMed ID: 21820409
PubMed ID: 12473186
Title: Protein kinase C eta (PKC eta): its involvement in keratinocyte differentiation.
PubMed ID: 12473186
PubMed ID: 22304920
Title: PKCepsilon promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria.
PubMed ID: 22304920
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 34593629
Title: Unraveling the hidden role of a uORF-encoded peptide as a kinase inhibitor of PKCs.
PubMed ID: 34593629
PubMed ID: 16973127
Title: Structure of human protein kinase C eta (PKCeta) C2 domain and identification of phosphorylation sites.
PubMed ID: 16973127
PubMed ID: 17206144
Title: A nonsynonymous SNP in PRKCH (protein kinase C eta) increases the risk of cerebral infarction.
PubMed ID: 17206144
DOI: 10.1038/ng1945
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 683
- Mass: 77828
- Checksum: 0A29806CE31912F2
- Sequence:
MSSGTMKFNG YLRVRIGEAV GLQPTRWSLR HSLFKKGHQL LDPYLTVSVD QVRVGQTSTK QKTNKPTYNE EFCANVTDGG HLELAVFHET PLGYDHFVAN CTLQFQELLR TTGASDTFEG WVDLEPEGKV FVVITLTGSF TEATLQRDRI FKHFTRKRQR AMRRRVHQIN GHKFMATYLR QPTYCSHCRE FIWGVFGKQG YQCQVCTCVV HKRCHHLIVT ACTCQNNINK VDSKIAEQRF GINIPHKFSI HNYKVPTFCD HCGSLLWGIM RQGLQCKICK MNVHIRCQAN VAPNCGVNAV ELAKTLAGMG LQPGNISPTS KLVSRSTLRR QGKESSKEGN GIGVNSSNRL GIDNFEFIRV LGKGSFGKVM LARVKETGDL YAVKVLKKDV ILQDDDVECT MTEKRILSLA RNHPFLTQLF CCFQTPDRLF FVMEFVNGGD LMFHIQKSRR FDEARARFYA AEIISALMFL HDKGIIYRDL KLDNVLLDHE GHCKLADFGM CKEGICNGVT TATFCGTPDY IAPEILQEML YGPAVDWWAM GVLLYEMLCG HAPFEAENED DLFEAILNDE VVYPTWLHED ATGILKSFMT KNPTMRLGSL TQGGEHAILR HPFFKEIDWA QLNHRQIEPP FRPRIKSRED VSNFDPDFIK EEPVLTPIDE GHLPMINQDE FRNFSYVSPE LQP