PSMD8 | ENSG00000099341 | NCBI 5714

Details for: PSMD8

Gene ID: 5714

Symbol: PSMD8

Ensembl ID: ENSG00000099341

Description: proteasome 26S subunit, non-ATPase 8

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporter disorders
(R-HSA-5619084)
Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apoptosis
(R-HSA-109581)
Assembly of the pre-replicative complex
(R-HSA-68867)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular response to hypoxia
(R-HSA-1234174)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective cftr causes cystic fibrosis
(R-HSA-5678895)
Degradation of axin
(R-HSA-4641257)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of dvl
(R-HSA-4641258)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream tcr signaling
(R-HSA-202424)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Formation of paraxial mesoderm
(R-HSA-9793380)
G1/s dna damage checkpoints
(R-HSA-69615)
G2/m checkpoints
(R-HSA-69481)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Hedgehog 'off' state
(R-HSA-5610787)
Hedgehog 'on' state
(R-HSA-5632684)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Hh mutants abrogate ligand secretion
(R-HSA-5387390)
Hh mutants are degraded by erad
(R-HSA-5362768)
Hiv infection
(R-HSA-162906)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of polyamines
(R-HSA-351202)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
Neddylation
(R-HSA-8951664)
Nervous system development
(R-HSA-9675108)
Nik-->noncanonical nf-kb signaling
(R-HSA-5676590)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
Pcp/ce pathway
(R-HSA-4086400)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Proteasome assembly
(R-HSA-9907900)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of activated pak-2p34 by proteasome mediated degradation
(R-HSA-211733)
Regulation of apoptosis
(R-HSA-169911)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Regulation of ornithine decarboxylase (odc)
(R-HSA-350562)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by notch4
(R-HSA-9013694)
Signaling by robo receptors
(R-HSA-376176)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Transport of small molecules
(R-HSA-382551)
Ub-specific processing proteases
(R-HSA-5689880)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 405.9912
Cell Significance Index: -63.1500
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 254.2152
Cell Significance Index: -64.4800
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 202.7928
Cell Significance Index: -83.5400
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 168.2825
Cell Significance Index: -79.4500
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 167.7755
Cell Significance Index: -68.1600
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 150.2765
Cell Significance Index: -77.3000
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 118.8187
Cell Significance Index: -79.7300
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 72.3336
Cell Significance Index: -69.0600
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 62.6705
Cell Significance Index: -77.2700
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 20.6612
Cell Significance Index: -81.5300
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 16.7510
Cell Significance Index: -51.4500
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 15.2714
Cell Significance Index: -40.9100
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 14.2923
Cell Significance Index: -31.2800
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 5.9978
Cell Significance Index: 50.3800
Cell Name: kidney cell (CL1000497)
Fold Change: 2.9759
Cell Significance Index: 23.7600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.8056
Cell Significance Index: 130.8100
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.6869
Cell Significance Index: 78.9100
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.5141
Cell Significance Index: 162.2000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 2.4745
Cell Significance Index: 51.8000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 2.4128
Cell Significance Index: 113.4000
Cell Name: cell in vitro (CL0001034)
Fold Change: 2.3439
Cell Significance Index: 1280.0400
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 2.1977
Cell Significance Index: 76.3700
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.1310
Cell Significance Index: 158.8200
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 2.0973
Cell Significance Index: 22.8000
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.0452
Cell Significance Index: 55.6700
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.0348
Cell Significance Index: 279.4400
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.9709
Cell Significance Index: 871.3800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.9462
Cell Significance Index: 350.8300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.9053
Cell Significance Index: 234.2700
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.8439
Cell Significance Index: 130.4100
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.7931
Cell Significance Index: 47.1500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.7367
Cell Significance Index: 49.7900
Cell Name: peg cell (CL4033014)
Fold Change: 1.6917
Cell Significance Index: 39.0900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.6776
Cell Significance Index: 197.8400
Cell Name: lactocyte (CL0002325)
Fold Change: 1.6135
Cell Significance Index: 208.4500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.5814
Cell Significance Index: 83.0300
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.5371
Cell Significance Index: 14.1600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.1548
Cell Significance Index: 59.9900
Cell Name: odontoblast (CL0000060)
Fold Change: 1.0536
Cell Significance Index: 135.0700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.0415
Cell Significance Index: 54.2500
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.9383
Cell Significance Index: 10.6600
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.9344
Cell Significance Index: 24.9500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.8068
Cell Significance Index: 36.5700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.7030
Cell Significance Index: 69.5400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.4762
Cell Significance Index: 95.5200
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.4676
Cell Significance Index: 79.8400
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.3555
Cell Significance Index: 6.5700
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3472
Cell Significance Index: 68.9000
Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.2994
Cell Significance Index: 7.3100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2234
Cell Significance Index: 14.0800
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2156
Cell Significance Index: 41.0300
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1552
Cell Significance Index: 55.6500
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.0959
