Details for: MAP2K5
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 320.0355
Cell Significance Index: -49.7800 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 191.5288
Cell Significance Index: -48.5800 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 96.2814
Cell Significance Index: -39.1200 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 41.0791
Cell Significance Index: -39.2200 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 40.6746
Cell Significance Index: -50.1500 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 16.7497
Cell Significance Index: -44.8700 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 16.5586
Cell Significance Index: -36.2400 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 14.7715
Cell Significance Index: -45.3700 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 12.7393
Cell Significance Index: -50.2700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.7346
Cell Significance Index: 548.5500 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 2.7195
Cell Significance Index: 102.9800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 2.6673
Cell Significance Index: 117.9800 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 2.5894
Cell Significance Index: 174.1100 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 2.5521
Cell Significance Index: 72.8300 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 2.2504
Cell Significance Index: 126.2800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 2.1760
Cell Significance Index: 166.9900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.0258
Cell Significance Index: 726.6200 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.8659
Cell Significance Index: 39.8900 - Cell Name: preadipocyte (CL0002334)
Fold Change: 1.8481
Cell Significance Index: 36.0700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.7550
Cell Significance Index: 348.2900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.4284
Cell Significance Index: 39.9200 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.3617
Cell Significance Index: 941.8300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 1.2866
Cell Significance Index: 79.0800 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 1.2817
Cell Significance Index: 32.0400 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.2360
Cell Significance Index: 15.3300 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 1.2050
Cell Significance Index: 28.9000 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.1158
Cell Significance Index: 28.6800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8863
Cell Significance Index: 800.2400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.7077
Cell Significance Index: 73.6900 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.6107
Cell Significance Index: 60.4200 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.4930
Cell Significance Index: 10.6800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4879
Cell Significance Index: 79.3500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.4860
Cell Significance Index: 915.1100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.4799
Cell Significance Index: 217.8200 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.4236
Cell Significance Index: 3.7600 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4081
Cell Significance Index: 44.3900 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.4037
Cell Significance Index: 8.8400 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.3031
Cell Significance Index: 5.2000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.2875
Cell Significance Index: 33.5000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.2857
Cell Significance Index: 181.4400 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.2738
Cell Significance Index: 6.6800 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2723
Cell Significance Index: 7.8500 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.2482
Cell Significance Index: 6.6500 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2427
Cell Significance Index: 11.0000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.2395
Cell Significance Index: 441.7700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.2079
Cell Significance Index: 320.0200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2014
Cell Significance Index: 38.3300 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1532
Cell Significance Index: 9.2000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1496
Cell Significance Index: 203.4400 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0508
Cell Significance Index: 3.5200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0259
Cell Significance Index: 4.6700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0159
Cell Significance Index: 8.6600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0148
Cell Significance Index: 6.5400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0195
Cell Significance Index: -2.8300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0251
Cell Significance Index: -3.0900 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.0425
Cell Significance Index: -0.6100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0530
Cell Significance Index: -38.8500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0558
Cell Significance Index: -41.3200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0668
Cell Significance Index: -50.5500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0862
Cell Significance Index: -48.6000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0871
Cell Significance Index: -54.3600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0893
Cell Significance Index: -15.2400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1237
Cell Significance Index: -16.9900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1440
Cell Significance Index: -41.4400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1511
Cell Significance Index: -5.3100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1973
Cell Significance Index: -20.1500 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -0.2074
Cell Significance Index: -2.9000 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.2148
Cell Significance Index: -3.0900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.2328
Cell Significance Index: -30.0700 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2379
Cell Significance Index: -28.0500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2487
Cell Significance Index: -52.3800 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.2534
Cell Significance Index: -3.3800 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.2707
Cell Significance Index: -34.7000 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: -0.2907
Cell Significance Index: -3.6600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.3048
Cell Significance Index: -14.2100 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.3308
Cell Significance Index: -7.0200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.3331
Cell Significance Index: -17.3500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.3355
Cell Significance Index: -17.4300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.3417
Cell Significance Index: -16.0600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3515
Cell Significance Index: -21.5500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3773
Cell Significance Index: -43.2300 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.3969
Cell Significance Index: -5.8600 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.3990
Cell Significance Index: -7.8900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.4050
Cell Significance Index: -26.1300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.4290
Cell Significance Index: -11.4600 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.4435
Cell Significance Index: -9.2000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4811
Cell Significance Index: -25.2600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.4964
Cell Significance Index: -15.9000 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.4990
Cell Significance Index: -6.2200 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: -0.5025
Cell Significance Index: -3.1000 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.5065
Cell Significance Index: -16.1300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.5201
Cell Significance Index: -32.7800 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.5232
Cell Significance Index: -17.1300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.5317
Cell Significance Index: -39.6300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5367
Cell Significance Index: -42.5100 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.5890
Cell Significance Index: -41.6600 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.6052
Cell Significance Index: -12.1500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.6217
Cell Significance Index: -13.2400 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: -0.6369
Cell Significance Index: -8.2600 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.6685
Cell Significance Index: -10.1700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1586169584
Symbol: MP2K5_HUMAN
Name: Dual specificity mitogen-activated protein kinase kinase 5
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7759517
Title: Components of a new human protein kinase signal transduction pathway.
PubMed ID: 7759517
PubMed ID: 9384584
Title: BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C.
PubMed ID: 9384584
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16572171
Title: Analysis of the DNA sequence and duplication history of human chromosome 15.
PubMed ID: 16572171
DOI: 10.1038/nature04601
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 16728640
Title: Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation.
PubMed ID: 16728640
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 448
- Mass: 50112
- Checksum: F23BB327E2A9C7DC
- Sequence:
MLWLALGPFP AMENQVLVIR IKIPNSGAVD WTVHSGPQLL FRDVLDVIGQ VLPEATTTAF EYEDEDGDRI TVRSDEEMKA MLSYYYSTVM EQQVNGQLIE PLQIFPRACK PPGERNIHGL KVNTRAGPSQ HSSPAVSDSL PSNSLKKSSA ELKKILANGQ MNEQDIRYRD TLGHGNGGTV YKAYHVPSGK ILAVKVILLD ITLELQKQIM SELEILYKCD SSYIIGFYGA FFVENRISIC TEFMDGGSLD VYRKMPEHVL GRIAVAVVKG LTYLWSLKIL HRDVKPSNML VNTRGQVKLC DFGVSTQLVN SIAKTYVGTN AYMAPERISG EQYGIHSDVW SLGISFMELA LGRFPYPQIQ KNQGSLMPLQ LLQCIVDEDS PVLPVGEFSE PFVHFITQCM RKQPKERPAP EELMGHPFIV QFNDGNAAVV SMWVCRALEE RRSQQGPP
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.