Details for: PSPN

Gene ID: 5623

Symbol: PSPN

Ensembl ID: ENSG00000125650

Description: persephin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 35.8095
    Cell Significance Index: -5.5700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 21.6840
    Cell Significance Index: -5.5000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.6311
    Cell Significance Index: -5.7100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.0643
    Cell Significance Index: -5.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6425
    Cell Significance Index: 63.5600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5747
    Cell Significance Index: 93.4800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5125
    Cell Significance Index: 462.7800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3486
    Cell Significance Index: 37.9200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3109
    Cell Significance Index: 18.6700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1844
    Cell Significance Index: 12.7600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1604
    Cell Significance Index: 7.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1299
    Cell Significance Index: 24.7300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.1092
    Cell Significance Index: 1.8000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.1082
    Cell Significance Index: 1.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0962
    Cell Significance Index: 5.0000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0886
    Cell Significance Index: 1.9200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0879
    Cell Significance Index: 5.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0831
    Cell Significance Index: 1.7700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0799
    Cell Significance Index: 2.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0651
    Cell Significance Index: 1.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0593
    Cell Significance Index: 2.0900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0570
    Cell Significance Index: 0.8000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0557
    Cell Significance Index: 0.7600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0450
    Cell Significance Index: 31.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0308
    Cell Significance Index: 16.8300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0280
    Cell Significance Index: 0.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0248
    Cell Significance Index: 8.9000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0221
    Cell Significance Index: 0.4800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0208
    Cell Significance Index: 0.5200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0199
    Cell Significance Index: 0.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0135
    Cell Significance Index: 0.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0124
    Cell Significance Index: 5.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0091
    Cell Significance Index: 1.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0049
    Cell Significance Index: 0.8900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0040
    Cell Significance Index: 0.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0026
    Cell Significance Index: 0.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0012
    Cell Significance Index: 0.1500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0007
    Cell Significance Index: -0.1000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0022
    Cell Significance Index: -0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0024
    Cell Significance Index: -4.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0038
    Cell Significance Index: -2.8200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0040
    Cell Significance Index: -7.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0049
    Cell Significance Index: -7.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0058
    Cell Significance Index: -7.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0064
    Cell Significance Index: -1.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0065
    Cell Significance Index: -4.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0066
    Cell Significance Index: -4.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0072
    Cell Significance Index: -5.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0099
    Cell Significance Index: -5.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0112
    Cell Significance Index: -3.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0126
    Cell Significance Index: -5.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0168
    Cell Significance Index: -1.9600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0175
    Cell Significance Index: -0.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0201
    Cell Significance Index: -1.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0205
    Cell Significance Index: -2.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0206
    Cell Significance Index: -3.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0226
    Cell Significance Index: -2.3100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0232
    Cell Significance Index: -1.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0301
    Cell Significance Index: -4.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0316
    Cell Significance Index: -6.6600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0319
    Cell Significance Index: -0.9400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0332
    Cell Significance Index: -2.3500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0349
    Cell Significance Index: -4.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0368
    Cell Significance Index: -4.7600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0384
    Cell Significance Index: -0.2600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0432
    Cell Significance Index: -2.7900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0463
    Cell Significance Index: -0.9700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0505
    Cell Significance Index: -0.8500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0528
    Cell Significance Index: -4.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0557
    Cell Significance Index: -5.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0600
    Cell Significance Index: -3.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0617
    Cell Significance Index: -4.6000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0620
    Cell Significance Index: -4.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0634
    Cell Significance Index: -2.0300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0685
    Cell Significance Index: -2.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0745
    Cell Significance Index: -5.7200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0819
