Details for: PSMA4

Gene ID: 5685

Symbol: PSMA4

Ensembl ID: ENSG00000041357

Description: proteasome 20S subunit alpha 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 319.7141
    Cell Significance Index: -49.7300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 187.5238
    Cell Significance Index: -77.2500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 175.2855
    Cell Significance Index: -44.4600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 160.1695
    Cell Significance Index: -65.0700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 155.8705
    Cell Significance Index: -73.5900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 141.1199
    Cell Significance Index: -72.5900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 110.2497
    Cell Significance Index: -73.9800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 69.1233
    Cell Significance Index: -66.0000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 55.4440
    Cell Significance Index: -68.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.7953
    Cell Significance Index: -50.3500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.6414
    Cell Significance Index: -73.5600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.1166
    Cell Significance Index: -46.4300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.7010
    Cell Significance Index: -23.4200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 5.5121
    Cell Significance Index: 44.0100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 4.7796
    Cell Significance Index: 166.0900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.3681
    Cell Significance Index: 70.5000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.2312
    Cell Significance Index: 84.9700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.8479
    Cell Significance Index: 30.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.1612
    Cell Significance Index: 139.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.1429
    Cell Significance Index: 1170.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.0693
    Cell Significance Index: 254.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.0286
    Cell Significance Index: 365.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.9540
    Cell Significance Index: 26.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.8229
    Cell Significance Index: 250.3300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.7804
    Cell Significance Index: 125.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.6458
    Cell Significance Index: 727.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5548
    Cell Significance Index: 42.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.5499
    Cell Significance Index: 72.8500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.5431
    Cell Significance Index: 13.2600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.4709
    Cell Significance Index: 16.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.4265
    Cell Significance Index: 168.2300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3824
    Cell Significance Index: 1248.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.3223
    Cell Significance Index: 98.5500
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.3004
    Cell Significance Index: 7.6400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2989
    Cell Significance Index: 141.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.2926
    Cell Significance Index: 165.7100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.2228
    Cell Significance Index: 22.6000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.1362
    Cell Significance Index: 33.3700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.1279
    Cell Significance Index: 58.7500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9995
    Cell Significance Index: 51.9200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8808
    Cell Significance Index: 23.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8487
    Cell Significance Index: 39.5700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7725
    Cell Significance Index: 76.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7620
    Cell Significance Index: 98.4500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.7612
    Cell Significance Index: 7.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7070
    Cell Significance Index: 37.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6287
    Cell Significance Index: 13.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6091
    Cell Significance Index: 120.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5668
    Cell Significance Index: 113.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3680
    Cell Significance Index: 59.8600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3653
    Cell Significance Index: 8.4400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3230
    Cell Significance Index: 14.6400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2825
    Cell Significance Index: 53.7600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2070
    Cell Significance Index: 74.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1916
    Cell Significance Index: 32.7100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1213
    Cell Significance Index: 2.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1160
    Cell Significance Index: 87.8400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0258
    Cell Significance Index: 0.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0055
    Cell Significance Index: 4.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0112
    Cell Significance Index: -8.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0195
    Cell Significance Index: -36.7200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0298
    Cell Significance Index: -18.6400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0334
