Details for: PTHLH
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 20.2089
Cell Significance Index: -8.2100 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 8.5939
Cell Significance Index: -8.2100 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 6.8807
Cell Significance Index: 42.3500 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 3.8217
Cell Significance Index: 32.8400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 3.8195
Cell Significance Index: 234.1700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 2.5842
Cell Significance Index: 55.9900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.5287
Cell Significance Index: 188.4700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.9047
Cell Significance Index: 61.0100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.4031
Cell Significance Index: 63.6000 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 1.3345
Cell Significance Index: 20.1100 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.0865
Cell Significance Index: 206.7700 - Cell Name: keratocyte (CL0002363)
Fold Change: 0.7324
Cell Significance Index: 11.6200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.6905
Cell Significance Index: 68.3100 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6018
Cell Significance Index: 543.3800 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.4883
Cell Significance Index: 10.4000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3725
Cell Significance Index: 60.5900 - Cell Name: epithelial cell of lacrimal sac (CL1000436)
Fold Change: 0.3599
Cell Significance Index: 2.5900 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3564
Cell Significance Index: 38.7700 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.3422
Cell Significance Index: 8.2900 - Cell Name: chandelier cell (CL4023083)
Fold Change: 0.3319
Cell Significance Index: 2.6800 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2154
Cell Significance Index: 12.9300 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2008
Cell Significance Index: 13.8900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.1673
Cell Significance Index: 19.5000 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: 0.1549
Cell Significance Index: 3.1100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1479
Cell Significance Index: 65.3800 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.1217
Cell Significance Index: 1.6600 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.1081
Cell Significance Index: 3.1000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1032
Cell Significance Index: 4.8100 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.0215
Cell Significance Index: 2.7800 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0152
Cell Significance Index: 0.3800 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0112
Cell Significance Index: 7.7700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0044
Cell Significance Index: 2.3900 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.0000
Cell Significance Index: 0.0000 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.0006
Cell Significance Index: -0.0100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0012
Cell Significance Index: -0.1600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0034
Cell Significance Index: -0.1200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0042
Cell Significance Index: -7.9700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0049
Cell Significance Index: -9.1100 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0052
Cell Significance Index: -0.1500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0059
Cell Significance Index: -3.3000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0059
Cell Significance Index: -9.1100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0069
Cell Significance Index: -9.4000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0115
Cell Significance Index: -8.5100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0122
Cell Significance Index: -9.2200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0126
Cell Significance Index: -9.2700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0135
Cell Significance Index: -4.8500 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.0172
Cell Significance Index: -0.3600 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0192
Cell Significance Index: -0.9700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0200
Cell Significance Index: -9.0800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0218
Cell Significance Index: -4.3800 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0271
Cell Significance Index: -7.8100 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0350
Cell Significance Index: -4.4900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0356
Cell Significance Index: -4.0800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0395
Cell Significance Index: -7.1300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0415
Cell Significance Index: -1.9500 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0419
Cell Significance Index: -8.3200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0420
Cell Significance Index: -5.1700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0430
Cell Significance Index: -7.3500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0459
Cell Significance Index: -9.6700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0603
Cell Significance Index: -8.7700 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0647
Cell Significance Index: -6.6100 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0757
Cell Significance Index: -1.9900 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0786
Cell Significance Index: -1.6300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0820
Cell Significance Index: -4.2600 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0838
Cell Significance Index: -9.8800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0848
Cell Significance Index: -8.8300 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0952
Cell Significance Index: -6.7300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0989
Cell Significance Index: -6.6500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1032
Cell Significance Index: -2.8900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1196
Cell Significance Index: -9.1800 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: -0.1326
Cell Significance Index: -1.7200 - Cell Name: myometrial cell (CL0002366)
Fold Change: -0.1328
Cell Significance Index: -1.5300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1375
Cell Significance Index: -8.4500 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1429
Cell Significance Index: -7.4500 - Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.1496
Cell Significance Index: -1.4800 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.1668
Cell Significance Index: -4.0000 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: -0.1693
Cell Significance Index: -2.1800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1695
Cell Significance Index: -8.9000 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1707
Cell Significance Index: -2.4500 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1761
Cell Significance Index: -9.8800 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1776
Cell Significance Index: -6.5200 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1776
Cell Significance Index: -7.2800 - Cell Name: connective tissue cell (CL0002320)
Fold Change: -0.1784
Cell Significance Index: -1.7200 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1869
Cell Significance Index: -6.1200 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1871
Cell Significance Index: -8.1300 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.1906
Cell Significance Index: -3.1400 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1960
Cell Significance Index: -8.6700 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1972
Cell Significance Index: -6.9100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2266
Cell Significance Index: -8.5800 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2283
Cell Significance Index: -7.2700 - Cell Name: thymocyte (CL0000893)
Fold Change: -0.2390
Cell Significance Index: -3.0200 - Cell Name: endocardial cell (CL0002350)
Fold Change: -0.2405
Cell Significance Index: -1.4200 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.2520
Cell Significance Index: -7.1900 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2560
Cell Significance Index: -6.5800 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.2623
Cell Significance Index: -5.4900 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2768
Cell Significance Index: -9.6200 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.2775
Cell Significance Index: -5.8900 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.2861
Cell Significance Index: -3.6100 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2862
Cell Significance Index: -7.6600 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.2907
Cell Significance Index: -7.2600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2609766213
Symbol: PTHR_HUMAN
Name: Parathyroid hormone-related protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3616618
Title: A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression.