Cell Significance Index: 1.7000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0848
Cell Significance Index: 64.1600
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.0821
Cell Significance Index: 1.2300
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0674
Cell Significance Index: 49.4100
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0630
Cell Significance Index: 1.0600
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.0568
Cell Significance Index: 1.5200
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.0004
Cell Significance Index: -0.0100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0215
Cell Significance Index: -15.9600
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0226
Cell Significance Index: -42.6300
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0319
Cell Significance Index: -3.2600
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0433
Cell Significance Index: -79.7700
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0455
Cell Significance Index: -28.4200
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0480
Cell Significance Index: -33.2100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0503
Cell Significance Index: -77.4900
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.0570
Cell Significance Index: -0.6800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0617
Cell Significance Index: -83.8400
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0714
Cell Significance Index: -40.2700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0811
Cell Significance Index: -51.5300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1357
Cell Significance Index: -61.6000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1612
Cell Significance Index: -33.9500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2272
Cell Significance Index: -65.3800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2930
Cell Significance Index: -22.4900
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -0.3095
Cell Significance Index: -1.9000
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3359
Cell Significance Index: -8.5800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3639
Cell Significance Index: -41.6900
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.4177
Cell Significance Index: -60.7200
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.4220
Cell Significance Index: -49.1800
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.4298
Cell Significance Index: -26.4200
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4843
Cell Significance Index: -55.2800
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.5030
Cell Significance Index: -8.6200
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5547
Cell Significance Index: -43.9300
Cell Name: perivascular cell (CL4033054)
Fold Change: -0.6129
Cell Significance Index: -2.8300
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.6731
Cell Significance Index: -46.5500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.6743
Cell Significance Index: -9.2000
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.7124
Cell Significance Index: -19.9100
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.7515
Cell Significance Index: -24.0700
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.7688
Cell Significance Index: -80.0500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.7928
Cell Significance Index: -16.8900
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.8438
Cell Significance Index: -56.7400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.8470
Cell Significance Index: -47.5300
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.8855
Cell Significance Index: -5.3500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -1.0338
Cell Significance Index: -62.0700
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -1.2504
Cell Significance Index: -18.4600
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.2693
Cell Significance Index: -27.5000
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.2758
Cell Significance Index: -78.2200
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.3023
Cell Significance Index: -34.9000
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -1.3142
Cell Significance Index: -13.6100
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.3967
Cell Significance Index: -41.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Proteasome subunit**: PSMD8 is a non-ATPase subunit of the 26S proteasome, which is composed of two large subunits (α, β, and β'-like) and two small subunits (β2, β5, and β6). 2. **Ubiquitin-proteasome pathway**: PSMD8 is involved in the ubiquitin-proteasome pathway, which is responsible for the degradation of damaged or misfolded proteins. 3. **Cell cycle regulation**: PSMD8 has been shown to regulate cell cycle progression by degrading proteins involved in the G1/S transition and mitosis. 4. **Apoptosis**: PSMD8 is also involved in regulating apoptosis by degrading proteins involved in the apoptosis pathway. 5. **Immune response**: PSMD8 is highly expressed in immune cells, suggesting its involvement in the regulation of immune responses. **Pathways and Functions** 1. **Ubiquitin-proteasome pathway**: PSMD8 is involved in the ubiquitin-proteasome pathway, which is responsible for the degradation of damaged or misfolded proteins. 2. **Cell cycle regulation**: PSMD8 regulates cell cycle progression by degrading proteins involved in the G1/S transition and mitosis. 3. **Apoptosis**: PSMD8 is involved in regulating apoptosis by degrading proteins involved in the apoptosis pathway. 4. **Immune response**: PSMD8 is highly expressed in immune cells, suggesting its involvement in the regulation of immune responses. 5. **Hedgehog signaling**: PSMD8 has been shown to regulate hedgehog signaling by degrading proteins involved in this pathway. **Clinical Significance** 1. **Cancer**: Alterations in PSMD8 expression have been associated with various types of cancer, including breast cancer, prostate cancer, and leukemia. 2. **Autoimmune diseases**: PSMD8 has been implicated in the regulation of immune responses, suggesting its involvement in autoimmune diseases such as rheumatoid arthritis and lupus. 3. **Neurodegenerative diseases**: PSMD8 has been shown to be involved in the regulation of protein homeostasis, suggesting its potential involvement in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. 4. **Infectious diseases**: PSMD8 has been implicated in the regulation of immune responses, suggesting its potential involvement in infectious diseases such as HIV and tuberculosis. In conclusion, PSMD8 is a critical component of the ubiquitin-proteasome pathway and plays a vital role in regulating various cellular processes, including cell cycle progression, apoptosis, and immune response. Its dysregulation has been implicated in various diseases, including cancer, autoimmune diseases, and neurodegenerative diseases. Further research is needed to fully understand the role of PSMD8 in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