    Cell Significance Index: -2.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0843
    Cell Significance Index: -4.7300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0855
    Cell Significance Index: -4.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0887
    Cell Significance Index: -4.1700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0899
    Cell Significance Index: -2.3100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0907
    Cell Significance Index: -1.0300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0971
    Cell Significance Index: -1.3800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1012
    Cell Significance Index: -0.6600
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.1153
    Cell Significance Index: -1.2400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1166
    Cell Significance Index: -0.7900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1198
    Cell Significance Index: -5.3000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1223
    Cell Significance Index: -5.3200
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1268
    Cell Significance Index: -1.7600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1285
    Cell Significance Index: -5.2700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1311
    Cell Significance Index: -2.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1344
    Cell Significance Index: -3.5900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1412
    Cell Significance Index: -2.4200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1415
    Cell Significance Index: -5.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1419
    Cell Significance Index: -3.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1429
    Cell Significance Index: -5.4100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1446
    Cell Significance Index: -3.7000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1482
    Cell Significance Index: -5.1900
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1490
    Cell Significance Index: -0.7800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1526
    Cell Significance Index: -1.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PSPN is a secreted protein that belongs to the fibroblast growth factor family. It is highly expressed in the developing nervous system, particularly in the cerebral cortex, forebrain, and spinal cord. PSPN is also found in the peripheral nervous system, where it plays a role in the development and maintenance of neurons. The protein has a high affinity for binding to its receptor, FGFR2, which triggers a signaling cascade that regulates various cellular processes. **Pathways and Functions:** PSPN functions through the FGFR2 signaling pathway, which is involved in axon guidance, neuronal migration, and development. The pathway also regulates the expression of genes involved in neuronal differentiation and survival. Additionally, PSPN interacts with other signaling pathways, including the MAPK/ERK and PI3K/AKT pathways, which are involved in cell proliferation, differentiation, and survival. PSPN has been shown to play a role in the development of the nervous system, including the formation of neural connections, neuronal migration, and the differentiation of neural cells. The protein also regulates the expression of genes involved in synaptic plasticity and neuronal survival. Furthermore, PSPN has been implicated in the development of various neurological disorders, including autism, schizophrenia, and Alzheimer's disease. **Clinical Significance:** Dysregulation of PSPN has been implicated in various neurological disorders, including: 1. **Autism Spectrum Disorder (ASD):** Studies have shown that PSPN is downregulated in individuals with ASD, suggesting a link between PSPN and the development of autism. 2. **Schizophrenia:** PSPN has been shown to be involved in the regulation of neural circuits and synaptic plasticity, which are disrupted in schizophrenia. 3. **Alzheimer's Disease:** PSPN has been implicated in the regulation of neuronal survival and synaptic plasticity, which are impaired in Alzheimer's disease. 4. **Neuropathic Pain:** PSPN has been shown to regulate the expression of genes involved in pain signaling, suggesting a role in the development of neuropathic pain. In conclusion, PSPN is a critical regulator of the developing and adult nervous system, and its dysregulation has been implicated in various neurological disorders. Further research is needed to fully understand the role of PSPN in the development and function of the nervous system and to explore its potential as a therapeutic target for neurological disorders. **Recommendations:** 1. Further studies are needed to investigate the role of PSPN in the development and function of the nervous system. 2. The development of PSPN as a therapeutic target for neurological disorders, such as autism, schizophrenia, and Alzheimer's disease, should be explored. 3. The regulation of PSPN expression and signaling pathways should be investigated in order to understand its role in neurological disorders. **Limitations:** 1. The current understanding of PSPN is based on in vitro and animal studies, and more research is needed to confirm its role in human neurological disorders. 2. The clinical significance of PSPN is still limited, and further studies are needed to fully understand its role in human disease. **Future Directions:** 1. The development of PSPN as a biomarker for neurological disorders should be explored. 2. The regulation of PSPN expression and signaling pathways should be investigated in order to understand its role in neurological disorders. 3. The development of PSPN as a therapeutic target for neurological disorders should be explored. In conclusion, PSPN is a critical regulator of the developing and adult nervous system, and its dysregulation has been implicated in various neurological disorders. Further research is needed to fully understand the role of PSPN in the development and function of the nervous system and to explore its potential as a therapeutic target for neurological disorders.

Genular Protein ID: 2133308806

Symbol: PSPN_HUMAN

Name: N/A

UniProtKB Accession Codes:

O60542

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9491986

Title: Persephin, a novel neurotrophic factor related to GDNF and neurturin.

PubMed ID: 9491986

DOI: 10.1016/s0896-6273(00)80453-5

PubMed ID: 11116144

Title: Human glial cell line-derived neurotrophic factor receptor alpha4 is the receptor for persephin and is predominantly expressed in normal and malignant thyroid medullary cells.

PubMed ID: 11116144

DOI: 10.1074/jbc.m008279200

Sequence Information:

  • Length: 156
  • Mass: 16600
  • Checksum: 6547751653A7044A
  • Sequence:
    • MAVGKFLLGS LLLLSLQLGQ GWGPDARGVP VADGEFSSEQ VAKAGGTWLG THRPLARLRR 
ALSGPCQLWS LTLSVAELGL GYASEEKVIF RYCAGSCPRG ARTQHGLALA RLQGQGRAHG 
GPCCRPTRYT DVAFLDDRHR WQRLPQLSAA ACGCGG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.