Details for: PSMB3

Gene ID: 5691

Symbol: PSMB3

Ensembl ID: ENSG00000277791

Description: proteasome 20S subunit beta 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 183.4214
    Cell Significance Index: -75.5600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 169.5478
    Cell Significance Index: -68.8800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 155.0656
    Cell Significance Index: -73.2100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 142.2280
    Cell Significance Index: -73.1600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 109.4599
    Cell Significance Index: -73.4500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 72.7630
    Cell Significance Index: -69.4700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 15.1517
    Cell Significance Index: 156.8500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.8538
    Cell Significance Index: -39.4800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 11.6649
    Cell Significance Index: 290.8900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.2021
    Cell Significance Index: -27.3300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.2594
    Cell Significance Index: -20.2700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.1471
    Cell Significance Index: 76.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 3.1487
    Cell Significance Index: 321.6400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.7237
    Cell Significance Index: 29.6100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.6526
    Cell Significance Index: 69.7500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.3883
    Cell Significance Index: 49.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.3350
    Cell Significance Index: 109.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.3128
    Cell Significance Index: 272.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.2269
    Cell Significance Index: 165.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.1208
    Cell Significance Index: 98.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.0961
    Cell Significance Index: 135.2300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.0131
    Cell Significance Index: 22.8700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.8244
    Cell Significance Index: 996.3500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.7998
    Cell Significance Index: 14.3700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.7524
    Cell Significance Index: 47.7000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.6386
    Cell Significance Index: 115.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.6133
    Cell Significance Index: 198.3800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.5956
    Cell Significance Index: 705.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5846
    Cell Significance Index: 257.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.5720
    Cell Significance Index: 283.3800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.5456
    Cell Significance Index: 92.7900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.3425
    Cell Significance Index: 46.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.3183
    Cell Significance Index: 181.0400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.2560
    Cell Significance Index: 162.2600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.1247
    Cell Significance Index: 32.2400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.1072
    Cell Significance Index: 19.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.0032
    Cell Significance Index: 128.6100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9508
    Cell Significance Index: 49.3900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.8579
    Cell Significance Index: 7.9000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7363
    Cell Significance Index: 17.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5819
    Cell Significance Index: 30.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3643
    Cell Significance Index: 36.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3141
    Cell Significance Index: 9.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2901
    Cell Significance Index: 58.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2454
    Cell Significance Index: 185.7700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2398
    Cell Significance Index: 12.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2354
    Cell Significance Index: 46.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1547
    Cell Significance Index: 29.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1374
    Cell Significance Index: 8.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1211
    Cell Significance Index: 20.6800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1069
    Cell Significance Index: 1.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0584
    Cell Significance Index: 1.5600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0395
    Cell Significance Index: 28.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0339
    Cell Significance Index: 1.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0166
    Cell Significance Index: 5.9400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0201
    Cell Significance Index: -37.9400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0374
    Cell Significance Index: -1.8900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0437
    Cell Significance Index: -80.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0542
    Cell Significance Index: -83.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0673
    Cell Significance Index: -91.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0698
    Cell Significance Index: -51.7400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0818
    Cell Significance Index: -51.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1121
    Cell Significance Index: -63.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1348
    Cell Significance Index: -61.2000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1399
    Cell Significance Index: -87.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1445
    Cell Significance Index: -16.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2405
    Cell Significance Index: -6.7200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2482
    Cell Significance Index: -10.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2535
    Cell Significance Index: -72.9300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2619
    Cell Significance Index: -6.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2894
    Cell Significance Index: -33.7300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.3101
    Cell Significance Index: -33.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3376
    Cell Significance Index: -71.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3856
    Cell Significance Index: -56.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.5343
    Cell Significance Index: -24.2200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.5400
    Cell Significance Index: -4.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5672
    Cell Significance Index: -44.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.5871
    Cell Significance Index: -40.6000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6698
    Cell Significance Index: -11.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6752
    Cell Significance Index: -70.3100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7748
    Cell Significance Index: -22.8200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7847
    Cell Significance Index: -60.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.8377
    Cell Significance Index: -47.0100
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.8878
    Cell Significance Index: -6.9000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.8889
    Cell Significance Index: -5.2800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.9777
    Cell Significance Index: -13.3400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -1.0587
    Cell Significance Index: -14.8500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.1338
    Cell Significance Index: -14.5200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -1.1342
    Cell Significance Index: -6.9800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.1562
    Cell Significance Index: -29.7200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.1590
    Cell Significance Index: -25.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1928
    Cell Significance Index: -73.1300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.2695
    Cell Significance Index: -7.6700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.4607
    Cell Significance Index: -12.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.4636
    Cell Significance Index: -64.7400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.5227
    Cell Significance Index: -26.2500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.6328
    Cell Significance Index: -59.9400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.6450
    Cell Significance Index: -28.1900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -1.6511
    Cell Significance Index: -27.7700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.6596
    Cell Significance Index: -58.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Gene location**: The PSMB3 gene is located on chromosome 6p21.3 in humans. 2. **Protein structure**: The PSMB3 protein is a subunit of the 20S proteasome, a complex composed of four alpha subunits and eight beta subunits. 3. **Expression**: PSMB3 is expressed in multiple cell types, including tracheal goblet cells, monocytes, skeletal muscle satellite cells, and myeloid dendritic cells. 4. **Function**: The PSMB3 protein is involved in protein degradation, cell cycle regulation, and immune response. **Pathways and Functions** 1. **Adaptive immune system**: PSMB3 is involved in the degradation of antigens and the presentation of peptides to T-cells, which is essential for adaptive immune responses. 2. **Antigen processing-cross presentation**: PSMB3 plays a role in the processing and presentation of antigens to T-cells, which is critical for the activation of immune responses. 3. **Apoptosis**: The proteasome, including PSMB3, is involved in the regulation of apoptosis (programmed cell death) by degrading pro-apoptotic proteins. 4. **Cell cycle regulation**: PSMB3 is involved in the regulation of cell cycle progression by degrading proteins that inhibit cell cycle progression. 5. **Immune system**: PSMB3 is involved in the regulation of immune responses, including the activation of immune cells and the production of cytokines. **Clinical Significance** 1. **Immunodeficiency disorders**: Mutations in the PSMB3 gene have been associated with immunodeficiency disorders, including X-linked immunodeficiency disease. 2. **Cancer**: The proteasome, including PSMB3, is often overexpressed in cancer cells, leading to the degradation of tumor suppressor proteins and the promotion of cancer progression. 3. **Autoimmune diseases**: PSMB3 is involved in the regulation of immune responses, and dysregulation of PSMB3 has been implicated in autoimmune diseases, such as rheumatoid arthritis. 4. **Infectious diseases**: The proteasome, including PSMB3, is involved in the regulation of immune responses to infections, and dysregulation of PSMB3 has been implicated in infectious diseases, such as tuberculosis. In conclusion, the PSMB3 gene plays a critical role in various cellular processes, including protein degradation, cell cycle regulation, and immune response. Understanding the function and regulation of PSMB3 is essential for the development of novel therapeutic strategies for immunodeficiency disorders, cancer, autoimmune diseases, and infectious diseases.

