Details for: MAPK1

Gene ID: 5594

Symbol: MAPK1

Ensembl ID: ENSG00000100030

Description: mitogen-activated protein kinase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 409.0129
    Cell Significance Index: -63.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 251.0612
    Cell Significance Index: -63.6800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 143.1514
    Cell Significance Index: -67.5900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 140.9083
    Cell Significance Index: -57.2500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 124.4204
    Cell Significance Index: -64.0000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 100.8685
    Cell Significance Index: -67.6900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 60.1052
    Cell Significance Index: -57.3900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 52.7837
    Cell Significance Index: -65.0800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 22.3835
    Cell Significance Index: -68.7500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.7644
    Cell Significance Index: -55.6300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.8168
    Cell Significance Index: -66.3600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.4568
    Cell Significance Index: -31.6400
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 6.8928
    Cell Significance Index: 18.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.5997
    Cell Significance Index: 114.9900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.4841
    Cell Significance Index: 94.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4290
    Cell Significance Index: 487.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.3731
    Cell Significance Index: 159.5700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.1393
    Cell Significance Index: 54.9900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.0805
    Cell Significance Index: 59.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8965
    Cell Significance Index: 376.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.7030
    Cell Significance Index: 610.8400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3218
    Cell Significance Index: 143.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.2644
    Cell Significance Index: 70.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1737
    Cell Significance Index: 90.0700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9978
    Cell Significance Index: 59.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8518
    Cell Significance Index: 52.3600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8496
    Cell Significance Index: 587.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8194
    Cell Significance Index: 155.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7629
    Cell Significance Index: 93.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6938
    Cell Significance Index: 125.0700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6794
    Cell Significance Index: 613.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5793
    Cell Significance Index: 16.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5117
    Cell Significance Index: 279.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3955
    Cell Significance Index: 174.8600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3833
    Cell Significance Index: 24.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2923
    Cell Significance Index: 40.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2411
    Cell Significance Index: 109.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2223
    Cell Significance Index: 6.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2116
    Cell Significance Index: 36.1300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1418
    Cell Significance Index: 3.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1346
    Cell Significance Index: 6.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1188
    Cell Significance Index: 223.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0655
    Cell Significance Index: 4.5300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0584
    Cell Significance Index: 1.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0557
    Cell Significance Index: 35.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0389
    Cell Significance Index: 59.8200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0282
    Cell Significance Index: 2.7900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0208
    Cell Significance Index: 38.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0195
    Cell Significance Index: 0.9200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0119
    Cell Significance Index: 16.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0057
    Cell Significance Index: -0.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0227
    Cell Significance Index: -14.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0264
    Cell Significance Index: -3.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0269
    Cell Significance Index: -19.9600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0332
    Cell Significance Index: -24.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0455
    Cell Significance Index: -34.4500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0579
    Cell Significance Index: -6.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0595
    Cell Significance Index: -2.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0771
    Cell Significance Index: -2.0600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0883
    Cell Significance Index: -14.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0939
    Cell Significance Index: -52.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1477
    Cell Significance Index: -15.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1718
    Cell Significance Index: -22.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1861
    Cell Significance Index: -39.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2044
