Details for: PRKCH
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 163.6823
Cell Significance Index: -25.4600 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 87.5245
Cell Significance Index: -22.2000 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 67.3219
Cell Significance Index: -27.3500 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 56.0183
Cell Significance Index: -28.8200 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 28.7302
Cell Significance Index: -27.4300 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 20.7550
Cell Significance Index: -25.5900 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 17.6004
Cell Significance Index: -38.5200 - Cell Name: hepatic pit cell (CL2000054)
Fold Change: 12.2607
Cell Significance Index: 32.8500 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 9.5883
Cell Significance Index: -29.4500 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 6.5889
Cell Significance Index: -26.0000 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 6.2506
Cell Significance Index: 89.9000 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 3.9810
Cell Significance Index: 106.3000 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 3.3787
Cell Significance Index: 35.0000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 3.1026
Cell Significance Index: 161.6100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 2.9094
Cell Significance Index: 110.1700 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 2.5691
Cell Significance Index: 22.8100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 2.4210
Cell Significance Index: 64.8700 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 2.2435
Cell Significance Index: -6.0100 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 2.0270
Cell Significance Index: 89.6600 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 1.6154
Cell Significance Index: 9.7600 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.4425
Cell Significance Index: 8.9000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.3401
Cell Significance Index: 37.4500 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.2157
Cell Significance Index: 11.2000 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.1468
Cell Significance Index: 33.6800 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.6872
Cell Significance Index: 14.6900 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.6351
Cell Significance Index: 62.8300 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5818
Cell Significance Index: 525.3100 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5534
Cell Significance Index: 90.0100 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.4782
Cell Significance Index: 8.4500 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2963
Cell Significance Index: 58.8100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2610
Cell Significance Index: 32.1000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2403
Cell Significance Index: 26.1400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2203
Cell Significance Index: 39.7200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1833
Cell Significance Index: 9.5200 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.1568
Cell Significance Index: 3.0600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1502
Cell Significance Index: 7.0100 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.1433
Cell Significance Index: 18.5200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1386
Cell Significance Index: 49.7100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1212
Cell Significance Index: 66.1900 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1065
Cell Significance Index: 5.0100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0937
Cell Significance Index: 59.5000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0643
Cell Significance Index: 12.9000 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0642
Cell Significance Index: 4.4400 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.0623
Cell Significance Index: 3.7400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0572
Cell Significance Index: 25.3100 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0377
Cell Significance Index: 1.0900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0134
Cell Significance Index: 2.5500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0106
Cell Significance Index: 14.3800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0022
Cell Significance Index: 4.0500 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0034
Cell Significance Index: -0.2100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0081
Cell Significance Index: -12.4100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0091
Cell Significance Index: -16.8000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0129
Cell Significance Index: -8.0300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0132
Cell Significance Index: -9.7800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0155
Cell Significance Index: -7.0300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0203
Cell Significance Index: -1.5600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0222
Cell Significance Index: -12.5000 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0249
Cell Significance Index: -18.8800 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: -0.0298
Cell Significance Index: -0.2400 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0305
Cell Significance Index: -0.6500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0387
Cell Significance Index: -28.3600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0430
Cell Significance Index: -7.3500 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0456
Cell Significance Index: -2.0700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0548
Cell Significance Index: -7.9600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0658
Cell Significance Index: -6.7200 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0669
Cell Significance Index: -7.8000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0680
Cell Significance Index: -14.3300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0714
Cell Significance Index: -20.5300 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0980
Cell Significance Index: -11.5600 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1052
Cell Significance Index: -7.8400 - Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
Fold Change: -0.1269
Cell Significance Index: -1.2700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1449
Cell Significance Index: -5.0900 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.1594
Cell Significance Index: -20.4400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1607
Cell Significance Index: -22.0700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1800
Cell Significance Index: -20.6200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1870
Cell Significance Index: -5.9900 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.1884
Cell Significance Index: -4.7100 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2053
Cell Significance Index: -23.4400 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.2153
Cell Significance Index: -5.8600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2215
Cell Significance Index: -23.0600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2780
Cell Significance Index: -18.6900 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.2810
Cell Significance Index: -5.8300 - Cell Name: DN3 thymocyte (CL0000807)
Fold Change: -0.2902
Cell Significance Index: -2.9100 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.3262
Cell Significance Index: -23.0700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.3314
Cell Significance Index: -7.1800 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.3531
Cell Significance Index: -22.7800 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.3554
Cell Significance Index: -5.0900 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3614
Cell Significance Index: -28.6200 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.3679
Cell Significance Index: -5.0200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3808
Cell Significance Index: -21.3700 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.4078
Cell Significance Index: -7.0300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.4084
Cell Significance Index: -25.1000 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.4553
Cell Significance Index: -12.1800 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4622
Cell Significance Index: -29.1300 - Cell Name: mature T cell (CL0002419)
Fold Change: -0.5156
Cell Significance Index: -3.7100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.5285
Cell Significance Index: -27.7500 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.5371
Cell Significance Index: -13.7200 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -0.5375
Cell Significance Index: -3.3400 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.5495
Cell Significance Index: -8.2800 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.5736
Cell Significance Index: -9.8300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2925223137
Symbol: KPCL_HUMAN
Name: Protein kinase C eta type
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1986216
Title: Isolation and characterization of PKC-L, a new member of the protein kinase C-related gene family specifically expressed in lung, skin, and heart.
