Details for: MAPK6

Gene ID: 5597

Symbol: MAPK6

Ensembl ID: ENSG00000069956

Description: mitogen-activated protein kinase 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 314.1209
    Cell Significance Index: -48.8600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 193.7760
    Cell Significance Index: -49.1500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 124.3847
    Cell Significance Index: -51.2400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 109.4101
    Cell Significance Index: -51.6600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 94.1901
    Cell Significance Index: -48.4500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 77.0392
    Cell Significance Index: -51.7000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 40.9909
    Cell Significance Index: -50.5400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.5452
    Cell Significance Index: -49.6800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.8711
    Cell Significance Index: -50.7900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.6845
    Cell Significance Index: -38.9600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.1527
    Cell Significance Index: -22.2200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.9823
    Cell Significance Index: 40.6900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.0226
    Cell Significance Index: 57.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.0149
    Cell Significance Index: 399.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5930
    Cell Significance Index: 82.7500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5018
    Cell Significance Index: 40.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3473
    Cell Significance Index: 270.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.2477
    Cell Significance Index: 34.8700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9414
    Cell Significance Index: 102.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9237
    Cell Significance Index: 26.6200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8666
    Cell Significance Index: 45.5000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8254
    Cell Significance Index: 49.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7698
    Cell Significance Index: 138.7700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.7084
    Cell Significance Index: 18.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7065
    Cell Significance Index: 69.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7049
    Cell Significance Index: 86.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6579
    Cell Significance Index: 36.9200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6400
    Cell Significance Index: 29.0100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5588
    Cell Significance Index: 14.9200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5271
    Cell Significance Index: 475.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5201
    Cell Significance Index: 284.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4911
    Cell Significance Index: 33.9700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4853
    Cell Significance Index: 174.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4830
    Cell Significance Index: 22.5200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4527
    Cell Significance Index: 200.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4337
    Cell Significance Index: 33.2900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3881
    Cell Significance Index: 63.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3782
    Cell Significance Index: 28.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3144
    Cell Significance Index: 43.1700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.3114
    Cell Significance Index: 2.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2763
    Cell Significance Index: 12.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2484
    Cell Significance Index: 8.7300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2167
    Cell Significance Index: 3.6500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1841
    Cell Significance Index: 127.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1718
    Cell Significance Index: 22.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1578
    Cell Significance Index: 30.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1559
    Cell Significance Index: 293.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1123
    Cell Significance Index: 14.3900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1010
    Cell Significance Index: 1.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0924
    Cell Significance Index: 3.5000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0586
    Cell Significance Index: 79.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0583
    Cell Significance Index: 9.9500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0473
    Cell Significance Index: 2.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0453
    Cell Significance Index: 28.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0413
    Cell Significance Index: 63.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0269
    Cell Significance Index: 1.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0250
    Cell Significance Index: 46.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0196
    Cell Significance Index: 8.9100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0080
    Cell Significance Index: -5.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0195
    Cell Significance Index: -12.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0499
    Cell Significance Index: -36.6200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0509
    Cell Significance Index: -3.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0534
    Cell Significance Index: -30.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0540
    Cell Significance Index: -40.9100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0610
    Cell Significance Index: -1.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1291
    Cell Significance Index: -27.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1383
    Cell Significance Index: -16.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1431
    Cell Significance Index: -41.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1502
    Cell Significance Index: -21.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1519
    Cell Significance Index: -17.9100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1563
    Cell Significance Index: -15.9700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1985
    Cell Significance Index: -22.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2396
    Cell Significance Index: -27.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2646
    Cell Significance Index: -5.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3314
    Cell Significance Index: -7.1800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3352
    Cell Significance Index: -20.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3484
    Cell Significance Index: -36.2800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3581
    Cell Significance Index: -2.9200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3724
    Cell Significance Index: -2.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3824
    Cell Significance Index: -24.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3837
    Cell Significance Index: -12.2900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4038
    Cell Significance Index: -27.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4127
    Cell Significance Index: -14.3400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4168
    Cell Significance Index: -10.4200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4412
    Cell Significance Index: -7.4200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4658
    Cell Significance Index: -5.5500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5106
    Cell Significance Index: -8.5500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.5353
    Cell Significance Index: -7.6200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.5470
    Cell Significance Index: -6.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5540
    Cell Significance Index: -43.8800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.6239
    Cell Significance Index: -5.7500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6813
    Cell Significance Index: -18.2600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.7094
    Cell Significance Index: -10.4700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8351
    Cell Significance Index: -51.2000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.8657
    Cell Significance Index: -16.0000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.8861
    Cell Significance Index: -21.6200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.9109
    Cell Significance Index: -5.6600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.9682
    Cell Significance Index: -27.6300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.0286
    Cell Significance Index: -30.2100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0648
    Cell Significance Index: -34.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MAPK6 is a member of the MAPK family, which is involved in signal transduction pathways that regulate a wide range of cellular processes. It is characterized by its ability to phosphorylate and activate downstream targets, including transcription factors, kinases, and other signaling molecules. MAPK6 is also known for its role in regulating cell growth, differentiation, and apoptosis. Its expression is tightly regulated by various post-translational modifications, including phosphorylation, ubiquitination, and proteasomal degradation. **Pathways and Functions:** MAPK6 is integral to several signaling pathways, including: 1. **MAPK cascade:** MAPK6 activates downstream targets, such as ERK1/2, p38, and JNK, which regulate cell growth, differentiation, and survival. 2. **Cell cycle regulation:** MAPK6 phosphorylates and activates cyclin-dependent kinases, influencing cell cycle progression and proliferation. 3. **Apoptosis regulation:** MAPK6 modulates the activity of pro-apoptotic and anti-apoptotic proteins, influencing cell survival and death. 4. **Inflammation regulation:** MAPK6 is involved in the regulation of inflammatory responses, modulating the activity of pro-inflammatory and anti-inflammatory cytokines. **Clinical Significance:** MAPK6 has been implicated in various diseases, including: 1. **Cancer:** Overexpression of MAPK6 has been observed in several types of cancer, including breast, lung, and colon cancer, where it contributes to tumor growth and metastasis. 2. **Neurological disorders:** MAPK6 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where it regulates synaptic plasticity and neuronal survival. 3. **Inflammatory diseases:** MAPK6 has been linked to the regulation of inflammatory responses, contributing to the pathogenesis of diseases such as arthritis and asthma. 4. **Cardiovascular disease:** MAPK6 has been implicated in the regulation of cardiovascular function, influencing blood pressure regulation and cardiovascular remodeling. In conclusion, MAPK6 is a critical regulator of cellular signaling, influencing cell growth, differentiation, and survival. Its dysregulation has been implicated in various diseases, highlighting the importance of MAPK6 in maintaining cellular homeostasis and promoting disease prevention. Further research is needed to fully elucidate the mechanisms by which MAPK6 regulates cellular processes and to explore its therapeutic potential in disease prevention and treatment.