    Cell Significance Index: -0.5000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0435
    Cell Significance Index: -80.2300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0445
    Cell Significance Index: -30.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0502
    Cell Significance Index: -77.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0582
    Cell Significance Index: -79.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0610
    Cell Significance Index: -6.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0750
    Cell Significance Index: -47.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0822
    Cell Significance Index: -46.3800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1163
    Cell Significance Index: -2.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1305
    Cell Significance Index: -59.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1798
    Cell Significance Index: -37.8700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1938
    Cell Significance Index: -4.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2023
    Cell Significance Index: -58.2000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2376
    Cell Significance Index: -7.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2598
    Cell Significance Index: -7.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2918
    Cell Significance Index: -33.4300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3295
    Cell Significance Index: -38.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3421
    Cell Significance Index: -21.0300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3492
    Cell Significance Index: -2.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3861
    Cell Significance Index: -56.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3935
    Cell Significance Index: -8.3800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4077
    Cell Significance Index: -10.9300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4594
    Cell Significance Index: -25.7800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4812
    Cell Significance Index: -54.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5128
    Cell Significance Index: -39.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5158
    Cell Significance Index: -32.5100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6581
    Cell Significance Index: -52.1200
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.6869
    Cell Significance Index: -4.3000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7023
    Cell Significance Index: -47.2200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7129
    Cell Significance Index: -74.2300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.7991
    Cell Significance Index: -8.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0152
    Cell Significance Index: -62.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.0200
    Cell Significance Index: -27.2900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.1874
    Cell Significance Index: -14.1600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.2019
    Cell Significance Index: -35.4000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.2185
    Cell Significance Index: -31.3200
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -1.3179
    Cell Significance Index: -14.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.3644
    Cell Significance Index: -60.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PSMA4 is a member of the proteasome subunit family, which is characterized by its ability to degrade proteins through a process called proteolysis. The 20S proteasome is a barrel-shaped complex composed of 14 subunits, with PSMA4 being one of the four alpha subunits. Each subunit has a unique binding specificity, allowing the proteasome to target specific proteins for degradation. PSMA4 has been shown to have a high affinity for ubiquitinated proteins, which are proteins that have been tagged with ubiquitin, a small protein that marks proteins for degradation. **Pathways and Functions** PSMA4 plays a critical role in various cellular processes, including: 1. **Protein degradation**: PSMA4 is involved in the degradation of damaged or unneeded proteins, which is essential for maintaining protein homeostasis. 2. **Cell cycle regulation**: PSMA4 has been shown to regulate the cell cycle by degrading proteins involved in cell cycle progression, such as cyclin-dependent kinases. 3. **Apoptosis**: PSMA4 is involved in the regulation of apoptosis, or programmed cell death, by degrading proteins that promote cell survival. 4. **Immune responses**: PSMA4 has been shown to regulate immune responses by degrading proteins involved in immune cell activation and signaling. 5. **Hedgehog signaling**: PSMA4 has been implicated in the regulation of hedgehog signaling, a pathway involved in embryonic development and cancer. **Clinical Significance** Dysregulation of the 20S proteasome, including PSMA4, has been implicated in various diseases, including: 1. **Cancer**: Overexpression of PSMA4 has been observed in various types of cancer, including prostate cancer, and has been associated with poor prognosis. 2. **Neurodegenerative disorders**: Dysregulation of the 20S proteasome has been implicated in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Immune disorders**: PSMA4 has been shown to play a role in immune responses, and dysregulation of the 20S proteasome has been implicated in autoimmune disorders, such as multiple sclerosis. In summary, PSMA4 is a critical component of the 20S proteasome that plays a key role in protein degradation and regulation of various cellular processes. Its dysregulation has been implicated in various diseases, including cancer, neurodegenerative disorders, and immune disorders. Further research is needed to fully understand the role of PSMA4 in these diseases and to develop therapeutic strategies that target this gene.