26S proteasome non-ATPase regulatory subunit 8

Genular Protein ID: 2977022067

Symbol: PSMD8_HUMAN

Name: 26S proteasome non-ATPase regulatory subunit 8

UniProtKB Accession Codes:

P48556 B4DX18 Q6P1L7

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7621825

Title: Nin1p, a regulatory subunit of the 26S proteasome, is necessary for activation of Cdc28p kinase of Saccharomyces cerevisiae.

PubMed ID: 7621825

DOI: 10.1002/j.1460-2075.1995.tb07313.x

PubMed ID: 1317798

Title: Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms.

PubMed ID: 1317798

DOI: 10.1111/j.1432-1033.1992.tb16961.x

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29290612

Title: Removal of RTF2 from Stalled Replisomes Promotes Maintenance of Genome Integrity.

PubMed ID: 29290612

DOI: 10.1016/j.molcel.2017.11.035

PubMed ID: 27428775

Title: An atomic structure of the human 26S proteasome.

PubMed ID: 27428775

DOI: 10.1038/nsmb.3273

PubMed ID: 27342858

Title: Structure of the human 26S proteasome at a resolution of 3.9 Aa.

PubMed ID: 27342858

DOI: 10.1073/pnas.1608050113

Sequence Information:

Length: 350
Mass: 39612
Checksum: FF20203213333CB3
Sequence:

MFIKGRAPRA PPRERRRATR GGLRQVVAPP RALGSTSRPH FRRASVCRRR CRKSGGLLAA 
SRKMAAAAVN GAAGFSSSGP AATSGAVLQA ATGMYEQLKG EWNRKSPNLS KCGEELGRLK 
LVLLELNFLP TTGTKLTKQQ LILARDILEI GAQWSILRKD IPSFERYMAQ LKCYYFDYKE 
QLPESAYMHQ LLGLNLLFLL SQNRVAEFHT ELERLPAKDI QTNVYIKHPV SLEQYLMEGS 
YNKVFLAKGN IPAESYTFFI DILLDTIRDE IAGCIEKAYE KILFTEATRI LFFNTPKKMT 
DYAKKRGWVL GPNNYYSFAS QQQKPEDTTI PSTELAKQVI EYARQLEMIV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PSMD8

Associated with

Cells (max top 100)

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Nin1p, a regulatory subunit of the 26S proteasome, is necessary for activation of Cdc28p kinase of Saccharomyces cerevisiae. PubMed ID: 7621825

Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms. PubMed ID: 1317798

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. PubMed ID: 17323924

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Removal of RTF2 from Stalled Replisomes Promotes Maintenance of Genome Integrity. PubMed ID: 29290612

An atomic structure of the human 26S proteasome. PubMed ID: 27428775

Structure of the human 26S proteasome at a resolution of 3.9 Aa. PubMed ID: 27342858