Genular Protein ID: 500440957

Symbol: MK06_HUMAN

Name: Mitogen-activated protein kinase 6

UniProtKB Accession Codes:

Q16659 B2R945 B5BU65 Q68DH4 Q8IYN8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 2 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EC 3 EMBL 7 Ensembl 6 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7969157

Title: Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3.

PubMed ID: 7969157

DOI: 10.1128/mcb.14.12.8202-8211.1994

PubMed ID: 8875998

Title: Primary structure, expression and chromosomal locus of a human homolog of rat ERK3.

PubMed ID: 8875998

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15226418

Title: N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome.

PubMed ID: 15226418

DOI: 10.1128/mcb.24.14.6140-6150.2004

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21177870

Title: Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway.

PubMed ID: 21177870

DOI: 10.1074/jbc.m110.181529

PubMed ID: 22645313

Title: Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes.

PubMed ID: 22645313

DOI: 10.1128/mcb.00201-12

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 721
  • Mass: 82681
  • Checksum: DAA3AAA9B98BB31F
  • Sequence:
    • MAEKFESLMN IHGFDLGSRY MDLKPLGCGG NGLVFSAVDN DCDKRVAIKK IVLTDPQSVK 
HALREIKIIR RLDHDNIVKV FEILGPSGSQ LTDDVGSLTE LNSVYIVQEY METDLANVLE 
QGPLLEEHAR LFMYQLLRGL KYIHSANVLH RDLKPANLFI NTEDLVLKIG DFGLARIMDP 
HYSHKGHLSE GLVTKWYRSP RLLLSPNNYT KAIDMWAAGC IFAEMLTGKT LFAGAHELEQ 
MQLILESIPV VHEEDRQELL SVIPVYIRND MTEPHKPLTQ LLPGISREAL DFLEQILTFS 
PMDRLTAEEA LSHPYMSIYS FPMDEPISSH PFHIEDEVDD ILLMDETHSH IYNWERYHDC 
QFSEHDWPVH NNFDIDEVQL DPRALSDVTD EEEVQVDPRK YLDGDREKYL EDPAFDTNYS 
TEPCWQYSDH HENKYCDLEC SHTCNYKTRS SSYLDNLVWR ESEVNHYYEP KLIIDLSNWK 
EQSKEKSDKK GKSKCERNGL VKAQIALEEA SQQLAGKERE KNQGFDFDSF IAGTIQLSSQ 
HEPTDVVDKL NDLNSSVSQL ELKSLISKSV SQEKQEKGMA NLAQLEALYQ SSWDSQFVSG 
GEDCFFINQF CEVRKDEQVE KENTYTSYLD KFFSRKEDTE MLETEPVEDG KLGERGHEEG 
FLNNSGEFLF NKQLESIGIP QFHSPVGSPL KSIQATLTPS AMKSSPQIPH QTYSSILKHL 
N

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.