PubMed ID: 1986216
PubMed ID: 1545821
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12508121
Title: The DNA sequence and analysis of human chromosome 14.
PubMed ID: 12508121
DOI: 10.1038/nature01348
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7988719
Title: Identification of multiple, novel, protein kinase C-related gene products.
PubMed ID: 7988719
PubMed ID: 11112424
Title: Overexpression of protein kinase C-eta attenuates caspase activation and tumor necrosis factor-alpha-induced cell death.
PubMed ID: 11112424
PubMed ID: 10806212
Title: Phorbol 12-myristate 13-acetate induces protein kinase ceta-specific proliferative response in astrocytic tumor cells.
PubMed ID: 10806212
PubMed ID: 11772428
Title: Protein kinase C-eta regulates resistance to UV- and gamma-irradiation-induced apoptosis in glioblastoma cells by preventing caspase-9 activation.
PubMed ID: 11772428
DOI: 10.1093/neuonc/4.1.9
PubMed ID: 15489897
Title: PKC-eta mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways.
PubMed ID: 15489897
PubMed ID: 15632189
Title: Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C.
PubMed ID: 15632189
PubMed ID: 17146445
Title: The protein kinase C-eta isoform induces proliferation in glioblastoma cell lines through an ERK/Elk-1 pathway.
PubMed ID: 17146445
PubMed ID: 18780722
Title: PKC eta directs induction of IRF-4 expression and Ig kappa gene rearrangement in pre-BCR signaling pathway.
PubMed ID: 18780722
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19797084
Title: Translational control of protein kinase Ceta by two upstream open reading frames.
PubMed ID: 19797084
DOI: 10.1128/mcb.01044-09
PubMed ID: 19114660
Title: PKC eta regulates occludin phosphorylation and epithelial tight junction integrity.
PubMed ID: 19114660
PubMed ID: 20558593
Title: Protein kinase C-eta and phospholipase D2 pathway regulates foam cell formation via regulator of G protein signaling 2.
PubMed ID: 20558593
PubMed ID: 21820409
Title: Protein kinase C? activates NF-?B in response to camptothecin-induced DNA damage.
PubMed ID: 21820409
PubMed ID: 12473186
Title: Protein kinase C eta (PKC eta): its involvement in keratinocyte differentiation.
PubMed ID: 12473186
PubMed ID: 22304920
Title: PKCepsilon promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria.
PubMed ID: 22304920
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 34593629
Title: Unraveling the hidden role of a uORF-encoded peptide as a kinase inhibitor of PKCs.
PubMed ID: 34593629
PubMed ID: 16973127
Title: Structure of human protein kinase C eta (PKCeta) C2 domain and identification of phosphorylation sites.
PubMed ID: 16973127
PubMed ID: 17206144
Title: A nonsynonymous SNP in PRKCH (protein kinase C eta) increases the risk of cerebral infarction.
PubMed ID: 17206144
DOI: 10.1038/ng1945
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 683
- Mass: 77828
- Checksum: 0A29806CE31912F2
- Sequence:
MSSGTMKFNG YLRVRIGEAV GLQPTRWSLR HSLFKKGHQL LDPYLTVSVD QVRVGQTSTK QKTNKPTYNE EFCANVTDGG HLELAVFHET PLGYDHFVAN CTLQFQELLR TTGASDTFEG WVDLEPEGKV FVVITLTGSF TEATLQRDRI FKHFTRKRQR AMRRRVHQIN GHKFMATYLR QPTYCSHCRE FIWGVFGKQG YQCQVCTCVV HKRCHHLIVT ACTCQNNINK VDSKIAEQRF GINIPHKFSI HNYKVPTFCD HCGSLLWGIM RQGLQCKICK MNVHIRCQAN VAPNCGVNAV ELAKTLAGMG LQPGNISPTS KLVSRSTLRR QGKESSKEGN GIGVNSSNRL GIDNFEFIRV LGKGSFGKVM LARVKETGDL YAVKVLKKDV ILQDDDVECT MTEKRILSLA RNHPFLTQLF CCFQTPDRLF FVMEFVNGGD LMFHIQKSRR FDEARARFYA AEIISALMFL HDKGIIYRDL KLDNVLLDHE GHCKLADFGM CKEGICNGVT TATFCGTPDY IAPEILQEML YGPAVDWWAM GVLLYEMLCG HAPFEAENED DLFEAILNDE VVYPTWLHED ATGILKSFMT KNPTMRLGSL TQGGEHAILR HPFFKEIDWA QLNHRQIEPP FRPRIKSRED VSNFDPDFIK EEPVLTPIDE GHLPMINQDE FRNFSYVSPE LQP
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.