PubMed ID: 3616618
PubMed ID: 2829195
Title: Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy.
PubMed ID: 2829195
PubMed ID: 2708388
Title: Characterization of the human parathyroid hormone-like peptide gene. Functional and evolutionary aspects.
PubMed ID: 2708388
PubMed ID: 3290897
Title: Human renal carcinoma expresses two messages encoding a parathyroid hormone-like peptide: evidence for the alternative splicing of a single-copy gene.
PubMed ID: 3290897
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2744490
Title: Structure of the 5' flanking region of the gene encoding human parathyroid-hormone-related protein (PTHrP).
PubMed ID: 2744490
PubMed ID: 2885845
Title: Parathyroid hormone-related protein purified from a human lung cancer cell line.
PubMed ID: 2885845
PubMed ID: 2928340
Title: Isolation and characterization of the human parathyroid hormone-like peptide gene.
PubMed ID: 2928340
PubMed ID: 1915066
Title: A carboxyl-terminal peptide from the parathyroid hormone-related protein inhibits bone resorption by osteoclasts.
PubMed ID: 1915066
PubMed ID: 1954916
Title: A potent inhibitor of osteoclastic bone resorption within a highly conserved pentapeptide region of parathyroid hormone-related protein; PTHrP107-111.
PubMed ID: 1954916
PubMed ID: 9144344
Title: C-terminal parathyroid hormone-related protein inhibits proliferation and differentiation of human osteoblast-like cells.
PubMed ID: 9144344
PubMed ID: 9048639
Title: Parathyroid hormone-related protein-(107-139) inhibits bone resorption in vivo.
PubMed ID: 9048639
PubMed ID: 12852260
Title: Parathyroid hormone-related protein (PTHrP): a nucleocytoplasmic shuttling protein with distinct paracrine and intracrine roles.
PubMed ID: 12852260
PubMed ID: 11401507
Title: Molecular dissection of the importin beta1-recognized nuclear targeting signal of parathyroid hormone-related protein.
PubMed ID: 11401507
PubMed ID: 12538599
Title: Minireview: parathyroid hormone-related protein as an intracrine factor -- trafficking mechanisms and functional consequences.
PubMed ID: 12538599
PubMed ID: 20637541
Title: PTHrP promotes colon cancer cell migration and invasion in an integrin alpha6beta4-dependent manner through activation of Rac1.
PubMed ID: 20637541
PubMed ID: 10050767
Title: The structure of human parathyroid hormone-related protein(1-34) in near-physiological solution.
PubMed ID: 10050767
PubMed ID: 12504010
Title: Molecular basis for the recognition of a nonclassical nuclear localization signal by importin beta.
PubMed ID: 12504010
PubMed ID: 19674967
Title: Structural basis for parathyroid hormone-related protein binding to the parathyroid hormone receptor and design of conformation-selective peptides.
PubMed ID: 19674967
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
PubMed ID: 20170896
Title: Deletion and point mutations of PTHLH cause brachydactyly type E.
PubMed ID: 20170896
Sequence Information:
- Length: 177
- Mass: 20194
- Checksum: 449FDFEE954C51DB
- Sequence:
MQRRLVQQWS VAVFLLSYAV PSCGRSVEGL SRRLKRAVSE HQLLHDKGKS IQDLRRRFFL HHLIAEIHTA EIRATSEVSP NSKPSPNTKN HPVRFGSDDE GRYLTQETNK VETYKEQPLK TPGKKKKGKP GKRKEQEKKK RRTRSAWLDS GVTGSGLEGD HLSDTSTTSL ELDSRRH
Genular Protein ID: 3182773271
Symbol: Q53XY9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11181995
Sequence Information:
- Length: 175
- Mass: 19901
- Checksum: 4FEE954C51DB3E7D
- Sequence:
MQRRLVQQWS VAVFLLSYAV PSCGRSVEGL SRRLKRAVSE HQLLHDKGKS IQDLRRRFFL HHLIAEIHTA EIRATSEVSP NSKPSPNTKN HPVRFGSDDE GRYLTQETNK VETYKEQPLK TPGKKKKGKP GKRKEQEKKK RRTRSAWLDS GVTGSGLEGD HLSDTSTTSL ELDSR
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.