Genular Protein ID: 2383033972

Symbol: PSB3_HUMAN

Name: Proteasome chain 13

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7918633

Title: Sequence analyses and inter-species comparisons of three novel human proteasomal subunits, HsN3, HsC7-I and HsC10-II, confine potential proteolytic active-site residues.

PubMed ID: 7918633

DOI: 10.1016/0167-4781(94)90060-4

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 7811265

Title: Human proteasome subunits from 2-dimensional gels identified by partial sequencing.

PubMed ID: 7811265

DOI: 10.1006/bbrc.1994.2876

PubMed ID: 8610016

Title: A role for the proteasome regulator PA28alpha in antigen presentation.

PubMed ID: 8610016

DOI: 10.1038/381166a0

PubMed ID: 12181345

Title: Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome.

PubMed ID: 12181345

DOI: 10.1091/mbc.e02-03-0122

PubMed ID: 14550573

Title: Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits.

PubMed ID: 14550573

DOI: 10.1016/s0014-5793(03)01025-1

PubMed ID: 15244466

Title: 20S proteasome prevents aggregation of heat-denatured proteins without PA700 regulatory subcomplex like a molecular chaperone.

PubMed ID: 15244466

DOI: 10.1021/bm049957a

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 18281682

Title: Identification of proteomic differences in asthenozoospermic sperm samples.

PubMed ID: 18281682

DOI: 10.1093/humrep/den024

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23495936

Title: Molecular architecture and assembly of the eukaryotic proteasome.

PubMed ID: 23495936

DOI: 10.1146/annurev-biochem-060410-150257

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27176742

Title: Human 20S proteasome activity towards fluorogenic peptides of various chain lengths.

PubMed ID: 27176742

DOI: 10.1515/hsz-2016-0176

PubMed ID: 26133119

Title: Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core.

PubMed ID: 26133119

DOI: 10.1038/ncomms8573

PubMed ID: 25599644

Title: Crystal structure of the human 20S proteasome in complex with carfilzomib.

PubMed ID: 25599644

DOI: 10.1016/j.str.2014.11.017

PubMed ID: 27428775

Title: An atomic structure of the human 26S proteasome.

PubMed ID: 27428775

DOI: 10.1038/nsmb.3273

PubMed ID: 27342858

Title: Structure of the human 26S proteasome at a resolution of 3.9 Aa.

PubMed ID: 27342858

DOI: 10.1073/pnas.1608050113

PubMed ID: 27493187

Title: The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.

PubMed ID: 27493187

DOI: 10.1126/science.aaf8993

PubMed ID: 34711951

Title: AKIRIN2 controls the nuclear import of proteasomes in vertebrates.

PubMed ID: 34711951

DOI: 10.1038/s41586-021-04035-8

Sequence Information:

  • Length: 205
  • Mass: 22949
  • Checksum: 624972384C0112FD
  • Sequence:
  • MSIMSYNGGA VMAMKGKNCV AIAADRRFGI QAQMVTTDFQ KIFPMGDRLY IGLAGLATDV 
    QTVAQRLKFR LNLYELKEGR QIKPYTLMSM VANLLYEKRF GPYYTEPVIA GLDPKTFKPF 
    ICSLDLIGCP MVTDDFVVSG TCAEQMYGMC ESLWEPNMDP DHLFETISQA MLNAVDRDAV 
    SGMGVIVHII EKDKITTRTL KARMD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.