    Cell Significance Index: -58.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2120
    Cell Significance Index: -24.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2377
    Cell Significance Index: -34.5500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2513
    Cell Significance Index: -32.2200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2664
    Cell Significance Index: -5.7000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2680
    Cell Significance Index: -5.2300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2722
    Cell Significance Index: -31.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3484
    Cell Significance Index: -7.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3740
    Cell Significance Index: -19.4300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4218
    Cell Significance Index: -29.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4334
    Cell Significance Index: -32.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4989
    Cell Significance Index: -51.9500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6354
    Cell Significance Index: -13.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6442
    Cell Significance Index: -51.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7169
    Cell Significance Index: -37.6400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7341
    Cell Significance Index: -46.2700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7429
    Cell Significance Index: -13.7300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7679
    Cell Significance Index: -40.0000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.7773
    Cell Significance Index: -11.1800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7794
    Cell Significance Index: -20.8900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.8359
    Cell Significance Index: -14.0800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.8359
    Cell Significance Index: -18.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8431
    Cell Significance Index: -51.6900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.8812
    Cell Significance Index: -13.0100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.9437
    Cell Significance Index: -11.7100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.9475
    Cell Significance Index: -25.7900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9761
    Cell Significance Index: -27.9800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9819
    Cell Significance Index: -31.4500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.0184
    Cell Significance Index: -35.3900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.0413
    Cell Significance Index: -27.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.0579
    Cell Significance Index: -17.7100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.0595
    Cell Significance Index: -23.2000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.1139
    Cell Significance Index: -6.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.1310
    Cell Significance Index: -36.0200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.1536
    Cell Significance Index: -37.7700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.1937
    Cell Significance Index: -25.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural Homology:** MAPK1 is a member of the MAPK family, which consists of three subfamilies: the extracellular signal-regulated kinases (ERKs), the p38 MAPKs, and the c-Jun N-terminal kinases (JNKs). MAPK1 is structurally similar to ERK1 and ERK2, sharing a high degree of sequence homology. 2. **Kinase Activity:** MAPK1 possesses intrinsic kinase activity, enabling it to phosphorylate and activate downstream targets. 3. **Subcellular Localization:** MAPK1 is primarily cytoplasmic, but can also be found in the nucleus, where it regulates gene expression and transcription. 4. **Regulation:** MAPK1 is regulated by various mechanisms, including phosphorylation, dephosphorylation, and post-translational modifications. **Pathways and Functions:** 1. **Cell Signaling:** MAPK1 is involved in numerous signaling pathways, including the MAPK/ERK pathway, the p38 MAPK pathway, and the JNK pathway. These pathways regulate various cellular processes, such as cell growth, differentiation, and apoptosis. 2. **Apoptosis:** MAPK1 plays a crucial role in regulating apoptosis, a process of programmed cell death. Its dysregulation has been implicated in various cancers and neurodegenerative diseases. 3. **Stress Responses:** MAPK1 is activated in response to various forms of cellular stress, including heat shock, oxidative stress, and endoplasmic reticulum stress. 4. **Gene Expression:** MAPK1 regulates gene expression through the phosphorylation and activation of transcription factors, such as CREB and NF-κB. 5. **Cancer:** MAPK1 is overexpressed in various types of cancer, including breast, lung, and colon cancer. Its dysregulation contributes to tumor growth, metastasis, and resistance to therapy. **Clinical Significance:** 1. **Cancer Therapy:** MAPK1 is a potential therapeutic target in cancer treatment, as its dysregulation contributes to tumor growth and metastasis. 2. **Neurological Disorders:** MAPK1 is implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Its dysregulation contributes to neuronal damage and degeneration. 3. **Inflammatory Conditions:** MAPK1 is activated in response to inflammatory stimuli, contributing to the pathogenesis of inflammatory conditions, such as arthritis and asthma. 4. **Cardiovascular Disease:** MAPK1 is involved in the regulation of cardiovascular disease, including hypertension, atherosclerosis, and heart failure. In conclusion, MAPK1 is a multifaceted regulator of cellular signaling pathways, playing a crucial role in various physiological and pathological processes. Its dysregulation has been implicated in numerous diseases, highlighting the importance of MAPK1 in disease pathogenesis. Further research is necessary to fully elucidate the mechanisms of MAPK1 regulation and its potential therapeutic applications.

