Details for: MAP2K5

Gene ID: 5607

Symbol: MAP2K5

Ensembl ID: ENSG00000137764

Description: mitogen-activated protein kinase kinase 5

Associated with

  • Signaling by ntrk1 (trka)
    (R-HSA-187037)
  • Signaling by ntrks
    (R-HSA-166520)
  • Signaling by receptor tyrosine kinases
    (R-HSA-9006934)
  • Signalling to erk5
    (R-HSA-198765)
  • Atp binding
    (GO:0005524)
  • Cellular response to growth factor stimulus
    (GO:0071363)
  • Cellular response to laminar fluid shear stress
    (GO:0071499)
  • Erk5 cascade
    (GO:0070375)
  • Heart development
    (GO:0007507)
  • Insulin-like growth factor receptor signaling pathway
    (GO:0048009)
  • Mapk cascade
    (GO:0000165)
  • Map kinase kinase activity
    (GO:0004708)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of canonical nf-kappab signal transduction
    (GO:0043124)
  • Negative regulation of cell migration involved in sprouting angiogenesis
    (GO:0090051)
  • Negative regulation of chemokine (c-x-c motif) ligand 2 production
    (GO:2000342)
  • Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
    (GO:2001240)
  • Negative regulation of heterotypic cell-cell adhesion
    (GO:0034115)
  • Negative regulation of interleukin-8 production
    (GO:0032717)
  • Negative regulation of response to cytokine stimulus
    (GO:0060761)
  • Negative regulation of smooth muscle cell apoptotic process
    (GO:0034392)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Positive regulation of cell growth
    (GO:0030307)
  • Positive regulation of epithelial cell proliferation
    (GO:0050679)
  • Positive regulation of protein metabolic process
    (GO:0051247)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Protein kinase activity
    (GO:0004672)
  • Protein phosphorylation
    (GO:0006468)
  • Protein serine/threonine kinase activity
    (GO:0004674)
  • Protein serine kinase activity
    (GO:0106310)
  • Protein tyrosine kinase activity
    (GO:0004713)
  • Signal transduction
    (GO:0007165)
  • Spindle
    (GO:0005819)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 320.0355
    Cell Significance Index: -49.7800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 191.5288
    Cell Significance Index: -48.5800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 96.2814
    Cell Significance Index: -39.1200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 41.0791
    Cell Significance Index: -39.2200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 40.6746
    Cell Significance Index: -50.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.7497
    Cell Significance Index: -44.8700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.5586
    Cell Significance Index: -36.2400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.7715
    Cell Significance Index: -45.3700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.7393
    Cell Significance Index: -50.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.7346
    Cell Significance Index: 548.5500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.7195
    Cell Significance Index: 102.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.6673
    Cell Significance Index: 117.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.5894
    Cell Significance Index: 174.1100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.5521
    Cell Significance Index: 72.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.2504
    Cell Significance Index: 126.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.1760
    Cell Significance Index: 166.9900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.0258
    Cell Significance Index: 726.6200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.8659
    Cell Significance Index: 39.8900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.8481
    Cell Significance Index: 36.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7550
    Cell Significance Index: 348.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.4284
    Cell Significance Index: 39.9200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.3617
    Cell Significance Index: 941.8300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.2866
    Cell Significance Index: 79.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.2817
    Cell Significance Index: 32.0400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.2360
    Cell Significance Index: 15.3300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.2050
    Cell Significance Index: 28.9000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.1158
    Cell Significance Index: 28.6800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8863
    Cell Significance Index: 800.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.7077
    Cell Significance Index: 73.6900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6107
    Cell Significance Index: 60.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4930
    Cell Significance Index: 10.6800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4879
    Cell Significance Index: 79.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4860
    Cell Significance Index: 915.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.4799
    Cell Significance Index: 217.8200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.4236
    Cell Significance Index: 3.7600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4081
    Cell Significance Index: 44.3900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4037
    Cell Significance Index: 8.8400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3031
    Cell Significance Index: 5.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2875
    Cell Significance Index: 33.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2857
    Cell Significance Index: 181.4400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.2738
    Cell Significance Index: 6.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2723
    Cell Significance Index: 7.8500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2482
    Cell Significance Index: 6.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2427
    Cell Significance Index: 11.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2395
    Cell Significance Index: 441.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2079
    Cell Significance Index: 320.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2014
    Cell Significance Index: 38.3300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1532
    Cell Significance Index: 9.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1496
    Cell Significance Index: 203.4400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0508
    Cell Significance Index: 3.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0259
    Cell Significance Index: 4.6700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0159
    Cell Significance Index: 8.6600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0148
    Cell Significance Index: 6.5400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0195
    Cell Significance Index: -2.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0251
    Cell Significance Index: -3.0900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0425
    Cell Significance Index: -0.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0530
    Cell Significance Index: -38.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0558
    Cell Significance Index: -41.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0668
    Cell Significance Index: -50.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0862
    Cell Significance Index: -48.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0871
    Cell Significance Index: -54.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0893
    Cell Significance Index: -15.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1237
    Cell Significance Index: -16.9900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1440
    Cell Significance Index: -41.4400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1511
    Cell Significance Index: -5.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1973
    Cell Significance Index: -20.1500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.2074
    Cell Significance Index: -2.9000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2148
    Cell Significance Index: -3.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2328
    Cell Significance Index: -30.0700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2379
    Cell Significance Index: -28.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2487
    Cell Significance Index: -52.3800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.2534
    Cell Significance Index: -3.3800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2707
    Cell Significance Index: -34.7000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.2907
    Cell Significance Index: -3.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3048
    Cell Significance Index: -14.2100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3308
    Cell Significance Index: -7.0200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3331
    Cell Significance Index: -17.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3355
    Cell Significance Index: -17.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3417
    Cell Significance Index: -16.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3515
    Cell Significance Index: -21.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3773
    Cell Significance Index: -43.2300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3969
    Cell Significance Index: -5.8600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3990
    Cell Significance Index: -7.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4050
    Cell Significance Index: -26.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4290
    Cell Significance Index: -11.4600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4435
    Cell Significance Index: -9.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4811
    Cell Significance Index: -25.2600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4964
    Cell Significance Index: -15.9000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4990
    Cell Significance Index: -6.2200
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.5025
    Cell Significance Index: -3.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5065
    Cell Significance Index: -16.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5201
    Cell Significance Index: -32.7800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5232
    Cell Significance Index: -17.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5317
    Cell Significance Index: -39.6300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5367
    Cell Significance Index: -42.5100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5890
    Cell Significance Index: -41.6600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6052
    Cell Significance Index: -12.1500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6217
    Cell Significance Index: -13.2400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.6369
    Cell Significance Index: -8.2600
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.6685
    Cell Significance Index: -10.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MAP2K5 is a serine/threonine kinase that exhibits dual specificity, meaning it can phosphorylate both serine and threonine residues on its substrates. This unique property allows MAP2K5 to regulate a wide range of cellular processes, including: 1. Cell growth and proliferation: MAP2K5 is involved in the regulation of cell growth and proliferation by phosphorylating and activating downstream kinases, such as MAPKs. 2. Apoptosis: MAP2K5 can regulate apoptosis by phosphorylating and activating pro-apoptotic proteins, such as BAX and BAK. 3. Migration and invasion: MAP2K5 is involved in the regulation of cell migration and invasion by phosphorylating and activating proteins involved in the actin cytoskeleton and cell adhesion. 4. Differentiation: MAP2K5 can regulate differentiation by phosphorylating and activating transcription factors, such as NF-κB and AP-1. **Pathways and Functions** MAP2K5 is involved in various signaling pathways, including: 1. The ERK5 (MAPK cascade) pathway: MAP2K5 phosphorylates and activates ERK5, a member of the MAPK family, which regulates cell growth, differentiation, and survival. 2. The insulin-like growth factor receptor (IGF-1R) signaling pathway: MAP2K5 phosphorylates and activates IGF-1R, which regulates cell growth, differentiation, and survival. 3. The NTRK1 (TRKA) signaling pathway: MAP2K5 phosphorylates and activates NTRK1, a receptor tyrosine kinase involved in neuronal development and survival. 4. The NF-κB signaling pathway: MAP2K5 phosphorylates and activates NF-κB, a transcription factor involved in inflammation, immune responses, and cell survival. **Clinical Significance** MAP2K5 has been implicated in various human diseases, including: 1. Cancer: MAP2K5 has been found to be overexpressed in several types of cancer, including breast, lung, and colon cancer, where it contributes to tumor growth and progression. 2. Neurological disorders: MAP2K5 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it contributes to neuronal degeneration and death. 3. Cardiovascular disease: MAP2K5 has been found to be involved in cardiovascular disease, where it contributes to vascular smooth muscle cell proliferation and apoptosis. 4. Neurodevelopmental disorders: MAP2K5 has been implicated in neurodevelopmental disorders, such as autism and schizophrenia, where it contributes to neuronal development and function. In conclusion, MAP2K5 is a multifunctional kinase that plays a critical role in various cellular processes, including cell growth, differentiation, migration, and apoptosis. Its dysregulation has been implicated in various human diseases, highlighting the importance of MAP2K5 in human health and disease.