Genular Protein ID: 649163982

Symbol: PSA4_HUMAN

Name: Macropain subunit C9

UniProtKB Accession Codes:

P25789 D3DW86 Q53XP2 Q567Q5 Q8TBD1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 14 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 10 EMDB 68 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 91 PDBsum 91 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 59 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2025653

Title: Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes).

PubMed ID: 2025653

DOI: 10.1016/0167-4781(91)90090-9

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7811265

Title: Human proteasome subunits from 2-dimensional gels identified by partial sequencing.

PubMed ID: 7811265

DOI: 10.1006/bbrc.1994.2876

PubMed ID: 8610016

Title: A role for the proteasome regulator PA28alpha in antigen presentation.

PubMed ID: 8610016

DOI: 10.1038/381166a0

PubMed ID: 8692272

Title: Effects on NF-kappa B1/p105 processing of the interaction between the HTLV-1 transactivator Tax and the proteasome.

PubMed ID: 8692272

DOI: 10.1038/381328a0

PubMed ID: 11521686

Title: Gene expression induced by BO-653, probucol and BHQ in human endothelial cells.

PubMed ID: 11521686

DOI: 10.5551/jat1994.7.223

PubMed ID: 12181345

Title: Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome.

PubMed ID: 12181345

DOI: 10.1091/mbc.e02-03-0122

PubMed ID: 15244466

Title: 20S proteasome prevents aggregation of heat-denatured proteins without PA700 regulatory subcomplex like a molecular chaperone.

PubMed ID: 15244466

DOI: 10.1021/bm049957a

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23495936

Title: Molecular architecture and assembly of the eukaryotic proteasome.

PubMed ID: 23495936

DOI: 10.1146/annurev-biochem-060410-150257

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27176742

Title: Human 20S proteasome activity towards fluorogenic peptides of various chain lengths.

PubMed ID: 27176742

DOI: 10.1515/hsz-2016-0176

PubMed ID: 26133119

Title: Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core.

PubMed ID: 26133119

DOI: 10.1038/ncomms8573

PubMed ID: 25599644

Title: Crystal structure of the human 20S proteasome in complex with carfilzomib.

PubMed ID: 25599644

DOI: 10.1016/j.str.2014.11.017

PubMed ID: 27428775

Title: An atomic structure of the human 26S proteasome.

PubMed ID: 27428775

DOI: 10.1038/nsmb.3273

PubMed ID: 27342858

Title: Structure of the human 26S proteasome at a resolution of 3.9 Aa.

PubMed ID: 27342858

DOI: 10.1073/pnas.1608050113

PubMed ID: 27493187

Title: The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.

PubMed ID: 27493187

DOI: 10.1126/science.aaf8993

PubMed ID: 34711951

Title: AKIRIN2 controls the nuclear import of proteasomes in vertebrates.

PubMed ID: 34711951

DOI: 10.1038/s41586-021-04035-8

Sequence Information:

  • Length: 261
  • Mass: 29484
  • Checksum: 7867422B1B31F3B9
  • Sequence:
    • MSRRYDSRTT IFSPEGRLYQ VEYAMEAIGH AGTCLGILAN DGVLLAAERR NIHKLLDEVF 
FSEKIYKLNE DMACSVAGIT SDANVLTNEL RLIAQRYLLQ YQEPIPCEQL VTALCDIKQA 
YTQFGGKRPF GVSLLYIGWD KHYGFQLYQS DPSGNYGGWK ATCIGNNSAA AVSMLKQDYK 
EGEMTLKSAL ALAIKVLNKT MDVSKLSAEK VEIATLTREN GKTVIRVLKQ KEVEQLIKKH 
EEEEAKAERE KKEKEQKEKD K

Genular Protein ID: 2090971873

Symbol: H0YLC2_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0YLC2

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneTree 1 HGNC 1 InterPro 6 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 174
  • Mass: 19654
  • Checksum: D460FA2903E98F50
  • Sequence:
    • MSRRYDSRTT IFSPEGRLYQ VEYAMEAIGH AGTCLGILAN DGVLLAAERR NIHKLLDEVF 
FSEKIYKLNE DMACSVAGIT SDANVLTNEL RLIAQRYLLQ YQEPIPCEQL VTALCDIKQA 
YTQFGGKRPF GVSLLYIGWD KHYGFQLYQS DPSGNYGGWK ATCIGNNSAW KLQH

Genular Protein ID: 1871866337

Symbol: H0YN18_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0YN18

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 230
  • Mass: 26282
  • Checksum: CF22629F371B4A6A
  • Sequence:
    • MSRRYDSRTT IFSPEAERRN IHKLLDEVFF SEKIYKLNED MACSVAGITS DANVLTNELR 
LIAQRYLLQY QEPIPCEQLV TALCDIKQAY TQFGGKRPFG VSLLYIGWDK HYGFQLYQSD 
PSGNYGGWKA TCIGNNSAAA VSMLKQDYKE GEMTLKSALA LAIKVLNKTM DVSKLSAEKV 
EIATLTRENG KTVIRVLKQK EVEQLIKKHE EEEAKAEREK KEKEQKEKDK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.