Genular Protein ID: 3154856641

Symbol: MK01_HUMAN

Name: ERT1

UniProtKB Accession Codes:

P28482 A8CZ64

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 15 CPTC 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 20 DrugCentral 1 EC 3 ELM 1 EMBL 8 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 88 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 MoonDB 1 MoonProt 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 62 RefSeq 2 Rhea 6 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1540184

Title: Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs.

PubMed ID: 1540184

DOI: 10.1016/0006-291x(92)91891-s

PubMed ID: 1319925

Title: Heterogeneous expression of four MAP kinase isoforms in human tissues.

PubMed ID: 1319925

DOI: 10.1016/0014-5793(92)80612-k

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 7588608

Title: ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation.

PubMed ID: 7588608

DOI: 10.1002/j.1460-2075.1995.tb00160.x

PubMed ID: 8622688

Title: 3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region.

PubMed ID: 8622688

DOI: 10.1128/mcb.16.3.868

PubMed ID: 8794306

Title: Human immunodeficiency virus type 1 Nef binds directly to LCK and mitogen-activated protein kinase, inhibiting kinase activity.

PubMed ID: 8794306

DOI: 10.1128/jvi.70.10.6701-6708.1996

PubMed ID: 9480836

Title: MAPKAPK5, a novel mitogen-activated protein kinase (MAPK)-activated protein kinase, is a substrate of the extracellular-regulated kinase (ERK) and p38 kinase.

PubMed ID: 9480836

DOI: 10.1006/bbrc.1998.8135

PubMed ID: 9687510

Title: Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.

PubMed ID: 9687510

DOI: 10.1093/emboj/17.15.4426

PubMed ID: 9649500

Title: Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor.

PubMed ID: 9649500

DOI: 10.1101/gad.12.13.1953

PubMed ID: 9788880

Title: Isolation of the human genes encoding the Pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases.

PubMed ID: 9788880

DOI: 10.1242/jcs.111.22.3389

PubMed ID: 9596579

Title: Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase.

PubMed ID: 9596579

DOI: 10.1126/science.280.5367.1262

PubMed ID: 10224087

Title: Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway.

PubMed ID: 10224087

DOI: 10.1074/jbc.274.19.13271

PubMed ID: 10637505

Title: ERK activation induces phosphorylation of Elk-1 at multiple S/T-P motifs to high stoichiometry.

PubMed ID: 10637505

DOI: 10.1038/sj.onc.1203362

PubMed ID: 10617468

Title: Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation.

PubMed ID: 10617468

DOI: 10.1126/science.286.5449.2514

PubMed ID: 11154262

Title: The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells.

PubMed ID: 11154262

DOI: 10.1128/mcb.21.3.743-754.2001

PubMed ID: 12110590

Title: Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38.

PubMed ID: 12110590

DOI: 10.1093/emboj/cdf361

PubMed ID: 12356731

Title: IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation.

PubMed ID: 12356731

DOI: 10.1093/emboj/cdf488

PubMed ID: 11912194

Title: Insulin receptor substrate 4 associates with the protein IRAS.

PubMed ID: 11912194

DOI: 10.1074/jbc.m111838200

PubMed ID: 12974390

Title: EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2.

PubMed ID: 12974390

DOI: 10.1515/bc.2003.134

PubMed ID: 12794087

Title: Activation of ERK induces phosphorylation of MAPK phosphatase-7, a JNK specific phosphatase, at Ser-446.

PubMed ID: 12794087

DOI: 10.1074/jbc.m213254200

PubMed ID: 12792650

Title: Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK.

PubMed ID: 12792650

DOI: 10.1038/ncb1005

PubMed ID: 15358203

Title: Nek2A specifies the centrosomal localization of Erk2.

PubMed ID: 15358203

DOI: 10.1016/j.bbrc.2004.06.171

PubMed ID: 15526160

Title: Signal transduction via the stem cell factor receptor/c-Kit.

PubMed ID: 15526160

DOI: 10.1007/s00018-004-4189-6

PubMed ID: 15184391

Title: Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin.

PubMed ID: 15184391

DOI: 10.1074/jbc.m402304200

PubMed ID: 15241487

Title: MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol.

PubMed ID: 15241487

DOI: 10.1038/sj.onc.1207692

PubMed ID: 15952796

Title: Phosphorylation of Grb10 by mitogen-activated protein kinase: identification of Ser150 and Ser476 of human Grb10zeta as major phosphorylation sites.