Genular Protein ID: 1586169584

Symbol: MP2K5_HUMAN

Name: Dual specificity mitogen-activated protein kinase kinase 5

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7759517

Title: Components of a new human protein kinase signal transduction pathway.

PubMed ID: 7759517

DOI: 10.1074/jbc.270.21.12665

PubMed ID: 9384584

Title: BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C.

PubMed ID: 9384584

DOI: 10.1093/emboj/16.23.7054

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16728640

Title: Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation.

PubMed ID: 16728640

DOI: 10.1126/science.1126867

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 448
  • Mass: 50112
  • Checksum: F23BB327E2A9C7DC
  • Sequence:
  • MLWLALGPFP AMENQVLVIR IKIPNSGAVD WTVHSGPQLL FRDVLDVIGQ VLPEATTTAF 
    EYEDEDGDRI TVRSDEEMKA MLSYYYSTVM EQQVNGQLIE PLQIFPRACK PPGERNIHGL 
    KVNTRAGPSQ HSSPAVSDSL PSNSLKKSSA ELKKILANGQ MNEQDIRYRD TLGHGNGGTV 
    YKAYHVPSGK ILAVKVILLD ITLELQKQIM SELEILYKCD SSYIIGFYGA FFVENRISIC 
    TEFMDGGSLD VYRKMPEHVL GRIAVAVVKG LTYLWSLKIL HRDVKPSNML VNTRGQVKLC 
    DFGVSTQLVN SIAKTYVGTN AYMAPERISG EQYGIHSDVW SLGISFMELA LGRFPYPQIQ 
    KNQGSLMPLQ LLQCIVDEDS PVLPVGEFSE PFVHFITQCM RKQPKERPAP EELMGHPFIV 
    QFNDGNAAVV SMWVCRALEE RRSQQGPP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.