PubMed ID: 15952796

DOI: 10.1021/bi050413i

PubMed ID: 15616583

Title: Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK.

PubMed ID: 15616583

DOI: 10.1038/sj.emboj.7600510

PubMed ID: 16288922

Title: New insights into the catalytic activation of the MAPK phosphatase PAC-1 induced by its substrate MAPK ERK2 binding.

PubMed ID: 16288922

DOI: 10.1016/j.jmb.2005.10.006

PubMed ID: 15788397

Title: Phosphorylation of serine 147 of tis21/BTG2/pc3 by p-Erk1/2 induces Pin-1 binding in cytoplasm and cell death.

PubMed ID: 15788397

DOI: 10.1074/jbc.m500318200

PubMed ID: 15664191

Title: Regulation of Raf-1 by direct feedback phosphorylation.

PubMed ID: 15664191

DOI: 10.1016/j.molcel.2004.11.055

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18211802

Title: ERK1/2 phosphorylate GEF-H1 to enhance its guanine nucleotide exchange activity toward RhoA.

PubMed ID: 18211802

DOI: 10.1016/j.bbrc.2008.01.066

PubMed ID: 16581800

Title: Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26.

PubMed ID: 16581800

DOI: 10.1128/mcb.26.8.3282-3294.2006

PubMed ID: 17274988

Title: ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation.

PubMed ID: 17274988

DOI: 10.1016/j.febslet.2007.01.039

PubMed ID: 18435604

Title: Mutations of beta-arrestin 2 that limit self-association also interfere with interactions with the beta2-adrenoceptor and the ERK1/2 MAPKs: implications for beta2-adrenoceptor signalling via the ERK1/2 MAPKs.

PubMed ID: 18435604

DOI: 10.1042/bj20080685

PubMed ID: 18296648

Title: Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma.

PubMed ID: 18296648

DOI: 10.1158/1541-7786.mcr-07-2028

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18760948

Title: Identification and characterization of a general nuclear translocation signal in signaling proteins.

PubMed ID: 18760948

DOI: 10.1016/j.molcel.2008.08.007

PubMed ID: 18794356

Title: Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction.

PubMed ID: 18794356

DOI: 10.1128/mcb.00925-08

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19879846

Title: Profiling the human protein-DNA interactome reveals ERK2 as a transcriptional repressor of interferon signaling.

PubMed ID: 19879846

DOI: 10.1016/j.cell.2009.08.037

PubMed ID: 19265199

Title: The D816V mutation of c-Kit circumvents a requirement for Src family kinases in c-Kit signal transduction.

PubMed ID: 19265199

DOI: 10.1074/jbc.m808058200

PubMed ID: 19494114

Title: Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases.

PubMed ID: 19494114

DOI: 10.1074/jbc.m109.002758

PubMed ID: 19447520

Title: Protein kinase SGK1 enhances MEK/ERK complex formation through the phosphorylation of ERK2: implication for the positive regulatory role of SGK1 on the ERK function during liver regeneration.

PubMed ID: 19447520

DOI: 10.1016/j.jhep.2009.02.027

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19060905

Title: A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy.

PubMed ID: 19060905

DOI: 10.1038/nm.1893

PubMed ID: 16393692

Title: The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions.

PubMed ID: 16393692

DOI: 10.1080/02699050500284218

PubMed ID: 19565474

Title: The ERK signaling cascade--views from different subcellular compartments.

PubMed ID: 19565474

DOI: 10.1002/biof.52

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21779493

Title: The ERK cascade: distinct functions within various subcellular organelles.

PubMed ID: 21779493

DOI: 10.1177/1947601911407328

PubMed ID: 22033920

Title: Mitogen-activated protein kinase extracellular signal-regulated kinase 2 phosphorylates and promotes Pin1 protein-dependent promyelocytic leukemia protein turnover.

PubMed ID: 22033920

DOI: 10.1074/jbc.m111.289512

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23847209

Title: Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2.

PubMed ID: 23847209

DOI: 10.1073/pnas.1301985110

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 32051553

Title: The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.

PubMed ID: 32051553

DOI: 10.1038/s41388-020-1206-7

PubMed ID: 34497368

Title: TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination.

PubMed ID: 34497368

DOI: 10.1038/s41556-021-00732-8

PubMed ID: 9827991

Title: A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase.

PubMed ID: 9827991

DOI: 10.1002/pro.5560071102

PubMed ID: 16139248

Title: Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex.

PubMed ID: 16139248

DOI: 10.1016/j.bbrc.2005.08.082

PubMed ID: 16242327

Title: Crystal structure of human ERK2 complexed with a pyrazolo[3,4-c]pyridazine derivative.

PubMed ID: 16242327

DOI: 10.1016/j.bmcl.2005.09.055

PubMed ID: 17194451

Title: Role of a cysteine residue in the active site of ERK and the MAPKK family.

PubMed ID: 17194451

DOI: 10.1016/j.bbrc.2006.12.083

PubMed ID: 17300186

Title: Flipped out: structure-guided design of selective pyrazolylpyrrole ERK inhibitors.

PubMed ID: 17300186

DOI: 10.1021/jm061381f

PubMed ID: 19053285

Title: Structural basis of substrate recognition by hematopoietic tyrosine phosphatase.

PubMed ID: 19053285

DOI: 10.1021/bi801724n

PubMed ID: 19827834

Title: Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control.

PubMed ID: 19827834

DOI: 10.1021/jm900630q

PubMed ID: 32721402

Title: Enhanced MAPK1 function causes a neurodevelopmental disorder within the RASopathy clinical spectrum.

PubMed ID: 32721402

DOI: 10.1016/j.ajhg.2020.06.018

Sequence Information:

  • Length: 360
  • Mass: 41390
  • Checksum: E85D0B2A5D2D724E
  • Sequence:
    • MAAAAAAGAG PEMVRGQVFD VGPRYTNLSY IGEGAYGMVC SAYDNVNKVR VAIKKISPFE 
HQTYCQRTLR EIKILLRFRH ENIIGINDII RAPTIEQMKD VYIVQDLMET DLYKLLKTQH 
LSNDHICYFL YQILRGLKYI HSANVLHRDL KPSNLLLNTT CDLKICDFGL ARVADPDHDH 
TGFLTEYVAT RWYRAPEIML NSKGYTKSID IWSVGCILAE MLSNRPIFPG KHYLDQLNHI 
LGILGSPSQE DLNCIINLKA RNYLLSLPHK NKVPWNRLFP NADSKALDLL DKMLTFNPHK 
RIEVEQALAH PYLEQYYDPS DEPIAEAPFK FDMELDDLPK EKLKELIFEE TARFQPGYRS

Genular Protein ID: 2567941732

Symbol: Q499G7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q499G7

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 12 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 2 GO 16 Gene3D 1 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 Rhea 6 RuleBase 2 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 360
  • Mass: 41331
  • Checksum: D4271876ABA25E32
  • Sequence:
    • MAAAAAAGAG PEMVRGQVFD VGPRYTNLSY IGEGAYGMVC SAYDNVNKVR VAIKKISPFE 
HQTYCQRTLR EIKILLRSRH ENIIGINDII RAPTIEQMKD VYIVQDLMET DLYKLLKTQH 
LSNDHICYFL YQILRGLKYI HSANVLHRDL KPSNLLLNTT CDLEICDFGL ARVADPDHDH 
TGFLTEYVAT RWYRAPEIML NSKGYTKSID IWSVGCILAE MLSNRPIFPG KHYLDQLNHI 
LGILGSPSQE DLNCIINLKA RNYLLSLPHK NKVPWNRLFP NADSKALDLL DKMLTFNPHK 
RIEVEQALAH PYLEQYYDPS DEPIAEAPFK FDMELDDLPK EKLKELIFEE TARFQPGYRS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.